iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000071127.16	ENST00000499869.6	ENSP00000427687.1
ENSG00000071127.16	ENST00000502702.5	ENSP00000426725.1
ENSG00000071127.16	ENST00000508079.1	ENSP00000425481.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2	LncRNADisease
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.60e-36	122.6	233	264
UBD/Beta-Prp	4.10e-60	205.2	56	277

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           H ++++++++ +d t+l+s+s+D+t k+WD++
   Q: 233  HDGGIYAISWsPDsTHLLSASGDKTSKIWDVS 264
           99*********999****************85 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtlkghed 95
           +h +++ + k++p++ ++a+g  +g++++wd+t++  l ++  +   ++++++ + +d+k ++ ++e   ++  v+  ++g+ v  ++gh++
   Q: 56   EHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLKYeyQPFAGKIKDIAWTEDSKRIAVVGEGreKFGAVFLWDSGSSVGEITGHNK 147
           455666678*************************998777742334567***********99999999887777777789************ PP
   S: 96   svlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl..tgghtdsvy 184
            + s+++ +s+ ++l++Gs+d+ +  ++ +  +    t   h+++vncv+++pdgn ++++s+D+++ ++d ktg+ +  l  +++h++ +y
   Q: 148  VINSVDIKQSRpYRLATGSDDNCAAFFEGPPFKFKF-TIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALggSKAHDGGIY 238
           *********999*****************9999998.99********************************************888****** PP
   S: 185  slsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtd 223
            +s+++++++l+s+s d+t k+wd++ +++v t+   ++
   Q: 239  AISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGST 277
           *******************************99976544 PP

Organism

Homo sapiens

Functional Description
(View)

Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565).

Protein Sequence
(Fasta)

MPYEIKKVFA SLPQVERGVS KIIGGDPKGN NFLYTNGKCV ILRNIDNPAL ADIYTEHAHQ 60
VVVAKYAPSG FYIASGDVSG KLRIWDTTQK EHLLKYEYQP FAGKIKDIAW TEDSKRIAVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCAGCCGC CGAGCCGAGC GCTTGACTAT ATATGGTCAA AGCTGGGGGC GAGCCGCGCG 60
CGGGACCGCG CTTCCGGGTT CGGGGCGTCC GCAACCACAG CGCGCAGGGC AGGCGCGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR011045--N2O_reductase_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0042643--C:actomyosin, actin portion
GO:0042995--C:cell projection
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005576--C:extracellular region
GO:0043209--C:myelin sheath
GO:0002102--C:podosome
GO:0051015--F:actin filament binding
GO:0030043--P:actin filament fragmentation
GO:0043297--P:apical junction assembly
GO:0030865--P:cortical cytoskeleton organization
GO:0042247--P:establishment of planar polarity of follicular epithelium
GO:0040011--P:locomotion
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0002446--P:neutrophil mediated immunity
GO:1990266--P:neutrophil migration
GO:0002576--P:platelet degranulation
GO:0030220--P:platelet formation
GO:0030836--P:positive regulation of actin filament depolymerization
GO:0030834--P:regulation of actin filament depolymerization
GO:0008360--P:regulation of cell shape
GO:0048713--P:regulation of oligodendrocyte differentiation
GO:0060307--P:regulation of ventricular cardiac muscle cell membrane repolarization
GO:0045214--P:sarcomere organization
GO:0007605--P:sensory perception of sound

