iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000061938.16	ENST00000416152.5	ENSP00000398614.1
ENSG00000061938.16	ENST00000381916.6	ENSP00000371341.2
ENSG00000061938.16	ENST00000333602.10	ENSP00000329425.6
ENSG00000061938.16	ENST00000428187.5	ENSP00000392546.1
ENSG00000061938.16	ENST00000439230.5	ENSP00000395588.1
ENSG00000061938.16	ENST00000424563.5	ENSP00000390435.1
ENSG00000061938.16	ENST00000411741.1	ENSP00000415126.1
ENSG00000061938.16	ENST00000438207.5	ENSP00000392253.1
ENSG00000061938.16	ENST00000430929.1	ENSP00000409462.1
ENSG00000061938.16	ENST00000447060.5	ENSP00000393707.1
ENSG00000061938.16	ENST00000427576.1	ENSP00000390088.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRecords
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	PHOSIDA	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	17182860; 20979614; 24413169

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	5.00e-05	25.0	960	993

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGFdreealqaLraannnleaAveyL 38
           dk++ ++  G ++ee++ aL+ +++++++A+ yL
   Q: 960  DKIQMAMVHGVTTEECQAALQCHGWSVQRAAQYL 993
           89******************************99 PP

Organism

Homo sapiens

Functional Description
(View)

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.

Protein Sequence
(Fasta)

MQPEEGTGWL LELLSEVQLQ QYFLRLRDDL NVTRLSHFEY VKNEDLEKIG MGRPGQRRLW 60
EAVKRRKALC KRKSWMSKVF SGKRLEAEFP PHHSQSTFRK TSPAPGGPAG EGPLQSLTCL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTTTTAG TCTGGGGCTC CTTCCTCATG TCAGCTCCCT AGTGGCAGAG CAGTCTCCCT 60
CGGTGTCTCT CTGGCCACCA TGATCAGTGT CACGGACACA TCCCAGCATA GCCCCAGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0168--Coated pit
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0254--Endocytosis
KW-0967--Endosome
KW-0418--Kinase
KW-0460--Magnesium
KW-0472--Membrane
KW-0479--Metal-binding
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation

Interpro

IPR015116--Cdc42_binding_dom-like
IPR011009--Kinase-like_dom
IPR021619--Mig-6
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50002--SH3

Pfam

PF09027--GTPase_binding
PF11555--Inhibitor_Mig-6
PF07714--Pkinase_Tyr
PF14604--SH3_9

PRINTS

PR00109--TYRKINASE

SMART

SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005912--C:adherens junction
GO:0005905--C:clathrin-coated pit
GO:0030136--C:clathrin-coated vesicle
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005768--C:endosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0070436--C:Grb2-EGFR complex
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0005154--F:epidermal growth factor receptor binding
GO:0005095--F:GTPase inhibitor activity
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0050699--F:WW domain binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0007166--P:cell surface receptor signaling pathway
GO:0006897--P:endocytosis
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0016310--P:phosphorylation
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0042127--P:regulation of cell proliferation
GO:2000369--P:regulation of clathrin-dependent endocytosis
GO:0007264--P:small GTPase mediated signal transduction
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

hsa:10188

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002166	Ailuropoda melanoleuca	91.30	0.00e+00	1637.00
IUUC-Aca-004315	Anolis carolinensis	88.97	2.00e-73	268.00
IUUC-Ame-011350	Astyanax mexicanus	54.05	0.00e+00	1030.00
IUUC-Bta-012325	Bos taurus	94.71	0.00e+00	1715.00
IUUC-Cel-018130	Caenorhabditis elegans	36.96	2.00e-89	324.00
IUUC-Cja-019545	Callithrix jacchus	90.93	0.00e+00	1618.00
IUUC-Cfa-020706	Canis familiaris	94.04	0.00e+00	1728.00
IUUC-Cpo-022032	Cavia porcellus	87.86	0.00e+00	1626.00
IUUC-Csa-023936	Chlorocebus sabaeus	96.78	0.00e+00	1759.00
IUUC-Csv-026328	Ciona savignyi	58.84	5.00e-173	600.00
IUUC-Dre-028714	Danio rerio	62.25	0.00e+00	1201.00
IUUC-Dno-029525	Dasypus novemcinctus	95.00	0.00e+00	1743.00
IUUC-Dme-031778	Drosophila melanogaster	55.90	4.00e-144	506.00
IUUC-Ete-032225	Echinops telfairi	90.41	0.00e+00	854.00
IUUC-Fca-035664	Felis catus	94.91	0.00e+00	1777.00
IUUC-Gmo-039543	Gadus morhua	59.27	0.00e+00	942.00
IUUC-Gga-040241	Gallus gallus	68.66	0.00e+00	1299.00
IUUC-Gac-041457	Gasterosteus aculeatus	61.66	0.00e+00	1122.00
IUUC-Ggo-045333	Gorilla gorilla	95.55	0.00e+00	1753.00
IUUC-Itr-048054	Ictidomys tridecemlineatus	92.88	0.00e+00	1724.00
IUUC-Lch-049670	Latimeria chalumnae	61.57	0.00e+00	1187.00
IUUC-Loc-052870	Lepisosteus oculatus	62.86	0.00e+00	1253.00
IUUC-Laf-053782	Loxodonta africana	90.70	0.00e+00	1640.00
IUUC-Mcc-055874	Macaca mulatta	97.15	0.00e+00	1763.00
IUUC-Mga-059717	Meleagris gallopavo	70.04	0.00e+00	1344.00
IUUC-Mdo-062270	Monodelphis domestica	85.63	0.00e+00	1594.00
IUUC-Mmu-063861	Mus musculus	93.08	0.00e+00	1756.00
IUUC-Mpu-066127	Mustela putorius furo	94.82	0.00e+00	1365.00
IUUC-Mlu-067937	Myotis lucifugus	84.63	0.00e+00	1615.00
IUUC-Nle-069298	Nomascus leucogenys	97.07	0.00e+00	1449.00
IUUC-Ont-072437	Oreochromis niloticus	59.18	0.00e+00	1186.00
IUUC-Oan-073708	Ornithorhynchus anatinus	69.44	3.00e-110	392.00
IUUC-Ola-087023	Oryzias latipes	61.41	0.00e+00	1124.00
IUUC-Pan-091857	Papio anubis	89.82	2.00e-94	338.00
IUUC-Psi-093401	Pelodiscus sinensis	55.15	3.00e-149	522.00
IUUC-Pfo-097455	Poecilia formosa	58.67	0.00e+00	1177.00
IUUC-Rno-105586	Rattus norvegicus	92.51	0.00e+00	1725.00
IUUC-Sha-106868	Sarcophilus harrisii	84.91	0.00e+00	1599.00
IUUC-Ssc-116250	Sus scrofa	94.24	0.00e+00	1667.00
IUUC-Tgu-116592	Taeniopygia guttata	69.38	0.00e+00	1300.00
IUUC-Tru-117852	Takifugu rubripes	70.25	8.00e-180	625.00
IUUC-Tsy-119087	Tarsius syrichta	98.51	2.00e-158	553.00
IUUC-Tni-120826	Tetraodon nigroviridis	61.57	0.00e+00	1201.00
IUUC-Xtr-132069	Xenopus tropicalis	64.40	0.00e+00	1174.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence