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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046059
Ensembl Protein ID ENSP00000339299.4
UniProt Accession O75962; D3DTD1; Q13458; Q59EQ7; Q6PJC9; Q6ZN05; Q8IWK8; TRIO_HUMAN
Genbank Protein ID BAD18570.1; EAX08047.1; EAX08048.1; AAH35585.1; AAH17268.1; AAC34245.1; AAC43042.1; BAD92991.1
Protein Name Triple functional domain protein; PTPRF-interacting protein
Genbank Nucleotide ID AK131423; AC010419; CH471102; BC035585; BC017268; U42390; AF091395; AB209754
Gene Name TRIO
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000038382.17 ENST00000344204.8 ENSP00000339299.4
ENSG00000038382.17 ENST00000512070.6 ENSP00000421555.2
ENSG00000038382.17 ENST00000509967.6 ENSP00000445592.1
ENSG00000038382.17 ENST00000513206.5 ENSP00000426342.2
ENSG00000038382.17 ENST00000344135.5 ENSP00000339291.5
ENSG00000038382.17 ENST00000620511.1 ENSP00000483869.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosSNPPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 5.80e-13 50.2 1661 1712
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk..elegkrGlfP 55
             v++d++a n++eLt+++G +v+v+e  +   +W+           +Gl+P
   Q: 1661 TVVIHDFTACNSNELTIRRGQTVEVLERPHDKPDWCLVRTtdRSPAAEGLVP 1712
           679********************************97755334445678887 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity).
 Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity).
Protein Sequence
(Fasta)
MSGSSGGAAA PAASSGPAAA ASAAGSGCGG GAGEGAEEAA KDLADIAAFF RSGFRKNDEM 60
KAMDVLPILK EKVAYLSGGR DKRGGPILTF PARSNHDRIR QEDLRRLISY LACIPSEEVC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046059|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGCCGCGG GCGCCGCCGC AGCCATGAGC GGCAGCAGCG GCGGAGCCGC CGCCCCCGCC 60
GCGTCCTCCG GCCCCGCCGC GGCGGCCAGC GCGGCTGGCT CGGGCTGCGG GGGCGGTGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046059|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-1015--Disulfide bond
KW-0344--Guanine-nucleotide releasing factor
KW-0393--Immunoglobulin domain
KW-0418--Kinase
KW-0991--Mental retardation
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0808--Transferase
Interpro

IPR001251--CRAL-TRIO_dom
IPR000219--DH-domain
IPR007110--Ig-like_dom
IPR013783--Ig-like_fold
IPR013098--Ig_I-set
IPR003599--Ig_sub
IPR003598--Ig_sub2
IPR011009--Kinase-like_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR001452--SH3_domain
IPR018159--Spectrin/alpha-actinin
IPR002017--Spectrin_repeat
IPR028570--TRIO
PROSITE

PS50191--CRAL_TRIO
PS50010--DH_2
PS50835--IG_LIKE
PS50003--PH_DOMAIN
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50002--SH3
Pfam

PF00650--CRAL_TRIO
PF07679--I-set
PF00169--PH
PF00069--Pkinase
PF00621--RhoGEF
PF00018--SH3_1
PF00435--Spectrin
SMART

SM00409--IG
SM00408--IGc2
SM00233--PH
SM00325--RhoGEF
SM00220--S_TKc
SM00516--SEC14
SM00326--SH3
SM00150--SPEC
Gene Ontology

GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0043065--P:positive regulation of apoptotic process
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007185--P:transmembrane receptor protein tyrosine phosphatase signaling pathway
KEGG hsa:7204
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001797 Ailuropoda melanoleuca 95.05 0.00e+00 5654.00
IUUC-Apl-003498 Anas platyrhynchos 93.87 0.00e+00 5219.00
IUUC-Bta-013121 Bos taurus 94.24 0.00e+00 5540.00
IUUC-Cja-018919 Callithrix jacchus 99.73 0.00e+00 4450.00
IUUC-Cfa-020547 Canis familiaris 95.45 0.00e+00 5572.00
IUUC-Cpo-022301 Cavia porcellus 96.77 0.00e+00 5721.00
IUUC-Csa-023889 Chlorocebus sabaeus 99.96 0.00e+00 4437.00
IUUC-Dre-028386 Danio rerio 88.84 0.00e+00 3928.00
IUUC-Dno-028888 Dasypus novemcinctus 94.88 0.00e+00 5588.00
IUUC-Dor-030992 Dipodomys ordii 88.82 0.00e+00 4576.00
IUUC-Ete-033167 Echinops telfairi 91.97 0.00e+00 1717.00
IUUC-Eca-033685 Equus caballus 98.70 0.00e+00 4368.00
IUUC-Fca-035647 Felis catus 98.08 0.00e+00 4391.00
IUUC-Fal-036845 Ficedula albicollis 93.71 0.00e+00 5579.00
IUUC-Gga-040959 Gallus gallus 94.10 0.00e+00 5636.00
IUUC-Gac-041349 Gasterosteus aculeatus 87.53 0.00e+00 3803.00
IUUC-Ggo-045170 Gorilla gorilla 99.96 0.00e+00 4417.00
IUUC-Lch-050010 Latimeria chalumnae 92.92 0.00e+00 4100.00
IUUC-Loc-052783 Lepisosteus oculatus 86.04 0.00e+00 5101.00
IUUC-Laf-053884 Loxodonta africana 95.00 0.00e+00 5621.00
IUUC-Mcc-055804 Macaca mulatta 99.38 0.00e+00 4427.00
IUUC-Mga-060008 Meleagris gallopavo 92.48 0.00e+00 5556.00
IUUC-Mmr-061081 Microcebus murinus 96.66 0.00e+00 5683.00
IUUC-Mdo-062888 Monodelphis domestica 98.66 0.00e+00 4055.00
IUUC-Mmu-063327 Mus musculus 96.02 0.00e+00 5623.00
IUUC-Mpu-066905 Mustela putorius furo 95.39 0.00e+00 5568.00
IUUC-Mlu-068215 Myotis lucifugus 96.08 0.00e+00 4326.00
IUUC-Nle-069414 Nomascus leucogenys 97.36 0.00e+00 4285.00
IUUC-Opr-070819 Ochotona princeps 94.51 0.00e+00 4249.00
IUUC-Ont-072678 Oreochromis niloticus 89.09 0.00e+00 3906.00
IUUC-Oan-072974 Ornithorhynchus anatinus 98.35 0.00e+00 4399.00
IUUC-Ocu-074919 Oryctolagus cuniculus 95.99 0.00e+00 5618.00
IUUC-Oga-088068 Otolemur garnettii 96.73 0.00e+00 5724.00
IUUC-Oar-090050 Ovis aries 95.72 0.00e+00 4269.00
IUUC-Ptr-090841 Pan troglodytes 99.96 0.00e+00 4439.00
IUUC-Psi-093088 Pelodiscus sinensis 93.32 0.00e+00 5601.00
IUUC-Pfo-097201 Poecilia formosa 77.78 0.00e+00 3435.00
IUUC-Pab-098130 Pongo abelii 99.82 0.00e+00 4430.00
IUUC-Pca-100839 Procavia capensis 91.60 0.00e+00 3840.00
IUUC-Pva-102115 Pteropus vampyrus 95.12 0.00e+00 2913.00
IUUC-Rno-105207 Rattus norvegicus 95.68 0.00e+00 5586.00
IUUC-Sha-107011 Sarcophilus harrisii 90.14 0.00e+00 4304.00
IUUC-Tgu-116970 Taeniopygia guttata 93.52 0.00e+00 5526.00
IUUC-Tru-117758 Takifugu rubripes 87.72 0.00e+00 3866.00
IUUC-Ttr-128857 Tursiops truncatus 90.60 0.00e+00 4002.00
IUUC-Xtr-131909 Xenopus tropicalis 87.09 0.00e+00 5205.00
Created Date 25-Jun-2017

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