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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046886
Ensembl Protein ID ENSP00000222823.4
UniProt Accession Q9Y239; B4DTU3; Q549U4; Q8IWF5; NOD1_HUMAN
Genbank Protein ID AAD29125.1; AAD43922.1; AAD28350.1; BAG62105.1; AAS46897.1; AAH40339.1
Protein Name Nucleotide-binding oligomerization domain-containing protein 1; Caspase recruitment domain-containing protein 4
Genbank Nucleotide ID AF126484; AF149774; AF113925; AK300367; AC005154; BC040339
Gene Name NOD1; CARD4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000106100.10 ENST00000222823.8 ENSP00000222823.4
ENSG00000106100.10 ENST00000434755.5 ENSP00000416946.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmicroRNATRANSFACTargetScan
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/CARD CARD 23300079
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.
 Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathway activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB. Recruits NLRP10 to the cell membrane following bacterial infection.
Protein Sequence
(Fasta)
MEEQGHSEME IIPSESHPHI QLLKSNRELL VTHIRNTQCL VDNLLKNDYF SAEDAEIVCA 60
CPTQPDKVRK ILDLVQSKGE EVSEFFLYLL QQLADAYVDL RPWLLEIGFS PSLLTQSKVV 120
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Protein Fasta Sequence


>IUUC-Hsa-046886|UBD,CARD|Homo sapiens
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Nucleotide Sequence
(Fasta)
AGTTCCCGTT CCGGGCCCGC GAGGCAGCCG CCCCGGTCCT GCCCCTCCCT CGCGCTACTG 60
CGGGAGCAGC GTCCTCCCGG GCCACGGCGC TTCCCGGCCC CGGCGTCCCC GGACCATGGC 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046886|UBD,CARD|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-0433--Leucine-rich repeat
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
Interpro

IPR007109--Brix
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
PROSITE

PS50209--CARD
PS50837--NACHT
Pfam

PF00619--CARD
PF13516--LRR_6
Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0016323--C:basolateral plasma membrane
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0050700--F:CARD domain binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0042802--F:identical protein binding
GO:0042834--F:peptidoglycan binding
GO:0042803--F:protein homodimerization activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0000187--P:activation of MAPK activity
GO:0006915--P:apoptotic process
GO:0071225--P:cellular response to muramyl dipeptide
GO:0006952--P:defense response
GO:0042742--P:defense response to bacterium
GO:0050830--P:defense response to Gram-positive bacterium
GO:0016045--P:detection of bacterium
GO:0009595--P:detection of biotic stimulus
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0042228--P:interleukin-8 biosynthetic process
GO:0035556--P:intracellular signal transduction
GO:0007254--P:JNK cascade
GO:0070423--P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0002606--P:positive regulation of dendritic cell antigen processing and presentation
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032731--P:positive regulation of interleukin-1 beta production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0051000--P:positive regulation of nitric-oxide synthase activity
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:1904417--P:positive regulation of xenophagy
GO:0016579--P:protein deubiquitination
GO:0051259--P:protein oligomerization
GO:0007165--P:signal transduction
KEGG hsa:10392
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001299 Ailuropoda melanoleuca 82.79 0.00e+00 1415.00
IUUC-Apl-003908 Anas platyrhynchos 62.37 0.00e+00 1148.00
IUUC-Aca-005144 Anolis carolinensis 60.81 0.00e+00 1125.00
IUUC-Ame-010829 Astyanax mexicanus 51.26 0.00e+00 897.00
IUUC-Bta-013358 Bos taurus 83.23 0.00e+00 1491.00
IUUC-Cja-019392 Callithrix jacchus 94.02 0.00e+00 1702.00
IUUC-Cfa-020776 Canis familiaris 83.84 0.00e+00 1474.00
IUUC-Cpo-021393 Cavia porcellus 79.77 0.00e+00 1464.00
IUUC-Csa-023872 Chlorocebus sabaeus 97.06 0.00e+00 1781.00
IUUC-Cho-024569 Choloepus hoffmanni 74.12 0.00e+00 629.00
IUUC-Dre-027478 Danio rerio 50.85 0.00e+00 874.00
IUUC-Dno-029231 Dasypus novemcinctus 83.84 0.00e+00 1531.00
IUUC-Dor-030251 Dipodomys ordii 57.55 8.00e-156 544.00
IUUC-Ete-032484 Echinops telfairi 73.30 0.00e+00 778.00
IUUC-Eca-033564 Equus caballus 86.33 0.00e+00 1556.00
IUUC-Eeu-034456 Erinaceus europaeus 66.75 3.00e-141 495.00
IUUC-Fca-036372 Felis catus 83.00 0.00e+00 1483.00
IUUC-Fal-037418 Ficedula albicollis 62.53 0.00e+00 1141.00
IUUC-Gmo-038740 Gadus morhua 50.81 0.00e+00 894.00
IUUC-Gga-040775 Gallus gallus 62.53 0.00e+00 1176.00
IUUC-Gac-041612 Gasterosteus aculeatus 49.69 0.00e+00 899.00
IUUC-Ggo-045161 Gorilla gorilla 99.88 0.00e+00 1557.00
IUUC-Itr-048414 Ictidomys tridecemlineatus 85.59 0.00e+00 1630.00
IUUC-Lch-049764 Latimeria chalumnae 58.90 0.00e+00 1016.00
IUUC-Loc-052143 Lepisosteus oculatus 54.30 0.00e+00 1001.00
IUUC-Laf-053503 Loxodonta africana 82.98 0.00e+00 1514.00
IUUC-Mcc-054992 Macaca mulatta 96.43 0.00e+00 1773.00
IUUC-Meu-056406 Macropus eugenii 62.86 0.00e+00 1107.00
IUUC-Mga-059351 Meleagris gallopavo 61.88 0.00e+00 1172.00
IUUC-Mmr-061537 Microcebus murinus 86.15 0.00e+00 1496.00
IUUC-Mdo-061832 Monodelphis domestica 65.08 0.00e+00 1078.00
IUUC-Mmu-064282 Mus musculus 81.63 0.00e+00 1496.00
IUUC-Mpu-066399 Mustela putorius furo 84.05 0.00e+00 1509.00
IUUC-Mlu-067265 Myotis lucifugus 81.62 0.00e+00 1446.00
IUUC-Nle-069078 Nomascus leucogenys 97.17 0.00e+00 1778.00
IUUC-Opr-070946 Ochotona princeps 74.77 0.00e+00 1359.00
IUUC-Ont-071355 Oreochromis niloticus 49.16 0.00e+00 900.00
IUUC-Oan-072937 Ornithorhynchus anatinus 73.78 0.00e+00 1365.00
IUUC-Ocu-073815 Oryctolagus cuniculus 81.74 0.00e+00 1540.00
IUUC-Ola-087381 Oryzias latipes 49.30 0.00e+00 871.00
IUUC-Oga-088725 Otolemur garnettii 85.31 0.00e+00 1572.00
IUUC-Oar-090401 Ovis aries 80.92 0.00e+00 1503.00
IUUC-Ptr-090590 Pan troglodytes 99.58 0.00e+00 1825.00
IUUC-Pan-091765 Papio anubis 96.75 0.00e+00 1778.00
IUUC-Psi-093182 Pelodiscus sinensis 62.11 0.00e+00 1160.00
IUUC-Pfo-097422 Poecilia formosa 48.88 0.00e+00 872.00
IUUC-Pab-098289 Pongo abelii 98.22 0.00e+00 1792.00
IUUC-Pca-100165 Procavia capensis 73.29 0.00e+00 1019.00
IUUC-Pva-102943 Pteropus vampyrus 85.20 0.00e+00 1545.00
IUUC-Rno-104930 Rattus norvegicus 81.53 0.00e+00 1518.00
IUUC-Sha-106800 Sarcophilus harrisii 50.21 0.00e+00 801.00
IUUC-Sar-113205 Sorex araneus 70.92 0.00e+00 982.00
IUUC-Ssc-115910 Sus scrofa 83.43 0.00e+00 1317.00
IUUC-Tgu-117179 Taeniopygia guttata 63.28 0.00e+00 1157.00
IUUC-Tru-118220 Takifugu rubripes 48.23 0.00e+00 850.00
IUUC-Tsy-119418 Tarsius syrichta 84.40 0.00e+00 1258.00
IUUC-Tni-120033 Tetraodon nigroviridis 51.62 4.00e-71 261.00
IUUC-Tbe-127308 Tupaia belangeri 85.83 0.00e+00 628.00
IUUC-Ttr-129233 Tursiops truncatus 83.11 0.00e+00 1501.00
IUUC-Vpa-130620 Vicugna pacos 80.88 1.00e-110 394.00
IUUC-Xtr-132075 Xenopus tropicalis 52.89 0.00e+00 993.00
Created Date 25-Jun-2017

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