iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000063978.15	ENST00000314289.12	ENSP00000315212.8
ENSG00000063978.15	ENST00000509258.5	ENSP00000422500.1
ENSG00000063978.15	ENST00000513284.5	ENSP00000425724.1
ENSG00000063978.15	ENST00000513578.5	ENSP00000422938.1
ENSG00000063978.15	ENST00000511859.5	ENSP00000426615.1
ENSG00000063978.15	ENST00000508235.1	ENSP00000427212.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18408734; 19380586; 20212317; 20026589; 22661230; 22635276

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.70e-08	35.8	132	177

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf......kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++ +       +  +++ CgHvf+ +Cl       +s +++ +CP+Cr
   Q: 132  CPICMDGYseivqnGRLIVSTECGHVFCSQCL------RDSLKNANTCPTCR 177
           ********55553322255788*********9......4559*********8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation.

Protein Sequence
(Fasta)

MSTRKRRGGA INSRQAQKRT REATSTPEIS LEAEPIELVE TAGDEIVDLT CESLEPVVVD 60
LTHNDSVVIV DERRRPRRNA RRLPQDHADS CVVSSDDEEL SRDRDVYVTT HTPRNARDEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGAAGTGCT GGAGACTCCC CCAACCCCTC CAGCCCCTGA GCGGTGGTAC TGTCTAGGAG 60
CGCGCCGCGG CCCCTGGGCC TCGCTGTCTG TCCTAAATCA TTCCGGTGAA CCTCTCCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0050681--F:androgen receptor binding
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0031491--F:nucleosome binding
GO:0032184--F:SUMO polymer binding
GO:0003713--F:transcription coactivator activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030521--P:androgen receptor signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0090234--P:regulation of kinetochore assembly
GO:0090169--P:regulation of spindle assembly
GO:0046685--P:response to arsenic-containing substance
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:6047

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000620	Aegilops tauschii	39.34	2.00e-10	59.70
IUUC-Aml-002206	Ailuropoda melanoleuca	93.58	6.00e-85	306.00
IUUC-Atr-002771	Amborella trichopoda	35.38	5.00e-09	54.70
IUUC-Apl-004120	Anas platyrhynchos	70.92	1.00e-70	258.00
IUUC-Aca-004236	Anolis carolinensis	63.16	1.00e-60	225.00
IUUC-Ame-011555	Astyanax mexicanus	50.93	1.00e-36	145.00
IUUC-Bta-012913	Bos taurus	86.84	2.00e-86	311.00
IUUC-Bdi-014655	Brachypodium distachyon	42.62	1.00e-10	60.10
IUUC-Bol-016418	Brassica oleracea	37.70	5.00e-09	55.10
IUUC-Bra-016890	Brassica rapa	36.84	1.00e-07	50.10
IUUC-Cel-018585	Caenorhabditis elegans	33.33	2.00e-08	52.40
IUUC-Cja-019151	Callithrix jacchus	95.81	3.00e-87	314.00
IUUC-Cfa-020868	Canis familiaris	90.53	2.00e-81	295.00
IUUC-Cpo-022249	Cavia porcellus	87.17	9.00e-74	269.00
IUUC-Csa-024125	Chlorocebus sabaeus	98.42	1.00e-91	328.00
IUUC-Cin-025749	Ciona intestinalis	40.98	2.00e-13	69.30
IUUC-Csv-026318	Ciona savignyi	40.98	7.00e-13	67.00
IUUC-Dre-028145	Danio rerio	43.75	1.00e-32	132.00
IUUC-Dno-029605	Dasypus novemcinctus	92.11	9.00e-94	335.00
IUUC-Dor-030898	Dipodomys ordii	87.37	2.00e-89	321.00
IUUC-Dme-032177	Drosophila melanogaster	42.37	1.00e-10	60.50
IUUC-Ete-032694	Echinops telfairi	83.96	2.00e-71	261.00
IUUC-Eca-033443	Equus caballus	94.74	2.00e-87	314.00
IUUC-Eeu-034603	Erinaceus europaeus	95.15	6.00e-56	208.00
IUUC-Fca-035507	Felis catus	91.44	6.00e-81	293.00
IUUC-Fal-037382	Ficedula albicollis	67.86	6.00e-64	236.00
IUUC-Gmo-038960	Gadus morhua	71.43	8.00e-19	85.90
IUUC-Gga-040493	Gallus gallus	68.21	4.00e-67	246.00
IUUC-Gac-042194	Gasterosteus aculeatus	49.01	1.00e-35	142.00
IUUC-Ggo-044726	Gorilla gorilla	100.00	1.00e-92	331.00
IUUC-Hvu-047337	Hordeum vulgare	37.70	2.00e-10	59.70
IUUC-Itr-047892	Ictidomys tridecemlineatus	96.26	9.00e-86	308.00
IUUC-Lpe-050920	Leersia perrieri	34.57	5.00e-11	61.20
IUUC-Loc-051907	Lepisosteus oculatus	47.59	2.00e-35	142.00
IUUC-Laf-054145	Loxodonta africana	89.84	4.00e-80	290.00
IUUC-Mcc-055689	Macaca mulatta	98.95	2.00e-91	328.00
IUUC-Meu-056654	Macropus eugenii	46.52	1.00e-39	155.00
IUUC-Mtr-058314	Medicago truncatula	45.45	1.00e-10	58.90
IUUC-Mga-059303	Meleagris gallopavo	69.90	8.00e-70	256.00
IUUC-Mmr-061355	Microcebus murinus	96.84	5.00e-89	319.00
IUUC-Mdo-062968	Monodelphis domestica	65.61	1.00e-65	242.00
IUUC-Mmu-064421	Mus musculus	91.44	2.00e-92	331.00
IUUC-Mac-064573	Musa acuminata	31.68	7.00e-12	64.70
IUUC-Mpu-066522	Mustela putorius furo	93.58	6.00e-85	306.00
IUUC-Mlu-067065	Myotis lucifugus	89.30	9.00e-81	292.00
IUUC-Nle-069198	Nomascus leucogenys	98.42	3.00e-91	327.00
IUUC-Opr-071141	Ochotona princeps	88.24	1.00e-86	311.00
IUUC-Oan-073341	Ornithorhynchus anatinus	66.67	3.00e-36	144.00
IUUC-Ocu-073787	Oryctolagus cuniculus	95.19	1.00e-94	338.00
IUUC-Oba-075460	Oryza barthii	40.32	5.00e-11	61.60
IUUC-Obr-076349	Oryza brachyantha	37.70	9.00e-10	57.40
IUUC-Ogl-077094	Oryza glaberrima	37.97	2.00e-12	66.20
IUUC-Ogu-078677	Oryza glumaepatula	40.32	4.00e-11	61.60
IUUC-Oin-079992	Oryza indica	37.97	2.00e-12	66.20
IUUC-Olo-080257	Oryza longistaminata	41.94	3.00e-11	62.00
IUUC-Ome-081943	Oryza meridionalis	37.97	2.00e-12	66.60
IUUC-Oni-082671	Oryza nivara	40.32	5.00e-11	61.60
IUUC-Opu-083644	Oryza punctata	40.32	7.00e-11	60.80
IUUC-Oru-084650	Oryza rufipogon	40.32	5.00e-11	61.60
IUUC-Osa-086110	Oryza sativa	37.97	2.00e-12	66.20
IUUC-Ola-086970	Oryzias latipes	43.37	1.00e-33	135.00
IUUC-Olu-087634	Ostreococcus lucimarinus	37.29	3.00e-10	58.20
IUUC-Oga-088242	Otolemur garnettii	95.72	2.00e-95	341.00
IUUC-Oar-089469	Ovis aries	87.70	6.00e-90	323.00
IUUC-Ptr-091254	Pan troglodytes	94.21	2.00e-85	308.00
IUUC-Pan-092776	Papio anubis	98.95	2.00e-91	328.00
IUUC-Psi-093929	Pelodiscus sinensis	70.05	1.00e-67	248.00
IUUC-Pma-094118	Petromyzon marinus	50.62	4.00e-21	92.00
IUUC-Ppa-095567	Physcomitrella patens	44.26	3.00e-11	62.40
IUUC-Pfo-097412	Poecilia formosa	47.83	6.00e-34	136.00
IUUC-Pab-098424	Pongo abelii	99.47	4.00e-92	330.00
IUUC-Pop-099483	Populus trichocarpa	37.10	7.00e-09	53.90
IUUC-Pca-100463	Procavia capensis	83.69	9.00e-50	189.00
IUUC-Pva-102594	Pteropus vampyrus	89.36	3.00e-61	227.00
IUUC-Rno-105460	Rattus norvegicus	91.01	2.00e-82	298.00
IUUC-Sha-107487	Sarcophilus harrisii	70.37	5.00e-67	246.00
IUUC-Sit-109959	Setaria italica	36.07	4.00e-05	42.40
IUUC-Stu-112694	Solanum tuberosum	39.06	4.00e-09	54.70
IUUC-Sar-113601	Sorex araneus	88.77	8.00e-79	285.00
IUUC-Sbi-114398	Sorghum bicolor	36.07	1.00e-04	40.40
IUUC-Ssc-115911	Sus scrofa	94.21	1.00e-86	311.00
IUUC-Tgu-117264	Taeniopygia guttata	68.25	2.00e-61	228.00
IUUC-Tru-117663	Takifugu rubripes	47.90	3.00e-36	144.00
IUUC-Tsy-118883	Tarsius syrichta	89.19	5.00e-68	249.00
IUUC-Tae-124035	Triticum aestivum	39.34	1.00e-10	60.10
IUUC-Tur-126408	Triticum urartu	39.34	2.00e-10	59.70
IUUC-Ttr-128950	Tursiops truncatus	65.26	2.00e-65	242.00
IUUC-Vvi-130833	Vitis vinifera	40.32	4.00e-10	58.50
IUUC-Xtr-132879	Xenopus tropicalis	60.39	2.00e-39	154.00
IUUC-Xma-133319	Xiphophorus maculatus	46.94	2.00e-32	130.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence