iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028816

UUCD1 version

UUC-DaR-01420

Ensembl Protein ID

ENSDARP00000114334.1

UniProt Accession

Q08BW0; A9JTE0; B0UYD0; B0UYD1; Q8JFX0; OTU5A_DANRE

Genbank Protein ID

CAD43417.1; CAQ14391.1; CAQ14392.1; AAI24534.1; AAI55305.1

Protein Name

OTU domain-containing protein 5-A; Deubiquitinating enzyme A

Genbank Nucleotide ID

AL590148; CR450685; CR450685; BC124533; BC155304

Gene Name

otud5a; otud5; si:dkey-83k24.3; si:rp71-30i22.1; zgc:154072

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000059006.6	ENSDART00000144986.2	ENSDARP00000114334.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.20e-30	107.7	212	333

Active Site

Position(s)	Description	Evidence
219	N/A	{ECO:0000255}
222	Nucleophile	ECO:0000250}
327		{ECO:0000250}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfdddslsdalveaLreltseylqkesdffsefieekedekefcqklvepeakgeeihifaLaqiLs 90
           +i+k+k+DG CL+rAv+++   v++d+     ++e++r+++++yl+k++d+fs++++e  d++++++++ +++++g++i+++a+a++++
   Q: 212  VIKKMKEDGACLFRAVADQ---VYGDQD----MHEVVRKHCMDYLMKNADYFSNYVTE--DFTTYINRKRKNNCHGNHIEMQAMAEMYN 291
           799****************...******....*************************9..9**************************** PP
   S: 91   rpiivvdvdsleskvggillpllfpeeklkkpivLlY.rsgHYdaLva 137
           rp++v+++ +      +i++++ +++++ ++pi ++Y r++HY+++v+
   Q: 292  RPVEVYQSGTE-----PINTFHGIHQNN-DEPIRVSYhRNIHYNSVVN 333
           ******98776.....6***********.********99*******96 PP

Organism

Danio rerio

Functional Description
(View)

Deubiquitinating enzyme that may function as negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity).

Protein Sequence
(Fasta)

MTILPKKKPN SSVGVSDHPD DPDRRTGSDP HQHQHQHSHG VRPGARPRAS PPPWSYQAAP 60
PASREDRRTE SSSRPQQASP PPVGAGSSGG PGDATGMACV SGNRAELSGG VGCGGGMGGC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGTGTGGC AACAGCAGGA CCGAGGGACG GAAGACGGTT TGTTTTTGTT CTGTTATCCG 60
CCGTTTTTAC CCTCAAAATC ACCTCGAGTT GAATCAAATT CGCTCCGGGG TGAAAGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR031084--OTU5/OTLD1
IPR003323--OTU_dom

PROSITE

PS50802--OTU

Pfam

PF02338--OTU

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0032496--P:response to lipopolysaccharide

KEGG

dre:555459

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000541	Aegilops tauschii	39.41	4.00e-28	118.00
IUUC-Aml-002177	Ailuropoda melanoleuca	83.79	0.00e+00	633.00
IUUC-Aca-004481	Anolis carolinensis	86.74	3.00e-164	570.00
IUUC-Ame-011904	Astyanax mexicanus	89.66	2.00e-113	402.00
IUUC-Bta-012384	Bos taurus	84.29	0.00e+00	637.00
IUUC-Cja-019439	Callithrix jacchus	76.72	3.00e-179	621.00
IUUC-Cfa-020478	Canis familiaris	84.65	0.00e+00	645.00
IUUC-Cpo-021956	Cavia porcellus	84.29	0.00e+00	643.00
IUUC-Csa-023878	Chlorocebus sabaeus	86.21	2.00e-178	618.00
IUUC-Cme-027140	Cyanidioschyzon merolae	26.09	7.00e-07	47.40
IUUC-Dno-028962	Dasypus novemcinctus	90.31	1.00e-139	489.00
IUUC-Dor-030616	Dipodomys ordii	80.06	1.00e-134	473.00
IUUC-Ete-032848	Echinops telfairi	83.29	0.00e+00	626.00
IUUC-Eca-033321	Equus caballus	84.65	0.00e+00	645.00
IUUC-Eeu-034527	Erinaceus europaeus	84.00	1.00e-168	585.00
IUUC-Fca-036105	Felis catus	84.04	0.00e+00	634.00
IUUC-Gga-040905	Gallus gallus	82.24	3.00e-135	475.00
IUUC-Gac-042254	Gasterosteus aculeatus	70.97	3.00e-22	98.60
IUUC-Hsa-046538	Homo sapiens	83.46	0.00e+00	637.00
IUUC-Itr-048844	Ictidomys tridecemlineatus	84.82	4.00e-176	610.00
IUUC-Lch-050108	Latimeria chalumnae	85.68	0.00e+00	653.00
IUUC-Loc-052485	Lepisosteus oculatus	90.70	0.00e+00	638.00
IUUC-Laf-053682	Loxodonta africana	83.21	0.00e+00	634.00
IUUC-Mcc-055784	Macaca mulatta	84.50	0.00e+00	640.00
IUUC-Mla-059150	Melampsora laricipopulina	30.19	3.00e-17	83.60
IUUC-Mmr-061057	Microcebus murinus	84.50	0.00e+00	638.00
IUUC-Mmu-063714	Mus musculus	79.24	0.00e+00	634.00
IUUC-Mpu-065767	Mustela putorius furo	84.50	0.00e+00	642.00
IUUC-Mlu-067114	Myotis lucifugus	82.72	0.00e+00	656.00
IUUC-Nle-070088	Nomascus leucogenys	86.04	5.00e-163	566.00
IUUC-Opr-070389	Ochotona princeps	83.46	2.00e-176	612.00
IUUC-Ont-072302	Oreochromis niloticus	73.45	0.00e+00	692.00
IUUC-Ocu-074654	Oryctolagus cuniculus	84.50	0.00e+00	642.00
IUUC-Ola-087549	Oryzias latipes	70.99	0.00e+00	686.00
IUUC-Oga-089093	Otolemur garnettii	83.37	0.00e+00	635.00
IUUC-Oar-089766	Ovis aries	83.51	9.00e-172	596.00
IUUC-Ptr-091163	Pan troglodytes	84.01	4.00e-180	624.00
IUUC-Pan-091928	Papio anubis	83.25	0.00e+00	631.00
IUUC-Psi-093696	Pelodiscus sinensis	34.44	5.00e-12	67.40
IUUC-Pfo-096666	Poecilia formosa	75.04	0.00e+00	722.00
IUUC-Pab-098420	Pongo abelii	83.46	0.00e+00	636.00
IUUC-Pva-102130	Pteropus vampyrus	90.55	2.00e-140	492.00
IUUC-Rno-105724	Rattus norvegicus	84.65	0.00e+00	645.00
IUUC-Sar-113717	Sorex araneus	84.49	2.00e-171	595.00
IUUC-Ssc-116201	Sus scrofa	83.79	0.00e+00	629.00
IUUC-Tru-118312	Takifugu rubripes	68.58	0.00e+00	680.00
IUUC-Tni-119704	Tetraodon nigroviridis	70.07	0.00e+00	659.00
IUUC-Ttr-129296	Tursiops truncatus	83.58	0.00e+00	634.00
IUUC-Vpa-130415	Vicugna pacos	56.78	5.00e-61	229.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence