iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000049283.17	ENST00000268933.7	ENSP00000268933.3
ENSG00000049283.17	ENST00000512291.5	ENSP00000421936.1
ENSG00000049283.17	ENST00000510045.5	ENSP00000421933.1
ENSG00000049283.17	ENST00000574464.5	ENSP00000460911.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	11919637

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UIM	5.20e-07	30.6	236	254
UBD/Alpha-Helix/UIM	2e-05	16.6	209	227

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           dEd++LqlAl+lS+qE+e+
   Q: 236  DEDLQLQLALRLSRQEHEK 254
           7****************96 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+++LqlAla+S++E+e+
   Q: 209  EEELQLQLALAMSREEAEK 227
           79***************95 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MTTSALRRQV KNIVHNYSEA EIKVREATSN DPWGPPSSLM SEIADLTFNT VAFTEVMGML 60
WRRLNDSGKN WRHVYKALTL LDYLLKTGSE RVAHQCRENL YTIQTLKDFQ YIDRDGKDQG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAGCAGAGG GGATCAGGTC GCCAGCACTG GCTCCAGATG TGCACTTCCT GGGGGCGGCC 60
AACAGGCAGG CCCCCCACCT CTCAATGCAC CACTTGCCTG GCCAGCAGGA AGGGGTTAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0446--Lipid-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR013809--ENTH
IPR008942--ENTH_VHS
IPR027318--Epsin-3_metazoa
IPR003903--UIM_dom

PROSITE

PS50942--ENTH
PS50330--UIM

Pfam

PF01417--ENTH
PF02809--UIM

SMART

SM00273--ENTH
SM00726--UIM

Gene Ontology

GO:0005905--C:clathrin-coated pit
GO:0030136--C:clathrin-coated vesicle
GO:0070062--C:extracellular exosome
GO:0019897--C:extrinsic component of plasma membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0008289--F:lipid binding

KEGG

hsa:55040

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002202	Ailuropoda melanoleuca	80.10	2.00e-157	548.00
IUUC-Apl-003938	Anas platyrhynchos	61.42	1.00e-86	312.00
IUUC-Aca-005019	Anolis carolinensis	64.76	0.00e+00	643.00
IUUC-Acl-008167	Aspergillus clavatus	53.03	3.00e-38	153.00
IUUC-Afl-008626	Aspergillus flavus	54.92	3.00e-36	145.00
IUUC-Afu-009110	Aspergillus fumigatus	53.03	2.00e-38	154.00
IUUC-Ani-009183	Aspergillus nidulans	53.03	4.00e-37	149.00
IUUC-Ang-009835	Aspergillus niger	54.55	5.00e-39	155.00
IUUC-Aor-009899	Aspergillus oryzae	53.79	2.00e-38	154.00
IUUC-Ate-010292	Aspergillus terreus	55.30	2.00e-39	157.00
IUUC-Ame-011143	Astyanax mexicanus	46.13	3.00e-93	336.00
IUUC-Bgr-012103	Blumeria graminis	40.80	3.00e-45	176.00
IUUC-Bta-012344	Bos taurus	79.06	0.00e+00	812.00
IUUC-Bci-013887	Botrytis cinerea	57.58	7.00e-41	162.00
IUUC-Cja-018801	Callithrix jacchus	95.15	0.00e+00	966.00
IUUC-Cfa-020215	Canis familiaris	89.84	0.00e+00	904.00
IUUC-Cpo-021844	Cavia porcellus	83.61	0.00e+00	808.00
IUUC-Csa-024257	Chlorocebus sabaeus	96.67	0.00e+00	969.00
IUUC-Dre-027620	Danio rerio	46.23	3.00e-98	352.00
IUUC-Dno-029944	Dasypus novemcinctus	79.59	0.00e+00	779.00
IUUC-Dor-030270	Dipodomys ordii	85.33	0.00e+00	899.00
IUUC-Dse-031529	Dothistroma septosporum	49.69	5.00e-43	169.00
IUUC-Eca-033368	Equus caballus	85.69	0.00e+00	916.00
IUUC-Fca-035598	Felis catus	86.12	0.00e+00	783.00
IUUC-Fal-036930	Ficedula albicollis	60.13	8.00e-167	580.00
IUUC-Gmo-039660	Gadus morhua	49.66	6.00e-108	385.00
IUUC-Gga-040600	Gallus gallus	62.93	3.00e-158	551.00
IUUC-Gac-042303	Gasterosteus aculeatus	52.60	3.00e-107	382.00
IUUC-Ggo-045604	Gorilla gorilla	97.18	0.00e+00	1017.00
IUUC-Itr-048835	Ictidomys tridecemlineatus	87.27	0.00e+00	931.00
IUUC-Lch-050652	Latimeria chalumnae	58.01	4.00e-142	498.00
IUUC-Loc-052572	Lepisosteus oculatus	56.31	8.00e-134	471.00
IUUC-Lma-053140	Leptosphaeria maculans	54.48	2.00e-39	158.00
IUUC-Laf-054462	Loxodonta africana	86.47	0.00e+00	930.00
IUUC-Mcc-055207	Macaca mulatta	97.32	0.00e+00	979.00
IUUC-Meu-056064	Macropus eugenii	72.61	0.00e+00	783.00
IUUC-Mla-058947	Melampsora laricipopulina	44.31	8.00e-47	181.00
IUUC-Mga-059375	Meleagris gallopavo	64.00	4.00e-162	564.00
IUUC-Mmr-061041	Microcebus murinus	90.68	0.00e+00	896.00
IUUC-Mdo-062185	Monodelphis domestica	80.19	0.00e+00	843.00
IUUC-Mmu-063485	Mus musculus	81.34	0.00e+00	824.00
IUUC-Mpu-066311	Mustela putorius furo	86.78	0.00e+00	919.00
IUUC-Mlu-067152	Myotis lucifugus	80.81	0.00e+00	659.00
IUUC-Nfi-068548	Neosartorya fischeri	53.03	2.00e-38	154.00
IUUC-Nle-069899	Nomascus leucogenys	95.30	0.00e+00	973.00
IUUC-Opr-070654	Ochotona princeps	86.39	0.00e+00	914.00
IUUC-Ont-071755	Oreochromis niloticus	49.10	4.00e-101	362.00
IUUC-Oan-072854	Ornithorhynchus anatinus	66.43	7.00e-177	613.00
IUUC-Ocu-074810	Oryctolagus cuniculus	89.53	0.00e+00	847.00
IUUC-Olu-087896	Ostreococcus lucimarinus	34.81	1.00e-17	82.80
IUUC-Oga-088099	Otolemur garnettii	82.40	0.00e+00	785.00
IUUC-Oar-090276	Ovis aries	83.58	0.00e+00	867.00
IUUC-Pan-092255	Papio anubis	94.69	0.00e+00	988.00
IUUC-Psi-093981	Pelodiscus sinensis	63.23	2.00e-179	622.00
IUUC-Pno-095066	Phaeosphaeria nodorum	56.88	2.00e-32	133.00
IUUC-Pfo-096086	Poecilia formosa	47.68	1.00e-105	377.00
IUUC-Pab-098401	Pongo abelii	97.99	0.00e+00	1019.00
IUUC-Pca-100477	Procavia capensis	85.51	0.00e+00	926.00
IUUC-Pva-102611	Pteropus vampyrus	75.81	0.00e+00	794.00
IUUC-Pgr-103451	Puccinia graminis	61.24	2.00e-42	166.00
IUUC-Ptt-103708	Puccinia triticina	63.56	5.00e-41	161.00
IUUC-Pte-104048	Pyrenophora teres	54.55	7.00e-39	155.00
IUUC-Pyt-104596	Pyrenophora triticirepentis	54.55	1.00e-38	155.00
IUUC-Rno-105902	Rattus norvegicus	78.35	0.00e+00	780.00
IUUC-Sha-107372	Sarcophilus harrisii	80.19	0.00e+00	843.00
IUUC-Sja-107671	Schizosaccharomyces japonicus	47.73	2.00e-42	167.00
IUUC-Ssl-108625	Sclerotinia sclerotiorum	57.58	8.00e-41	161.00
IUUC-Sar-112960	Sorex araneus	79.85	7.00e-105	374.00
IUUC-Ssc-115921	Sus scrofa	80.90	0.00e+00	812.00
IUUC-Tgu-117395	Taeniopygia guttata	60.98	1.00e-173	603.00
IUUC-Tme-127215	Tuber melanosporum	54.93	2.00e-43	170.00
IUUC-Ttr-128552	Tursiops truncatus	85.10	2.00e-170	592.00
IUUC-Xma-133053	Xiphophorus maculatus	54.01	3.00e-124	439.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence