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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045919
Ensembl Protein ID ENSP00000341344.4
UniProt Accession Q9UJY5; A8K3D3; B0QYR7; Q5R3N1; Q5TG07; Q6IC75; Q86YA9; Q8NCS6; Q9BW94; Q9UG00; Q9UGW0; Q9UGW1; GGA1_HUMAN
Genbank Protein ID AAF05707.1; AAF42847.1; AAF35393.1; CAG30379.1; BAC11501.1; BAG53788.1; BAF83237.1; CAI20951.1; CAI20951.1; CAI20369.1; CAI20369.1; CAQ08834.1; CAQ08834.1; CAQ09781.1; CAQ09781.1; EAW60169.1; AAH00538.2; AAH10917.1; AAH29388.1; AAH44629.1; CAB53679.1
Protein Name ADP-ribosylation factor-binding protein GGA1; Gamma-adaptin-related protein 1; Golgi-localized, gamma ear-containing, ARF-binding protein 1
Genbank Nucleotide ID AF190862; AF218584; AF233521; CR456493; AK075256; AK122898; AK290548; AL035496; Z83844; Z83844; AL035496; AL035496; Z83844; Z83844; AL035496; CH471095; BC000538; BC010917; BC029388; BC044629; AL110219
Gene Name GGA1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000100083.18 ENST00000343632.8 ENSP00000341344.4
ENSG00000100083.18 ENST00000381756.9 ENSP00000371175.5
ENSG00000100083.18 ENST00000405147.7 ENSP00000384030.3
ENSG00000100083.18 ENST00000325180.12 ENSP00000321288.8
ENSG00000100083.18 ENST00000449944.5 ENSP00000390416.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/GAT GAT 17494868
Classification
Family E-value Score Start End
UBD/Alpha-Helix/GAT 9.00e-52 176.1 171 298
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/GAT
   S: 1    deeksklLerLlkskkPeDLreAnkLikelvkededkaekikkliseleevksnvkllnemlselspegeep.ednellqelyetckaarpk 91
           deeksk+L+rLlks++PeDLr+AnkLike+v+ed++++eki+k+++++eev++nvkll+em++++s++g+++ ++++l++ely++c+++rp+
   Q: 171  DEEKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGGAAAgSSEDLMKELYQRCERMRPT 262
           79*********************************************************************9999***************** PP
   S: 92   llklieeeedndellaellkanDelnqvlnkykqlk 127
           l++l++++ednde+lae+l+anD+l+qv+n ykql+
   Q: 263  LFRLASDTEDNDEALAEILQANDNLTQVINLYKQLV 298
           *********************************987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
 Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.
Protein Sequence
(Fasta)
MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL LAHKIQSPQE 60
WEAIQALTVL ETCMKSCGKR FHDEVGKFRF LNELIKVVSP KYLGSRTSEK VKNKILELLY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045919|UBD,GAT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAAGTGGCCT CAGAGCCCCT CAGCAACATG CCCGCAGAGA ATTCTTCCGG AGGCGGTCAC 60
AGACATCTCC GTGACGCAGA ACGAGTTAGA GCGTCCCTTG GGGTTTCCAT GGTGCTGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045919|UBD,GAT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
Interpro

IPR008152--Clathrin_a/b/g-adaptin_app_Ig
IPR008153--Clathrin_g-adaptin_app
IPR013041--Coatomer/clathrin_app_Ig-like
IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR002014--VHS_dom
PROSITE

PS50180--GAE
PS50909--GAT
PS50179--VHS
Pfam

PF02883--Alpha_adaptinC2
PF03127--GAT
PF00790--VHS
SMART

SM00809--Alpha_adaptinC2
SM00288--VHS
Gene Ontology

GO:0030131--C:clathrin adaptor complex
GO:0031901--C:early endosome membrane
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0044267--P:cellular protein metabolic process
GO:0006886--P:intracellular protein transport
GO:0061024--P:membrane organization
GO:0045732--P:positive regulation of protein catabolic process
GO:1901998--P:toxin transport
GO:0016192--P:vesicle-mediated transport
KEGG hsa:26088
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001226 Ailuropoda melanoleuca 86.91 0.00e+00 988.00
IUUC-Apl-003932 Anas platyrhynchos 81.41 3.00e-152 532.00
IUUC-Aca-004431 Anolis carolinensis 84.52 2.00e-141 496.00
IUUC-Acl-008243 Aspergillus clavatus 27.13 1.00e-18 88.60
IUUC-Afl-008682 Aspergillus flavus 27.41 7.00e-21 95.90
IUUC-Ang-009840 Aspergillus niger 26.59 1.00e-15 78.60
IUUC-Aor-010219 Aspergillus oryzae 27.41 8.00e-21 95.50
IUUC-Ate-010290 Aspergillus terreus 26.52 7.00e-15 75.90
IUUC-Ame-011684 Astyanax mexicanus 72.28 9.00e-140 490.00
IUUC-Bta-012975 Bos taurus 93.43 0.00e+00 1059.00
IUUC-Cel-018437 Caenorhabditis elegans 30.08 1.00e-32 134.00
IUUC-Cja-019098 Callithrix jacchus 84.74 0.00e+00 907.00
IUUC-Cfa-020394 Canis familiaris 93.27 0.00e+00 1035.00
IUUC-Cpo-022352 Cavia porcellus 92.64 0.00e+00 1053.00
IUUC-Csa-024037 Chlorocebus sabaeus 98.44 0.00e+00 1055.00
IUUC-Dre-027709 Danio rerio 63.95 0.00e+00 713.00
IUUC-Dno-029170 Dasypus novemcinctus 82.22 0.00e+00 894.00
IUUC-Dor-030638 Dipodomys ordii 88.34 0.00e+00 1035.00
IUUC-Dse-031293 Dothistroma septosporum 26.07 2.00e-18 87.80
IUUC-Dme-031654 Drosophila melanogaster 32.76 2.00e-38 154.00
IUUC-Eca-034275 Equus caballus 91.71 0.00e+00 1055.00
IUUC-Eeu-035068 Erinaceus europaeus 72.30 0.00e+00 819.00
IUUC-Fca-036278 Felis catus 97.00 5.00e-160 558.00
IUUC-Fal-036971 Ficedula albicollis 79.10 0.00e+00 875.00
IUUC-Fox-037776 Fusarium oxysporum 28.46 6.00e-17 82.80
IUUC-Gmo-039301 Gadus morhua 55.52 3.00e-140 492.00
IUUC-Ggr-039779 Gaeumannomyces graminis 28.36 5.00e-16 79.70
IUUC-Gga-040880 Gallus gallus 76.29 0.00e+00 847.00
IUUC-Gac-041955 Gasterosteus aculeatus 62.62 0.00e+00 674.00
IUUC-Ggo-045652 Gorilla gorilla 97.10 0.00e+00 1043.00
IUUC-Itr-048105 Ictidomys tridecemlineatus 90.03 0.00e+00 1073.00
IUUC-Lch-049488 Latimeria chalumnae 67.43 0.00e+00 760.00
IUUC-Laf-053697 Loxodonta africana 90.45 0.00e+00 999.00
IUUC-Mcc-054687 Macaca mulatta 92.24 0.00e+00 958.00
IUUC-Meu-056352 Macropus eugenii 74.37 0.00e+00 813.00
IUUC-Mor-057096 Magnaporthe oryzae 27.76 1.00e-15 78.60
IUUC-Mpo-057584 Magnaporthe poae 28.57 9.00e-09 55.10
IUUC-Mga-059936 Meleagris gallopavo 80.84 0.00e+00 892.00
IUUC-Mmr-060805 Microcebus murinus 88.84 0.00e+00 1001.00
IUUC-Mdo-061808 Monodelphis domestica 74.23 0.00e+00 863.00
IUUC-Mmu-063131 Mus musculus 90.92 0.00e+00 979.00
IUUC-Mpu-066602 Mustela putorius furo 91.11 0.00e+00 1046.00
IUUC-Mlu-068220 Myotis lucifugus 91.86 0.00e+00 996.00
IUUC-Ncr-068625 Neurospora crassa 27.10 1.00e-16 82.00
IUUC-Nle-069039 Nomascus leucogenys 96.49 0.00e+00 1036.00
IUUC-Opr-070709 Ochotona princeps 83.61 0.00e+00 961.00
IUUC-Ont-072069 Oreochromis niloticus 61.53 0.00e+00 692.00
IUUC-Oan-072906 Ornithorhynchus anatinus 71.40 0.00e+00 779.00
IUUC-Ola-086728 Oryzias latipes 56.70 0.00e+00 647.00
IUUC-Oga-088189 Otolemur garnettii 86.36 0.00e+00 961.00
IUUC-Oar-089226 Ovis aries 89.67 0.00e+00 1017.00
IUUC-Pan-092529 Papio anubis 98.75 0.00e+00 1058.00
IUUC-Psi-093412 Pelodiscus sinensis 76.92 4.00e-166 578.00
IUUC-Pma-094269 Petromyzon marinus 64.04 8.00e-106 376.00
IUUC-Pfo-096458 Poecilia formosa 61.38 0.00e+00 702.00
IUUC-Pab-097684 Pongo abelii 97.81 0.00e+00 992.00
IUUC-Pca-100546 Procavia capensis 89.12 0.00e+00 772.00
IUUC-Pva-102877 Pteropus vampyrus 83.99 0.00e+00 962.00
IUUC-Rno-104917 Rattus norvegicus 90.64 0.00e+00 865.00
IUUC-Sha-107248 Sarcophilus harrisii 82.35 2.00e-145 509.00
IUUC-Ssc-115539 Sus scrofa 84.38 3.00e-122 431.00
IUUC-Tgu-117227 Taeniopygia guttata 78.95 0.00e+00 872.00
IUUC-Tru-118666 Takifugu rubripes 59.59 0.00e+00 684.00
IUUC-Tni-120663 Tetraodon nigroviridis 61.63 0.00e+00 659.00
IUUC-Tbe-127589 Tupaia belangeri 90.08 0.00e+00 1000.00
IUUC-Ttr-128616 Tursiops truncatus 90.69 0.00e+00 1054.00
IUUC-Xtr-132596 Xenopus tropicalis 64.35 1.00e-153 536.00
IUUC-Xma-133092 Xiphophorus maculatus 58.46 0.00e+00 680.00
IUUC-Yli-134564 Yarrowia lipolytica 26.04 4.00e-16 79.70
Created Date 25-Jun-2017

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