iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046100

UUCD1 version

UUC-HoS-00323

Ensembl Protein ID

ENSP00000356480.3

UniProt Accession

Q99496; B2RBS7; B3KRH1; Q5TEN1; Q5TEN2; RING2_HUMAN

Genbank Protein ID

CAA71596.1; AAD29717.1; BAG52383.1; BAG37324.1; CAC00611.1; CAI17849.1; CAI17850.1; EAW91187.1; EAW91188.1; AAH12583.1

Protein Name

E3 ubiquitin-protein ligase RING2; Huntingtin-interacting protein 2-interacting protein 3; Protein DinG; RING finger protein 1B; RING finger protein 2; RING finger protein BAP-1; RING-type E3 ubiquitin transferase RING2

Genbank Nucleotide ID

Y10571; AF141327; AK091574; AK314793; AL109865; AL109865; AL109865; CH471067; CH471067; BC012583

Gene Name

RNF2; BAP1; DING; HIPI3; RING1B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000121481.10	ENST00000367510.7	ENSP00000356480.3
ENSG00000121481.10	ENST00000367509.8	ENSP00000356479.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19956605; 19164757; 21245042; 17088979; 26151332
ULD/UDP/UFD/RAWUL	RAWUL	19791798; 23523425

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	5.40e-07	31.7	51	91

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl+++k+   +  C H f+adC+  ++       s++  CP+Cr
   Q: 51   CPICLDMLKNTMTTKECLHRFCADCIiTAL------RSGNKECPTCR 91
           **********555555*********98888......**********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes.

Protein Sequence
(Fasta)

MSQAVQTNGT QPLSKTWELS LYELQRTPQE AITDGLEIVV SPRSLHSELM CPICLDMLKN 60
TMTTKECLHR FCADCIITAL RSGNKECPTC RKKLVSKRSL RPDPNFDALI SKIYPSRDEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGCACCC TCCCTCGCGC CGCGGGCCTC CCCGCGCCGT GCACGTCCTC GTCCCGCGCC 60
TCCGCCCCTC GCTCGCTCGC TCCTTCCCGC CCTCCCCGCA GCGCCGGCCG AGCCGGCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032443--RAWUL
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF16207--RAWUL

SMART

SM00184--RING

Gene Ontology

GO:0000791--C:euchromatin
GO:0071339--C:MLL1 complex
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0001739--C:sex chromatin
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0071535--F:RING-like zinc finger domain binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0009948--P:anterior/posterior axis specification
GO:0001702--P:gastrulation with mouth forming second
GO:0007281--P:germ cell development
GO:0035518--P:histone H2A monoubiquitination
GO:0036353--P:histone H2A-K119 monoubiquitination
GO:0000278--P:mitotic cell cycle
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:6045

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000516	Aegilops tauschii	57.81	7.00e-19	88.60
IUUC-Aml-001250	Ailuropoda melanoleuca	99.10	0.00e+00	692.00
IUUC-Apl-003587	Anas platyrhynchos	98.21	0.00e+00	693.00
IUUC-Aca-004928	Anolis carolinensis	97.62	0.00e+00	691.00
IUUC-Aly-005766	Arabidopsis lyrata	44.55	5.00e-23	102.00
IUUC-Ath-006899	Arabidopsis thaliana	50.00	6.00e-23	102.00
IUUC-Ame-010622	Astyanax mexicanus	89.29	0.00e+00	634.00
IUUC-Bta-013553	Bos taurus	99.40	0.00e+00	701.00
IUUC-Bdi-014202	Brachypodium distachyon	55.42	2.00e-24	107.00
IUUC-Bol-015993	Brassica oleracea	48.94	7.00e-24	105.00
IUUC-Bra-017150	Brassica rapa	48.04	6.00e-24	105.00
IUUC-Cja-019093	Callithrix jacchus	99.70	0.00e+00	702.00
IUUC-Cfa-020681	Canis familiaris	99.11	0.00e+00	696.00
IUUC-Cpo-021402	Cavia porcellus	84.23	8.00e-162	562.00
IUUC-Cre-022709	Chlamydomonas reinhardtii	35.48	5.00e-07	49.70
IUUC-Csa-024231	Chlorocebus sabaeus	100.00	0.00e+00	704.00
IUUC-Cho-024843	Choloepus hoffmanni	84.23	4.00e-163	566.00
IUUC-Csv-026314	Ciona savignyi	47.03	1.00e-82	300.00
IUUC-Dre-027685	Danio rerio	89.29	0.00e+00	634.00
IUUC-Dno-029993	Dasypus novemcinctus	98.51	0.00e+00	696.00
IUUC-Dor-030986	Dipodomys ordii	71.43	2.00e-132	465.00
IUUC-Dme-031721	Drosophila melanogaster	78.91	8.00e-68	251.00
IUUC-Ete-032564	Echinops telfairi	82.14	2.00e-160	558.00
IUUC-Eca-033251	Equus caballus	99.40	0.00e+00	701.00
IUUC-Eeu-034951	Erinaceus europaeus	99.40	0.00e+00	701.00
IUUC-Fca-036240	Felis catus	99.11	0.00e+00	695.00
IUUC-Fal-037376	Ficedula albicollis	97.92	0.00e+00	692.00
IUUC-Gmo-038879	Gadus morhua	85.55	5.00e-166	576.00
IUUC-Gga-041134	Gallus gallus	97.92	0.00e+00	692.00
IUUC-Gac-042589	Gasterosteus aculeatus	85.88	1.00e-167	582.00
IUUC-Gma-044386	Glycine max	33.77	2.00e-23	103.00
IUUC-Ggo-044529	Gorilla gorilla	100.00	0.00e+00	704.00
IUUC-Hvu-047152	Hordeum vulgare	54.22	5.00e-24	105.00
IUUC-Itr-047891	Ictidomys tridecemlineatus	99.11	0.00e+00	699.00
IUUC-Lch-049494	Latimeria chalumnae	89.88	6.00e-178	616.00
IUUC-Lpe-050923	Leersia perrieri	44.35	6.00e-25	108.00
IUUC-Loc-052544	Lepisosteus oculatus	88.30	0.00e+00	630.00
IUUC-Laf-053675	Loxodonta africana	99.03	0.00e+00	635.00
IUUC-Mcc-055685	Macaca mulatta	100.00	0.00e+00	703.00
IUUC-Mtr-058234	Medicago truncatula	50.60	1.00e-23	104.00
IUUC-Mga-059354	Meleagris gallopavo	98.21	0.00e+00	694.00
IUUC-Mmr-060809	Microcebus murinus	99.70	0.00e+00	702.00
IUUC-Mdo-062206	Monodelphis domestica	98.81	0.00e+00	698.00
IUUC-Mmu-063715	Mus musculus	99.70	0.00e+00	702.00
IUUC-Mpu-066460	Mustela putorius furo	99.40	0.00e+00	701.00
IUUC-Mlu-067743	Myotis lucifugus	99.40	0.00e+00	701.00
IUUC-Nle-069512	Nomascus leucogenys	100.00	0.00e+00	704.00
IUUC-Opr-070807	Ochotona princeps	98.90	1.00e-105	376.00
IUUC-Ont-072541	Oreochromis niloticus	86.26	1.00e-169	588.00
IUUC-Oan-073454	Ornithorhynchus anatinus	98.81	0.00e+00	697.00
IUUC-Ocu-073981	Oryctolagus cuniculus	99.11	0.00e+00	700.00
IUUC-Oba-075605	Oryza barthii	53.01	1.00e-23	105.00
IUUC-Obr-076282	Oryza brachyantha	44.35	4.00e-25	109.00
IUUC-Ogl-077288	Oryza glaberrima	43.48	9.00e-25	108.00
IUUC-Ogu-078992	Oryza glumaepatula	53.01	1.00e-23	104.00
IUUC-Oin-079939	Oryza indica	43.48	8.00e-25	108.00
IUUC-Olo-080262	Oryza longistaminata	45.22	3.00e-25	110.00
IUUC-Ome-081418	Oryza meridionalis	44.35	5.00e-25	108.00
IUUC-Oni-083103	Oryza nivara	43.48	9.00e-25	108.00
IUUC-Opu-083314	Oryza punctata	44.35	7.00e-25	108.00
IUUC-Oru-084356	Oryza rufipogon	51.81	2.00e-23	104.00
IUUC-Osa-085727	Oryza sativa	43.48	8.00e-25	108.00
IUUC-Ola-086937	Oryzias latipes	87.24	2.00e-169	588.00
IUUC-Oga-089078	Otolemur garnettii	84.55	4.00e-119	419.00
IUUC-Oar-089823	Ovis aries	99.40	0.00e+00	700.00
IUUC-Ptr-090557	Pan troglodytes	100.00	0.00e+00	704.00
IUUC-Pan-091950	Papio anubis	100.00	0.00e+00	704.00
IUUC-Psi-093349	Pelodiscus sinensis	97.92	0.00e+00	692.00
IUUC-Ppa-095164	Physcomitrella patens	58.21	6.00e-22	98.60
IUUC-Pfo-096803	Poecilia formosa	85.96	2.00e-168	584.00
IUUC-Pab-098392	Pongo abelii	99.11	0.00e+00	699.00
IUUC-Pop-100011	Populus trichocarpa	50.52	4.00e-25	109.00
IUUC-Pca-100946	Procavia capensis	98.81	3.00e-150	523.00
IUUC-Ppe-101894	Prunus persica	61.82	2.00e-17	83.20
IUUC-Pva-102498	Pteropus vampyrus	99.25	1.00e-77	283.00
IUUC-Rno-105492	Rattus norvegicus	99.70	0.00e+00	702.00
IUUC-Sha-107645	Sarcophilus harrisii	98.51	0.00e+00	697.00
IUUC-Sit-109707	Setaria italica	44.35	2.00e-25	110.00
IUUC-Sly-111537	Solanum lycopersicum	54.41	4.00e-19	89.40
IUUC-Sar-113064	Sorex araneus	97.62	4.00e-72	264.00
IUUC-Sbi-114798	Sorghum bicolor	43.48	2.00e-24	107.00
IUUC-Ssc-115830	Sus scrofa	99.40	0.00e+00	700.00
IUUC-Tgu-116694	Taeniopygia guttata	98.51	0.00e+00	696.00
IUUC-Tru-117837	Takifugu rubripes	85.67	2.00e-167	581.00
IUUC-Tsy-119174	Tarsius syrichta	97.92	0.00e+00	686.00
IUUC-Tni-120389	Tetraodon nigroviridis	85.71	1.00e-166	578.00
IUUC-Tca-121428	Theobroma cacao	32.69	1.00e-24	107.00
IUUC-Tae-125498	Triticum aestivum	54.22	4.00e-24	106.00
IUUC-Tur-126796	Triticum urartu	54.22	5.00e-24	105.00
IUUC-Tbe-127428	Tupaia belangeri	98.90	1.00e-105	375.00
IUUC-Ttr-128796	Tursiops truncatus	99.11	0.00e+00	699.00
IUUC-Vpa-130691	Vicugna pacos	99.40	0.00e+00	701.00
IUUC-Vvi-131143	Vitis vinifera	42.42	3.00e-25	109.00
IUUC-Xtr-132022	Xenopus tropicalis	93.75	0.00e+00	665.00
IUUC-Xma-133424	Xiphophorus maculatus	85.67	2.00e-168	585.00
IUUC-Yli-134563	Yarrowia lipolytica	41.07	9.00e-07	47.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence