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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Sce-106137
Ensembl Protein ID YDR419W
UniProt Accession Q04049; D6VT49; POLH_YEAST
Genbank Protein ID AAB64856.1; DAA12259.1
Protein Name DNA polymerase eta; Radiation-sensitive protein 30
Genbank Nucleotide ID U33007; BK006938
Gene Name RAD30; DBH1; YDR419W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDR419W YDR419W YDR419W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/UBZ UBZ 17251197
Reviewed
Classification
Family Identity E-value Score Source Orthology
UBD/ZnF/UBZ 23.11 1.00e-20 99.40 IUUC-Hsa-046608
UBD/Alpha-Helix/UBM 25.45 1.00e-16 85.10 IUUC-Xtr-132975
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. Efficiently incorporates nucleotides opposite to other UV or oxidative DNA damages like O(6)-methylguanine, 7,8-dihydro-8-oxoguanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine of 2'-deoxyguanosine (FaPydG), or p-benzoquinone DNA adducts.
 DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. Efficiently incorporates nucleotides opposite to other UV or oxidative DNA damages like O(6)-methylguanine, 7,8-dihydro-8-oxoguanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine of 2'-deoxyguanosine (FaPydG), or p-benzoquinone DNA adducts.
Protein Sequence
(Fasta)
MSKFTWKELI QLGSPSKAYE SSLACIAHID MNAFFAQVEQ MRCGLSKEDP VVCVQWNSII 60
AVSYAARKYG ISRMDTIQEA LKKCSNLIPI HTAVFKKGED FWQYHDGCGS WVQDPAKQIS 120
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Protein Fasta Sequence


>IUUC-Sce-106137|UBD,UBZ;UBD,UBM|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
ATGTCAAAAT TTACTTGGAA GGAGTTGATT CAGCTTGGTT CCCCCAGTAA AGCATACGAG 60
TCCTCCTTAG CATGTATCGC CCACATAGAT ATGAATGCCT TTTTTGCACA GGTTGAGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106137|UBD,UBZ;UBD,UBM|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0235--DNA replication
KW-0237--DNA synthesis
KW-0238--DNA-binding
KW-0239--DNA-directed DNA polymerase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0515--Mutator protein
KW-0548--Nucleotidyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
Interpro

IPR017961--DNA_pol_Y-fam_little_finger
IPR001126--UmuC
PROSITE

PS50173--UMUC
Pfam

PF00817--IMS
PF11799--IMS_C
Gene Ontology

GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0005657--C:replication fork
GO:0003684--F:damaged DNA binding
GO:0003887--F:DNA-directed DNA polymerase activity
GO:0046872--F:metal ion binding
GO:0007059--P:chromosome segregation
GO:0006260--P:DNA replication
GO:0070987--P:error-free translesion synthesis
GO:0042276--P:error-prone translesion synthesis
GO:0007064--P:mitotic sister chromatid cohesion
KEGG sce:YDR419W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000901 Aegilops tauschii 27.15 1.00e-18 84.70
IUUC-Aml-001521 Ailuropoda melanoleuca 22.69 4.00e-20 91.30
IUUC-Atr-002484 Amborella trichopoda 26.83 6.00e-26 110.00
IUUC-Apl-003696 Anas platyrhynchos 23.56 3.00e-09 55.10
IUUC-Aca-005058 Anolis carolinensis 24.55 2.00e-20 92.00
IUUC-Aly-006400 Arabidopsis lyrata 26.28 5.00e-19 87.40
IUUC-Ath-007504 Arabidopsis thaliana 25.75 2.00e-21 95.50
IUUC-Ago-007927 Ashbya gossypii 46.43 2.00e-165 573.00
IUUC-Acl-008115 Aspergillus clavatus 29.10 4.00e-50 190.00
IUUC-Afl-008392 Aspergillus flavus 28.76 4.00e-48 184.00
IUUC-Afu-008955 Aspergillus fumigatus 27.61 3.00e-50 191.00
IUUC-Ani-009140 Aspergillus nidulans 28.50 5.00e-51 193.00
IUUC-Ang-009579 Aspergillus niger 28.62 6.00e-51 193.00
IUUC-Aor-010144 Aspergillus oryzae 29.32 4.00e-49 187.00
IUUC-Ate-010589 Aspergillus terreus 28.49 2.00e-48 185.00
IUUC-Ame-010824 Astyanax mexicanus 22.68 1.00e-18 85.90
IUUC-Bgr-012128 Blumeria graminis 29.77 1.00e-54 205.00
IUUC-Bta-013570 Bos taurus 24.43 4.00e-21 94.40
IUUC-Bci-013638 Botrytis cinerea 29.30 3.00e-54 204.00
IUUC-Bdi-014945 Brachypodium distachyon 27.36 3.00e-24 104.00
IUUC-Bol-016267 Brassica oleracea 26.79 5.00e-21 94.40
IUUC-Bra-017812 Brassica rapa 24.67 3.00e-19 88.60
IUUC-Cel-018475 Caenorhabditis elegans 23.26 2.00e-17 81.60
IUUC-Cja-019032 Callithrix jacchus 24.06 4.00e-15 74.70
IUUC-Cfa-021182 Canis familiaris 23.43 2.00e-20 92.00
IUUC-Cpo-021579 Cavia porcellus 23.48 3.00e-20 91.70
IUUC-Cre-022939 Chlamydomonas reinhardtii 31.47 3.00e-13 68.60
IUUC-Csa-023918 Chlorocebus sabaeus 24.12 6.00e-20 90.50
IUUC-Cho-024661 Choloepus hoffmanni 24.11 2.00e-19 89.00
IUUC-Cin-025717 Ciona intestinalis 23.78 7.00e-15 72.00
IUUC-Csv-026134 Ciona savignyi 28.47 6.00e-11 58.20
IUUC-Cgl-026574 Colletotrichum gloeosporioides 29.57 1.00e-53 202.00
IUUC-Cne-026787 Cryptococcus neoformans 26.19 6.00e-34 137.00
IUUC-Cme-027172 Cyanidioschyzon merolae 37.50 2.00e-21 95.50
IUUC-Dre-028594 Danio rerio 23.57 4.00e-22 98.20
IUUC-Dno-029221 Dasypus novemcinctus 24.69 5.00e-21 94.40
IUUC-Dor-030274 Dipodomys ordii 22.94 4.00e-15 74.70
IUUC-Dse-031223 Dothistroma septosporum 29.81 1.00e-46 179.00
IUUC-Dme-031727 Drosophila melanogaster 23.92 2.00e-17 82.80
IUUC-Ete-033036 Echinops telfairi 23.37 3.00e-22 98.60
IUUC-Eca-034307 Equus caballus 24.24 9.00e-19 86.70
IUUC-Eeu-035197 Erinaceus europaeus 31.62 5.00e-12 64.30
IUUC-Fca-035449 Felis catus 24.18 9.00e-19 86.70
IUUC-Fal-036901 Ficedula albicollis 25.86 8.00e-08 50.10
IUUC-Fox-037911 Fusarium oxysporum 30.83 7.00e-59 219.00
IUUC-Fso-038351 Fusarium solani 30.99 5.00e-54 203.00
IUUC-Gmo-039408 Gadus morhua 23.87 4.00e-19 88.20
IUUC-Ggr-039856 Gaeumannomyces graminis 31.02 6.00e-46 177.00
IUUC-Gga-040686 Gallus gallus 23.99 1.00e-15 76.30
IUUC-Gac-041577 Gasterosteus aculeatus 25.56 6.00e-19 87.00
IUUC-Gma-043642 Glycine max 25.98 5.00e-23 100.00
IUUC-Ggo-045651 Gorilla gorilla 23.68 8.00e-16 77.00
IUUC-Hsa-046608 Homo sapiens 24.12 2.00e-20 92.00
IUUC-Hvu-047627 Hordeum vulgare 27.09 8.00e-25 106.00
IUUC-Itr-048689 Ictidomys tridecemlineatus 24.23 8.00e-21 93.60
IUUC-Kpa-049113 Komagataella pastoris 39.53 2.00e-93 334.00
IUUC-Lch-050019 Latimeria chalumnae 22.14 5.00e-15 74.30
IUUC-Lpe-051542 Leersia perrieri 27.18 2.00e-23 102.00
IUUC-Loc-052755 Lepisosteus oculatus 23.75 2.00e-15 75.50
IUUC-Lma-053317 Leptosphaeria maculans 31.00 9.00e-56 209.00
IUUC-Laf-053792 Loxodonta africana 24.69 2.00e-21 95.50
IUUC-Mcc-055144 Macaca mulatta 24.43 1.00e-19 88.60
IUUC-Meu-056553 Macropus eugenii 23.88 5.00e-12 63.20
IUUC-Mor-057207 Magnaporthe oryzae 30.23 8.00e-45 173.00
IUUC-Mpo-057497 Magnaporthe poae 32.82 1.00e-47 182.00
IUUC-Mtr-058741 Medicago truncatula 26.14 2.00e-22 98.60
IUUC-Mla-059160 Melampsora laricipopulina 32.24 3.00e-53 201.00
IUUC-Mga-059487 Meleagris gallopavo 24.42 1.00e-09 56.20
IUUC-Mvi-060508 Microbotryum violaceum 28.15 1.00e-40 159.00
IUUC-Mmr-061610 Microcebus murinus 23.86 7.00e-21 93.60
IUUC-Mdo-061810 Monodelphis domestica 22.24 3.00e-19 88.60
IUUC-Mmu-063400 Mus musculus 24.23 2.00e-20 92.40
IUUC-Mac-064894 Musa acuminata 26.25 2.00e-22 99.00
IUUC-Mpu-066225 Mustela putorius furo 22.61 7.00e-12 63.50
IUUC-Mlu-067052 Myotis lucifugus 23.71 5.00e-21 94.40
IUUC-Nfi-068296 Neosartorya fischeri 27.95 5.00e-50 190.00
IUUC-Ncr-068957 Neurospora crassa 29.33 2.00e-58 218.00
IUUC-Nle-069730 Nomascus leucogenys 24.91 6.00e-12 63.90
IUUC-Opr-070343 Ochotona princeps 24.82 3.00e-18 84.70
IUUC-Ont-071788 Oreochromis niloticus 21.54 6.00e-19 87.40
IUUC-Oan-073017 Ornithorhynchus anatinus 25.77 1.00e-22 99.40
IUUC-Ocu-074059 Oryctolagus cuniculus 23.90 1.00e-19 89.40
IUUC-Oba-075708 Oryza barthii 26.98 4.00e-24 103.00
IUUC-Obr-076475 Oryza brachyantha 26.64 4.00e-22 97.80
IUUC-Ogl-077868 Oryza glaberrima 26.98 4.00e-24 104.00
IUUC-Ogu-078157 Oryza glumaepatula 26.98 3.00e-24 104.00
IUUC-Oin-079707 Oryza indica 27.72 2.00e-18 85.10
IUUC-Olo-080763 Oryza longistaminata 28.57 2.00e-24 105.00
IUUC-Ome-081300 Oryza meridionalis 32.65 4.00e-04 36.20
IUUC-Oni-082290 Oryza nivara 26.70 3.00e-24 104.00
IUUC-Opu-083795 Oryza punctata 26.27 9.00e-24 103.00
IUUC-Oru-085178 Oryza rufipogon 26.98 3.00e-24 104.00
IUUC-Osa-086176 Oryza sativa 26.98 4.00e-24 104.00
IUUC-Ola-087517 Oryzias latipes 21.57 8.00e-22 96.70
IUUC-Olu-087640 Ostreococcus lucimarinus 24.82 9.00e-22 96.30
IUUC-Oga-088142 Otolemur garnettii 24.49 1.00e-20 92.80
IUUC-Oar-089974 Ovis aries 24.43 2.00e-22 98.60
IUUC-Ptr-090591 Pan troglodytes 24.12 2.00e-20 92.00
IUUC-Pan-091688 Papio anubis 24.12 4.00e-20 90.90
IUUC-Psi-093115 Pelodiscus sinensis 24.44 9.00e-16 76.60
IUUC-Pno-094892 Phaeosphaeria nodorum 34.01 4.00e-49 187.00
IUUC-Ppa-095710 Physcomitrella patens 32.32 4.00e-31 127.00
IUUC-Pfo-096290 Poecilia formosa 25.90 7.00e-20 90.50
IUUC-Pab-098022 Pongo abelii 23.68 1.00e-12 66.20
IUUC-Pop-099023 Populus trichocarpa 24.11 3.00e-20 91.30
IUUC-Pca-100689 Procavia capensis 25.48 2.00e-12 65.90
IUUC-Ppe-101947 Prunus persica 27.40 2.00e-22 98.60
IUUC-Pva-102392 Pteropus vampyrus 23.71 1.00e-20 92.80
IUUC-Pgr-103588 Puccinia graminis 27.57 5.00e-48 183.00
IUUC-Ptt-103860 Puccinia triticina 35.26 2.00e-45 175.00
IUUC-Pte-104326 Pyrenophora teres 31.71 1.00e-53 202.00
IUUC-Pyt-104573 Pyrenophora triticirepentis 30.74 1.00e-52 199.00
IUUC-Rno-105209 Rattus norvegicus 25.76 1.00e-20 93.20
IUUC-Sha-106467 Sarcophilus harrisii 23.10 4.00e-21 94.40
IUUC-Sja-107701 Schizosaccharomyces japonicus 27.36 4.00e-43 167.00
IUUC-Spo-108204 Schizosaccharomyces pombe 27.89 4.00e-54 204.00
IUUC-Ssl-108431 Sclerotinia sclerotiorum 26.47 1.00e-41 162.00
IUUC-Smo-109141 Selaginella moellendorffii 25.71 3.00e-14 70.90
IUUC-Sit-110280 Setaria italica 28.37 3.00e-26 111.00
IUUC-Sly-111756 Solanum lycopersicum 25.69 2.00e-22 99.00
IUUC-Stu-112504 Solanum tuberosum 25.36 7.00e-14 69.30
IUUC-Sar-113088 Sorex araneus 26.04 3.00e-15 75.10
IUUC-Sbi-114731 Sorghum bicolor 27.21 6.00e-25 107.00
IUUC-Sre-115144 Sporisorium reilianum 42.24 5.00e-28 117.00
IUUC-Ssc-115300 Sus scrofa 24.12 9.00e-20 90.10
IUUC-Tgu-117128 Taeniopygia guttata 25.64 3.00e-07 46.60
IUUC-Tru-118550 Takifugu rubripes 21.54 1.00e-20 92.80
IUUC-Tsy-119086 Tarsius syrichta 22.61 1.00e-12 66.60
IUUC-Tni-120908 Tetraodon nigroviridis 21.98 9.00e-20 90.10
IUUC-Tca-121449 Theobroma cacao 25.40 9.00e-22 96.70
IUUC-Tre-122135 Trichoderma reesei 31.19 1.00e-58 219.00
IUUC-Tvi-122467 Trichoderma virens 31.77 2.00e-57 214.00
IUUC-Tae-125677 Triticum aestivum 26.69 1.00e-22 99.80
IUUC-Tur-126600 Triticum urartu 25.67 3.00e-19 88.20
IUUC-Tme-126967 Tuber melanosporum 30.26 8.00e-51 192.00
IUUC-Tbe-127444 Tupaia belangeri 24.87 5.00e-18 84.30
IUUC-Ttr-128797 Tursiops truncatus 26.07 3.00e-18 85.10
IUUC-Uma-129609 Ustilago maydis 42.24 7.00e-27 114.00
IUUC-Vda-130004 Verticillium dahliae 29.22 7.00e-52 196.00
IUUC-Vpa-130029 Vicugna pacos 25.44 6.00e-13 67.00
IUUC-Vvi-131117 Vitis vinifera 27.32 1.00e-19 90.10
IUUC-Xtr-132975 Xenopus tropicalis 25.55 4.00e-18 84.70
IUUC-Xma-133429 Xiphophorus maculatus 25.27 4.00e-19 87.80
IUUC-Yli-134477 Yarrowia lipolytica 39.27 1.00e-58 219.00
IUUC-Zma-135837 Zea mays 27.88 5.00e-24 103.00
Created Date 25-Jun-2017

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