KEGG

hsa:9948

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000457	Aegilops tauschii	35.47	3.00e-82	299.00
IUUC-Aml-002368	Ailuropoda melanoleuca	96.51	0.00e+00	1181.00
IUUC-Atr-003160	Amborella trichopoda	37.62	2.00e-115	410.00
IUUC-Apl-004012	Anas platyrhynchos	87.29	0.00e+00	1076.00
IUUC-Aca-004707	Anolis carolinensis	83.17	0.00e+00	1053.00
IUUC-Aly-006465	Arabidopsis lyrata	38.05	2.00e-111	396.00
IUUC-Ath-006740	Arabidopsis thaliana	37.56	6.00e-111	394.00
IUUC-Ago-007920	Ashbya gossypii	27.75	8.00e-72	265.00
IUUC-Acl-008262	Aspergillus clavatus	36.26	2.00e-106	379.00
IUUC-Afl-008471	Aspergillus flavus	33.85	5.00e-80	292.00
IUUC-Afu-008989	Aspergillus fumigatus	38.06	6.00e-96	344.00
IUUC-Ani-009167	Aspergillus nidulans	38.20	9.00e-116	410.00
IUUC-Ang-009595	Aspergillus niger	37.67	2.00e-103	369.00
IUUC-Aor-009908	Aspergillus oryzae	37.16	2.00e-103	370.00
IUUC-Ate-010580	Aspergillus terreus	38.02	4.00e-109	390.00
IUUC-Ame-011269	Astyanax mexicanus	60.50	9.00e-134	470.00
IUUC-Bgr-011996	Blumeria graminis	34.15	3.00e-106	379.00
IUUC-Bta-013278	Bos taurus	95.54	0.00e+00	1209.00
IUUC-Bci-013925	Botrytis cinerea	35.83	6.00e-107	381.00
IUUC-Bdi-014659	Brachypodium distachyon	35.90	3.00e-104	372.00
IUUC-Bol-016043	Brassica oleracea	35.78	7.00e-107	381.00
IUUC-Bra-017139	Brassica rapa	36.97	8.00e-110	391.00
IUUC-Cel-018417	Caenorhabditis elegans	41.23	2.00e-123	436.00
IUUC-Cja-019952	Callithrix jacchus	97.69	0.00e+00	1176.00
IUUC-Cfa-020225	Canis familiaris	96.37	0.00e+00	1194.00
IUUC-Cpo-021900	Cavia porcellus	95.01	0.00e+00	1176.00
IUUC-Csa-023028	Chlorocebus sabaeus	99.01	0.00e+00	1187.00
IUUC-Cho-025030	Choloepus hoffmanni	69.00	0.00e+00	762.00
IUUC-Cin-025152	Ciona intestinalis	56.03	3.00e-81	294.00
IUUC-Csv-025986	Ciona savignyi	38.28	3.00e-93	335.00
IUUC-Cgl-026597	Colletotrichum gloeosporioides	38.21	1.00e-110	393.00
IUUC-Cne-026814	Cryptococcus neoformans	34.09	5.00e-97	348.00
IUUC-Dre-027498	Danio rerio	80.51	8.00e-96	342.00
IUUC-Dno-029383	Dasypus novemcinctus	95.38	0.00e+00	1152.00
IUUC-Dor-030633	Dipodomys ordii	93.94	0.00e+00	1088.00
IUUC-Dse-031526	Dothistroma septosporum	38.39	4.00e-116	412.00
IUUC-Dme-031597	Drosophila melanogaster	48.10	5.00e-168	584.00
IUUC-Ete-032780	Echinops telfairi	83.44	0.00e+00	1032.00
IUUC-Eca-034306	Equus caballus	94.51	0.00e+00	1145.00
IUUC-Eeu-034531	Erinaceus europaeus	74.77	6.00e-137	481.00
IUUC-Fca-036301	Felis catus	97.00	0.00e+00	1209.00
IUUC-Fal-037361	Ficedula albicollis	87.11	0.00e+00	1121.00
IUUC-Fox-037924	Fusarium oxysporum	35.50	2.00e-100	360.00
IUUC-Fso-038199	Fusarium solani	34.96	4.00e-97	348.00
IUUC-Gmo-039238	Gadus morhua	71.99	0.00e+00	893.00
IUUC-Ggr-039830	Gaeumannomyces graminis	35.17	2.00e-95	343.00
IUUC-Gga-040235	Gallus gallus	88.61	0.00e+00	1106.00
IUUC-Gac-042363	Gasterosteus aculeatus	71.33	0.00e+00	922.00
IUUC-Gma-044189	Glycine max	37.32	2.00e-113	403.00
IUUC-Ggo-044632	Gorilla gorilla	97.20	0.00e+00	1160.00
IUUC-Hvu-047517	Hordeum vulgare	35.35	7.00e-108	384.00
IUUC-Itr-048076	Ictidomys tridecemlineatus	96.34	0.00e+00	1181.00
IUUC-Kpa-049183	Komagataella pastoris	33.22	4.00e-85	309.00
IUUC-Lch-050428	Latimeria chalumnae	76.44	0.00e+00	1004.00
IUUC-Lpe-051306	Leersia perrieri	35.95	3.00e-109	389.00
IUUC-Loc-052096	Lepisosteus oculatus	71.92	0.00e+00	904.00
IUUC-Lma-053313	Leptosphaeria maculans	38.95	1.00e-115	412.00
IUUC-Laf-054060	Loxodonta africana	92.74	0.00e+00	1139.00
IUUC-Mcc-055619	Macaca mulatta	96.89	0.00e+00	1159.00
IUUC-Meu-056689	Macropus eugenii	78.14	0.00e+00	632.00
IUUC-Mor-056940	Magnaporthe oryzae	35.17	7.00e-97	348.00
IUUC-Mpo-057557	Magnaporthe poae	28.37	6.00e-57	215.00
IUUC-Mtr-057922	Medicago truncatula	36.50	4.00e-110	392.00
IUUC-Mla-059103	Melampsora laricipopulina	33.63	6.00e-76	278.00
IUUC-Mga-060150	Meleagris gallopavo	88.25	0.00e+00	1094.00
IUUC-Mvi-060448	Microbotryum violaceum	30.59	2.00e-73	270.00
IUUC-Mmr-061226	Microcebus murinus	95.21	0.00e+00	1167.00
IUUC-Mdo-062674	Monodelphis domestica	92.08	0.00e+00	1150.00
IUUC-Mmu-064170	Mus musculus	95.21	0.00e+00	1185.00
IUUC-Mac-065124	Musa acuminata	37.81	1.00e-113	403.00
IUUC-Mpu-066001	Mustela putorius furo	93.80	0.00e+00	1182.00
IUUC-Mlu-067253	Myotis lucifugus	94.01	0.00e+00	1169.00
IUUC-Nfi-068550	Neosartorya fischeri	37.96	1.00e-110	394.00
IUUC-Ncr-068948	Neurospora crassa	36.66	1.00e-113	403.00
IUUC-Nle-070115	Nomascus leucogenys	95.61	0.00e+00	1090.00
IUUC-Opr-070254	Ochotona princeps	93.00	0.00e+00	1108.00
IUUC-Ont-071666	Oreochromis niloticus	75.41	0.00e+00	960.00
IUUC-Oan-073594	Ornithorhynchus anatinus	92.19	2.00e-168	584.00
IUUC-Ocu-074824	Oryctolagus cuniculus	93.89	0.00e+00	1136.00
IUUC-Oba-075010	Oryza barthii	36.33	3.00e-110	392.00
IUUC-Obr-076364	Oryza brachyantha	36.70	5.00e-111	395.00
IUUC-Ogl-077019	Oryza glaberrima	36.33	3.00e-110	392.00
IUUC-Ogu-078496	Oryza glumaepatula	36.33	3.00e-110	392.00
IUUC-Oin-080116	Oryza indica	36.50	9.00e-111	394.00
IUUC-Olo-080290	Oryza longistaminata	36.33	4.00e-110	392.00
IUUC-Ome-081969	Oryza meridionalis	36.33	4.00e-110	392.00
IUUC-Oni-082075	Oryza nivara	36.33	3.00e-110	392.00
IUUC-Opu-083959	Oryza punctata	36.38	3.00e-110	392.00
IUUC-Oru-084711	Oryza rufipogon	36.33	3.00e-110	392.00
IUUC-Osa-085958	Oryza sativa	36.50	9.00e-111	394.00
IUUC-Ola-086968	Oryzias latipes	76.07	0.00e+00	971.00
IUUC-Oga-089108	Otolemur garnettii	95.91	0.00e+00	1220.00
IUUC-Oar-089986	Ovis aries	89.67	0.00e+00	1115.00
IUUC-Ptr-091281	Pan troglodytes	99.67	0.00e+00	1207.00
IUUC-Pan-092585	Papio anubis	99.17	0.00e+00	1191.00
IUUC-Psi-093811	Pelodiscus sinensis	86.21	0.00e+00	1114.00
IUUC-Pma-094396	Petromyzon marinus	70.08	0.00e+00	907.00
IUUC-Pno-095086	Phaeosphaeria nodorum	37.46	1.00e-108	387.00
IUUC-Ppa-095876	Physcomitrella patens	36.17	1.00e-110	394.00
IUUC-Pfo-096973	Poecilia formosa	74.92	0.00e+00	990.00
IUUC-Pab-098391	Pongo abelii	98.84	0.00e+00	1191.00
IUUC-Pop-098850	Populus trichocarpa	37.03	2.00e-112	399.00
IUUC-Pca-100257	Procavia capensis	60.26	1.00e-90	327.00
IUUC-Ppe-101578	Prunus persica	38.07	1.00e-115	410.00
IUUC-Pva-102872	Pteropus vampyrus	90.12	0.00e+00	1131.00
IUUC-Pgr-103593	Puccinia graminis	33.33	4.00e-79	288.00
IUUC-Pte-104365	Pyrenophora teres	39.48	5.00e-111	395.00
IUUC-Pyt-104689	Pyrenophora triticirepentis	38.83	2.00e-113	402.00
IUUC-Rno-105737	Rattus norvegicus	95.87	0.00e+00	1217.00
IUUC-Sce-106383	Saccharomyces cerevisiae	28.91	7.00e-67	248.00
IUUC-Sha-107084	Sarcophilus harrisii	90.02	0.00e+00	1011.00
IUUC-Sja-107688	Schizosaccharomyces japonicus	35.63	6.00e-110	391.00
IUUC-Spo-108309	Schizosaccharomyces pombe	33.83	3.00e-96	346.00
IUUC-Ssl-108408	Sclerotinia sclerotiorum	35.50	2.00e-106	379.00
IUUC-Smo-109255	Selaginella moellendorffii	34.65	3.00e-99	355.00
IUUC-Sit-109962	Setaria italica	37.42	1.00e-112	400.00
IUUC-Sly-110897	Solanum lycopersicum	38.56	5.00e-117	415.00
IUUC-Stu-111971	Solanum tuberosum	38.56	2.00e-116	413.00
IUUC-Sar-113415	Sorex araneus	72.69	6.00e-109	388.00
IUUC-Sbi-114857	Sorghum bicolor	36.93	3.00e-110	392.00
IUUC-Sre-114900	Sporisorium reilianum	33.17	4.00e-91	328.00
IUUC-Tgu-117256	Taeniopygia guttata	87.04	0.00e+00	1117.00
IUUC-Tru-117871	Takifugu rubripes	69.75	0.00e+00	888.00
IUUC-Tsy-119172	Tarsius syrichta	97.08	2.00e-139	489.00
IUUC-Tni-120339	Tetraodon nigroviridis	69.80	0.00e+00	924.00
IUUC-Tca-121609	Theobroma cacao	37.48	9.00e-114	404.00
IUUC-Tre-122076	Trichoderma reesei	35.67	9.00e-93	334.00
IUUC-Tvi-122528	Trichoderma virens	34.65	3.00e-95	342.00
IUUC-Tae-123530	Triticum aestivum	35.73	4.00e-109	388.00
IUUC-Tur-126845	Triticum urartu	35.45	7.00e-81	295.00
IUUC-Tme-127217	Tuber melanosporum	35.31	1.00e-104	374.00
IUUC-Tbe-127526	Tupaia belangeri	93.73	0.00e+00	1163.00
IUUC-Ttr-128898	Tursiops truncatus	87.97	0.00e+00	1095.00
IUUC-Uma-129631	Ustilago maydis	32.14	3.00e-94	339.00
IUUC-Vda-129732	Verticillium dahliae	35.02	3.00e-92	332.00
IUUC-Vvi-131217	Vitis vinifera	38.54	7.00e-114	404.00
IUUC-Xtr-132860	Xenopus tropicalis	74.88	0.00e+00	953.00
IUUC-Xma-133830	Xiphophorus maculatus	75.25	0.00e+00	993.00
IUUC-Yli-134335	Yarrowia lipolytica	32.95	3.00e-76	279.00
IUUC-Zma-135907	Zea mays	37.09	3.00e-111	395.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence