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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064183
UUCD1 version UUC-MuM-01046
Ensembl Protein ID ENSMUSP00000113928.1
UniProt Accession Q9WVM3; Q3UBM7; Q8BSR2; Q91W13; APC7_MOUSE
Genbank Protein ID AAD39343.2; BAC27131.1; BAE29831.1; BAE29937.1; BAE31731.1; BAE35152.1; BAE37680.1; AAH06635.1
Protein Name Anaphase-promoting complex subunit 7; Cyclosome subunit 7; Prediabetic NOD sera-reactive autoantigen
Genbank Nucleotide ID AF076607; AK030775; AK150764; AK150891; AK153114; AK159523; AK164202; BC006635
Gene Name Anapc7; Apc7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029466.11 ENSMUST00000122010.7 ENSMUSP00000113928.1
ENSMUSG00000029466.11 ENSMUST00000119792.1 ENSMUSP00000112658.1
ENSMUSG00000029466.11 ENSMUST00000154074.1 ENSMUSP00000123365.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexMentha
Post-translational Modifications (PTMs)
CPLMPhosphositePlusUniProtmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 98.23 0.00e+00 1026.00 IUUC-Hsa-046926
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Protein Sequence
(Fasta)
MSVIDHVRDM AAAGLHSNVR LLSSLLLTMS NNNPELFSPS QKYQLLVYHA DSLFHDKEYR 60
NAVSKYAMAL QQKKALSKTS KVRPSTGNSA STPQSQCLPS EIEVKYKMAE CYTMLKLDKD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064183|E3,APC_C|Mus musculus
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Nucleotide Sequence
(Fasta)
TGTTGTTTGT TTGTTTGTTT GTTTCAATGT ATTTTTATGA GTATCTGCAT GCCTGAGTGT 60
GTATGTCTGT GCACCACATG CATGTATGTG CCCATAGACG CCAGAGGAAG GAGTCGGATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064183|E3,APC_C|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
PROSITE

PS50005--TPR
PS50293--TPR_REGION
Pfam

PF13181--TPR_8
SMART

SM00028--TPR
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005634--C:nucleus
GO:0019903--F:protein phosphatase binding
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0070979--P:protein K11-linked ubiquitination
KEGG mmu:56317
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002083 Ailuropoda melanoleuca 98.58 0.00e+00 1030.00
IUUC-Atr-003140 Amborella trichopoda 28.68 4.00e-52 199.00
IUUC-Apl-003343 Anas platyrhynchos 95.16 0.00e+00 1011.00
IUUC-Aca-005258 Anolis carolinensis 95.06 0.00e+00 1048.00
IUUC-Aly-005478 Arabidopsis lyrata 27.18 3.00e-36 146.00
IUUC-Ath-007040 Arabidopsis thaliana 27.18 4.00e-41 162.00
IUUC-Ame-010782 Astyanax mexicanus 89.38 0.00e+00 984.00
IUUC-Bdi-014872 Brachypodium distachyon 26.95 3.00e-44 173.00
IUUC-Bol-016501 Brassica oleracea 26.71 8.00e-43 169.00
IUUC-Bra-018097 Brassica rapa 26.51 8.00e-43 168.00
IUUC-Cja-018884 Callithrix jacchus 98.58 0.00e+00 1031.00
IUUC-Cfa-020235 Canis familiaris 98.58 0.00e+00 1030.00
IUUC-Cpo-021616 Cavia porcellus 98.32 0.00e+00 1008.00
IUUC-Cho-024848 Choloepus hoffmanni 82.06 7.00e-158 550.00
IUUC-Csv-026317 Ciona savignyi 35.41 2.00e-88 319.00
IUUC-Dre-028548 Danio rerio 89.58 0.00e+00 1003.00
IUUC-Dno-029381 Dasypus novemcinctus 98.39 0.00e+00 935.00
IUUC-Dor-030225 Dipodomys ordii 90.21 0.00e+00 901.00
IUUC-Dme-031693 Drosophila melanogaster 25.95 6.00e-41 162.00
IUUC-Eca-033603 Equus caballus 98.41 0.00e+00 1024.00
IUUC-Eeu-035107 Erinaceus europaeus 68.55 4.00e-89 322.00
IUUC-Fca-036408 Felis catus 98.58 0.00e+00 1031.00
IUUC-Fal-036872 Ficedula albicollis 96.11 0.00e+00 1042.00
IUUC-Gmo-039212 Gadus morhua 90.09 0.00e+00 978.00
IUUC-Gga-040183 Gallus gallus 91.50 0.00e+00 965.00
IUUC-Gac-041690 Gasterosteus aculeatus 90.27 0.00e+00 995.00
IUUC-Gma-042697 Glycine max 28.94 3.00e-49 189.00
IUUC-Ggo-045188 Gorilla gorilla 76.15 0.00e+00 756.00
IUUC-Hsa-046926 Homo sapiens 98.23 0.00e+00 1026.00
IUUC-Hvu-047507 Hordeum vulgare 36.84 1.00e-21 96.30
IUUC-Itr-048217 Ictidomys tridecemlineatus 97.88 0.00e+00 1026.00
IUUC-Lch-050119 Latimeria chalumnae 89.70 0.00e+00 970.00
IUUC-Lpe-050905 Leersia perrieri 28.46 3.00e-47 183.00
IUUC-Loc-052439 Lepisosteus oculatus 90.62 0.00e+00 993.00
IUUC-Laf-054340 Loxodonta africana 97.88 0.00e+00 1016.00
IUUC-Meu-056210 Macropus eugenii 96.11 0.00e+00 1034.00
IUUC-Mtr-058264 Medicago truncatula 29.12 6.00e-51 195.00
IUUC-Mga-059761 Meleagris gallopavo 96.43 0.00e+00 1035.00
IUUC-Mmr-061752 Microcebus murinus 89.63 0.00e+00 910.00
IUUC-Mdo-063053 Monodelphis domestica 97.35 0.00e+00 1021.00
IUUC-Mac-064710 Musa acuminata 28.06 2.00e-50 193.00
IUUC-Mpu-065854 Mustela putorius furo 98.58 0.00e+00 1030.00
IUUC-Mlu-067159 Myotis lucifugus 98.41 0.00e+00 1028.00
IUUC-Nle-069297 Nomascus leucogenys 96.81 0.00e+00 1005.00
IUUC-Opr-070794 Ochotona princeps 82.48 0.00e+00 839.00
IUUC-Ont-071802 Oreochromis niloticus 90.09 0.00e+00 993.00
IUUC-Oan-073628 Ornithorhynchus anatinus 96.23 0.00e+00 949.00
IUUC-Ocu-074743 Oryctolagus cuniculus 98.41 0.00e+00 1029.00
IUUC-Oba-075920 Oryza barthii 28.08 1.00e-45 177.00
IUUC-Obr-076650 Oryza brachyantha 26.16 1.00e-43 171.00
IUUC-Ogl-077604 Oryza glaberrima 28.08 2.00e-45 177.00
IUUC-Ogu-078587 Oryza glumaepatula 28.08 1.00e-45 177.00
IUUC-Oin-079624 Oryza indica 28.08 2.00e-45 177.00
IUUC-Ome-081464 Oryza meridionalis 28.08 2.00e-45 176.00
IUUC-Oni-082743 Oryza nivara 28.08 2.00e-45 177.00
IUUC-Opu-083895 Oryza punctata 28.02 7.00e-42 165.00
IUUC-Oru-085274 Oryza rufipogon 28.28 6.00e-46 178.00
IUUC-Osa-085306 Oryza sativa 28.08 2.00e-45 177.00
IUUC-Ola-086494 Oryzias latipes 89.24 0.00e+00 1004.00
IUUC-Olu-087678 Ostreococcus lucimarinus 25.17 7.00e-24 105.00
IUUC-Oga-088978 Otolemur garnettii 98.41 0.00e+00 1029.00
IUUC-Oar-089894 Ovis aries 97.71 0.00e+00 1022.00
IUUC-Pan-091984 Papio anubis 92.78 0.00e+00 953.00
IUUC-Psi-094087 Pelodiscus sinensis 96.59 0.00e+00 923.00
IUUC-Ppa-095620 Physcomitrella patens 27.45 2.00e-52 200.00
IUUC-Pfo-097117 Poecilia formosa 89.38 0.00e+00 965.00
IUUC-Pop-098940 Populus trichocarpa 28.23 3.00e-50 193.00
IUUC-Ppe-101732 Prunus persica 27.68 2.00e-45 177.00
IUUC-Pva-103096 Pteropus vampyrus 98.23 0.00e+00 1026.00
IUUC-Rno-104947 Rattus norvegicus 98.76 0.00e+00 1033.00
IUUC-Sha-107198 Sarcophilus harrisii 97.17 0.00e+00 1019.00
IUUC-Smo-109520 Selaginella moellendorffii 29.59 2.00e-51 197.00
IUUC-Sit-110721 Setaria italica 26.76 9.00e-46 177.00
IUUC-Sly-111676 Solanum lycopersicum 29.26 2.00e-51 197.00
IUUC-Sar-113646 Sorex araneus 98.58 0.00e+00 1031.00
IUUC-Sbi-114239 Sorghum bicolor 25.40 4.00e-40 159.00
IUUC-Ssc-115401 Sus scrofa 97.88 0.00e+00 1026.00
IUUC-Tgu-116712 Taeniopygia guttata 96.28 0.00e+00 1044.00
IUUC-Tru-117766 Takifugu rubripes 88.65 0.00e+00 978.00
IUUC-Tni-119801 Tetraodon nigroviridis 87.46 0.00e+00 961.00
IUUC-Tca-121284 Theobroma cacao 28.03 7.00e-47 181.00
IUUC-Tae-123683 Triticum aestivum 27.04 6.00e-43 168.00
IUUC-Tur-126825 Triticum urartu 22.42 2.00e-30 127.00
IUUC-Tbe-127885 Tupaia belangeri 97.23 9.00e-129 453.00
IUUC-Ttr-128641 Tursiops truncatus 97.52 0.00e+00 1014.00
IUUC-Vpa-130810 Vicugna pacos 87.08 0.00e+00 897.00
IUUC-Vvi-131044 Vitis vinifera 28.44 7.00e-52 198.00
IUUC-Xtr-132617 Xenopus tropicalis 93.45 0.00e+00 989.00
IUUC-Xma-133575 Xiphophorus maculatus 89.20 0.00e+00 964.00
Created Date 25-Jun-2017

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