iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048036

Ensembl Protein ID

ENSSTOP00000009983.2

UniProt Accession

I3MGR1; I3MGR1_ICTTR

Genbank Protein ID

ENSSTOP00000009983

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AGTP01102394

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000011115.2	ENSSTOT00000011129.2	ENSSTOP00000009983.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	93.94	0.00e+00	1726.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
776	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Ictidomys tridecemlineatus

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

MPSAVDVASA LPLQVAPTAV PMDLRLDHQF PLPVAEPALR EQQLQQELLA LKQKQQIQRQ 60
ILIAEFQRQH EQLSRQHEAQ LHEHMKQQQE MLALKHQQEL LEHQRKLERH RQEQELEKQH 120

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Nucleotide Sequence
(Fasta)

TTGGAGCTCT TGTTTACGTG GAAAATTTGA GCCATTTTGA ATCCATTAAA GGTGCAGACG 60
CTGCTAGCAA TGAGCTCCCA AAGCCATCCA GGTAAGGCTG CCTCCTCCAT TCCCTGCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0042641--C:actomyosin
GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0031594--C:neuromuscular junction
GO:0017053--C:transcriptional repressor complex
GO:0003682--F:chromatin binding
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003714--F:transcription corepressor activity
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045820--P:negative regulation of glycolytic process
GO:0010832--P:negative regulation of myotube differentiation
GO:0045668--P:negative regulation of osteoblast differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0002076--P:osteoblast development
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0010882--P:regulation of cardiac muscle contraction by calcium ion signaling
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0048742--P:regulation of skeletal muscle fiber development
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0070555--P:response to interleukin-1
GO:0001501--P:skeletal system development
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	91.49	0.00e+00	1653.00
IUUC-Apl-003250	Anas platyrhynchos	86.88	0.00e+00	1560.00
IUUC-Aca-004668	Anolis carolinensis	81.70	0.00e+00	1555.00
IUUC-Bta-013215	Bos taurus	92.40	0.00e+00	1682.00
IUUC-Cja-019816	Callithrix jacchus	93.47	0.00e+00	1726.00
IUUC-Cfa-020861	Canis familiaris	92.01	0.00e+00	1660.00
IUUC-Cpo-021562	Cavia porcellus	94.71	0.00e+00	1749.00
IUUC-Csa-023612	Chlorocebus sabaeus	93.31	0.00e+00	1717.00
IUUC-Csv-026359	Ciona savignyi	55.07	7.00e-95	339.00
IUUC-Dre-028284	Danio rerio	78.47	0.00e+00	1320.00
IUUC-Dno-029951	Dasypus novemcinctus	89.64	0.00e+00	1595.00
IUUC-Dor-030362	Dipodomys ordii	83.30	0.00e+00	1424.00
IUUC-Dme-031766	Drosophila melanogaster	58.45	7.00e-160	558.00
IUUC-Fca-036187	Felis catus	93.26	0.00e+00	1697.00
IUUC-Gmo-038473	Gadus morhua	76.06	0.00e+00	734.00
IUUC-Gga-040501	Gallus gallus	89.60	0.00e+00	1598.00
IUUC-Gac-042335	Gasterosteus aculeatus	69.55	0.00e+00	1243.00
IUUC-Ggo-045380	Gorilla gorilla	93.57	0.00e+00	1704.00
IUUC-Hsa-046925	Homo sapiens	93.95	0.00e+00	1709.00
IUUC-Lch-050325	Latimeria chalumnae	83.62	0.00e+00	1475.00
IUUC-Loc-052231	Lepisosteus oculatus	80.63	0.00e+00	1434.00
IUUC-Laf-054490	Loxodonta africana	86.34	0.00e+00	1628.00
IUUC-Mcc-055265	Macaca mulatta	93.43	0.00e+00	1732.00
IUUC-Meu-056676	Macropus eugenii	85.39	0.00e+00	756.00
IUUC-Mmr-061633	Microcebus murinus	85.66	0.00e+00	1528.00
IUUC-Mmu-063089	Mus musculus	93.97	0.00e+00	1664.00
IUUC-Mpu-065887	Mustela putorius furo	92.51	0.00e+00	1675.00
IUUC-Mlu-067470	Myotis lucifugus	92.97	0.00e+00	1718.00
IUUC-Nle-069099	Nomascus leucogenys	90.55	0.00e+00	1111.00
IUUC-Ont-071613	Oreochromis niloticus	71.68	0.00e+00	1254.00
IUUC-Oan-073275	Ornithorhynchus anatinus	88.96	0.00e+00	1610.00
IUUC-Ola-087031	Oryzias latipes	67.19	0.00e+00	1176.00
IUUC-Oga-088201	Otolemur garnettii	88.89	0.00e+00	1517.00
IUUC-Oar-089997	Ovis aries	84.83	0.00e+00	1397.00
IUUC-Ptr-091116	Pan troglodytes	94.15	0.00e+00	1749.00
IUUC-Pan-092132	Papio anubis	93.87	0.00e+00	1179.00
IUUC-Psi-093734	Pelodiscus sinensis	88.49	0.00e+00	1526.00
IUUC-Pma-094347	Petromyzon marinus	70.96	0.00e+00	709.00
IUUC-Pfo-096293	Poecilia formosa	69.21	0.00e+00	1184.00
IUUC-Pab-098491	Pongo abelii	90.98	0.00e+00	1647.00
IUUC-Pca-101004	Procavia capensis	83.41	0.00e+00	914.00
IUUC-Pva-102961	Pteropus vampyrus	70.85	0.00e+00	862.00
IUUC-Rno-105005	Rattus norvegicus	93.49	0.00e+00	1634.00
IUUC-Sha-107646	Sarcophilus harrisii	66.14	0.00e+00	947.00
IUUC-Ssc-115428	Sus scrofa	91.76	0.00e+00	1625.00
IUUC-Tgu-116776	Taeniopygia guttata	89.12	0.00e+00	1595.00
IUUC-Tru-118180	Takifugu rubripes	70.09	0.00e+00	1270.00
IUUC-Tsy-119468	Tarsius syrichta	89.02	0.00e+00	773.00
IUUC-Tni-120196	Tetraodon nigroviridis	70.65	0.00e+00	1251.00
IUUC-Ttr-128360	Tursiops truncatus	83.88	0.00e+00	1003.00
IUUC-Xtr-132956	Xenopus tropicalis	80.48	0.00e+00	1407.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence