iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000010810.17	ENST00000368682.7	ENSP00000357671.3
ENSG00000010810.17	ENST00000354650.7	ENSP00000346671.3
ENSG00000010810.17	ENST00000229471.8	ENSP00000229471.4
ENSG00000010810.17	ENST00000462598.7	ENSP00000429590.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	miRNAMap	SomamiR
miRcode	RAID2	LncRNADisease
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Drug and target
TTD	GRAC	PDTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	PhosphoBase	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.90e-15	56.2	87	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L+++kG++ +++  ++ +++W+++ + ++g  G +P+n+v+ ++
   Q: 87   FVALYDYEARTEDDLSFHKGEKFQIL--NSSEGDWWEARSLTTGETGYIPSNYVAPVD 142
           789***********************..89999*********************9987 PP

Organism

Homo sapiens

Functional Description
(View)

Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.

Protein Sequence
(Fasta)

MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 60
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGCATCAG CAAGAGTAGC AGCGAGCAGC CGCGCTGGTG GCGGCGGCGC GTCGTTGCAG 60
TTGCGCCATC TGTCAGGAGC GGAGCCGGCG AGGAGGGGGC TGCCGCGGGC GAGGAGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0945--Host-virus interaction
KW-0391--Immunity
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0464--Manganese
KW-0472--Membrane
KW-0479--Metal-binding
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005768--C:endosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0005524--F:ATP binding
GO:0046875--F:ephrin receptor binding
GO:0001948--F:glycoprotein binding
GO:0070851--F:growth factor receptor binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0046934--F:phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005088--F:Ras guanyl-nucleotide exchange factor activity
GO:0004871--F:signal transducer activity
GO:0050798--P:activated T cell proliferation
GO:0002250--P:adaptive immune response
GO:0007411--P:axon guidance
GO:0007596--P:blood coagulation
GO:0006816--P:calcium ion transport
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0071375--P:cellular response to peptide hormone stimulus
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0007417--P:central nervous system development
GO:0048813--P:dendrite morphogenesis
GO:0050966--P:detection of mechanical stimulus involved in sensory perception of pain
GO:0048013--P:ephrin receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0007631--P:feeding behavior
GO:0030900--P:forebrain development
GO:0045087--P:innate immune response
GO:0035556--P:intracellular signal transduction
GO:0007612--P:learning
GO:0050900--P:leukocyte migration
GO:0000165--P:MAPK cascade
GO:1902951--P:negative regulation of dendritic spine maintenance
GO:2001240--P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:0010629--P:negative regulation of gene expression
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0042177--P:negative regulation of protein catabolic process
GO:0031397--P:negative regulation of protein ubiquitination
GO:0001764--P:neuron migration
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0048015--P:phosphatidylinositol-mediated signaling
GO:0030168--P:platelet activation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1901216--P:positive regulation of neuron death
GO:0010976--P:positive regulation of neuron projection development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0090314--P:positive regulation of protein targeting to membrane
GO:0042523--P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0006468--P:protein phosphorylation
GO:0042981--P:regulation of apoptotic process
GO:1905664--P:regulation of calcium ion import across plasma membrane
GO:0042127--P:regulation of cell proliferation
GO:0008360--P:regulation of cell shape
GO:0050690--P:regulation of defense response to virus by virus
GO:0014066--P:regulation of phosphatidylinositol 3-kinase signaling
GO:1904645--P:response to beta-amyloid
GO:0042493--P:response to drug
GO:0045471--P:response to ethanol
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0042110--P:T cell activation
GO:0031295--P:T cell costimulation
GO:0050852--P:T cell receptor signaling pathway
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0016032--P:viral process

KEGG

hsa:2534

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002009	Ailuropoda melanoleuca	99.81	0.00e+00	1090.00
IUUC-Apl-003716	Anas platyrhynchos	92.76	0.00e+00	1003.00
IUUC-Aca-005065	Anolis carolinensis	98.88	0.00e+00	1080.00
IUUC-Ame-011533	Astyanax mexicanus	94.95	0.00e+00	912.00
IUUC-Bta-012645	Bos taurus	99.63	0.00e+00	1088.00
IUUC-Cel-018682	Caenorhabditis elegans	57.68	9.00e-150	523.00
IUUC-Cja-019027	Callithrix jacchus	99.81	0.00e+00	1090.00
IUUC-Cfa-021163	Canis familiaris	99.81	0.00e+00	1090.00
IUUC-Cpo-022315	Cavia porcellus	99.81	0.00e+00	1090.00
IUUC-Csa-023721	Chlorocebus sabaeus	100.00	0.00e+00	1092.00
IUUC-Cho-025014	Choloepus hoffmanni	99.63	0.00e+00	1088.00
IUUC-Dre-027985	Danio rerio	92.36	0.00e+00	1056.00
IUUC-Dno-030043	Dasypus novemcinctus	90.66	0.00e+00	1062.00
IUUC-Dor-031035	Dipodomys ordii	98.51	0.00e+00	1071.00
IUUC-Dme-031976	Drosophila melanogaster	60.65	2.00e-164	572.00
IUUC-Eca-033928	Equus caballus	90.21	0.00e+00	830.00
IUUC-Eeu-034582	Erinaceus europaeus	99.14	0.00e+00	687.00
IUUC-Fca-035582	Felis catus	99.81	0.00e+00	1090.00
IUUC-Fal-037320	Ficedula albicollis	93.11	0.00e+00	1007.00
IUUC-Gmo-038992	Gadus morhua	90.72	0.00e+00	1033.00
IUUC-Gga-041262	Gallus gallus	93.11	0.00e+00	1007.00
IUUC-Gac-042461	Gasterosteus aculeatus	90.50	0.00e+00	1036.00
IUUC-Ggo-044469	Gorilla gorilla	99.07	0.00e+00	1087.00
IUUC-Itr-048519	Ictidomys tridecemlineatus	99.81	0.00e+00	1090.00
IUUC-Lch-049825	Latimeria chalumnae	92.92	0.00e+00	1013.00
IUUC-Loc-052531	Lepisosteus oculatus	91.43	0.00e+00	1045.00
IUUC-Laf-053659	Loxodonta africana	99.63	0.00e+00	1087.00
IUUC-Mcc-055039	Macaca mulatta	93.91	0.00e+00	1019.00
IUUC-Mga-060067	Meleagris gallopavo	98.70	0.00e+00	1077.00
IUUC-Mmr-061194	Microcebus murinus	99.81	0.00e+00	1090.00
IUUC-Mdo-062628	Monodelphis domestica	99.63	0.00e+00	1088.00
IUUC-Mmu-063896	Mus musculus	99.44	0.00e+00	1087.00
IUUC-Mpu-066333	Mustela putorius furo	99.44	0.00e+00	1086.00
IUUC-Mlu-067315	Myotis lucifugus	99.81	0.00e+00	1090.00
IUUC-Nle-068978	Nomascus leucogenys	94.41	0.00e+00	1021.00
IUUC-Ont-072516	Oreochromis niloticus	91.81	0.00e+00	1051.00
IUUC-Oan-073714	Ornithorhynchus anatinus	99.56	0.00e+00	948.00
IUUC-Ocu-074284	Oryctolagus cuniculus	100.00	0.00e+00	1092.00
IUUC-Ola-087431	Oryzias latipes	91.62	0.00e+00	1047.00
IUUC-Oga-088789	Otolemur garnettii	94.04	0.00e+00	1016.00
IUUC-Oar-089408	Ovis aries	99.63	0.00e+00	1088.00
IUUC-Ptr-091068	Pan troglodytes	100.00	0.00e+00	1092.00
IUUC-Pan-092217	Papio anubis	100.00	0.00e+00	1092.00
IUUC-Psi-093602	Pelodiscus sinensis	98.70	0.00e+00	1079.00
IUUC-Pfo-097084	Poecilia formosa	92.18	0.00e+00	1054.00
IUUC-Pab-097673	Pongo abelii	99.63	0.00e+00	1088.00
IUUC-Pca-100245	Procavia capensis	97.53	0.00e+00	971.00
IUUC-Pva-102645	Pteropus vampyrus	97.95	0.00e+00	1052.00
IUUC-Rno-105372	Rattus norvegicus	99.63	0.00e+00	1088.00
IUUC-Sha-107637	Sarcophilus harrisii	99.26	0.00e+00	1075.00
IUUC-Sar-113016	Sorex araneus	88.45	0.00e+00	944.00
IUUC-Ssc-116389	Sus scrofa	99.44	0.00e+00	1083.00
IUUC-Tgu-117206	Taeniopygia guttata	93.11	0.00e+00	1007.00
IUUC-Tru-118241	Takifugu rubripes	90.94	0.00e+00	1043.00
IUUC-Tni-120031	Tetraodon nigroviridis	91.62	0.00e+00	1043.00
IUUC-Tbe-127707	Tupaia belangeri	96.75	0.00e+00	971.00
IUUC-Ttr-129145	Tursiops truncatus	99.81	0.00e+00	1090.00
IUUC-Vpa-130815	Vicugna pacos	97.00	0.00e+00	1034.00
IUUC-Xtr-132293	Xenopus tropicalis	90.32	0.00e+00	979.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence