iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/UBZ	5.30e-06	27.7	462	485

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/UBZ

   S: 1    llvCPvCqkmvdqtdfeeHlDeCl 24
           l+ CPvCq  v +++++eHlD+Cl
   Q: 462  LVNCPVCQGVVVESQINEHLDRCL 485
           589********************8 PP

Organism

Mus musculus

Functional Description
(View)

Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (By similarity).

Protein Sequence
(Fasta)

MDEDLVVALR LQEEWDVQMA RRAAAAREPV SLVDASWELV DPTPDLQALF LQFNDRFFWG 60
QLEAVEVKWS VRMTLCAGIC TYEGRGGMCS IRLSEPLLKL RPRKDLVETL LHEMIHAYLF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAAGTCAG AGGAGGGTCC GGCACGGACC AGACTTGACG TGTGTCGCCG GACCTCAGCG 60
GCTGTCAGGA GACAACCGGC TGCCTAAAGC CGTCCCCAGC CCGAGCCCAG CGTTCCTAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006640--SprT-like_domain
IPR006642--Znf_Rad18_put

PROSITE

PS00142--ZINC_PROTEASE

Pfam

PF10263--SprT-like

SMART

SM00731--SprT
SM00734--ZnF_Rad18

Gene Ontology

GO:0005694--C:chromosome
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0031398--P:positive regulation of protein ubiquitination
GO:0009411--P:response to UV
GO:0019985--P:translesion synthesis

KEGG

mmu:244666

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001028	Aegilops tauschii	34.33	3.00e-16	79.70
IUUC-Aml-001352	Ailuropoda melanoleuca	69.48	0.00e+00	667.00
IUUC-Atr-002445	Amborella trichopoda	44.44	2.00e-42	166.00
IUUC-Apl-003724	Anas platyrhynchos	41.85	3.00e-67	248.00
IUUC-Aca-005382	Anolis carolinensis	51.81	2.00e-133	468.00
IUUC-Ame-011053	Astyanax mexicanus	48.38	7.00e-103	367.00
IUUC-Bta-012578	Bos taurus	69.08	0.00e+00	655.00
IUUC-Bci-013808	Botrytis cinerea	50.00	1.90e-02	33.50
IUUC-Cel-018317	Caenorhabditis elegans	64.22	4.00e-82	298.00
IUUC-Cja-019824	Callithrix jacchus	70.73	0.00e+00	655.00
IUUC-Cfa-020307	Canis familiaris	72.29	0.00e+00	694.00
IUUC-Cpo-022142	Cavia porcellus	68.29	5.00e-173	600.00
IUUC-Cre-022820	Chlamydomonas reinhardtii	39.07	5.00e-31	128.00
IUUC-Csa-024002	Chlorocebus sabaeus	70.28	0.00e+00	651.00
IUUC-Cho-024371	Choloepus hoffmanni	61.08	3.00e-107	381.00
IUUC-Cin-025503	Ciona intestinalis	60.50	2.00e-89	322.00
IUUC-Csv-025903	Ciona savignyi	72.49	1.00e-89	322.00
IUUC-Cgl-026737	Colletotrichum gloeosporioides	28.21	3.00e-05	43.50
IUUC-Dre-027871	Danio rerio	50.12	1.00e-112	400.00
IUUC-Dno-029800	Dasypus novemcinctus	64.74	4.00e-177	614.00
IUUC-Dor-030856	Dipodomys ordii	57.11	6.00e-125	440.00
IUUC-Dme-031958	Drosophila melanogaster	55.35	2.00e-68	253.00
IUUC-Ete-032321	Echinops telfairi	81.67	1.00e-121	429.00
IUUC-Eca-033610	Equus caballus	69.88	0.00e+00	685.00
IUUC-Eeu-034608	Erinaceus europaeus	58.35	2.00e-153	535.00
IUUC-Fca-035456	Felis catus	69.04	0.00e+00	660.00
IUUC-Fal-036725	Ficedula albicollis	45.16	6.00e-95	341.00
IUUC-Fso-038353	Fusarium solani	34.38	7.00e-05	42.00
IUUC-Gmo-039428	Gadus morhua	61.09	9.00e-92	330.00
IUUC-Ggr-039914	Gaeumannomyces graminis	28.03	2.00e-04	40.40
IUUC-Gga-041138	Gallus gallus	50.43	5.00e-124	437.00
IUUC-Gac-041946	Gasterosteus aculeatus	59.76	9.00e-91	327.00
IUUC-Ggo-044909	Gorilla gorilla	69.56	0.00e+00	649.00
IUUC-Hsa-046804	Homo sapiens	69.76	0.00e+00	648.00
IUUC-Hvu-047629	Hordeum vulgare	29.65	4.00e-17	82.80
IUUC-Itr-048136	Ictidomys tridecemlineatus	70.36	1.00e-173	602.00
IUUC-Lch-050399	Latimeria chalumnae	44.35	2.00e-107	383.00
IUUC-Lpe-050694	Leersia perrieri	33.62	7.00e-19	89.00
IUUC-Loc-052526	Lepisosteus oculatus	55.75	2.00e-105	376.00
IUUC-Lma-053205	Leptosphaeria maculans	43.17	8.00e-49	187.00
IUUC-Laf-054101	Loxodonta africana	70.32	0.00e+00	712.00
IUUC-Mcc-055889	Macaca mulatta	70.48	0.00e+00	653.00
IUUC-Meu-056236	Macropus eugenii	64.00	5.00e-24	105.00
IUUC-Mor-057257	Magnaporthe oryzae	28.48	7.00e-08	51.60
IUUC-Mpo-057531	Magnaporthe poae	28.03	3.00e-04	40.00
IUUC-Mga-059774	Meleagris gallopavo	47.87	2.00e-105	375.00
IUUC-Mmr-061635	Microcebus murinus	67.20	0.00e+00	640.00
IUUC-Mdo-062699	Monodelphis domestica	64.50	1.00e-119	422.00
IUUC-Mac-065121	Musa acuminata	31.47	6.00e-20	91.70
IUUC-Mpu-065833	Mustela putorius furo	70.08	0.00e+00	684.00
IUUC-Mlu-067479	Myotis lucifugus	59.53	5.00e-127	447.00
IUUC-Ncr-068774	Neurospora crassa	30.89	1.00e-05	44.70
IUUC-Nle-069224	Nomascus leucogenys	69.35	0.00e+00	663.00
IUUC-Opr-070699	Ochotona princeps	58.23	6.00e-150	523.00
IUUC-Ont-072423	Oreochromis niloticus	56.39	7.00e-107	381.00
IUUC-Oan-073554	Ornithorhynchus anatinus	66.67	2.00e-34	136.00
IUUC-Ocu-074946	Oryctolagus cuniculus	86.99	7.00e-131	459.00
IUUC-Oba-075090	Oryza barthii	33.97	1.00e-19	91.70
IUUC-Obr-076066	Oryza brachyantha	33.18	3.00e-18	87.40
IUUC-Ogl-077154	Oryza glaberrima	33.97	1.00e-19	91.70
IUUC-Ogu-077955	Oryza glumaepatula	33.97	9.00e-20	92.00
IUUC-Oin-079055	Oryza indica	33.97	1.00e-19	91.30
IUUC-Olo-080733	Oryza longistaminata	41.44	3.00e-15	77.00
IUUC-Ome-081338	Oryza meridionalis	33.97	1.00e-19	91.70
IUUC-Oni-082257	Oryza nivara	33.97	1.00e-19	91.30
IUUC-Opu-083290	Oryza punctata	33.49	5.00e-19	89.70
IUUC-Oru-084633	Oryza rufipogon	33.97	5.00e-19	89.70
IUUC-Osa-086222	Oryza sativa	33.97	1.00e-19	91.70
IUUC-Ola-087333	Oryzias latipes	47.05	9.00e-113	400.00
IUUC-Olu-087722	Ostreococcus lucimarinus	33.77	9.00e-05	43.50
IUUC-Oga-088956	Otolemur garnettii	71.11	0.00e+00	676.00
IUUC-Oar-090014	Ovis aries	69.28	0.00e+00	650.00
IUUC-Ptr-091565	Pan troglodytes	69.76	0.00e+00	648.00
IUUC-Pan-092756	Papio anubis	70.68	0.00e+00	659.00
IUUC-Psi-093051	Pelodiscus sinensis	49.64	4.00e-104	371.00
IUUC-Pma-094409	Petromyzon marinus	71.64	9.00e-58	215.00
IUUC-Pno-094926	Phaeosphaeria nodorum	44.55	1.00e-46	179.00
IUUC-Pfo-096555	Poecilia formosa	53.85	2.00e-102	366.00
IUUC-Pab-098754	Pongo abelii	64.96	2.00e-129	455.00
IUUC-Pca-100166	Procavia capensis	65.21	0.00e+00	652.00
IUUC-Pva-102910	Pteropus vampyrus	61.32	4.00e-165	574.00
IUUC-Pte-104222	Pyrenophora teres	45.15	2.00e-47	182.00
IUUC-Pyt-104688	Pyrenophora triticirepentis	46.77	3.00e-46	179.00
IUUC-Rno-105616	Rattus norvegicus	82.53	0.00e+00	746.00
IUUC-Sha-106669	Sarcophilus harrisii	66.23	6.00e-126	444.00
IUUC-Smo-108867	Selaginella moellendorffii	47.83	3.00e-44	171.00
IUUC-Sit-110221	Setaria italica	26.61	3.00e-16	79.70
IUUC-Sar-113141	Sorex araneus	60.86	4.00e-160	557.00
IUUC-Sbi-114252	Sorghum bicolor	27.64	4.00e-16	79.30
IUUC-Ssc-115883	Sus scrofa	69.29	0.00e+00	665.00
IUUC-Tgu-116997	Taeniopygia guttata	45.71	1.00e-109	390.00
IUUC-Tru-117785	Takifugu rubripes	45.01	9.00e-103	367.00
IUUC-Tsy-119449	Tarsius syrichta	61.68	1.00e-133	469.00
IUUC-Tni-120379	Tetraodon nigroviridis	46.81	4.00e-114	405.00
IUUC-Tre-121886	Trichoderma reesei	41.94	1.00e-04	41.20
IUUC-Tvi-122337	Trichoderma virens	50.00	4.00e-03	36.20
IUUC-Tae-124356	Triticum aestivum	31.88	1.00e-18	88.60
IUUC-Tur-126257	Triticum urartu	29.65	2.00e-19	90.50
IUUC-Tbe-128156	Tupaia belangeri	64.55	1.00e-169	589.00
IUUC-Ttr-128748	Tursiops truncatus	68.30	5.00e-152	530.00
IUUC-Vda-129771	Verticillium dahliae	30.60	3.00e-05	43.50
IUUC-Vpa-130454	Vicugna pacos	61.40	5.00e-75	275.00
IUUC-Xtr-132163	Xenopus tropicalis	44.96	6.00e-111	394.00
IUUC-Xma-134184	Xiphophorus maculatus	51.90	2.00e-106	379.00
IUUC-Zma-134864	Zea mays	28.28	4.00e-17	82.80

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence