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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063584
UUCD1 version UUC-MuM-00512
Ensembl Protein ID ENSMUSP00000038229.9
UniProt Accession Q6P1G2; Q3V396; Q6PFD0; Q6ZPE8; Q9CSF7; Q9QZN6; KDM2B_MOUSE
Genbank Protein ID BAB28568.2; BAE20639.1; AAH57622.1; AAH65090.1; BAC98289.1; AAF09133.1
Protein Name Lysine-specific demethylase 2B; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B; [Histone-H3]-lysine-36 demethylase 1B
Genbank Nucleotide ID AK012952; AK043352; BC057622; BC065090; AK129479; AF176524
Gene Name Kdm2b; Fbl10; Fbxl10; Jhdm1b; Kiaa3014
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029475.17 ENSMUST00000046073.15 ENSMUSP00000038229.9
ENSMUSG00000029475.17 ENSMUST00000031435.13 ENSMUSP00000031435.7
ENSMUSG00000029475.17 ENSMUST00000118027.7 ENSMUSP00000114052.2
ENSMUSG00000029475.17 ENSMUST00000127403.7 ENSMUSP00000120912.1
ENSMUSG00000029475.17 ENSMUST00000152872.1 ENSMUSP00000119746.1
ENSMUSG00000029475.17 ENSMUST00000086200.10 ENSMUSP00000083376.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 2.30e-14 54.4 633 698
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggede.....k.....slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrsk 54
           +vClvCge+g+++     +     +l+eC++C+e++Hp+Clk++     v++elpn+  w+CpkC+++
   Q: 633  AVCLVCGEAGKEDtveeeEgkfnlMLMECSICNEIIHPGCLKIKesegvVNDELPNC--WECPKCNHA 698
           79*********9977765156789*********************************..*******85 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity).
 Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity).
Protein Sequence
(Fasta)
MEAEKDSGRR LRAIDRQRYD ENEDLSDVEE IVSVRGFSLE EKLRSQLYQG DFVHAMEGKD 60
FNYEYVQREA LRVPLVFRDK DGLGIKMPDP DFTVRDVKLL VGSRRLVDVM DVNTQKGTEM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063584|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
AAAAGTTATG CAGTCTGTAC AGATACAGTG CTGAGGTAAT TTCTTTCTGA GCCCCTCAGA 60
TGCCTCCTCC ATATGGCAGG TTCGCAAATG GATAAGGGTC TGGACAGGCT GGCCCCTCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063584|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-1017--Isopeptide bond
KW-0433--Leucine-rich repeat
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0694--RNA-binding
KW-0699--rRNA-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS50016--ZF_PHD_2
Pfam

PF00646--F-box
PF02373--JmjC
PF16866--PHD_4
PF02008--zf-CXXC
SMART

SM00558--JmjC
SM00367--LRR_CC
SM00249--PHD
Gene Ontology

GO:0005730--C:nucleolus
GO:0031519--C:PcG protein complex
GO:0032452--F:histone demethylase activity
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0019843--F:rRNA binding
GO:0008270--F:zinc ion binding
GO:0048596--P:embryonic camera-type eye morphogenesis
GO:0030900--P:forebrain development
GO:0021592--P:fourth ventricle development
GO:0030902--P:hindbrain development
GO:0035518--P:histone H2A monoubiquitination
GO:0070544--P:histone H3-K36 demethylation
GO:0021993--P:initiation of neural tube closure
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0021555--P:midbrain-hindbrain boundary morphogenesis
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:1902459--P:positive regulation of stem cell population maintenance
GO:0007283--P:spermatogenesis
GO:0021678--P:third ventricle development
GO:0006351--P:transcription, DNA-templated
KEGG mmu:30841
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001358 Ailuropoda melanoleuca 94.67 0.00e+00 2254.00
IUUC-Apl-003787 Anas platyrhynchos 82.22 0.00e+00 1882.00
IUUC-Aca-004247 Anolis carolinensis 77.40 0.00e+00 1780.00
IUUC-Ame-011463 Astyanax mexicanus 74.93 4.00e-173 602.00
IUUC-Bta-013531 Bos taurus 95.34 0.00e+00 2298.00
IUUC-Cel-018303 Caenorhabditis elegans 44.31 3.00e-83 303.00
IUUC-Cja-018876 Callithrix jacchus 90.44 0.00e+00 2098.00
IUUC-Cfa-020857 Canis familiaris 94.35 0.00e+00 2292.00
IUUC-Cpo-021967 Cavia porcellus 92.21 0.00e+00 2119.00
IUUC-Csa-023210 Chlorocebus sabaeus 94.36 0.00e+00 2209.00
IUUC-Dre-028272 Danio rerio 64.04 0.00e+00 1535.00
IUUC-Dno-030034 Dasypus novemcinctus 92.46 0.00e+00 2174.00
IUUC-Dor-030736 Dipodomys ordii 84.50 0.00e+00 972.00
IUUC-Eca-034255 Equus caballus 95.12 0.00e+00 2181.00
IUUC-Eeu-035038 Erinaceus europaeus 95.90 0.00e+00 1160.00
IUUC-Fca-035786 Felis catus 94.50 0.00e+00 2241.00
IUUC-Fal-037589 Ficedula albicollis 82.06 0.00e+00 2004.00
IUUC-Gmo-038781 Gadus morhua 63.11 0.00e+00 691.00
IUUC-Gga-041103 Gallus gallus 84.53 0.00e+00 1110.00
IUUC-Gac-041304 Gasterosteus aculeatus 61.52 0.00e+00 1512.00
IUUC-Ggo-044522 Gorilla gorilla 93.49 0.00e+00 1660.00
IUUC-Hsa-045877 Homo sapiens 94.38 0.00e+00 2211.00
IUUC-Itr-049003 Ictidomys tridecemlineatus 95.58 0.00e+00 1299.00
IUUC-Lch-049950 Latimeria chalumnae 76.16 0.00e+00 1884.00
IUUC-Loc-051972 Lepisosteus oculatus 69.52 0.00e+00 1080.00
IUUC-Laf-053623 Loxodonta africana 93.66 0.00e+00 2155.00
IUUC-Mcc-054943 Macaca mulatta 94.45 0.00e+00 2207.00
IUUC-Meu-056259 Macropus eugenii 84.82 0.00e+00 2026.00
IUUC-Mga-059671 Meleagris gallopavo 83.16 0.00e+00 1946.00
IUUC-Mmr-061003 Microcebus murinus 94.50 0.00e+00 2261.00
IUUC-Mpu-066056 Mustela putorius furo 94.58 0.00e+00 2252.00
IUUC-Mlu-067850 Myotis lucifugus 94.13 0.00e+00 2254.00
IUUC-Nle-069837 Nomascus leucogenys 91.00 0.00e+00 1973.00
IUUC-Opr-070943 Ochotona princeps 90.78 0.00e+00 2097.00
IUUC-Ont-071663 Oreochromis niloticus 65.45 0.00e+00 1583.00
IUUC-Oan-072934 Ornithorhynchus anatinus 73.80 0.00e+00 1234.00
IUUC-Ocu-074706 Oryctolagus cuniculus 94.76 0.00e+00 2260.00
IUUC-Ola-086543 Oryzias latipes 64.86 0.00e+00 1576.00
IUUC-Oga-088671 Otolemur garnettii 83.18 0.00e+00 994.00
IUUC-Oar-089560 Ovis aries 90.44 0.00e+00 2196.00
IUUC-Ptr-090875 Pan troglodytes 94.38 0.00e+00 2239.00
IUUC-Pan-091788 Papio anubis 91.70 0.00e+00 2163.00
IUUC-Psi-093382 Pelodiscus sinensis 82.52 0.00e+00 1998.00
IUUC-Pma-094687 Petromyzon marinus 52.56 6.00e-94 338.00
IUUC-Pfo-096272 Poecilia formosa 62.54 0.00e+00 1505.00
IUUC-Pab-097907 Pongo abelii 90.14 0.00e+00 2064.00
IUUC-Pca-100628 Procavia capensis 84.89 0.00e+00 1819.00
IUUC-Pva-102956 Pteropus vampyrus 93.14 0.00e+00 1160.00
IUUC-Rno-105722 Rattus norvegicus 96.40 0.00e+00 1838.00
IUUC-Sha-106626 Sarcophilus harrisii 79.90 0.00e+00 1790.00
IUUC-Ssc-115918 Sus scrofa 93.45 0.00e+00 1714.00
IUUC-Tru-118638 Takifugu rubripes 69.32 0.00e+00 979.00
IUUC-Tsy-118820 Tarsius syrichta 89.63 0.00e+00 745.00
IUUC-Tbe-127654 Tupaia belangeri 75.58 0.00e+00 1563.00
IUUC-Ttr-128821 Tursiops truncatus 87.79 0.00e+00 2032.00
IUUC-Xtr-131823 Xenopus tropicalis 73.93 0.00e+00 1757.00
Created Date 25-Jun-2017

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