iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000019825.3	ENSMMUT00000057836.1	ENSMMUP00000054011.1
ENSMMUG00000019825.3	ENSMMUT00000027859.3	ENSMMUP00000026064.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	2.70e-56	190.3	5	139
UBD/UBC-like/UBD_UBC	5.80e-84	280.2	5	142

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkee 89
           R++kel++l++dpp+++sa+pv + dl++w+++i+Gp+d+ Y+ggvF l+++fp+dYPfkPPk+ f+tki+hPn+++nG++Cl+il+  
   Q: 5    RIQKELSDLQRDPPAHCSAGPVGD-DLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILR-- 90
           9***********************.9************************************************************9.. PP
   S: 90   ekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           ++Wspal+v++vllsi+sll++pnp++pl  ++a+++k+++e+y++++r
   Q: 91   SQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAR 139
           *********************************************9987 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqw 89
           ri+kel+dl+rd++a++sa++v+ddlf+++ati+gppds+y+ggvfflt+++ptdypfkppk+af+tkiyhpninsngsicldilrsqw
   Q: 5    RIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQW 93
           8**************************************************************************************** PP
   S: 90   saaltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           s+alt+skvlls+csll+d++pddplv++ia+iyk+dkeky+r+arewt
   Q: 94   SPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWT 142
           ************************************************8 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MALKRIQKEL SDLQRDPPAH CSAGPVGDDL FHWQATIMGP PDSAYQGGVF FLTVHFPTDY 60
PFKPPKIAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGCCCGCA CACTCGCGCA CACTCGCGCT CGGGCGCAGA CTGAGCAGGG ACCGGCGCCC 60
GGAGCGAGCC AGGGAGCGGC GAACCGGGGA CCCACCGCGC GGAGCCAGCT GAGCTGCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mcc:701491

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001563	Ailuropoda melanoleuca	100.00	1.00e-85	308.00
IUUC-Apl-003639	Anas platyrhynchos	99.29	4.00e-81	292.00
IUUC-Aca-005254	Anolis carolinensis	100.00	1.00e-85	308.00
IUUC-Bta-013467	Bos taurus	100.00	1.00e-85	308.00
IUUC-Cja-019302	Callithrix jacchus	100.00	1.00e-85	308.00
IUUC-Cfa-021087	Canis familiaris	100.00	1.00e-85	308.00
IUUC-Csa-023668	Chlorocebus sabaeus	100.00	1.00e-85	308.00
IUUC-Cho-024987	Choloepus hoffmanni	100.00	1.00e-85	308.00
IUUC-Csv-026311	Ciona savignyi	84.25	8.00e-73	265.00
IUUC-Dno-030067	Dasypus novemcinctus	100.00	1.00e-85	308.00
IUUC-Dor-030474	Dipodomys ordii	100.00	1.00e-85	308.00
IUUC-Ete-032540	Echinops telfairi	100.00	1.00e-85	308.00
IUUC-Eca-034167	Equus caballus	100.00	1.00e-85	308.00
IUUC-Gga-040873	Gallus gallus	100.00	1.00e-85	308.00
IUUC-Hsa-045951	Homo sapiens	100.00	1.00e-85	308.00
IUUC-Itr-048743	Ictidomys tridecemlineatus	100.00	1.00e-85	308.00
IUUC-Laf-053673	Loxodonta africana	99.29	3.00e-81	293.00
IUUC-Mga-060138	Meleagris gallopavo	99.29	4.00e-81	292.00
IUUC-Mmr-061212	Microcebus murinus	100.00	1.00e-85	308.00
IUUC-Mdo-062402	Monodelphis domestica	100.00	1.00e-81	294.00
IUUC-Mmu-063779	Mus musculus	100.00	1.00e-85	308.00
IUUC-Mpu-065724	Mustela putorius furo	100.00	1.00e-85	308.00
IUUC-Mlu-067573	Myotis lucifugus	99.29	4.00e-81	292.00
IUUC-Nle-069950	Nomascus leucogenys	100.00	1.00e-85	308.00
IUUC-Oan-073149	Ornithorhynchus anatinus	95.92	4.00e-82	296.00
IUUC-Oga-088915	Otolemur garnettii	100.00	1.00e-85	308.00
IUUC-Oar-090418	Ovis aries	97.95	3.00e-83	300.00
IUUC-Ptr-091575	Pan troglodytes	100.00	1.00e-85	308.00
IUUC-Pan-092922	Papio anubis	100.00	1.00e-85	308.00
IUUC-Pab-098137	Pongo abelii	100.00	1.00e-85	308.00
IUUC-Pca-100678	Procavia capensis	100.00	1.00e-85	308.00
IUUC-Pva-102770	Pteropus vampyrus	100.00	1.00e-85	308.00
IUUC-Rno-106124	Rattus norvegicus	100.00	1.00e-85	308.00
IUUC-Sha-106489	Sarcophilus harrisii	95.86	8.00e-82	295.00
IUUC-Sar-113557	Sorex araneus	100.00	7.00e-81	291.00
IUUC-Tgu-117399	Taeniopygia guttata	100.00	6.00e-84	302.00
IUUC-Ttr-128363	Tursiops truncatus	100.00	1.00e-85	308.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence