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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045903
Ensembl Protein ID ENSP00000321826.6
UniProt Accession Q5T5C0; Q14DF3; Q5T5C1; Q5T5C2; Q8NBG8; Q96NG9; STXB5_HUMAN
Genbank Protein ID CAI20239.1; CAI20239.1; CAI20239.1; CAI20240.1; CAI20240.1; CAI20240.1; CAI20241.1; CAI20241.1; CAI20241.1; CAI40423.1; CAI40423.1; CAI40423.1; CAI40424.1; CAI40424.1; CAI40424.1; CAI40425.1; CAI40425.1; CAI40425.1; CAI40739.1; CAI40739.1; CAI40739.1; CAI40740.1; CAI40740.1; CAI40740.1; CAI40741.1; CAI40741.1; CAI40741.1; AAI13383.1; BAB70930.1; BAC03475.1
Protein Name Syntaxin-binding protein 5; Lethal(2) giant larvae protein homolog 3; Tomosyn-1
Genbank Nucleotide ID AL356415; AL355365; AL590709; AL356415; AL355365; AL590709; AL356415; AL355365; AL590709; AL355365; AL356415; AL590709; AL355365; AL356415; AL590709; AL355365; AL356415; AL590709; AL590709; AL355365; AL356415; AL590709; AL355365; AL356415; AL590709; AL355365; AL356415; BC113382; AK055484; AK090549
Gene Name STXBP5; LLGL3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000164506.14 ENST00000367481.7 ENSP00000356451.3
ENSG00000164506.14 ENST00000321680.10 ENSP00000321826.6
ENSG00000164506.14 ENST00000367480.7 ENSP00000356450.3
ENSG00000164506.14 ENST00000367475.6 ENSP00000356445.2
ENSG00000164506.14 ENST00000392291.2 ENSP00000376112.2
ENSG00000164506.14 ENST00000546097.5 ENSP00000441479.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosSNPPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.20e-12 49.2 239 269
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 5    svtclaf.sd.tllvsGsdDgtikvWDlrtg 33
            ++++a+ ++ + ++++  Dgt+ +W++r+ 
   Q: 239  AIHSVAWhHEgKQFICSHSDGTLTIWNVRSP 269
           69*****977799***************986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity).
 Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity).
Protein Sequence
(Fasta)
MRKFNIRKVL DGLTAGSSSA SQQQQQQHPP GNREPEIQET LQSEHFQLCK TVRHGFPYQP 60
SALAFDPVQK ILAVGTQTGA LRLFGRPGVE CYCQHDSGAA VIQLQFLINE GALVSALADD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045903|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTCCTCCGT TTCCGCGGTC GAAGCTGCCT TCGGCCCCGG GTGGTCTCCC CCGCCCGGGG 60
ACCCCCTGTG CCTCCCCTCC CGGGCTGCGG GGGAGCCCCT CCGAGACCAT GAGGAAATTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045903|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0268--Exocytosis
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR000664--Lethal2_giant
IPR013905--Lgl_C_dom
IPR013577--LLGL2
IPR001388--Synaptobrevin
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50892--V_SNARE
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08596--Lgl_C
PF08366--LLGL
PF00400--WD40
PRINTS

PR00962--LETHAL2GIANT
SMART

SM00320--WD40
Gene Ontology

GO:0005892--C:acetylcholine-gated channel complex
GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0008021--C:synaptic vesicle
GO:0005096--F:GTPase activator activity
GO:0017137--F:Rab GTPase binding
GO:0019905--F:syntaxin binding
GO:0017075--F:syntaxin-1 binding
GO:0006887--P:exocytosis
GO:0045921--P:positive regulation of exocytosis
GO:0015031--P:protein transport
GO:0030193--P:regulation of blood coagulation
GO:0017157--P:regulation of exocytosis
GO:0010468--P:regulation of gene expression
GO:0050708--P:regulation of protein secretion
KEGG hsa:134957
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001923 Ailuropoda melanoleuca 98.26 0.00e+00 2157.00
IUUC-Aca-004796 Anolis carolinensis 90.61 0.00e+00 2031.00
IUUC-Aly-005770 Arabidopsis lyrata 23.06 1.00e-22 102.00
IUUC-Ath-007643 Arabidopsis thaliana 22.18 6.00e-21 96.70
IUUC-Ago-007756 Ashbya gossypii 23.39 3.00e-19 91.30
IUUC-Ate-010462 Aspergillus terreus 21.21 1.00e-14 75.50
IUUC-Ame-010663 Astyanax mexicanus 79.04 0.00e+00 1763.00
IUUC-Bta-013413 Bos taurus 97.83 0.00e+00 2174.00
IUUC-Bci-013698 Botrytis cinerea 21.92 3.00e-14 74.70
IUUC-Cel-018519 Caenorhabditis elegans 39.22 1.00e-135 478.00
IUUC-Cja-018984 Callithrix jacchus 98.79 0.00e+00 2160.00
IUUC-Cfa-021212 Canis familiaris 98.35 0.00e+00 2150.00
IUUC-Cpo-021336 Cavia porcellus 94.29 0.00e+00 1894.00
IUUC-Csa-023249 Chlorocebus sabaeus 96.61 0.00e+00 2063.00
IUUC-Cin-025731 Ciona intestinalis 58.13 9.00e-88 316.00
IUUC-Csv-026036 Ciona savignyi 39.65 0.00e+00 712.00
IUUC-Cgl-026432 Colletotrichum gloeosporioides 20.70 3.00e-12 67.80
IUUC-Dre-027886 Danio rerio 79.38 0.00e+00 1759.00
IUUC-Dno-029866 Dasypus novemcinctus 89.32 0.00e+00 1960.00
IUUC-Dor-031024 Dipodomys ordii 90.92 0.00e+00 1898.00
IUUC-Dme-031607 Drosophila melanogaster 47.56 0.00e+00 661.00
IUUC-Ete-032893 Echinops telfairi 97.41 0.00e+00 1562.00
IUUC-Eeu-034491 Erinaceus europaeus 82.45 0.00e+00 1126.00
IUUC-Fca-036249 Felis catus 98.13 0.00e+00 2120.00
IUUC-Fal-036761 Ficedula albicollis 93.49 0.00e+00 2065.00
IUUC-Fox-037853 Fusarium oxysporum 22.76 2.00e-17 84.70
IUUC-Fso-038327 Fusarium solani 22.61 9.00e-16 79.70
IUUC-Gmo-039272 Gadus morhua 74.21 0.00e+00 1709.00
IUUC-Ggr-039723 Gaeumannomyces graminis 21.95 1.00e-15 79.00
IUUC-Gga-040415 Gallus gallus 90.97 0.00e+00 1999.00
IUUC-Gac-041699 Gasterosteus aculeatus 76.45 0.00e+00 1709.00
IUUC-Ggo-045391 Gorilla gorilla 99.91 0.00e+00 2135.00
IUUC-Itr-048722 Ictidomys tridecemlineatus 87.60 0.00e+00 1767.00
IUUC-Loc-052677 Lepisosteus oculatus 80.08 0.00e+00 1859.00
IUUC-Mcc-055526 Macaca mulatta 99.83 0.00e+00 2129.00
IUUC-Mor-057129 Magnaporthe oryzae 22.31 1.00e-15 79.00
IUUC-Mpo-057585 Magnaporthe poae 22.45 7.00e-16 80.10
IUUC-Mtr-057936 Medicago truncatula 25.11 2.00e-19 92.00
IUUC-Mla-058927 Melampsora laricipopulina 21.31 2.00e-06 48.50
IUUC-Mga-059965 Meleagris gallopavo 93.16 0.00e+00 1919.00
IUUC-Mvi-060348 Microbotryum violaceum 23.23 6.00e-11 63.90
IUUC-Mmr-061246 Microcebus murinus 98.61 0.00e+00 2120.00
IUUC-Mdo-062626 Monodelphis domestica 95.50 0.00e+00 2102.00
IUUC-Mmu-063848 Mus musculus 96.88 0.00e+00 2121.00
IUUC-Mpu-066690 Mustela putorius furo 95.59 0.00e+00 1792.00
IUUC-Mlu-067504 Myotis lucifugus 89.77 0.00e+00 1989.00
IUUC-Ncr-068624 Neurospora crassa 22.27 1.00e-17 85.50
IUUC-Nle-069640 Nomascus leucogenys 99.48 0.00e+00 2128.00
IUUC-Opr-070681 Ochotona princeps 81.20 0.00e+00 1044.00
IUUC-Ont-071645 Oreochromis niloticus 78.27 0.00e+00 1741.00
IUUC-Oan-073020 Ornithorhynchus anatinus 93.20 0.00e+00 1721.00
IUUC-Ocu-074803 Oryctolagus cuniculus 98.24 0.00e+00 2117.00
IUUC-Oba-075180 Oryza barthii 21.59 3.00e-19 91.30
IUUC-Obr-076139 Oryza brachyantha 21.65 2.00e-17 84.70
IUUC-Ogl-077142 Oryza glaberrima 21.59 3.00e-19 91.30
IUUC-Ogu-079037 Oryza glumaepatula 21.37 5.00e-18 87.80
IUUC-Olo-080693 Oryza longistaminata 22.48 2.00e-15 78.20
IUUC-Ome-081753 Oryza meridionalis 25.93 3.00e-08 54.30
IUUC-Oni-082885 Oryza nivara 21.77 6.00e-19 90.10
IUUC-Opu-083377 Oryza punctata 22.90 9.00e-06 46.20
IUUC-Osa-085916 Oryza sativa 21.59 8.00e-18 86.70
IUUC-Ola-087197 Oryzias latipes 73.03 0.00e+00 1516.00
IUUC-Oga-088333 Otolemur garnettii 94.40 0.00e+00 2026.00
IUUC-Oar-090222 Ovis aries 97.32 0.00e+00 2136.00
IUUC-Ptr-091012 Pan troglodytes 99.91 0.00e+00 2135.00
IUUC-Pan-091748 Papio anubis 98.96 0.00e+00 2123.00
IUUC-Psi-093405 Pelodiscus sinensis 91.20 0.00e+00 2049.00
IUUC-Pno-095147 Phaeosphaeria nodorum 22.75 4.00e-10 60.50
IUUC-Pfo-096143 Poecilia formosa 78.60 0.00e+00 1784.00
IUUC-Pab-098201 Pongo abelii 96.26 0.00e+00 2025.00
IUUC-Pop-099380 Populus trichocarpa 26.83 6.00e-17 83.60
IUUC-Pca-100605 Procavia capensis 92.56 0.00e+00 1573.00
IUUC-Ppe-101373 Prunus persica 27.78 3.00e-21 97.80
IUUC-Pva-102580 Pteropus vampyrus 92.80 0.00e+00 1982.00
IUUC-Rno-106102 Rattus norvegicus 96.88 0.00e+00 2122.00
IUUC-Sce-106140 Saccharomyces cerevisiae 23.83 2.00e-11 65.10
IUUC-Sit-110386 Setaria italica 22.77 1.00e-19 92.40
IUUC-Sar-113111 Sorex araneus 89.37 0.00e+00 1810.00
IUUC-Sbi-114175 Sorghum bicolor 22.06 3.00e-19 91.30
IUUC-Sre-115050 Sporisorium reilianum 22.89 3.00e-13 71.60
IUUC-Ssc-115307 Sus scrofa 94.87 0.00e+00 2089.00
IUUC-Tgu-116507 Taeniopygia guttata 93.40 0.00e+00 2070.00
IUUC-Tru-118038 Takifugu rubripes 72.73 0.00e+00 1645.00
IUUC-Tsy-119133 Tarsius syrichta 92.09 0.00e+00 1964.00
IUUC-Tni-120014 Tetraodon nigroviridis 76.86 0.00e+00 1732.00
IUUC-Tvi-122424 Trichoderma virens 23.37 5.00e-18 87.00
IUUC-Tbe-127510 Tupaia belangeri 93.38 0.00e+00 1332.00
IUUC-Ttr-128804 Tursiops truncatus 85.86 0.00e+00 1852.00
IUUC-Uma-129388 Ustilago maydis 22.57 4.00e-13 71.20
IUUC-Vda-129843 Verticillium dahliae 19.85 4.00e-13 70.50
IUUC-Vpa-130694 Vicugna pacos 89.15 0.00e+00 1889.00
IUUC-Vvi-131379 Vitis vinifera 23.73 2.00e-20 95.10
IUUC-Xtr-132160 Xenopus tropicalis 89.14 0.00e+00 1843.00
IUUC-Xma-133008 Xiphophorus maculatus 78.46 0.00e+00 1781.00
IUUC-Yli-134491 Yarrowia lipolytica 23.20 1.00e-16 82.00
Created Date 25-Jun-2017

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