iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000066422.4	ENST00000312938.4	ENSP00000326200.4
ENSG00000066422.4	ENST00000461821.1	ENSP00000417369.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	7.40e-12	47.1	214	278

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalf.lmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +Dv+l ++gee++ahk+vL+a S++F++lf +++  +s+ +  v++++    +f  ll+F Yt+ l
   Q: 214  CDVTLLIEGEEYKAHKSVLSANSEYFRDLFiEKGAVSSH-EAVVDLSGFCKASFLPLLEFAYTSVL 278
           9*****************************777777887.***********************987 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MSSEESYRAI LRYLTNEREP YAPGTEGNVK RKIRKAAACY VVRGGTLYYQ RRQRHRKTFA 60
ELEVVLQPER RRDLIEAAHL GPGGTHHTRH QTWHYLSKTY WWRGILKQVK DYIKQCSKCQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTCCAGAA GCCTGAAAAT ATGCTTTTAT GATGTTGGGA GTCTCAAACG TAAAAACGGA 60
CTCCTAACCC TCTGGATGTT TCGGCTGAAC TCTCAACTGT CCACCAGCTC CCCCTACACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:27107

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001445	Ailuropoda melanoleuca	94.31	0.00e+00	1895.00
IUUC-Apl-003855	Anas platyrhynchos	70.27	0.00e+00	1301.00
IUUC-Aca-004985	Anolis carolinensis	68.67	0.00e+00	1383.00
IUUC-Ame-011340	Astyanax mexicanus	61.47	0.00e+00	725.00
IUUC-Bta-013355	Bos taurus	92.31	0.00e+00	1813.00
IUUC-Cja-019644	Callithrix jacchus	96.87	0.00e+00	1996.00
IUUC-Cfa-020316	Canis familiaris	92.98	0.00e+00	1865.00
IUUC-Cpo-021816	Cavia porcellus	91.55	0.00e+00	1815.00
IUUC-Csa-023589	Chlorocebus sabaeus	98.10	0.00e+00	1989.00
IUUC-Cho-024529	Choloepus hoffmanni	81.40	0.00e+00	1536.00
IUUC-Dre-028002	Danio rerio	61.67	0.00e+00	741.00
IUUC-Dno-029051	Dasypus novemcinctus	91.27	0.00e+00	1861.00
IUUC-Dor-030254	Dipodomys ordii	94.68	1.00e-147	517.00
IUUC-Eca-033829	Equus caballus	93.48	0.00e+00	1659.00
IUUC-Eeu-034748	Erinaceus europaeus	95.75	7.00e-129	454.00
IUUC-Fca-035713	Felis catus	93.83	0.00e+00	1875.00
IUUC-Fal-037174	Ficedula albicollis	71.62	0.00e+00	1407.00
IUUC-Gmo-038881	Gadus morhua	60.07	0.00e+00	705.00
IUUC-Gga-040464	Gallus gallus	70.68	0.00e+00	1207.00
IUUC-Gac-042419	Gasterosteus aculeatus	54.76	0.00e+00	1077.00
IUUC-Ggo-045065	Gorilla gorilla	99.34	0.00e+00	1986.00
IUUC-Itr-048374	Ictidomys tridecemlineatus	93.07	0.00e+00	1890.00
IUUC-Lch-050372	Latimeria chalumnae	65.44	0.00e+00	1265.00
IUUC-Loc-052005	Lepisosteus oculatus	72.63	0.00e+00	819.00
IUUC-Mcc-055018	Macaca mulatta	97.88	0.00e+00	1759.00
IUUC-Meu-056816	Macropus eugenii	76.74	0.00e+00	1077.00
IUUC-Mga-059973	Meleagris gallopavo	70.33	0.00e+00	1299.00
IUUC-Mmr-061629	Microcebus murinus	93.73	0.00e+00	1889.00
IUUC-Mdo-062057	Monodelphis domestica	80.27	0.00e+00	1544.00
IUUC-Mmu-064263	Mus musculus	89.27	0.00e+00	1747.00
IUUC-Mpu-066635	Mustela putorius furo	93.64	0.00e+00	1867.00
IUUC-Mlu-067264	Myotis lucifugus	92.61	0.00e+00	1834.00
IUUC-Nle-069844	Nomascus leucogenys	98.77	0.00e+00	1976.00
IUUC-Opr-070850	Ochotona princeps	86.45	0.00e+00	1498.00
IUUC-Ont-072282	Oreochromis niloticus	63.96	0.00e+00	719.00
IUUC-Oan-073513	Ornithorhynchus anatinus	78.12	0.00e+00	964.00
IUUC-Ocu-074952	Oryctolagus cuniculus	93.16	0.00e+00	1867.00
IUUC-Ola-086512	Oryzias latipes	53.13	0.00e+00	1080.00
IUUC-Oar-090150	Ovis aries	90.92	0.00e+00	1793.00
IUUC-Ptr-090849	Pan troglodytes	99.81	0.00e+00	1994.00
IUUC-Pan-092775	Papio anubis	97.91	0.00e+00	1983.00
IUUC-Psi-092935	Pelodiscus sinensis	71.46	0.00e+00	1262.00
IUUC-Pfo-096660	Poecilia formosa	58.20	0.00e+00	694.00
IUUC-Pab-097689	Pongo abelii	99.52	0.00e+00	1948.00
IUUC-Pva-102201	Pteropus vampyrus	91.71	0.00e+00	1264.00
IUUC-Rno-105218	Rattus norvegicus	89.46	0.00e+00	1762.00
IUUC-Sha-106757	Sarcophilus harrisii	80.46	0.00e+00	1558.00
IUUC-Sar-113619	Sorex araneus	87.19	0.00e+00	1738.00
IUUC-Ssc-115684	Sus scrofa	91.75	0.00e+00	1821.00
IUUC-Tgu-116743	Taeniopygia guttata	71.62	0.00e+00	1362.00
IUUC-Tru-118748	Takifugu rubripes	61.91	0.00e+00	675.00
IUUC-Tsy-119197	Tarsius syrichta	98.46	2.00e-121	430.00
IUUC-Tni-119676	Tetraodon nigroviridis	63.19	0.00e+00	709.00
IUUC-Ttr-129007	Tursiops truncatus	91.00	0.00e+00	1785.00
IUUC-Vpa-130095	Vicugna pacos	90.91	0.00e+00	1792.00
IUUC-Xtr-132722	Xenopus tropicalis	63.40	0.00e+00	1254.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence