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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018266
Ensembl Protein ID K11D12.10c
UniProt Accession A0A0K3AV08; A0A0K3AS83; H2KYR3; Q8T7Z0; MLK1_CAEEL
Genbank Protein ID CCD64404.1; CCD64405.1; CTQ86850.1; CTQ86851.1
Protein Name Mitogen-activated protein kinase kinase kinase mlk-1; Mixed lineage kinase homolog 1
Genbank Nucleotide ID BX284605; BX284605; BX284605; BX284605
Gene Name mlk-1; K11D12.10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00003374 K11D12.10a K11D12.10a
WBGene00003374 K11D12.10b K11D12.10b
WBGene00003374 K11D12.10c K11D12.10c
WBGene00003374 K11D12.10d K11D12.10d
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Post-translational Modifications (PTMs)
UniProt
Protein Expression/Proteomics
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.20e-14 54.2 72 128
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           + + + y+yeaq+ddeL+l  G +++++  e+++ gW +g  el+gk GlfP+n+ +++
   Q: 72   KAFVASYEYEAQKDDELNLPLGAIITLVTVETNEDGWYRG--ELNGKVGLFPSNYAREV 128
           567899**********************************..9*************998 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Serine/threonine-protein kinase which, by phosphorylating and activating mek-1, plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1 (PubMed:15116070, PubMed:20008556). Involved in the response to environmental stress such as heavy metals (PubMed:15116070, PubMed:18809575). By activating the JNK pathway downstream of tyrosine receptor svh-2, plays a role in axon regeneration after injury (PubMed:21670305, PubMed:23072806, PubMed:22388962).
 Serine/threonine-protein kinase which, by phosphorylating and activating mek-1, plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1 (PubMed:15116070, PubMed:20008556). Involved in the response to environmental stress such as heavy metals (PubMed:15116070, PubMed:18809575). By activating the JNK pathway downstream of tyrosine receptor svh-2, plays a role in axon regeneration after injury (PubMed:21670305, PubMed:23072806, PubMed:22388962).
Protein Sequence
(Fasta)
MEQASVPSYV NIPPIAKTRS TSHLAPTPEH HRSVSYEDTT TASTSTDSVP EVRIRSESSQ 60
VSRESPPIRA SKAFVASYEY EAQKDDELNL PLGAIITLVT VETNEDGWYR GELNGKVGLF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018266|UBD,SH3|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATACGAGTAG AGTCACGGGA CACACAATGG AACAGGCTTC GGTCCCGTCT TACGTGAACA 60
TTCCACCAAT AGCCAAAAGT GAGTTTTCAT TTATTGTATC AATGAGAAAA ATGTTAAATA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018266|UBD,SH3|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0346--Stress response
KW-0808--Transferase
KW-0832--Ubl conjugation
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain
PROSITE

PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF14604--SH3_9
SMART

SM00220--S_TKc
SM00326--SH3
Gene Ontology

GO:0005622--C:intracellular
GO:0005524--F:ATP binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0046872--F:metal ion binding
GO:0019901--F:protein kinase binding
GO:0031103--P:axon regeneration
GO:0008340--P:determination of adult lifespan
GO:1903616--P:MAPK cascade involved in axon regeneration
GO:0048691--P:positive regulation of axon extension involved in regeneration
GO:0006468--P:protein phosphorylation
GO:0046688--P:response to copper ion
GO:0042594--P:response to starvation
KEGG cel:CELE_K11D12.10
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001439 Ailuropoda melanoleuca 32.00 7.00e-56 211.00
IUUC-Aca-004389 Anolis carolinensis 31.84 4.00e-55 208.00
IUUC-Ago-007935 Ashbya gossypii 47.17 8.00e-09 54.30
IUUC-Ame-011769 Astyanax mexicanus 32.82 8.00e-57 214.00
IUUC-Bta-012675 Bos taurus 31.84 7.00e-56 211.00
IUUC-Cja-018922 Callithrix jacchus 32.20 8.00e-56 211.00
IUUC-Cfa-020962 Canis familiaris 37.24 3.00e-39 156.00
IUUC-Cpo-021603 Cavia porcellus 31.96 1.00e-56 213.00
IUUC-Csa-023806 Chlorocebus sabaeus 31.57 1.00e-54 206.00
IUUC-Csv-026102 Ciona savignyi 32.34 3.00e-57 214.00
IUUC-Dre-027645 Danio rerio 31.74 7.00e-56 211.00
IUUC-Dno-029040 Dasypus novemcinctus 31.31 4.00e-57 215.00
IUUC-Dor-030866 Dipodomys ordii 37.29 3.00e-40 159.00
IUUC-Dme-032210 Drosophila melanogaster 31.68 6.00e-52 198.00
IUUC-Eca-033782 Equus caballus 32.65 6.00e-33 134.00
IUUC-Fca-035440 Felis catus 32.74 3.00e-43 169.00
IUUC-Fal-036753 Ficedula albicollis 31.74 4.00e-56 212.00
IUUC-Gmo-039264 Gadus morhua 34.55 8.00e-55 207.00
IUUC-Gga-040283 Gallus gallus 31.51 1.00e-55 210.00
IUUC-Gac-042299 Gasterosteus aculeatus 31.09 1.00e-54 206.00
IUUC-Ggo-044795 Gorilla gorilla 32.48 9.00e-43 167.00
IUUC-Hsa-045938 Homo sapiens 31.84 6.00e-56 211.00
IUUC-Itr-048561 Ictidomys tridecemlineatus 38.14 2.00e-42 166.00
IUUC-Lch-049585 Latimeria chalumnae 30.98 5.00e-55 208.00
IUUC-Loc-052411 Lepisosteus oculatus 31.16 9.00e-55 207.00
IUUC-Laf-053926 Loxodonta africana 31.61 4.00e-54 205.00
IUUC-Mcc-055636 Macaca mulatta 31.84 5.00e-56 211.00
IUUC-Meu-056762 Macropus eugenii 32.63 4.00e-49 188.00
IUUC-Mmr-061210 Microcebus murinus 31.69 9.00e-56 211.00
IUUC-Mdo-062056 Monodelphis domestica 32.51 8.00e-56 211.00
IUUC-Mmu-063275 Mus musculus 31.84 9.00e-56 211.00
IUUC-Mpu-066569 Mustela putorius furo 32.74 2.00e-43 169.00
IUUC-Mlu-067856 Myotis lucifugus 32.13 2.00e-55 209.00
IUUC-Nle-068969 Nomascus leucogenys 32.00 2.00e-55 210.00
IUUC-Opr-070869 Ochotona princeps 29.49 9.00e-44 171.00
IUUC-Ont-071274 Oreochromis niloticus 28.93 5.00e-57 214.00
IUUC-Ocu-074362 Oryctolagus cuniculus 30.28 1.00e-43 170.00
IUUC-Ola-087339 Oryzias latipes 34.00 2.00e-54 206.00
IUUC-Oga-088123 Otolemur garnettii 31.66 1.00e-55 210.00
IUUC-Oar-089467 Ovis aries 32.90 2.00e-44 172.00
IUUC-Ptr-091156 Pan troglodytes 32.43 7.00e-57 214.00
IUUC-Pan-091971 Papio anubis 31.84 5.00e-56 211.00
IUUC-Psi-093760 Pelodiscus sinensis 34.29 1.00e-51 196.00
IUUC-Pma-094398 Petromyzon marinus 32.73 3.00e-48 186.00
IUUC-Pfo-096248 Poecilia formosa 32.01 4.00e-55 209.00
IUUC-Pab-097753 Pongo abelii 31.84 9.00e-56 211.00
IUUC-Pca-100945 Procavia capensis 31.56 6.00e-35 141.00
IUUC-Pva-102748 Pteropus vampyrus 31.40 4.00e-56 212.00
IUUC-Rno-105729 Rattus norvegicus 32.06 8.00e-57 214.00
IUUC-Ssc-115831 Sus scrofa 31.04 2.00e-45 176.00
IUUC-Tru-117957 Takifugu rubripes 31.68 1.00e-54 207.00
IUUC-Tni-120577 Tetraodon nigroviridis 31.58 2.00e-56 212.00
IUUC-Tbe-128153 Tupaia belangeri 33.94 6.00e-55 208.00
IUUC-Ttr-128550 Tursiops truncatus 30.00 5.00e-49 188.00
IUUC-Xtr-131880 Xenopus tropicalis 33.68 3.00e-56 212.00
Created Date 25-Jun-2017

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