iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Dme-031941

UUCD1 version

UUC-DrM-00028

Ensembl Protein ID

FBpp0085754

UniProt Accession

Q9V8P9; TOPRS_DROME

Genbank Protein ID

AAF57614.1; AAM52698.1

Protein Name

E3 ubiquitin-protein ligase Topors; RING-type E3 ubiquitin transferase Topors; SUMO1-protein E3 ligase Topors; Topoisomerase I-binding RING finger protein; Topoisomerase I-binding arginine/serine-rich protein; dTopors

Genbank Nucleotide ID

AE013599; AY122186

Gene Name

Topors; CG15104

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
FBgn0267351	FBtr0086570	FBpp0085754

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16628226; 14871887

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00096	19.7	102	141

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCl+++++  ++ +C H+f+++Cl  w      s+ +  CPlC+
   Q: 102  CAICLSRCRRKCFTDSCMHQFCFKCLCEW------SKIKPECPLCK 141
           **********9**999*************......**********7 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Functions as a ubiquitin-protein E3 ligase. Negatively regulates the transcriptional repressor h/hairy by promoting its ubiquitination and subsequent degradation. Also directs the nuclear organization of the gypsy chromatin insulator. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them, and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may require the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may promote formation of nuclear insulator bodies by recruiting individual insulator complexes to the nuclear lamina.

Protein Sequence
(Fasta)

MAEENPGALA ANVPYLGVDE LGASVIVEPG LEGSNAGGRT LPAAAIKFAD LTESGSESGD 60
NEAEEPVSAG PDNANAIGEP GTSASAAEEN GTVERNSPPP NCAICLSRCR RKCFTDSCMH 120

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Nucleotide Sequence
(Fasta)

AGGTTCGAAA AGAAGTTTCT TGGAATTTGT AATTTACCCG CGCCACAATC TCACAAGATT 60
GTGTAATACA TCTAAAAATA TTTATTTTTC TCAAAATATC ACATTTCAAT TTATAAAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0005652--C:nuclear lamina
GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0005521--F:lamin binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0051299--P:centrosome separation
GO:0016569--P:covalent chromatin modification
GO:0007140--P:male meiosis
GO:0007060--P:male meiosis chromosome segregation
GO:0010032--P:meiotic chromosome condensation
GO:0007095--P:mitotic G2 DNA damage checkpoint
GO:0071763--P:nuclear membrane organization
GO:0006997--P:nucleus organization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dme:Dmel_CG15104

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002240	Ailuropoda melanoleuca	31.93	2.00e-36	147.00
IUUC-Apl-003666	Anas platyrhynchos	50.72	8.00e-19	88.20
IUUC-Aca-004984	Anolis carolinensis	29.64	2.00e-28	118.00
IUUC-Aly-005598	Arabidopsis lyrata	47.83	5.00e-12	65.90
IUUC-Ath-007025	Arabidopsis thaliana	47.89	1.00e-11	64.70
IUUC-Ame-011109	Astyanax mexicanus	41.35	3.00e-19	90.10
IUUC-Bta-012637	Bos taurus	32.28	2.00e-39	157.00
IUUC-Bol-015147	Brassica oleracea	47.89	2.00e-11	63.50
IUUC-Bra-016799	Brassica rapa	47.89	2.00e-11	63.20
IUUC-Cel-018658	Caenorhabditis elegans	43.18	2.00e-08	53.90
IUUC-Cja-019105	Callithrix jacchus	31.12	6.00e-37	149.00
IUUC-Cfa-021203	Canis familiaris	31.93	3.00e-36	146.00
IUUC-Cpo-022335	Cavia porcellus	32.76	6.00e-38	152.00
IUUC-Csa-023870	Chlorocebus sabaeus	54.69	3.00e-19	90.10
IUUC-Cho-024870	Choloepus hoffmanni	32.30	5.00e-38	152.00
IUUC-Cne-026788	Cryptococcus neoformans	39.62	5.00e-08	52.40
IUUC-Cme-027236	Cyanidioschyzon merolae	46.15	8.00e-06	42.70
IUUC-Dre-027535	Danio rerio	32.37	3.00e-37	149.00
IUUC-Dno-028963	Dasypus novemcinctus	48.31	7.00e-21	95.50
IUUC-Dor-030239	Dipodomys ordii	55.93	2.00e-18	87.80
IUUC-Ete-032300	Echinops telfairi	32.87	6.00e-37	149.00
IUUC-Eca-033690	Equus caballus	47.19	7.00e-20	92.00
IUUC-Eeu-035257	Erinaceus europaeus	32.64	2.00e-37	150.00
IUUC-Fca-036383	Felis catus	32.40	1.00e-36	148.00
IUUC-Fal-037209	Ficedula albicollis	50.68	7.00e-19	89.00
IUUC-Gmo-039416	Gadus morhua	41.57	4.00e-17	81.60
IUUC-Gga-041267	Gallus gallus	49.37	3.00e-19	90.10
IUUC-Gac-042227	Gasterosteus aculeatus	29.93	2.00e-34	139.00
IUUC-Ggo-044445	Gorilla gorilla	54.69	3.00e-19	90.10
IUUC-Hsa-045844	Homo sapiens	54.69	3.00e-19	90.10
IUUC-Itr-048818	Ictidomys tridecemlineatus	32.75	7.00e-39	155.00
IUUC-Lch-050031	Latimeria chalumnae	29.55	6.00e-37	149.00
IUUC-Loc-052944	Lepisosteus oculatus	43.75	7.00e-19	88.60
IUUC-Lma-053202	Leptosphaeria maculans	24.24	2.00e-11	62.00
IUUC-Laf-053820	Loxodonta africana	46.07	1.00e-19	91.70
IUUC-Mcc-054800	Macaca mulatta	54.69	4.00e-19	89.70
IUUC-Meu-056806	Macropus eugenii	34.45	8.00e-19	87.80
IUUC-Mtr-057959	Medicago truncatula	53.06	2.00e-11	63.90
IUUC-Mla-059017	Melampsora laricipopulina	39.34	2.00e-09	55.50
IUUC-Mvi-060417	Microbotryum violaceum	26.13	6.00e-17	82.00
IUUC-Mmr-061481	Microcebus murinus	54.69	2.00e-19	90.50
IUUC-Mdo-062219	Monodelphis domestica	34.45	1.00e-18	88.20
IUUC-Mmu-064138	Mus musculus	48.31	2.00e-20	94.00
IUUC-Mac-064730	Musa acuminata	52.08	3.00e-11	63.20
IUUC-Mlu-067088	Myotis lucifugus	31.93	3.00e-36	146.00
IUUC-Nle-069862	Nomascus leucogenys	54.69	3.00e-19	90.10
IUUC-Opr-071076	Ochotona princeps	49.37	1.00e-19	91.30
IUUC-Ont-072382	Oreochromis niloticus	50.00	3.00e-17	83.20
IUUC-Oan-073069	Ornithorhynchus anatinus	32.07	7.00e-38	150.00
IUUC-Ocu-074826	Oryctolagus cuniculus	31.36	1.00e-36	147.00
IUUC-Ogl-077444	Oryza glaberrima	39.29	1.00e-08	52.80
IUUC-Ogu-078603	Oryza glumaepatula	39.29	1.00e-08	52.80
IUUC-Opu-083698	Oryza punctata	39.29	2.00e-08	52.40
IUUC-Ola-087377	Oryzias latipes	43.82	4.00e-19	88.20
IUUC-Oga-088059	Otolemur garnettii	31.67	6.00e-37	149.00
IUUC-Oar-089592	Ovis aries	32.64	4.00e-39	156.00
IUUC-Ptr-091233	Pan troglodytes	54.69	3.00e-19	90.10
IUUC-Pan-092743	Papio anubis	54.69	3.00e-19	90.10
IUUC-Psi-093669	Pelodiscus sinensis	32.88	2.00e-39	156.00
IUUC-Ppa-095668	Physcomitrella patens	24.38	2.00e-16	79.70
IUUC-Pfo-096706	Poecilia formosa	43.82	1.00e-20	94.00
IUUC-Pop-099591	Populus trichocarpa	31.79	1.00e-13	70.90
IUUC-Pca-100967	Procavia capensis	54.69	5.00e-19	89.00
IUUC-Pva-102982	Pteropus vampyrus	32.28	3.00e-38	153.00
IUUC-Ptt-103977	Puccinia triticina	35.53	7.00e-07	46.60
IUUC-Rno-105730	Rattus norvegicus	31.83	2.00e-38	154.00
IUUC-Sha-106588	Sarcophilus harrisii	34.45	9.00e-19	88.60
IUUC-Smo-108936	Selaginella moellendorffii	37.31	3.00e-11	61.20
IUUC-Sly-111835	Solanum lycopersicum	40.58	3.00e-10	60.10
IUUC-Stu-112898	Solanum tuberosum	43.33	4.00e-10	60.10
IUUC-Sar-113622	Sorex araneus	35.29	1.00e-18	88.60
IUUC-Sre-115041	Sporisorium reilianum	51.11	1.00e-08	53.10
IUUC-Ssc-115244	Sus scrofa	32.28	7.00e-39	155.00
IUUC-Tgu-117180	Taeniopygia guttata	31.51	5.00e-38	152.00
IUUC-Tru-118393	Takifugu rubripes	31.36	1.00e-33	137.00
IUUC-Tsy-119408	Tarsius syrichta	32.98	2.00e-38	154.00
IUUC-Tni-120664	Tetraodon nigroviridis	43.82	2.00e-18	86.70
IUUC-Tca-121712	Theobroma cacao	24.57	2.00e-12	65.50
IUUC-Tbe-127301	Tupaia belangeri	31.11	6.00e-34	139.00
IUUC-Ttr-128204	Tursiops truncatus	31.93	3.00e-39	156.00
IUUC-Uma-129420	Ustilago maydis	44.26	1.00e-08	52.80
IUUC-Vpa-130297	Vicugna pacos	32.28	1.00e-38	154.00
IUUC-Vvi-131157	Vitis vinifera	37.74	2.00e-08	52.80
IUUC-Xtr-132845	Xenopus tropicalis	32.01	5.00e-41	162.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence