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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Dme-031777
UUCD1 version UUC-DrM-00023
Ensembl Protein ID FBpp0073787
UniProt Accession Q9NB71; Q8MZ36; Q9VXZ5; HIW_DROME
Genbank Protein ID AAF76150.1; AAF48411.2; AAM29381.1
Protein Name E3 ubiquitin-protein ligase highwire; Protein pam/highwire/rpm-1; RING-type E3 ubiquitin transferase highwire
Genbank Nucleotide ID AF262977; AE014298; AY113376
Gene Name hiw; CG32592
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0030600 FBtr0073970 FBpp0073787
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20009548
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 38.91 2.00e-120 432.00 IUUC-Cel-018686
E3 activity/RING/RING 62.38 0.00e+00 725.00 IUUC-Hsa-046977
E3 activity/RING/RING 62.57 0.00e+00 725.00 IUUC-Mmu-063569
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description



     E3 ubiquitin-protein ligases mediate ubiquitination and subsequent proteasomal degradation of target proteins. Has a role during synaptogenesis; negative regulator of synaptic growth.
E3 ubiquitin-protein ligases mediate ubiquitination and subsequent proteasomal degradation of target proteins. Has a role during synaptogenesis; negative regulator of synaptic growth.
Protein Sequence
(Fasta)
MVGLLNPLKY GDHFYELYTN STRRKMQHDR KVLTKRKSRK DKSAAAMAAA AAAAVLEGNA 60
GAGGLVNPLD PPLVKEQLMI LPSFPVAHIE LDPNASKFAV FSAIRSTVLE AETRYSLFQE 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Dme-031777|E3,RING|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTTCCCTCG TTCCCATTGT ACCGTTGCGT TGTCGCTCGG TGTGTGTTTC CTTTTTTTTG 60
GGTGAAAGTG ACAAAAGGCA AATGGCGAAA ACAAAGGGCA CTCAAATTGC CAGACGATGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Dme-031777|E3,RING|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR017868--Filamin/ABP280_repeat-like
IPR008979--Galactose-bd-like
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR012983--PHR
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51284--DOC
PS50194--FILAMIN_REPEAT
PS00626--RCC1_2
PS50012--RCC1_3
PS50089--ZF_RING_2

Pfam

PF08005--PHR
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM00184--RING

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007628--P:adult walking behavior
GO:0006914--P:autophagy
GO:0030509--P:BMP signaling pathway
GO:0050965--P:detection of temperature stimulus involved in sensory perception of pain
GO:0040011--P:locomotion
GO:0007616--P:long-term memory
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0045886--P:negative regulation of synaptic growth at neuromuscular junction
GO:0016567--P:protein ubiquitination
GO:0008582--P:regulation of synaptic growth at neuromuscular junction
GO:2000331--P:regulation of terminal button organization
GO:0048678--P:response to axon injury
GO:0050808--P:synapse organization
GO:0006351--P:transcription, DNA-templated

KEGG dme:Dmel_CG32592
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001951 Ailuropoda melanoleuca 62.57 0.00e+00 727.00
IUUC-Apl-003625 Anas platyrhynchos 60.97 0.00e+00 663.00
IUUC-Aca-005207 Anolis carolinensis 62.76 0.00e+00 690.00
IUUC-Ame-010649 Astyanax mexicanus 49.07 0.00e+00 1111.00
IUUC-Bta-012670 Bos taurus 62.57 0.00e+00 727.00
IUUC-Cel-018686 Caenorhabditis elegans 28.79 8.00e-148 519.00
IUUC-Cja-019910 Callithrix jacchus 62.76 0.00e+00 728.00
IUUC-Cfa-020184 Canis familiaris 62.57 0.00e+00 727.00
IUUC-Cpo-021334 Cavia porcellus 62.76 0.00e+00 727.00
IUUC-Csa-023291 Chlorocebus sabaeus 62.76 0.00e+00 728.00
IUUC-Cho-024927 Choloepus hoffmanni 36.79 2.00e-105 379.00
IUUC-Cin-025345 Ciona intestinalis 58.03 0.00e+00 654.00
IUUC-Csv-026264 Ciona savignyi 56.02 0.00e+00 628.00
IUUC-Dre-028645 Danio rerio 49.76 0.00e+00 1126.00
IUUC-Dno-029670 Dasypus novemcinctus 62.76 0.00e+00 729.00
IUUC-Dor-030993 Dipodomys ordii 57.91 0.00e+00 642.00
IUUC-Ete-032613 Echinops telfairi 58.47 0.00e+00 660.00
IUUC-Eca-034364 Equus caballus 62.76 0.00e+00 728.00
IUUC-Eeu-035200 Erinaceus europaeus 61.91 0.00e+00 713.00
IUUC-Fca-036054 Felis catus 62.76 0.00e+00 728.00
IUUC-Fal-036991 Ficedula albicollis 62.76 0.00e+00 694.00
IUUC-Gmo-038487 Gadus morhua 48.33 0.00e+00 1154.00
IUUC-Gga-041035 Gallus gallus 62.76 0.00e+00 694.00
IUUC-Gac-041637 Gasterosteus aculeatus 61.64 0.00e+00 681.00
IUUC-Ggo-045091 Gorilla gorilla 41.30 7.00e-114 406.00
IUUC-Hsa-046977 Homo sapiens 62.57 0.00e+00 728.00
IUUC-Itr-048995 Ictidomys tridecemlineatus 40.99 9.00e-113 401.00
IUUC-Lch-050171 Latimeria chalumnae 37.43 0.00e+00 1088.00
IUUC-Loc-052822 Lepisosteus oculatus 62.01 0.00e+00 686.00
IUUC-Laf-054065 Loxodonta africana 62.57 0.00e+00 726.00
IUUC-Mcc-054947 Macaca mulatta 62.76 0.00e+00 728.00
IUUC-Meu-056600 Macropus eugenii 58.78 6.00e-171 596.00
IUUC-Mga-059559 Meleagris gallopavo 61.82 0.00e+00 682.00
IUUC-Mmr-060973 Microcebus murinus 62.76 0.00e+00 728.00
IUUC-Mdo-061938 Monodelphis domestica 62.57 0.00e+00 691.00
IUUC-Mmu-063569 Mus musculus 62.76 0.00e+00 727.00
IUUC-Mpu-066457 Mustela putorius furo 60.80 0.00e+00 654.00
IUUC-Mlu-067165 Myotis lucifugus 41.80 1.00e-132 469.00
IUUC-Nle-069042 Nomascus leucogenys 62.20 0.00e+00 712.00
IUUC-Opr-070201 Ochotona princeps 43.07 1.00e-106 382.00
IUUC-Ont-072263 Oreochromis niloticus 49.72 0.00e+00 1129.00
IUUC-Oan-073108 Ornithorhynchus anatinus 41.08 2.00e-133 471.00
IUUC-Ocu-074359 Oryctolagus cuniculus 62.94 0.00e+00 730.00
IUUC-Ola-087074 Oryzias latipes 35.51 9.00e-109 389.00
IUUC-Oga-088322 Otolemur garnettii 62.76 0.00e+00 728.00
IUUC-Oar-089244 Ovis aries 62.57 0.00e+00 726.00
IUUC-Ptr-091449 Pan troglodytes 62.57 0.00e+00 727.00
IUUC-Pan-091756 Papio anubis 62.76 0.00e+00 728.00
IUUC-Psi-093387 Pelodiscus sinensis 62.38 0.00e+00 693.00
IUUC-Pma-094327 Petromyzon marinus 46.35 7.00e-66 243.00
IUUC-Ppa-095276 Physcomitrella patens 39.18 5.00e-51 195.00
IUUC-Pfo-097372 Poecilia formosa 61.64 0.00e+00 682.00
IUUC-Pab-097572 Pongo abelii 62.57 0.00e+00 729.00
IUUC-Pca-101007 Procavia capensis 55.12 4.00e-174 607.00
IUUC-Pva-102217 Pteropus vampyrus 63.91 0.00e+00 695.00
IUUC-Rno-105422 Rattus norvegicus 62.76 0.00e+00 727.00
IUUC-Sce-106318 Saccharomyces cerevisiae 31.48 2.60e-02 33.90
IUUC-Sha-107119 Sarcophilus harrisii 62.34 0.00e+00 687.00
IUUC-Smo-108712 Selaginella moellendorffii 42.12 5.00e-65 239.00
IUUC-Sar-113595 Sorex araneus 57.91 0.00e+00 645.00
IUUC-Ssc-115690 Sus scrofa 57.66 4.00e-153 537.00
IUUC-Tgu-116555 Taeniopygia guttata 62.76 0.00e+00 694.00
IUUC-Tru-117796 Takifugu rubripes 49.48 0.00e+00 1122.00
IUUC-Tsy-118924 Tarsius syrichta 60.15 0.00e+00 692.00
IUUC-Tni-120759 Tetraodon nigroviridis 49.80 0.00e+00 1117.00
IUUC-Tme-127029 Tuber melanosporum 37.72 1.00e-07 52.40
IUUC-Ttr-128814 Tursiops truncatus 62.57 0.00e+00 728.00
IUUC-Vpa-130430 Vicugna pacos 60.72 0.00e+00 650.00
IUUC-Xtr-131898 Xenopus tropicalis 46.86 8.00e-73 268.00
Created Date 25-Jun-2017

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