iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UFD/MUB	29.97	6.00e-19	92.40	IUUC-Ath-007357

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Homo sapiens

Functional Description
(View)

Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.

Protein Sequence
(Fasta)

MEDPSEPDRL ASADGGSPEE EEDGEREPLL PRIAWAHPRR GAPGSAVRLL DAAGEEGEAG 60
DEELPLPPGD VGVSRSSSAE LDRSRPAVSV TIGTSEMNAF LDDPEFADIM LRAEQAIEVG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGCGCGA GGTGGGGCGC GGCCGGCGGC GAGGCGGGAC AACCGCTGGG CGGGCGCCAA 60
GCGTGCCCGT GCGCTGGTGA GGTGGCGTCC GTTCTACCCG GTCGCTCCCG TTCCGCGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0418--Kinase
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase

Interpro

IPR000403--PI3/4_kinase_cat_dom

Pfam

PF00454--PI3_PI4_kinase

Gene Ontology

GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0016020--C:membrane
GO:0005886--C:plasma membrane
GO:0005802--C:trans-Golgi network
GO:0004430--F:1-phosphatidylinositol 4-kinase activity
GO:0005524--F:ATP binding
GO:0007032--P:endosome organization
GO:0007030--P:Golgi organization
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0046854--P:phosphatidylinositol phosphorylation

KEGG

hsa:55300

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000880	Aegilops tauschii	27.56	2.00e-14	74.70
IUUC-Aml-002168	Ailuropoda melanoleuca	81.22	0.00e+00	766.00
IUUC-Atr-002849	Amborella trichopoda	26.69	1.00e-14	75.50
IUUC-Apl-003641	Anas platyrhynchos	84.46	0.00e+00	692.00
IUUC-Aca-004310	Anolis carolinensis	76.16	0.00e+00	695.00
IUUC-Aly-005869	Arabidopsis lyrata	29.62	1.00e-18	88.20
IUUC-Ath-007357	Arabidopsis thaliana	29.97	9.00e-20	92.00
IUUC-Ago-007834	Ashbya gossypii	38.19	5.00e-60	225.00
IUUC-Acl-008056	Aspergillus clavatus	37.91	5.00e-48	186.00
IUUC-Afl-008443	Aspergillus flavus	32.82	2.00e-65	244.00
IUUC-Afu-008894	Aspergillus fumigatus	31.46	3.00e-57	216.00
IUUC-Ani-009242	Aspergillus nidulans	46.49	5.00e-44	172.00
IUUC-Ang-009698	Aspergillus niger	35.92	6.00e-72	265.00
IUUC-Aor-010129	Aspergillus oryzae	32.82	1.00e-65	244.00
IUUC-Ate-010366	Aspergillus terreus	33.33	7.00e-63	235.00
IUUC-Ame-011505	Astyanax mexicanus	59.84	2.00e-136	478.00
IUUC-Bgr-012207	Blumeria graminis	33.56	9.00e-63	235.00
IUUC-Bta-013130	Bos taurus	80.95	0.00e+00	738.00
IUUC-Bci-013857	Botrytis cinerea	31.42	5.00e-61	229.00
IUUC-Bdi-014227	Brachypodium distachyon	28.11	2.00e-14	74.30
IUUC-Bol-015769	Brassica oleracea	30.07	5.00e-19	89.70
IUUC-Bra-017779	Brassica rapa	29.51	1.00e-17	85.10
IUUC-Cel-018333	Caenorhabditis elegans	38.52	4.00e-65	241.00
IUUC-Cja-019512	Callithrix jacchus	93.97	0.00e+00	893.00
IUUC-Cfa-020046	Canis familiaris	90.91	0.00e+00	735.00
IUUC-Cpo-022524	Cavia porcellus	88.28	0.00e+00	694.00
IUUC-Cre-022842	Chlamydomonas reinhardtii	23.05	5.00e-06	45.10
IUUC-Csa-024215	Chlorocebus sabaeus	96.88	0.00e+00	886.00
IUUC-Cho-024651	Choloepus hoffmanni	75.60	2.00e-168	585.00
IUUC-Cin-025197	Ciona intestinalis	62.24	7.00e-150	523.00
IUUC-Csv-026330	Ciona savignyi	63.45	3.00e-149	521.00
IUUC-Cgl-026422	Colletotrichum gloeosporioides	34.43	4.00e-64	239.00
IUUC-Dre-028161	Danio rerio	79.38	0.00e+00	660.00
IUUC-Dno-029087	Dasypus novemcinctus	80.00	0.00e+00	744.00
IUUC-Dor-031108	Dipodomys ordii	81.54	0.00e+00	724.00
IUUC-Dse-031283	Dothistroma septosporum	32.64	4.00e-61	229.00
IUUC-Dme-032030	Drosophila melanogaster	60.98	5.00e-86	311.00
IUUC-Ete-032358	Echinops telfairi	69.43	8.00e-110	390.00
IUUC-Eca-034170	Equus caballus	87.89	0.00e+00	712.00
IUUC-Eeu-034549	Erinaceus europaeus	86.26	2.00e-94	339.00
IUUC-Fca-035541	Felis catus	82.38	0.00e+00	754.00
IUUC-Fal-037138	Ficedula albicollis	84.54	0.00e+00	689.00
IUUC-Fox-037982	Fusarium oxysporum	44.17	8.00e-43	169.00
IUUC-Fso-038407	Fusarium solani	45.55	4.00e-42	166.00
IUUC-Gmo-039406	Gadus morhua	60.49	5.00e-158	550.00
IUUC-Ggr-040017	Gaeumannomyces graminis	43.00	2.00e-40	160.00
IUUC-Gga-040594	Gallus gallus	83.42	0.00e+00	682.00
IUUC-Gac-041355	Gasterosteus aculeatus	76.09	0.00e+00	634.00
IUUC-Gma-043404	Glycine max	28.43	9.00e-17	82.00
IUUC-Ggo-044615	Gorilla gorilla	99.17	0.00e+00	879.00
IUUC-Hvu-047413	Hordeum vulgare	27.05	4.00e-13	70.10
IUUC-Itr-048839	Ictidomys tridecemlineatus	90.28	0.00e+00	754.00
IUUC-Kpa-049368	Komagataella pastoris	38.11	2.00e-68	253.00
IUUC-Lch-049861	Latimeria chalumnae	79.47	0.00e+00	679.00
IUUC-Lpe-051715	Leersia perrieri	25.98	7.00e-14	72.40
IUUC-Loc-052304	Lepisosteus oculatus	78.79	0.00e+00	671.00
IUUC-Lma-053303	Leptosphaeria maculans	34.59	1.00e-66	248.00
IUUC-Laf-053826	Loxodonta africana	83.26	0.00e+00	761.00
IUUC-Mcc-055372	Macaca mulatta	98.44	0.00e+00	793.00
IUUC-Meu-056312	Macropus eugenii	77.63	5.00e-178	617.00
IUUC-Mor-056958	Magnaporthe oryzae	46.49	2.00e-40	161.00
IUUC-Mpo-057554	Magnaporthe poae	41.83	3.00e-40	160.00
IUUC-Mtr-057995	Medicago truncatula	28.67	6.00e-17	82.80
IUUC-Mla-059000	Melampsora laricipopulina	39.22	3.00e-49	190.00
IUUC-Mga-059856	Meleagris gallopavo	82.82	0.00e+00	682.00
IUUC-Mvi-060280	Microbotryum violaceum	43.65	5.00e-34	140.00
IUUC-Mmr-061773	Microcebus murinus	85.98	0.00e+00	778.00
IUUC-Mdo-061817	Monodelphis domestica	84.69	0.00e+00	696.00
IUUC-Mmu-064384	Mus musculus	80.49	0.00e+00	753.00
IUUC-Mpu-066590	Mustela putorius furo	78.16	0.00e+00	749.00
IUUC-Mlu-067287	Myotis lucifugus	76.29	0.00e+00	697.00
IUUC-Nfi-068333	Neosartorya fischeri	32.66	8.00e-60	225.00
IUUC-Ncr-068800	Neurospora crassa	33.33	8.00e-65	242.00
IUUC-Nle-069534	Nomascus leucogenys	98.13	0.00e+00	888.00
IUUC-Opr-071136	Ochotona princeps	71.65	0.00e+00	627.00
IUUC-Ont-071667	Oreochromis niloticus	77.63	0.00e+00	653.00
IUUC-Oan-073489	Ornithorhynchus anatinus	85.27	0.00e+00	684.00
IUUC-Ocu-074482	Oryctolagus cuniculus	91.60	0.00e+00	761.00
IUUC-Oba-075598	Oryza barthii	25.42	6.00e-14	72.40
IUUC-Obr-076060	Oryza brachyantha	27.21	9.00e-15	75.90
IUUC-Ogl-077532	Oryza glaberrima	28.57	4.00e-16	79.70
IUUC-Ogu-079016	Oryza glumaepatula	25.42	6.00e-14	72.80
IUUC-Oin-079936	Oryza indica	27.05	1.00e-13	71.60
IUUC-Olo-080229	Oryza longistaminata	29.08	3.00e-18	87.00
IUUC-Ome-081235	Oryza meridionalis	25.63	1.00e-14	74.70
IUUC-Oni-082942	Oryza nivara	25.42	6.00e-14	72.80
IUUC-Opu-084094	Oryza punctata	27.53	8.00e-17	82.40
IUUC-Oru-084647	Oryza rufipogon	27.05	2.00e-13	71.20
IUUC-Osa-086157	Oryza sativa	27.05	1.00e-13	71.60
IUUC-Ola-086957	Oryzias latipes	76.29	0.00e+00	629.00
IUUC-Olu-087862	Ostreococcus lucimarinus	24.43	7.00e-10	57.40
IUUC-Oga-088698	Otolemur garnettii	85.28	0.00e+00	787.00
IUUC-Oar-090389	Ovis aries	77.98	0.00e+00	739.00
IUUC-Ptr-090638	Pan troglodytes	98.32	0.00e+00	890.00
IUUC-Pan-092030	Papio anubis	88.64	0.00e+00	783.00
IUUC-Psi-093599	Pelodiscus sinensis	79.36	0.00e+00	692.00
IUUC-Pma-094719	Petromyzon marinus	66.86	9.00e-137	479.00
IUUC-Pno-094843	Phaeosphaeria nodorum	30.69	8.00e-54	205.00
IUUC-Pfo-096221	Poecilia formosa	78.15	0.00e+00	651.00
IUUC-Pab-097653	Pongo abelii	97.51	0.00e+00	883.00
IUUC-Pop-099957	Populus trichocarpa	27.33	1.00e-15	78.20
IUUC-Pca-100747	Procavia capensis	72.43	4.00e-71	262.00
IUUC-Ppe-101716	Prunus persica	26.30	3.00e-14	73.90
IUUC-Pva-102926	Pteropus vampyrus	80.26	0.00e+00	741.00
IUUC-Pte-104342	Pyrenophora teres	41.41	7.00e-38	152.00
IUUC-Rno-105311	Rattus norvegicus	81.60	0.00e+00	759.00
IUUC-Sce-106456	Saccharomyces cerevisiae	34.43	2.00e-58	220.00
IUUC-Sha-106794	Sarcophilus harrisii	85.64	0.00e+00	706.00
IUUC-Sja-107883	Schizosaccharomyces japonicus	37.02	8.00e-60	224.00
IUUC-Spo-108111	Schizosaccharomyces pombe	34.06	7.00e-61	228.00
IUUC-Ssl-108516	Sclerotinia sclerotiorum	31.65	2.00e-60	227.00
IUUC-Smo-108951	Selaginella moellendorffii	29.43	3.00e-13	70.10
IUUC-Sit-110146	Setaria italica	28.83	2.00e-16	80.90
IUUC-Sly-111242	Solanum lycopersicum	27.21	1.00e-16	81.60
IUUC-Stu-111951	Solanum tuberosum	27.92	3.00e-17	83.60
IUUC-Sar-113055	Sorex araneus	84.46	0.00e+00	694.00
IUUC-Sbi-114147	Sorghum bicolor	28.11	9.00e-16	79.00
IUUC-Sre-114896	Sporisorium reilianum	45.39	3.00e-31	130.00
IUUC-Ssc-115853	Sus scrofa	68.22	5.00e-157	547.00
IUUC-Tgu-116711	Taeniopygia guttata	83.63	0.00e+00	688.00
IUUC-Tru-118416	Takifugu rubripes	77.78	0.00e+00	628.00
IUUC-Tsy-119014	Tarsius syrichta	92.06	0.00e+00	776.00
IUUC-Tni-120317	Tetraodon nigroviridis	78.50	0.00e+00	643.00
IUUC-Tca-121419	Theobroma cacao	27.92	9.00e-17	82.00
IUUC-Tre-122021	Trichoderma reesei	43.14	2.00e-41	164.00
IUUC-Tvi-122384	Trichoderma virens	41.67	8.00e-38	152.00
IUUC-Tae-122680	Triticum aestivum	27.92	5.00e-15	76.30
IUUC-Tur-126000	Triticum urartu	26.77	3.00e-13	70.10
IUUC-Tme-127049	Tuber melanosporum	37.80	1.00e-67	251.00
IUUC-Tbe-127365	Tupaia belangeri	81.84	0.00e+00	654.00
IUUC-Ttr-129032	Tursiops truncatus	82.79	0.00e+00	786.00
IUUC-Uma-129477	Ustilago maydis	43.42	4.00e-30	127.00
IUUC-Vda-129801	Verticillium dahliae	33.19	3.00e-63	236.00
IUUC-Vpa-130255	Vicugna pacos	83.33	0.00e+00	663.00
IUUC-Vvi-131314	Vitis vinifera	26.69	2.00e-17	84.30
IUUC-Xtr-132347	Xenopus tropicalis	75.22	0.00e+00	689.00
IUUC-Xma-133726	Xiphophorus maculatus	78.92	0.00e+00	659.00
IUUC-Yli-134389	Yarrowia lipolytica	38.50	2.00e-71	264.00
IUUC-Zma-134858	Zea mays	28.11	2.00e-14	73.90

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence