iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000004897.11	ENST00000066544.7	ENSP00000066544.3
ENSG00000004897.11	ENST00000531206.5	ENSP00000434614.1
ENSG00000004897.11	ENST00000570740.1	ENSP00000460830.1
ENSG00000004897.11	ENST00000533415.5	ENSP00000432211.1
ENSG00000004897.11	ENST00000571643.5	ENSP00000460279.1
ENSG00000004897.11	ENST00000527547.5	ENSP00000437339.1
ENSG00000004897.11	ENST00000526866.5	ENSP00000432105.1
ENSG00000004897.11	ENST00000573502.1	ENSP00000460132.1
ENSG00000004897.11	ENST00000574304.5	ENSP00000458904.1
ENSG00000004897.11	ENST00000576484.1	ENSP00000459307.1
ENSG00000004897.11	ENST00000573550.5	ENSP00000460424.1
ENSG00000004897.11	ENST00000570818.5	ENSP00000460061.1
ENSG00000004897.11	ENST00000575483.5	ENSP00000460454.1
ENSG00000004897.11	ENST00000532893.5	ENSP00000466424.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C	APC_C	20552012; 21107322; 16763193

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C	40.80	6.00e-63	237.00	IUUC-Sce-106187

Organism

Homo sapiens

Functional Description
(View)

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MTVLQEPVQA AIWQALNHYA YRDAVFLAER LYAEVHSEEA LFLLATCYYR SGKAYKAYRL 60
LKGHSCTTPQ CKYLLAKCCV DLSKLAEGEQ ILSGGVFNKQ KSHDDIVTEF GDSACFTLSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACGGTTTTC TCTCTCGTCG ACCAACCTCG GGTATTTCCG ACTCCCTTCG GGCTTTTCCG 60
TCTGGTTCCC GCTCGGCTTT CTCCACTTCG GGTATTCCCG TGTCCCGCTC GGAAGCACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR001440--TPR_1
IPR019734--TPR_repeat

PROSITE

PS50005--TPR
PS50293--TPR_REGION

Pfam

PF00515--TPR_1
PF13181--TPR_8

SMART

SM00028--TPR

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005819--C:spindle
GO:0019903--F:protein phosphatase binding
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0008283--P:cell proliferation
GO:0007091--P:metaphase/anaphase transition of mitotic cell cycle
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle

KEGG

hsa:996

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000478	Aegilops tauschii	48.72	1.00e-89	324.00
IUUC-Aml-002123	Ailuropoda melanoleuca	98.30	0.00e+00	1642.00
IUUC-Atr-002921	Amborella trichopoda	48.11	3.00e-96	346.00
IUUC-Apl-003652	Anas platyrhynchos	94.34	0.00e+00	1589.00
IUUC-Aca-004797	Anolis carolinensis	92.01	0.00e+00	1461.00
IUUC-Aly-006146	Arabidopsis lyrata	42.06	4.00e-85	309.00
IUUC-Ath-007523	Arabidopsis thaliana	46.69	9.00e-95	341.00
IUUC-Ago-007939	Ashbya gossypii	39.50	2.00e-64	240.00
IUUC-Acl-008169	Aspergillus clavatus	43.10	2.00e-84	307.00
IUUC-Afl-008631	Aspergillus flavus	37.41	1.00e-77	284.00
IUUC-Afu-008990	Aspergillus fumigatus	36.42	3.00e-85	309.00
IUUC-Ani-009208	Aspergillus nidulans	50.00	7.00e-49	188.00
IUUC-Ang-009561	Aspergillus niger	44.81	4.00e-85	309.00
IUUC-Aor-009958	Aspergillus oryzae	37.41	3.00e-77	283.00
IUUC-Ate-010597	Aspergillus terreus	39.49	1.00e-85	311.00
IUUC-Ame-010734	Astyanax mexicanus	79.57	0.00e+00	682.00
IUUC-Bgr-012282	Blumeria graminis	31.78	2.00e-94	340.00
IUUC-Bta-013499	Bos taurus	98.91	0.00e+00	1656.00
IUUC-Bci-013946	Botrytis cinerea	30.38	1.00e-93	338.00
IUUC-Bdi-014213	Brachypodium distachyon	48.08	6.00e-89	322.00
IUUC-Bol-016307	Brassica oleracea	46.48	2.00e-94	340.00
IUUC-Bra-017042	Brassica rapa	46.39	8.00e-95	341.00
IUUC-Cel-018481	Caenorhabditis elegans	40.51	1.00e-76	281.00
IUUC-Cja-019393	Callithrix jacchus	98.79	0.00e+00	1480.00
IUUC-Cfa-020221	Canis familiaris	99.03	0.00e+00	1657.00
IUUC-Cpo-021792	Cavia porcellus	98.42	0.00e+00	1628.00
IUUC-Csa-023091	Chlorocebus sabaeus	99.64	0.00e+00	1674.00
IUUC-Cin-025231	Ciona intestinalis	47.78	0.00e+00	671.00
IUUC-Csv-025983	Ciona savignyi	44.14	0.00e+00	671.00
IUUC-Cgl-026436	Colletotrichum gloeosporioides	42.77	2.00e-72	267.00
IUUC-Cne-026779	Cryptococcus neoformans	40.19	2.00e-63	237.00
IUUC-Cme-027126	Cyanidioschyzon merolae	36.18	2.00e-61	230.00
IUUC-Dre-028038	Danio rerio	79.59	0.00e+00	1263.00
IUUC-Dno-029681	Dasypus novemcinctus	98.54	0.00e+00	1644.00
IUUC-Dor-030742	Dipodomys ordii	76.92	2.00e-152	533.00
IUUC-Dse-031468	Dothistroma septosporum	35.51	1.00e-64	241.00
IUUC-Dme-031900	Drosophila melanogaster	45.20	7.00e-118	418.00
IUUC-Ete-032396	Echinops telfairi	88.85	0.00e+00	1459.00
IUUC-Eca-034414	Equus caballus	99.03	0.00e+00	1659.00
IUUC-Eeu-034864	Erinaceus europaeus	85.42	0.00e+00	763.00
IUUC-Fca-036459	Felis catus	98.65	0.00e+00	1636.00
IUUC-Fox-037700	Fusarium oxysporum	43.39	2.00e-68	252.00
IUUC-Fso-038112	Fusarium solani	42.63	5.00e-77	282.00
IUUC-Gmo-038876	Gadus morhua	73.75	0.00e+00	1175.00
IUUC-Ggr-039822	Gaeumannomyces graminis	44.05	2.00e-74	273.00
IUUC-Gga-040585	Gallus gallus	94.28	0.00e+00	1576.00
IUUC-Gac-042126	Gasterosteus aculeatus	75.66	0.00e+00	1234.00
IUUC-Gma-044263	Glycine max	46.25	1.00e-95	344.00
IUUC-Ggo-045272	Gorilla gorilla	86.06	0.00e+00	994.00
IUUC-Hvu-047421	Hordeum vulgare	49.80	2.00e-70	258.00
IUUC-Itr-048133	Ictidomys tridecemlineatus	99.40	0.00e+00	1003.00
IUUC-Kpa-049367	Komagataella pastoris	30.13	7.00e-87	315.00
IUUC-Lch-049755	Latimeria chalumnae	84.63	0.00e+00	1421.00
IUUC-Lpe-051689	Leersia perrieri	32.74	5.00e-105	375.00
IUUC-Loc-052907	Lepisosteus oculatus	84.96	0.00e+00	1336.00
IUUC-Lma-053272	Leptosphaeria maculans	43.71	6.00e-73	269.00
IUUC-Laf-054312	Loxodonta africana	98.07	0.00e+00	1649.00
IUUC-Mcc-055312	Macaca mulatta	99.64	0.00e+00	1674.00
IUUC-Meu-056290	Macropus eugenii	84.97	0.00e+00	1421.00
IUUC-Mor-057118	Magnaporthe oryzae	43.57	9.00e-75	275.00
IUUC-Mpo-057620	Magnaporthe poae	44.05	4.00e-75	276.00
IUUC-Mtr-058302	Medicago truncatula	33.66	6.00e-117	415.00
IUUC-Mla-058835	Melampsora laricipopulina	36.54	2.00e-60	226.00
IUUC-Mga-060010	Meleagris gallopavo	93.77	0.00e+00	1586.00
IUUC-Mvi-060340	Microbotryum violaceum	39.26	7.00e-61	229.00
IUUC-Mmr-060610	Microcebus murinus	97.83	0.00e+00	1618.00
IUUC-Mdo-062216	Monodelphis domestica	95.56	0.00e+00	1618.00
IUUC-Mmu-063476	Mus musculus	96.85	0.00e+00	1632.00
IUUC-Mac-065409	Musa acuminata	45.73	2.00e-94	340.00
IUUC-Mpu-066213	Mustela putorius furo	99.03	0.00e+00	1657.00
IUUC-Mlu-067540	Myotis lucifugus	98.66	0.00e+00	1639.00
IUUC-Nfi-068437	Neosartorya fischeri	38.43	7.00e-86	311.00
IUUC-Ncr-068882	Neurospora crassa	42.56	3.00e-76	280.00
IUUC-Nle-068976	Nomascus leucogenys	98.92	0.00e+00	1664.00
IUUC-Opr-071171	Ochotona princeps	79.67	0.00e+00	1261.00
IUUC-Ont-071295	Oreochromis niloticus	74.52	0.00e+00	1217.00
IUUC-Oan-072896	Ornithorhynchus anatinus	95.28	0.00e+00	716.00
IUUC-Ocu-074828	Oryctolagus cuniculus	98.67	0.00e+00	1687.00
IUUC-Oba-075176	Oryza barthii	30.33	3.00e-94	339.00
IUUC-Obr-076622	Oryza brachyantha	33.38	6.00e-115	408.00
IUUC-Ogu-078158	Oryza glumaepatula	33.75	1.00e-108	387.00
IUUC-Oin-079840	Oryza indica	34.77	2.00e-117	416.00
IUUC-Olo-080632	Oryza longistaminata	49.19	2.00e-92	333.00
IUUC-Ome-081193	Oryza meridionalis	34.85	4.00e-117	415.00
IUUC-Oni-082335	Oryza nivara	30.98	8.00e-96	345.00
IUUC-Opu-083857	Oryza punctata	48.43	1.00e-83	304.00
IUUC-Oru-085165	Oryza rufipogon	30.98	1.00e-95	343.00
IUUC-Osa-085529	Oryza sativa	48.62	2.00e-97	348.00
IUUC-Olu-087803	Ostreococcus lucimarinus	47.15	3.00e-87	315.00
IUUC-Oga-088851	Otolemur garnettii	98.05	0.00e+00	1628.00
IUUC-Oar-089794	Ovis aries	99.03	0.00e+00	1660.00
IUUC-Ptr-091588	Pan troglodytes	99.76	0.00e+00	1675.00
IUUC-Pan-092083	Papio anubis	93.81	0.00e+00	1558.00
IUUC-Psi-093368	Pelodiscus sinensis	94.55	0.00e+00	1582.00
IUUC-Pma-094306	Petromyzon marinus	65.16	0.00e+00	1052.00
IUUC-Pno-094898	Phaeosphaeria nodorum	31.05	3.00e-84	306.00
IUUC-Ppa-095288	Physcomitrella patens	48.19	2.00e-104	373.00
IUUC-Pfo-097263	Poecilia formosa	72.84	0.00e+00	1155.00
IUUC-Pab-097782	Pongo abelii	99.39	0.00e+00	1669.00
IUUC-Pca-100771	Procavia capensis	84.02	0.00e+00	1291.00
IUUC-Ppe-102042	Prunus persica	40.45	9.00e-99	354.00
IUUC-Pva-103207	Pteropus vampyrus	98.67	0.00e+00	1654.00
IUUC-Pgr-103352	Puccinia graminis	37.88	1.00e-52	201.00
IUUC-Ptt-103992	Puccinia triticina	39.62	9.00e-29	122.00
IUUC-Pte-104138	Pyrenophora teres	42.41	4.00e-75	276.00
IUUC-Pyt-104652	Pyrenophora triticirepentis	30.11	4.00e-89	322.00
IUUC-Rno-105451	Rattus norvegicus	97.45	0.00e+00	1640.00
IUUC-Sce-106187	Saccharomyces cerevisiae	40.80	2.00e-63	237.00
IUUC-Sha-107398	Sarcophilus harrisii	71.83	0.00e+00	1149.00
IUUC-Sja-107984	Schizosaccharomyces japonicus	43.87	6.00e-75	275.00
IUUC-Spo-108274	Schizosaccharomyces pombe	45.45	1.00e-83	303.00
IUUC-Smo-109678	Selaginella moellendorffii	55.28	3.00e-112	399.00
IUUC-Sit-110813	Setaria italica	32.09	5.00e-110	392.00
IUUC-Sly-111637	Solanum lycopersicum	46.63	8.00e-101	361.00
IUUC-Stu-112086	Solanum tuberosum	46.75	4.00e-98	352.00
IUUC-Sar-113214	Sorex araneus	98.06	0.00e+00	1607.00
IUUC-Sre-114904	Sporisorium reilianum	34.94	6.00e-33	137.00
IUUC-Ssc-115692	Sus scrofa	97.78	0.00e+00	1338.00
IUUC-Tgu-116466	Taeniopygia guttata	93.83	0.00e+00	1564.00
IUUC-Tru-118417	Takifugu rubripes	74.25	0.00e+00	1187.00
IUUC-Tsy-118796	Tarsius syrichta	93.92	0.00e+00	1532.00
IUUC-Tni-120331	Tetraodon nigroviridis	85.99	0.00e+00	662.00
IUUC-Tca-121321	Theobroma cacao	48.47	3.00e-95	343.00
IUUC-Tre-122083	Trichoderma reesei	41.41	2.00e-73	270.00
IUUC-Tvi-122558	Trichoderma virens	40.80	2.00e-73	270.00
IUUC-Tae-125209	Triticum aestivum	33.01	2.00e-107	383.00
IUUC-Tur-126187	Triticum urartu	42.95	3.00e-70	259.00
IUUC-Tme-127012	Tuber melanosporum	31.96	6.00e-98	352.00
IUUC-Tbe-127774	Tupaia belangeri	85.94	0.00e+00	1366.00
IUUC-Ttr-128605	Tursiops truncatus	95.52	0.00e+00	1587.00
IUUC-Uma-129576	Ustilago maydis	33.67	3.00e-32	134.00
IUUC-Vda-129996	Verticillium dahliae	43.08	2.00e-57	215.00
IUUC-Vpa-130122	Vicugna pacos	98.91	0.00e+00	1650.00
IUUC-Vvi-131580	Vitis vinifera	46.50	8.00e-101	361.00
IUUC-Xtr-131756	Xenopus tropicalis	89.93	0.00e+00	1455.00
IUUC-Xma-133214	Xiphophorus maculatus	72.84	0.00e+00	1191.00
IUUC-Yli-134473	Yarrowia lipolytica	42.77	2.00e-74	273.00
IUUC-Zma-135179	Zea mays	32.47	1.00e-113	404.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence