iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20009548

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/RING/RING	38.91	2.00e-120	432.00	IUUC-Cel-018686
E3 activity/RING/RING	62.38	0.00e+00	725.00	IUUC-Hsa-046977
E3 activity/RING/RING	62.57	0.00e+00	725.00	IUUC-Mmu-063569

Organism

Drosophila melanogaster

Functional Description
(View)

E3 ubiquitin-protein ligases mediate ubiquitination and subsequent proteasomal degradation of target proteins. Has a role during synaptogenesis; negative regulator of synaptic growth.

Protein Sequence
(Fasta)

MVGLLNPLKY GDHFYELYTN STRRKMQHDR KVLTKRKSRK DKSAAAMAAA AAAAVLEGNA 60
GAGGLVNPLD PPLVKEQLMI LPSFPVAHIE LDPNASKFAV FSAIRSTVLE AETRYSLFQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTCCCTCG TTCCCATTGT ACCGTTGCGT TGTCGCTCGG TGTGTGTTTC CTTTTTTTTG 60
GGTGAAAGTG ACAAAAGGCA AATGGCGAAA ACAAAGGGCA CTCAAATTGC CAGACGATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR017868--Filamin/ABP280_repeat-like
IPR008979--Galactose-bd-like
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR012983--PHR
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51284--DOC
PS50194--FILAMIN_REPEAT
PS00626--RCC1_2
PS50012--RCC1_3
PS50089--ZF_RING_2

Pfam

PF08005--PHR
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM00184--RING

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007628--P:adult walking behavior
GO:0006914--P:autophagy
GO:0030509--P:BMP signaling pathway
GO:0050965--P:detection of temperature stimulus involved in sensory perception of pain
GO:0040011--P:locomotion
GO:0007616--P:long-term memory
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0045886--P:negative regulation of synaptic growth at neuromuscular junction
GO:0016567--P:protein ubiquitination
GO:0008582--P:regulation of synaptic growth at neuromuscular junction
GO:2000331--P:regulation of terminal button organization
GO:0048678--P:response to axon injury
GO:0050808--P:synapse organization
GO:0006351--P:transcription, DNA-templated

KEGG

dme:Dmel_CG32592

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001951	Ailuropoda melanoleuca	62.57	0.00e+00	727.00
IUUC-Apl-003625	Anas platyrhynchos	60.97	0.00e+00	663.00
IUUC-Aca-005207	Anolis carolinensis	62.76	0.00e+00	690.00
IUUC-Ame-010649	Astyanax mexicanus	49.07	0.00e+00	1111.00
IUUC-Bta-012670	Bos taurus	62.57	0.00e+00	727.00
IUUC-Cel-018686	Caenorhabditis elegans	28.79	8.00e-148	519.00
IUUC-Cja-019910	Callithrix jacchus	62.76	0.00e+00	728.00
IUUC-Cfa-020184	Canis familiaris	62.57	0.00e+00	727.00
IUUC-Cpo-021334	Cavia porcellus	62.76	0.00e+00	727.00
IUUC-Csa-023291	Chlorocebus sabaeus	62.76	0.00e+00	728.00
IUUC-Cho-024927	Choloepus hoffmanni	36.79	2.00e-105	379.00
IUUC-Cin-025345	Ciona intestinalis	58.03	0.00e+00	654.00
IUUC-Csv-026264	Ciona savignyi	56.02	0.00e+00	628.00
IUUC-Dre-028645	Danio rerio	49.76	0.00e+00	1126.00
IUUC-Dno-029670	Dasypus novemcinctus	62.76	0.00e+00	729.00
IUUC-Dor-030993	Dipodomys ordii	57.91	0.00e+00	642.00
IUUC-Ete-032613	Echinops telfairi	58.47	0.00e+00	660.00
IUUC-Eca-034364	Equus caballus	62.76	0.00e+00	728.00
IUUC-Eeu-035200	Erinaceus europaeus	61.91	0.00e+00	713.00
IUUC-Fca-036054	Felis catus	62.76	0.00e+00	728.00
IUUC-Fal-036991	Ficedula albicollis	62.76	0.00e+00	694.00
IUUC-Gmo-038487	Gadus morhua	48.33	0.00e+00	1154.00
IUUC-Gga-041035	Gallus gallus	62.76	0.00e+00	694.00
IUUC-Gac-041637	Gasterosteus aculeatus	61.64	0.00e+00	681.00
IUUC-Ggo-045091	Gorilla gorilla	41.30	7.00e-114	406.00
IUUC-Hsa-046977	Homo sapiens	62.57	0.00e+00	728.00
IUUC-Itr-048995	Ictidomys tridecemlineatus	40.99	9.00e-113	401.00
IUUC-Lch-050171	Latimeria chalumnae	37.43	0.00e+00	1088.00
IUUC-Loc-052822	Lepisosteus oculatus	62.01	0.00e+00	686.00
IUUC-Laf-054065	Loxodonta africana	62.57	0.00e+00	726.00
IUUC-Mcc-054947	Macaca mulatta	62.76	0.00e+00	728.00
IUUC-Meu-056600	Macropus eugenii	58.78	6.00e-171	596.00
IUUC-Mga-059559	Meleagris gallopavo	61.82	0.00e+00	682.00
IUUC-Mmr-060973	Microcebus murinus	62.76	0.00e+00	728.00
IUUC-Mdo-061938	Monodelphis domestica	62.57	0.00e+00	691.00
IUUC-Mmu-063569	Mus musculus	62.76	0.00e+00	727.00
IUUC-Mpu-066457	Mustela putorius furo	60.80	0.00e+00	654.00
IUUC-Mlu-067165	Myotis lucifugus	41.80	1.00e-132	469.00
IUUC-Nle-069042	Nomascus leucogenys	62.20	0.00e+00	712.00
IUUC-Opr-070201	Ochotona princeps	43.07	1.00e-106	382.00
IUUC-Ont-072263	Oreochromis niloticus	49.72	0.00e+00	1129.00
IUUC-Oan-073108	Ornithorhynchus anatinus	41.08	2.00e-133	471.00
IUUC-Ocu-074359	Oryctolagus cuniculus	62.94	0.00e+00	730.00
IUUC-Ola-087074	Oryzias latipes	35.51	9.00e-109	389.00
IUUC-Oga-088322	Otolemur garnettii	62.76	0.00e+00	728.00
IUUC-Oar-089244	Ovis aries	62.57	0.00e+00	726.00
IUUC-Ptr-091449	Pan troglodytes	62.57	0.00e+00	727.00
IUUC-Pan-091756	Papio anubis	62.76	0.00e+00	728.00
IUUC-Psi-093387	Pelodiscus sinensis	62.38	0.00e+00	693.00
IUUC-Pma-094327	Petromyzon marinus	46.35	7.00e-66	243.00
IUUC-Ppa-095276	Physcomitrella patens	39.18	5.00e-51	195.00
IUUC-Pfo-097372	Poecilia formosa	61.64	0.00e+00	682.00
IUUC-Pab-097572	Pongo abelii	62.57	0.00e+00	729.00
IUUC-Pca-101007	Procavia capensis	55.12	4.00e-174	607.00
IUUC-Pva-102217	Pteropus vampyrus	63.91	0.00e+00	695.00
IUUC-Rno-105422	Rattus norvegicus	62.76	0.00e+00	727.00
IUUC-Sce-106318	Saccharomyces cerevisiae	31.48	2.60e-02	33.90
IUUC-Sha-107119	Sarcophilus harrisii	62.34	0.00e+00	687.00
IUUC-Smo-108712	Selaginella moellendorffii	42.12	5.00e-65	239.00
IUUC-Sar-113595	Sorex araneus	57.91	0.00e+00	645.00
IUUC-Ssc-115690	Sus scrofa	57.66	4.00e-153	537.00
IUUC-Tgu-116555	Taeniopygia guttata	62.76	0.00e+00	694.00
IUUC-Tru-117796	Takifugu rubripes	49.48	0.00e+00	1122.00
IUUC-Tsy-118924	Tarsius syrichta	60.15	0.00e+00	692.00
IUUC-Tni-120759	Tetraodon nigroviridis	49.80	0.00e+00	1117.00
IUUC-Tme-127029	Tuber melanosporum	37.72	1.00e-07	52.40
IUUC-Ttr-128814	Tursiops truncatus	62.57	0.00e+00	728.00
IUUC-Vpa-130430	Vicugna pacos	60.72	0.00e+00	650.00
IUUC-Xtr-131898	Xenopus tropicalis	46.86	8.00e-73	268.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence