iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000050730.15	ENST00000057513.7	ENSP00000057513.3
ENSG00000050730.15	ENST00000509841.1	ENSP00000426613.1
ENSG00000050730.15	ENST00000515036.1	ENSP00000424284.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBAN	UBAN	18212736

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBAN	4.20e-26	92.3	190	250

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBAN

   S: 1    keelletvevLkqQveiYkeDFqaERadRErlneekeeLqeqveklqkqvsklndslkask 61
           +ee+++++evLkqQv+iY+eDF++ER+dRErln+ekeeLq+++e++q+q+++ln+++ka++
   Q: 190  HEEMRTEMEVLKQQVQIYEEDFKKERSDRERLNQEKEELQQINETSQSQLNRLNSQIKACQ 250
           89*********************************************************97 PP

Organism

Homo sapiens

Functional Description
(View)

Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.

Protein Sequence
(Fasta)

MAHFVQGTSR MIAAESSTEH KECAEPSTRK NLMNSLEQKI RCLEKQRKEL LEVNQQWDQQ 60
FRSMKELYER KVAELKTKLD AAERFLSTRE KDPHQRQRKD DRQREDDRQR DLTRDRLQRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGAGTCTTA AAGACAGGTC TCCGTATTAG ACCTTGTAAT ACGCTTACCT AGATCTGAGA 60
AGGACTTTCA GGATAGAACA TGGTGAGTAA CATAATGTCT TGTGCCTTTA CTTTCATTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0395--Inflammatory response
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR032419--CC2-LZ_dom
IPR033574--TNIP3

Pfam

PF16516--CC2-LZ

Gene Ontology

GO:0005829--C:cytosol
GO:0031593--F:polyubiquitin binding
GO:0071222--P:cellular response to lipopolysaccharide
GO:0006954--P:inflammatory response
GO:0002756--P:MyD88-independent toll-like receptor signaling pathway
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0034142--P:toll-like receptor 4 signaling pathway

KEGG

hsa:79931

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002067	Ailuropoda melanoleuca	77.36	2.00e-94	338.00
IUUC-Apl-004206	Anas platyrhynchos	53.96	5.00e-47	181.00
IUUC-Aca-005302	Anolis carolinensis	53.72	5.00e-50	191.00
IUUC-Bta-012335	Bos taurus	72.61	4.00e-99	354.00
IUUC-Cja-018962	Callithrix jacchus	90.14	9.00e-72	263.00
IUUC-Cfa-020391	Canis familiaris	76.85	9.00e-108	383.00
IUUC-Cpo-021748	Cavia porcellus	69.51	2.00e-104	371.00
IUUC-Csa-023223	Chlorocebus sabaeus	90.94	2.00e-124	438.00
IUUC-Cho-024692	Choloepus hoffmanni	85.83	1.00e-50	193.00
IUUC-Dno-029745	Dasypus novemcinctus	71.69	4.00e-117	414.00
IUUC-Dor-030845	Dipodomys ordii	51.59	6.00e-63	234.00
IUUC-Ete-032522	Echinops telfairi	65.89	2.00e-87	315.00
IUUC-Eca-033833	Equus caballus	79.02	2.00e-98	352.00
IUUC-Fca-035554	Felis catus	76.69	1.00e-91	330.00
IUUC-Fal-037572	Ficedula albicollis	52.26	5.00e-61	227.00
IUUC-Gga-040967	Gallus gallus	53.38	1.00e-68	253.00
IUUC-Ggo-044668	Gorilla gorilla	98.15	3.00e-146	511.00
IUUC-Itr-048604	Ictidomys tridecemlineatus	60.57	6.00e-60	224.00
IUUC-Lch-049514	Latimeria chalumnae	46.04	2.00e-48	186.00
IUUC-Loc-052227	Lepisosteus oculatus	37.92	2.00e-37	149.00
IUUC-Laf-053655	Loxodonta africana	77.57	3.00e-108	384.00
IUUC-Mcc-055640	Macaca mulatta	82.95	1.00e-93	336.00
IUUC-Mga-059657	Meleagris gallopavo	53.20	2.00e-65	242.00
IUUC-Mmr-061631	Microcebus murinus	85.71	2.00e-71	262.00
IUUC-Mpu-066506	Mustela putorius furo	64.33	3.00e-77	282.00
IUUC-Mlu-067825	Myotis lucifugus	62.73	1.00e-63	236.00
IUUC-Nle-069637	Nomascus leucogenys	94.75	4.00e-134	471.00
IUUC-Opr-071187	Ochotona princeps	70.73	2.00e-94	339.00
IUUC-Oan-072805	Ornithorhynchus anatinus	60.95	2.00e-52	199.00
IUUC-Ocu-074800	Oryctolagus cuniculus	77.54	1.00e-116	412.00
IUUC-Oga-088454	Otolemur garnettii	79.25	4.00e-98	351.00
IUUC-Oar-089705	Ovis aries	71.43	4.00e-116	410.00
IUUC-Ptr-091489	Pan troglodytes	99.66	1.00e-127	449.00
IUUC-Pan-092492	Papio anubis	92.28	3.00e-127	447.00
IUUC-Psi-092990	Pelodiscus sinensis	52.62	4.00e-70	258.00
IUUC-Pab-097583	Pongo abelii	95.06	4.00e-136	477.00
IUUC-Pca-100575	Procavia capensis	50.31	6.00e-53	201.00
IUUC-Pva-103246	Pteropus vampyrus	65.00	1.00e-73	270.00
IUUC-Pyt-104730	Pyrenophora triticirepentis	44.00	1.60e-01	29.60
IUUC-Rno-104934	Rattus norvegicus	55.90	2.00e-39	155.00
IUUC-Sar-113660	Sorex araneus	58.15	3.00e-87	315.00
IUUC-Ssc-116328	Sus scrofa	69.16	6.00e-111	393.00
IUUC-Tgu-117394	Taeniopygia guttata	53.59	4.00e-40	157.00
IUUC-Tsy-119152	Tarsius syrichta	81.36	1.00e-71	263.00
IUUC-Tbe-127856	Tupaia belangeri	71.64	3.00e-75	274.00
IUUC-Ttr-128333	Tursiops truncatus	64.31	6.00e-99	353.00
IUUC-Vpa-130185	Vicugna pacos	77.78	7.00e-58	217.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence