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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045792
UUCD1 version UUC-HoS-00560
Ensembl Protein ID ENSP00000427687.1
UniProt Accession O75083; A8K6E9; A8MPU4; O75313; Q8N6E5; Q9UG05; Q9UG78; Q9UQE0; WDR1_HUMAN
Genbank Protein ID AAD05044.1; AAD05045.1; BAA31855.2; BAF84303.1; AAH00201.1; AAH02489.1; AAH30541.1; CAB43276.1; CAB53674.2
Protein Name WD repeat-containing protein 1; Actin-interacting protein 1; NORI-1
Genbank Nucleotide ID AF020056; AF020260; AB010427; AK291614; AC005674; BC002489; BC030541; AL050108; AL110208
Gene Name WDR1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000071127.16 ENST00000499869.6 ENSP00000427687.1
ENSG00000071127.16 ENST00000502702.5 ENSP00000426725.1
ENSG00000071127.16 ENST00000508079.1 ENSP00000425481.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.60e-36 122.6 233 264
UBD/Beta-Prp 4.10e-60 205.2 56 277
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           H ++++++++ +d t+l+s+s+D+t k+WD++
   Q: 233  HDGGIYAISWsPDsTHLLSASGDKTSKIWDVS 264
           99*********999****************85 PP
   

   UBD/Beta-Prp
   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkghed 95
           +h +++ + k++p++ ++a+g  +g++++wd+t++  l ++  +   ++++++ + +d+k ++ ++e   ++  v+  ++g+ v  ++gh++
   Q: 56   EHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYeyQPFAGKIKDIAWTEDSKRIAVVGEGreKFGAVFLWDSGSSVGEITGHNK 147
           455666678*************************998777742334567***********99999999887777777789************ PP
   S: 96   svlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgghtdsvy 184
            + s+++ +s+ ++l++Gs+d+ +  ++ +  +    t   h+++vncv+++pdgn ++++s+D+++ ++d ktg+ +  l  +++h++ +y
   Q: 148  VINSVDIKQSRpYRLATGSDDNCAAFFEGPPFKFKF-TIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALggSKAHDGGIY 238
           *********999*****************9999998.99********************************************888****** PP
   S: 185  slsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtd 223
            +s+++++++l+s+s d+t k+wd++ +++v t+   ++
   Q: 239  AISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGST 277
           *******************************99976544 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).
 Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).
Protein Sequence
(Fasta)
MPYEIKKVFA SLPQVERGVS KIIGGDPKGN NFLYTNGKCV ILRNIDNPAL ADIYTEHAHQ 60
VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045792|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGCAGCCGC CGAGCCGAGC GCTTGACTAT ATATGGTCAA AGCTGGGGGC GAGCCGCGCG 60
CGGGACCGCG CTTCCGGGTT CGGGGCGTCC GCAACCACAG CGCGCAGGGC AGGCGCGAGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045792|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011045--N2O_reductase_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0042643--C:actomyosin, actin portion
GO:0042995--C:cell projection
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:0043209--C:myelin sheath
GO:0002102--C:podosome
GO:0051015--F:actin filament binding
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0040011--P:locomotion
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0002576--P:platelet degranulation
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0030834--P:regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0048713--P:regulation of oligodendrocyte differentiation
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization
GO:0007605--P:sensory perception of sound
KEGG hsa:9948
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000457 Aegilops tauschii 35.47 3.00e-82 299.00
IUUC-Aml-002368 Ailuropoda melanoleuca 96.51 0.00e+00 1181.00
IUUC-Atr-003160 Amborella trichopoda 37.62 2.00e-115 410.00
IUUC-Apl-004012 Anas platyrhynchos 87.29 0.00e+00 1076.00
IUUC-Aca-004707 Anolis carolinensis 83.17 0.00e+00 1053.00
IUUC-Aly-006465 Arabidopsis lyrata 38.05 2.00e-111 396.00
IUUC-Ath-006740 Arabidopsis thaliana 37.56 6.00e-111 394.00
IUUC-Ago-007920 Ashbya gossypii 27.75 8.00e-72 265.00
IUUC-Acl-008262 Aspergillus clavatus 36.26 2.00e-106 379.00
IUUC-Afl-008471 Aspergillus flavus 33.85 5.00e-80 292.00
IUUC-Afu-008989 Aspergillus fumigatus 38.06 6.00e-96 344.00
IUUC-Ani-009167 Aspergillus nidulans 38.20 9.00e-116 410.00
IUUC-Ang-009595 Aspergillus niger 37.67 2.00e-103 369.00
IUUC-Aor-009908 Aspergillus oryzae 37.16 2.00e-103 370.00
IUUC-Ate-010580 Aspergillus terreus 38.02 4.00e-109 390.00
IUUC-Ame-011269 Astyanax mexicanus 60.50 9.00e-134 470.00
IUUC-Bgr-011996 Blumeria graminis 34.15 3.00e-106 379.00
IUUC-Bta-013278 Bos taurus 95.54 0.00e+00 1209.00
IUUC-Bci-013925 Botrytis cinerea 35.83 6.00e-107 381.00
IUUC-Bdi-014659 Brachypodium distachyon 35.90 3.00e-104 372.00
IUUC-Bol-016043 Brassica oleracea 35.78 7.00e-107 381.00
IUUC-Bra-017139 Brassica rapa 36.97 8.00e-110 391.00
IUUC-Cel-018417 Caenorhabditis elegans 41.23 2.00e-123 436.00
IUUC-Cja-019952 Callithrix jacchus 97.69 0.00e+00 1176.00
IUUC-Cfa-020225 Canis familiaris 96.37 0.00e+00 1194.00
IUUC-Cpo-021900 Cavia porcellus 95.01 0.00e+00 1176.00
IUUC-Csa-023028 Chlorocebus sabaeus 99.01 0.00e+00 1187.00
IUUC-Cho-025030 Choloepus hoffmanni 69.00 0.00e+00 762.00
IUUC-Cin-025152 Ciona intestinalis 56.03 3.00e-81 294.00
IUUC-Csv-025986 Ciona savignyi 38.28 3.00e-93 335.00
IUUC-Cgl-026597 Colletotrichum gloeosporioides 38.21 1.00e-110 393.00
IUUC-Cne-026814 Cryptococcus neoformans 34.09 5.00e-97 348.00
IUUC-Dre-027498 Danio rerio 80.51 8.00e-96 342.00
IUUC-Dno-029383 Dasypus novemcinctus 95.38 0.00e+00 1152.00
IUUC-Dor-030633 Dipodomys ordii 93.94 0.00e+00 1088.00
IUUC-Dse-031526 Dothistroma septosporum 38.39 4.00e-116 412.00
IUUC-Dme-031597 Drosophila melanogaster 48.10 5.00e-168 584.00
IUUC-Ete-032780 Echinops telfairi 83.44 0.00e+00 1032.00
IUUC-Eca-034306 Equus caballus 94.51 0.00e+00 1145.00
IUUC-Eeu-034531 Erinaceus europaeus 74.77 6.00e-137 481.00
IUUC-Fca-036301 Felis catus 97.00 0.00e+00 1209.00
IUUC-Fal-037361 Ficedula albicollis 87.11 0.00e+00 1121.00
IUUC-Fox-037924 Fusarium oxysporum 35.50 2.00e-100 360.00
IUUC-Fso-038199 Fusarium solani 34.96 4.00e-97 348.00
IUUC-Gmo-039238 Gadus morhua 71.99 0.00e+00 893.00
IUUC-Ggr-039830 Gaeumannomyces graminis 35.17 2.00e-95 343.00
IUUC-Gga-040235 Gallus gallus 88.61 0.00e+00 1106.00
IUUC-Gac-042363 Gasterosteus aculeatus 71.33 0.00e+00 922.00
IUUC-Gma-044189 Glycine max 37.32 2.00e-113 403.00
IUUC-Ggo-044632 Gorilla gorilla 97.20 0.00e+00 1160.00
IUUC-Hvu-047517 Hordeum vulgare 35.35 7.00e-108 384.00
IUUC-Itr-048076 Ictidomys tridecemlineatus 96.34 0.00e+00 1181.00
IUUC-Kpa-049183 Komagataella pastoris 33.22 4.00e-85 309.00
IUUC-Lch-050428 Latimeria chalumnae 76.44 0.00e+00 1004.00
IUUC-Lpe-051306 Leersia perrieri 35.95 3.00e-109 389.00
IUUC-Loc-052096 Lepisosteus oculatus 71.92 0.00e+00 904.00
IUUC-Lma-053313 Leptosphaeria maculans 38.95 1.00e-115 412.00
IUUC-Laf-054060 Loxodonta africana 92.74 0.00e+00 1139.00
IUUC-Mcc-055619 Macaca mulatta 96.89 0.00e+00 1159.00
IUUC-Meu-056689 Macropus eugenii 78.14 0.00e+00 632.00
IUUC-Mor-056940 Magnaporthe oryzae 35.17 7.00e-97 348.00
IUUC-Mpo-057557 Magnaporthe poae 28.37 6.00e-57 215.00
IUUC-Mtr-057922 Medicago truncatula 36.50 4.00e-110 392.00
IUUC-Mla-059103 Melampsora laricipopulina 33.63 6.00e-76 278.00
IUUC-Mga-060150 Meleagris gallopavo 88.25 0.00e+00 1094.00
IUUC-Mvi-060448 Microbotryum violaceum 30.59 2.00e-73 270.00
IUUC-Mmr-061226 Microcebus murinus 95.21 0.00e+00 1167.00
IUUC-Mdo-062674 Monodelphis domestica 92.08 0.00e+00 1150.00
IUUC-Mmu-064170 Mus musculus 95.21 0.00e+00 1185.00
IUUC-Mac-065124 Musa acuminata 37.81 1.00e-113 403.00
IUUC-Mpu-066001 Mustela putorius furo 93.80 0.00e+00 1182.00
IUUC-Mlu-067253 Myotis lucifugus 94.01 0.00e+00 1169.00
IUUC-Nfi-068550 Neosartorya fischeri 37.96 1.00e-110 394.00
IUUC-Ncr-068948 Neurospora crassa 36.66 1.00e-113 403.00
IUUC-Nle-070115 Nomascus leucogenys 95.61 0.00e+00 1090.00
IUUC-Opr-070254 Ochotona princeps 93.00 0.00e+00 1108.00
IUUC-Ont-071666 Oreochromis niloticus 75.41 0.00e+00 960.00
IUUC-Oan-073594 Ornithorhynchus anatinus 92.19 2.00e-168 584.00
IUUC-Ocu-074824 Oryctolagus cuniculus 93.89 0.00e+00 1136.00
IUUC-Oba-075010 Oryza barthii 36.33 3.00e-110 392.00
IUUC-Obr-076364 Oryza brachyantha 36.70 5.00e-111 395.00
IUUC-Ogl-077019 Oryza glaberrima 36.33 3.00e-110 392.00
IUUC-Ogu-078496 Oryza glumaepatula 36.33 3.00e-110 392.00
IUUC-Oin-080116 Oryza indica 36.50 9.00e-111 394.00
IUUC-Olo-080290 Oryza longistaminata 36.33 4.00e-110 392.00
IUUC-Ome-081969 Oryza meridionalis 36.33 4.00e-110 392.00
IUUC-Oni-082075 Oryza nivara 36.33 3.00e-110 392.00
IUUC-Opu-083959 Oryza punctata 36.38 3.00e-110 392.00
IUUC-Oru-084711 Oryza rufipogon 36.33 3.00e-110 392.00
IUUC-Osa-085958 Oryza sativa 36.50 9.00e-111 394.00
IUUC-Ola-086968 Oryzias latipes 76.07 0.00e+00 971.00
IUUC-Oga-089108 Otolemur garnettii 95.91 0.00e+00 1220.00
IUUC-Oar-089986 Ovis aries 89.67 0.00e+00 1115.00
IUUC-Ptr-091281 Pan troglodytes 99.67 0.00e+00 1207.00
IUUC-Pan-092585 Papio anubis 99.17 0.00e+00 1191.00
IUUC-Psi-093811 Pelodiscus sinensis 86.21 0.00e+00 1114.00
IUUC-Pma-094396 Petromyzon marinus 70.08 0.00e+00 907.00
IUUC-Pno-095086 Phaeosphaeria nodorum 37.46 1.00e-108 387.00
IUUC-Ppa-095876 Physcomitrella patens 36.17 1.00e-110 394.00
IUUC-Pfo-096973 Poecilia formosa 74.92 0.00e+00 990.00
IUUC-Pab-098391 Pongo abelii 98.84 0.00e+00 1191.00
IUUC-Pop-098850 Populus trichocarpa 37.03 2.00e-112 399.00
IUUC-Pca-100257 Procavia capensis 60.26 1.00e-90 327.00
IUUC-Ppe-101578 Prunus persica 38.07 1.00e-115 410.00
IUUC-Pva-102872 Pteropus vampyrus 90.12 0.00e+00 1131.00
IUUC-Pgr-103593 Puccinia graminis 33.33 4.00e-79 288.00
IUUC-Pte-104365 Pyrenophora teres 39.48 5.00e-111 395.00
IUUC-Pyt-104689 Pyrenophora triticirepentis 38.83 2.00e-113 402.00
IUUC-Rno-105737 Rattus norvegicus 95.87 0.00e+00 1217.00
IUUC-Sce-106383 Saccharomyces cerevisiae 28.91 7.00e-67 248.00
IUUC-Sha-107084 Sarcophilus harrisii 90.02 0.00e+00 1011.00
IUUC-Sja-107688 Schizosaccharomyces japonicus 35.63 6.00e-110 391.00
IUUC-Spo-108309 Schizosaccharomyces pombe 33.83 3.00e-96 346.00
IUUC-Ssl-108408 Sclerotinia sclerotiorum 35.50 2.00e-106 379.00
IUUC-Smo-109255 Selaginella moellendorffii 34.65 3.00e-99 355.00
IUUC-Sit-109962 Setaria italica 37.42 1.00e-112 400.00
IUUC-Sly-110897 Solanum lycopersicum 38.56 5.00e-117 415.00
IUUC-Stu-111971 Solanum tuberosum 38.56 2.00e-116 413.00
IUUC-Sar-113415 Sorex araneus 72.69 6.00e-109 388.00
IUUC-Sbi-114857 Sorghum bicolor 36.93 3.00e-110 392.00
IUUC-Sre-114900 Sporisorium reilianum 33.17 4.00e-91 328.00
IUUC-Tgu-117256 Taeniopygia guttata 87.04 0.00e+00 1117.00
IUUC-Tru-117871 Takifugu rubripes 69.75 0.00e+00 888.00
IUUC-Tsy-119172 Tarsius syrichta 97.08 2.00e-139 489.00
IUUC-Tni-120339 Tetraodon nigroviridis 69.80 0.00e+00 924.00
IUUC-Tca-121609 Theobroma cacao 37.48 9.00e-114 404.00
IUUC-Tre-122076 Trichoderma reesei 35.67 9.00e-93 334.00
IUUC-Tvi-122528 Trichoderma virens 34.65 3.00e-95 342.00
IUUC-Tae-123530 Triticum aestivum 35.73 4.00e-109 388.00
IUUC-Tur-126845 Triticum urartu 35.45 7.00e-81 295.00
IUUC-Tme-127217 Tuber melanosporum 35.31 1.00e-104 374.00
IUUC-Tbe-127526 Tupaia belangeri 93.73 0.00e+00 1163.00
IUUC-Ttr-128898 Tursiops truncatus 87.97 0.00e+00 1095.00
IUUC-Uma-129631 Ustilago maydis 32.14 3.00e-94 339.00
IUUC-Vda-129732 Verticillium dahliae 35.02 3.00e-92 332.00
IUUC-Vvi-131217 Vitis vinifera 38.54 7.00e-114 404.00
IUUC-Xtr-132860 Xenopus tropicalis 74.88 0.00e+00 953.00
IUUC-Xma-133830 Xiphophorus maculatus 75.25 0.00e+00 993.00
IUUC-Yli-134335 Yarrowia lipolytica 32.95 3.00e-76 279.00
IUUC-Zma-135907 Zea mays 37.09 3.00e-111 395.00
Created Date 25-Jun-2017

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