iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000068024.16	ENST00000345617.7	ENSP00000264606.3
ENSG00000068024.16	ENST00000430200.1	ENSP00000410551.1
ENSG00000068024.16	ENST00000445704.1	ENSP00000391226.1
ENSG00000068024.16	ENST00000454542.5	ENSP00000405226.1
ENSG00000068024.16	ENST00000543185.5	ENSP00000440481.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	GWAS Central	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	18820298; 17218271; 15743823; 17218271; 19782030; 16166628; 19923268

Organism

Homo sapiens

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).

Protein Sequence
(Fasta)

MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVATALPL QVAPSAVPMD LRLDHQFSLP 60
VAEPALREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA 120

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Nucleotide Sequence
(Fasta)

CCACTGCCAG TATCCAAGAT GGACGCCGCG GCGAGGCCTG GCCGGCTCCC CGCGTTAGCC 60
TGCACCCCAT TGTGTGCCCT CTAAGCGCGA ATTAGGCTCG CAGACATGCG GTGCTGACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1268--Autism spectrum disorder
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0031672--C:A band
GO:0042641--C:actomyosin
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0017053--C:transcriptional repressor complex
GO:0030018--C:Z disc
GO:0033613--F:activating transcription factor binding
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0004407--F:histone deacetylase activity
GO:0042826--F:histone deacetylase binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0033558--F:protein deacetylase activity
GO:0070491--F:repressing transcription factor binding
GO:0001025--F:RNA polymerase III transcription factor binding
GO:0003714--F:transcription corepressor activity
GO:0008134--F:transcription factor binding
GO:0008270--F:zinc ion binding
GO:0042113--P:B cell activation
GO:0030183--P:B cell differentiation
GO:0014898--P:cardiac muscle hypertrophy in response to stress
GO:0071260--P:cellular response to mechanical stimulus
GO:0071374--P:cellular response to parathyroid hormone stimulus
GO:0071356--P:cellular response to tumor necrosis factor
GO:0006338--P:chromatin remodeling
GO:0016575--P:histone deacetylation
GO:0070932--P:histone H3 deacetylation
GO:0070933--P:histone H4 deacetylation
GO:0006954--P:inflammatory response
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007399--P:nervous system development
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0010592--P:positive regulation of lamellipodium assembly
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0033235--P:positive regulation of protein sumoylation
GO:1903428--P:positive regulation of reactive oxygen species biosynthetic process
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0014911--P:positive regulation of smooth muscle cell migration
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006476--P:protein deacetylation
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0042493--P:response to drug
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:9759

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	92.64	0.00e+00	1756.00
IUUC-Apl-003250	Anas platyrhynchos	87.84	0.00e+00	1607.00
IUUC-Aca-004668	Anolis carolinensis	83.21	0.00e+00	1658.00
IUUC-Bta-013215	Bos taurus	92.69	0.00e+00	1772.00
IUUC-Cja-019816	Callithrix jacchus	98.22	0.00e+00	1897.00
IUUC-Cfa-020861	Canis familiaris	93.45	0.00e+00	1767.00
IUUC-Cpo-021562	Cavia porcellus	93.06	0.00e+00	1805.00
IUUC-Csa-023612	Chlorocebus sabaeus	98.60	0.00e+00	1870.00
IUUC-Csv-026359	Ciona savignyi	55.41	3.00e-95	341.00
IUUC-Dre-028284	Danio rerio	77.14	0.00e+00	1367.00
IUUC-Dno-029951	Dasypus novemcinctus	90.31	0.00e+00	1612.00
IUUC-Dor-030362	Dipodomys ordii	83.26	0.00e+00	1503.00
IUUC-Dme-031766	Drosophila melanogaster	58.22	3.00e-159	556.00
IUUC-Fca-036187	Felis catus	94.38	0.00e+00	1746.00
IUUC-Gmo-038473	Gadus morhua	76.69	0.00e+00	741.00
IUUC-Gga-040501	Gallus gallus	90.51	0.00e+00	1690.00
IUUC-Gac-042335	Gasterosteus aculeatus	69.45	0.00e+00	1253.00
IUUC-Ggo-045380	Gorilla gorilla	99.06	0.00e+00	1882.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	93.94	0.00e+00	1726.00
IUUC-Lch-050325	Latimeria chalumnae	83.75	0.00e+00	1552.00
IUUC-Loc-052231	Lepisosteus oculatus	80.25	0.00e+00	1456.00
IUUC-Laf-054490	Loxodonta africana	86.15	0.00e+00	1654.00
IUUC-Mcc-055265	Macaca mulatta	98.79	0.00e+00	1885.00
IUUC-Meu-056676	Macropus eugenii	85.84	0.00e+00	759.00
IUUC-Mmr-061633	Microcebus murinus	86.44	0.00e+00	1572.00
IUUC-Mmu-063089	Mus musculus	93.56	0.00e+00	1727.00
IUUC-Mpu-065887	Mustela putorius furo	92.80	0.00e+00	1763.00
IUUC-Mlu-067470	Myotis lucifugus	93.83	0.00e+00	1763.00
IUUC-Nle-069099	Nomascus leucogenys	95.68	0.00e+00	1259.00
IUUC-Ont-071613	Oreochromis niloticus	71.78	0.00e+00	1274.00
IUUC-Oan-073275	Ornithorhynchus anatinus	89.06	0.00e+00	1675.00
IUUC-Ola-087031	Oryzias latipes	66.67	0.00e+00	1192.00
IUUC-Oga-088201	Otolemur garnettii	88.99	0.00e+00	1543.00
IUUC-Oar-089997	Ovis aries	84.83	0.00e+00	1434.00
IUUC-Ptr-091116	Pan troglodytes	99.53	0.00e+00	1926.00
IUUC-Pan-092132	Papio anubis	98.93	0.00e+00	1233.00
IUUC-Psi-093734	Pelodiscus sinensis	89.31	0.00e+00	1587.00
IUUC-Pma-094347	Petromyzon marinus	70.33	0.00e+00	704.00
IUUC-Pfo-096293	Poecilia formosa	69.21	0.00e+00	1202.00
IUUC-Pab-098491	Pongo abelii	95.98	0.00e+00	1815.00
IUUC-Pca-101004	Procavia capensis	83.72	0.00e+00	936.00
IUUC-Pva-102961	Pteropus vampyrus	71.86	0.00e+00	897.00
IUUC-Rno-105005	Rattus norvegicus	93.38	0.00e+00	1699.00
IUUC-Sha-107646	Sarcophilus harrisii	66.70	0.00e+00	983.00
IUUC-Ssc-115428	Sus scrofa	92.44	0.00e+00	1659.00
IUUC-Tgu-116776	Taeniopygia guttata	90.18	0.00e+00	1675.00
IUUC-Tru-118180	Takifugu rubripes	70.14	0.00e+00	1285.00
IUUC-Tsy-119468	Tarsius syrichta	90.45	0.00e+00	778.00
IUUC-Tni-120196	Tetraodon nigroviridis	69.74	0.00e+00	1273.00
IUUC-Ttr-128360	Tursiops truncatus	83.88	0.00e+00	1000.00
IUUC-Xtr-132956	Xenopus tropicalis	80.04	0.00e+00	1466.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence