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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045868
UUCD1 version UUC-HoS-00309
Ensembl Protein ID ENSP00000312634.7
UniProt Accession Q96JY6; D3DSR5; J3KNH4; Q7Z584; Q86WM8; Q8WZ29; Q9H4L9; Q9H7I2; PDLI2_HUMAN
Genbank Protein ID AAG16633.1; AAL65265.1; AAO45102.1; AAL55747.1; BAB15788.1; BAB55378.1; EAW63667.1; EAW63669.1; AAH21556.1; AAH71774.1
Protein Name PDZ and LIM domain protein 2; PDZ-LIM protein mystique
Genbank Nucleotide ID AY007729; AY070438; AY217349; AF289563; AK024498; AK027800; AC037459; CH471080; BC021556; BC071774
Gene Name PDLIM2; PP6345
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000120913.23 ENST00000308354.11 ENSP00000312634.7
ENSG00000120913.23 ENST00000409141.5 ENSP00000386868.1
ENSG00000120913.23 ENST00000265810.8 ENSP00000265810.4
ENSG00000120913.23 ENST00000416159.5 ENSP00000412936.1
ENSG00000120913.23 ENST00000448520.5 ENSP00000481074.1
ENSG00000120913.23 ENST00000622702.1 ENSP00000479453.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 17468759; 20889505
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/Other 74.52 2.00e-117 420.00 IUUC-Mmu-063244
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
 Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
Protein Sequence
(Fasta)
MRGGRARPAW ESFMGLPPRS SAKWGAGQSL DRLCCAPGSR GLAGAPGRMR APPAGRSQPA 60
GGPGDSLPHP PGGLGPGGSA WARRAEAAAS RARGGGRGGP GITWAEAGPG APGGLSPESG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045868|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACGAGAGGCG GCTCTATGGC CTTGAGGTCC CCGGAGAGAG GGTTGCCAGG TACGGCTTCT 60
CCTCCCCGAG CTGGCACCGG GGTCCCCTCC TTGGCTGCCC TCTCCTCATC CTTATAGCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045868|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0440--LIM domain
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
Interpro

IPR031847--DUF4749
IPR001478--PDZ
IPR001781--Znf_LIM
PROSITE

PS00478--LIM_DOMAIN_1
PS50023--LIM_DOMAIN_2
PS50106--PDZ
Pfam

PF15936--DUF4749
PF00412--LIM
PF00595--PDZ
SMART

SM00132--LIM
SM00228--PDZ
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
KEGG hsa:64236
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000431 Aegilops tauschii 32.73 1.30e+00 25.00
IUUC-Aml-001484 Ailuropoda melanoleuca 81.20 6.00e-133 467.00
IUUC-Aca-004512 Anolis carolinensis 52.25 5.00e-85 308.00
IUUC-Ame-011626 Astyanax mexicanus 44.82 1.00e-73 270.00
IUUC-Bta-012510 Bos taurus 75.84 9.00e-121 426.00
IUUC-Cja-019248 Callithrix jacchus 92.09 1.00e-149 522.00
IUUC-Cfa-020352 Canis familiaris 79.49 7.00e-133 466.00
IUUC-Cpo-021995 Cavia porcellus 83.63 2.00e-62 233.00
IUUC-Csa-024190 Chlorocebus sabaeus 98.01 1.00e-152 532.00
IUUC-Dre-027418 Danio rerio 41.85 2.00e-64 239.00
IUUC-Dor-030439 Dipodomys ordii 66.37 1.00e-75 276.00
IUUC-Dme-031753 Drosophila melanogaster 39.47 1.00e-11 64.30
IUUC-Eca-034183 Equus caballus 80.79 4.00e-132 464.00
IUUC-Eeu-034958 Erinaceus europaeus 77.18 3.00e-86 311.00
IUUC-Fca-035680 Felis catus 83.47 7.00e-134 470.00
IUUC-Fal-037626 Ficedula albicollis 32.35 7.00e-07 49.70
IUUC-Gmo-038558 Gadus morhua 54.01 4.00e-41 161.00
IUUC-Gac-041738 Gasterosteus aculeatus 42.74 9.00e-67 247.00
IUUC-Ggo-044609 Gorilla gorilla 99.15 8.00e-156 543.00
IUUC-Itr-048876 Ictidomys tridecemlineatus 84.27 1.00e-130 459.00
IUUC-Loc-052212 Lepisosteus oculatus 45.94 2.00e-74 272.00
IUUC-Laf-053824 Loxodonta africana 83.33 3.00e-128 451.00
IUUC-Mcc-054962 Macaca mulatta 98.01 1.00e-152 532.00
IUUC-Meu-056007 Macropus eugenii 87.01 8.00e-38 151.00
IUUC-Mmr-060607 Microcebus murinus 86.72 2.00e-131 462.00
IUUC-Mdo-062935 Monodelphis domestica 73.48 2.00e-51 196.00
IUUC-Mmu-063244 Mus musculus 72.88 4.00e-125 441.00
IUUC-Mpu-065888 Mustela putorius furo 84.18 5.00e-123 434.00
IUUC-Mlu-067124 Myotis lucifugus 84.27 1.00e-143 502.00
IUUC-Ncr-068674 Neurospora crassa 40.35 4.00e-07 50.40
IUUC-Nle-069063 Nomascus leucogenys 98.30 8.00e-113 399.00
IUUC-Opr-071221 Ochotona princeps 76.30 8.00e-117 414.00
IUUC-Ont-072000 Oreochromis niloticus 54.62 8.00e-43 167.00
IUUC-Oan-073012 Ornithorhynchus anatinus 60.11 1.00e-87 316.00
IUUC-Ocu-074376 Oryctolagus cuniculus 77.68 1.00e-120 426.00
IUUC-Ola-086915 Oryzias latipes 43.79 3.00e-67 248.00
IUUC-Oga-088393 Otolemur garnettii 84.03 1.00e-130 459.00
IUUC-Oar-089421 Ovis aries 75.84 3.00e-126 444.00
IUUC-Ptr-091089 Pan troglodytes 99.39 8.00e-137 479.00
IUUC-Pan-092163 Papio anubis 97.73 2.00e-142 498.00
IUUC-Psi-093043 Pelodiscus sinensis 45.40 3.00e-64 238.00
IUUC-Pno-094933 Phaeosphaeria nodorum 25.00 4.00e-04 40.00
IUUC-Pfo-096885 Poecilia formosa 55.38 9.00e-41 160.00
IUUC-Pab-097988 Pongo abelii 98.47 1.00e-135 476.00
IUUC-Pca-100131 Procavia capensis 63.64 1.00e-147 516.00
IUUC-Pva-102706 Pteropus vampyrus 66.67 2.00e-135 476.00
IUUC-Pte-104256 Pyrenophora teres 35.19 4.00e-06 47.00
IUUC-Pyt-104720 Pyrenophora triticirepentis 35.19 1.00e-05 44.30
IUUC-Rno-104992 Rattus norvegicus 71.47 3.00e-119 421.00
IUUC-Sha-107463 Sarcophilus harrisii 63.87 2.00e-73 268.00
IUUC-Sar-113038 Sorex araneus 39.56 1.00e-16 82.00
IUUC-Sre-115199 Sporisorium reilianum 32.20 2.60e-02 34.70
IUUC-Ssc-115811 Sus scrofa 80.78 1.00e-125 442.00
IUUC-Tbe-127240 Tupaia belangeri 60.91 2.00e-73 269.00
IUUC-Ttr-128236 Tursiops truncatus 62.96 1.00e-114 406.00
IUUC-Uma-129653 Ustilago maydis 29.31 5.50e-02 33.90
IUUC-Vpa-130569 Vicugna pacos 68.70 1.00e-64 239.00
Created Date 25-Jun-2017

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