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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045897
Ensembl Protein ID ENSP00000262891.3
UniProt Accession Q96L34; Q8NG37; Q96JG7; Q96SQ2; Q9BYD8; MARK4_HUMAN
Genbank Protein ID BAB39380.1; BAC03375.1; AAL23683.1; AAM55491.1; BAB47489.1; BAB55238.1; BAC11510.1
Protein Name MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1
Genbank Nucleotide ID AB049127; AB088047; AY057448; AX305105; AB058763; AK027619; AK075272
Gene Name MARK4; KIAA1860; MARKL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000007047.14 ENST00000262891.8 ENSP00000262891.3
ENSG00000007047.14 ENST00000300843.8 ENSP00000300843.3
ENSG00000007047.14 ENST00000592762.5 ENSP00000466702.1
ENSG00000007047.14 ENST00000592207.5 ENSP00000466843.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UBA UBA 14594945
Classification
Family E-value Score Start End
UBD/Alpha-Helix/UBA 0.0048 18.7 331 367
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UBA
   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLl 39
           d+  +e +v MG++ree+++ L +  +n   A+++Ll
   Q: 331  DTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLL 367
           577899******************9888888888887 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).
 Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).
Protein Sequence
(Fasta)
MSSRTVLAPG NDRNSDTHGT LGSGRSSDKG PSWSSRSLGA RCRNSIASCP EEQPHVGNYR 60
LLRTIGKGNF AKVKLARHIL TGREVAIKII DKTQLNPSSL QKLFREVRIM KGLNHPNIVK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045897|UBD,UBA|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGGTGGTGG GGGGTCGCCA GCAGGTTCCC TCTCCCCGGC CCCAGCTCTG GACGCTCACC 60
CCAGTGCAAC GCCCTGAGTG ACGGAAAGAG GTAGGACCGC GCCTGCAGCG CCGGCTGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045897|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0132--Cell division
KW-0966--Cell projection
KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0418--Kinase
KW-0498--Mitosis
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0832--Ubl conjugation
Interpro

IPR028375--KA1/Ssp2_C
IPR001772--KA1_dom
IPR011009--Kinase-like_dom
IPR033624--MARK/par1
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
PROSITE

PS50032--KA1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA
Pfam

PF02149--KA1
PF00069--Pkinase
PF00627--UBA
SMART

SM00220--S_TKc
SM00165--UBA
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0005829--C:cytosol
GO:0015630--C:microtubule cytoskeleton
GO:0005815--C:microtubule organizing center
GO:0043005--C:neuron projection
GO:0005524--F:ATP binding
GO:0043015--F:gamma-tubulin binding
GO:0008017--F:microtubule binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0050321--F:tau-protein kinase activity
GO:0043130--F:ubiquitin binding
GO:0051301--P:cell division
GO:0097711--P:ciliary basal body docking
GO:0030010--P:establishment of cell polarity
GO:0001578--P:microtubule bundle formation
GO:0000226--P:microtubule cytoskeleton organization
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0043068--P:positive regulation of programmed cell death
GO:0006468--P:protein phosphorylation
KEGG hsa:57787
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Bta-013546 Bos taurus 97.96 0.00e+00 1273.00
IUUC-Cja-019522 Callithrix jacchus 99.20 0.00e+00 1346.00
IUUC-Cfa-020231 Canis familiaris 96.36 0.00e+00 1278.00
IUUC-Cpo-022532 Cavia porcellus 96.94 0.00e+00 1281.00
IUUC-Csa-023700 Chlorocebus sabaeus 97.35 0.00e+00 1283.00
IUUC-Dor-030478 Dipodomys ordii 96.05 0.00e+00 1221.00
IUUC-Eca-033684 Equus caballus 96.55 0.00e+00 1066.00
IUUC-Fca-035898 Felis catus 97.69 0.00e+00 1311.00
IUUC-Gmo-039460 Gadus morhua 71.70 0.00e+00 939.00
IUUC-Gac-042324 Gasterosteus aculeatus 68.73 0.00e+00 983.00
IUUC-Ggo-044770 Gorilla gorilla 95.80 0.00e+00 1222.00
IUUC-Itr-049080 Ictidomys tridecemlineatus 99.07 0.00e+00 1382.00
IUUC-Lch-049752 Latimeria chalumnae 67.70 0.00e+00 946.00
IUUC-Laf-053534 Loxodonta africana 94.42 0.00e+00 1278.00
IUUC-Mcc-054804 Macaca mulatta 99.60 0.00e+00 1319.00
IUUC-Meu-056140 Macropus eugenii 94.41 0.00e+00 1330.00
IUUC-Mmr-060587 Microcebus murinus 98.54 0.00e+00 1345.00
IUUC-Mmu-064289 Mus musculus 97.61 0.00e+00 1355.00
IUUC-Mlu-067933 Myotis lucifugus 85.01 0.00e+00 1039.00
IUUC-Nle-069719 Nomascus leucogenys 93.89 0.00e+00 1051.00
IUUC-Opr-070607 Ochotona princeps 89.89 0.00e+00 1214.00
IUUC-Ont-071444 Oreochromis niloticus 70.28 0.00e+00 1004.00
IUUC-Ola-086790 Oryzias latipes 63.77 0.00e+00 919.00
IUUC-Oga-088194 Otolemur garnettii 98.94 0.00e+00 1309.00
IUUC-Oar-089936 Ovis aries 87.10 0.00e+00 1129.00
IUUC-Ptr-091413 Pan troglodytes 99.87 0.00e+00 1322.00
IUUC-Pab-098074 Pongo abelii 97.61 0.00e+00 1274.00
IUUC-Pva-103242 Pteropus vampyrus 99.34 0.00e+00 1291.00
IUUC-Rno-105368 Rattus norvegicus 97.74 0.00e+00 1334.00
IUUC-Tru-117575 Takifugu rubripes 67.82 0.00e+00 922.00
IUUC-Ttr-129093 Tursiops truncatus 96.33 0.00e+00 1233.00
IUUC-Xtr-132367 Xenopus tropicalis 71.82 0.00e+00 840.00
Created Date 25-Jun-2017

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