iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000147010.17	ENST00000397821.7	ENSP00000380921.3
ENSG00000147010.17	ENST00000379716.5	ENSP00000369039.1
ENSG00000147010.17	ENST00000379698.8	ENSP00000369020.4
ENSG00000147010.17	ENST00000379726.7	ENSP00000369049.3
ENSG00000147010.17	ENST00000379697.7	ENSP00000369019.3
ENSG00000147010.17	ENST00000432234.5	ENSP00000388766.1
ENSG00000147010.17	ENST00000431164.1	ENSP00000409292.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/SH3	SH3	17244534

Classification

Family	E-value	Score	Start	End
UBD/SH3	3.50e-67	223.9	268	326

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           sk++++v+++yeaqnddeLt+k+Gd+v++i+k++ d gW++g  el+g+rG+fP+nFv+ l
   Q: 268  SKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEG--ELNGRRGVFPDNFVKLL 326
           799***************************************..9*************976 PP

Organism

Homo sapiens

Functional Description
(View)

Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.

Protein Sequence
(Fasta)

MVEAIVEFDY QAQHDDELTI SVGEIITNIR KEDGGWWEGQ INGRRGLFPD NFVREIKKEM 60
KKDPLTNKAP EKPLHEVPSG NSLLSSETIL RTNKRGERRR RRCQVAFSYL PQNDDELELK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCAATTTCC ACTCGCGGGG AGCAGGAAAC CCGGCGCAGC CGGGCGCATT GGGCCGCGAT 60
GCAACAGCAG CAGCAGGAGT CGCCCCGGGG CAGCAGCGGC AGCAGCAGCA GAGGCAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0965--Cell junction
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0729--SH3-binding
KW-0770--Synapse
KW-0771--Synaptosome
KW-0832--Ubl conjugation

Interpro

IPR001452--SH3_domain

PROSITE

PS50002--SH3

Pfam

PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0030139--C:endocytic vesicle
GO:0005925--C:focal adhesion
GO:0043005--C:neuron projection
GO:0005886--C:plasma membrane
GO:0045202--C:synapse
GO:0006915--P:apoptotic process
GO:0016477--P:cell migration
GO:0007267--P:cell-cell signaling
GO:0007010--P:cytoskeleton organization
GO:0006897--P:endocytosis
GO:0061024--P:membrane organization
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0008360--P:regulation of cell shape

KEGG

hsa:30011

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001438	Ailuropoda melanoleuca	95.04	0.00e+00	962.00
IUUC-Aca-004302	Anolis carolinensis	66.25	0.00e+00	716.00
IUUC-Ame-011445	Astyanax mexicanus	57.98	5.00e-101	362.00
IUUC-Bta-013116	Bos taurus	95.85	0.00e+00	860.00
IUUC-Cel-018134	Caenorhabditis elegans	53.57	2.00e-14	74.30
IUUC-Cja-019960	Callithrix jacchus	99.26	0.00e+00	840.00
IUUC-Cfa-020798	Canis familiaris	96.25	0.00e+00	979.00
IUUC-Cpo-021383	Cavia porcellus	96.24	0.00e+00	996.00
IUUC-Csa-023514	Chlorocebus sabaeus	93.35	0.00e+00	999.00
IUUC-Cho-024892	Choloepus hoffmanni	59.85	2.00e-97	350.00
IUUC-Cin-025203	Ciona intestinalis	60.34	8.00e-15	74.70
IUUC-Dre-028767	Danio rerio	48.66	5.00e-105	375.00
IUUC-Dno-029821	Dasypus novemcinctus	88.84	0.00e+00	806.00
IUUC-Dor-030415	Dipodomys ordii	81.80	0.00e+00	777.00
IUUC-Dme-032184	Drosophila melanogaster	39.74	1.00e-29	125.00
IUUC-Ete-032658	Echinops telfairi	71.52	4.00e-88	318.00
IUUC-Eca-033923	Equus caballus	89.50	0.00e+00	853.00
IUUC-Eeu-034514	Erinaceus europaeus	86.94	0.00e+00	817.00
IUUC-Fca-036452	Felis catus	86.96	0.00e+00	778.00
IUUC-Fal-036800	Ficedula albicollis	74.13	0.00e+00	804.00
IUUC-Gmo-039271	Gadus morhua	42.69	5.00e-84	305.00
IUUC-Gga-041020	Gallus gallus	76.65	0.00e+00	775.00
IUUC-Gac-041864	Gasterosteus aculeatus	48.76	3.00e-100	359.00
IUUC-Ggo-045320	Gorilla gorilla	99.70	0.00e+00	1006.00
IUUC-Itr-048261	Ictidomys tridecemlineatus	72.55	2.00e-74	272.00
IUUC-Lch-049490	Latimeria chalumnae	53.95	3.00e-74	272.00
IUUC-Loc-052903	Lepisosteus oculatus	60.65	8.00e-93	334.00
IUUC-Laf-053962	Loxodonta africana	88.70	0.00e+00	939.00
IUUC-Mcc-055767	Macaca mulatta	93.09	0.00e+00	984.00
IUUC-Meu-056289	Macropus eugenii	75.15	0.00e+00	750.00
IUUC-Mga-060121	Meleagris gallopavo	68.32	2.00e-174	605.00
IUUC-Mmr-061156	Microcebus murinus	89.10	0.00e+00	931.00
IUUC-Mdo-062586	Monodelphis domestica	86.06	0.00e+00	865.00
IUUC-Mmu-063884	Mus musculus	88.29	0.00e+00	956.00
IUUC-Mpu-065723	Mustela putorius furo	88.74	0.00e+00	932.00
IUUC-Mlu-068066	Myotis lucifugus	88.31	0.00e+00	747.00
IUUC-Nle-069669	Nomascus leucogenys	95.49	0.00e+00	922.00
IUUC-Ont-071437	Oreochromis niloticus	52.11	7.00e-89	321.00
IUUC-Oan-073557	Ornithorhynchus anatinus	77.14	0.00e+00	768.00
IUUC-Ocu-073825	Oryctolagus cuniculus	95.93	0.00e+00	961.00
IUUC-Oga-088075	Otolemur garnettii	89.47	0.00e+00	794.00
IUUC-Oar-090245	Ovis aries	87.21	0.00e+00	798.00
IUUC-Pan-092138	Papio anubis	96.04	0.00e+00	881.00
IUUC-Psi-093515	Pelodiscus sinensis	77.15	0.00e+00	672.00
IUUC-Pma-094757	Petromyzon marinus	41.32	1.00e-30	126.00
IUUC-Pfo-096776	Poecilia formosa	52.60	2.00e-94	340.00
IUUC-Pab-097832	Pongo abelii	99.70	0.00e+00	1000.00
IUUC-Pca-100541	Procavia capensis	81.00	0.00e+00	788.00
IUUC-Pva-102718	Pteropus vampyrus	90.09	0.00e+00	864.00
IUUC-Rno-105482	Rattus norvegicus	90.79	0.00e+00	950.00
IUUC-Sha-106922	Sarcophilus harrisii	80.66	0.00e+00	682.00
IUUC-Sar-113614	Sorex araneus	83.22	8.00e-149	520.00
IUUC-Ssc-115772	Sus scrofa	90.00	0.00e+00	976.00
IUUC-Tgu-116556	Taeniopygia guttata	77.66	0.00e+00	793.00
IUUC-Tru-117631	Takifugu rubripes	51.69	1.00e-82	300.00
IUUC-Tsy-118989	Tarsius syrichta	91.09	0.00e+00	707.00
IUUC-Tni-120756	Tetraodon nigroviridis	52.46	7.00e-83	301.00
IUUC-Tbe-128043	Tupaia belangeri	93.15	0.00e+00	896.00
IUUC-Ttr-128634	Tursiops truncatus	96.39	0.00e+00	997.00
IUUC-Vpa-130612	Vicugna pacos	77.58	5.00e-131	461.00
IUUC-Xtr-132711	Xenopus tropicalis	60.93	3.00e-140	491.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence