iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000081803.15	ENST00000462699.5	ENSP00000419418.1
ENSG00000081803.15	ENST00000412584.6	ENSP00000400401.2
ENSG00000081803.15	ENST00000449022.6	ENSP00000398481.2
ENSG00000081803.15	ENST00000397721.4	ENSP00000380833.4
ENSG00000081803.15	ENST00000334010.11	ENSP00000333940.7
ENSG00000081803.15	ENST00000615869.4	ENSP00000484355.1
ENSG00000081803.15	ENST00000313070.11	ENSP00000325581.8

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	19690564

Organism

Homo sapiens

Functional Description
(View)

Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles (By similarity).

Protein Sequence
(Fasta)

MLDPSSSEEE SDEGLEEESR DVLVAAGSSQ RAPPAPTREG RRDAPGRAGG GGAARSVSPS 60
PSVLSEGRDE PQRQLDDEQE RRIRLQLYVF VVRCIAYPFN AKQPTDMARR QQKLNKQQLQ 120

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Nucleotide Sequence
(Fasta)

ATTCAATTCC ACGTGTTGCT TGTTGTAGGC GCCACAGGTT CCCCACCTGC GTCCGGGCGC 60
TCGGGCGGCT CCGCCTCTGC CGGCGGGCTC TGGGGAACCG CTGGGTCGGC GCGCCCGGGG 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0106--Calcium
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0268--Exocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0770--Synapse
KW-0813--Transport

Interpro

IPR000008--C2_dom
IPR033227--CAPS
IPR010439--CAPS_dom
IPR014770--Munc13_1
IPR011993--PH_dom-like
IPR001849--PH_domain

PROSITE

PS51258--MHD1
PS50003--PH_DOMAIN

Pfam

PF06292--DUF1041
PF00169--PH

SMART

SM01145--DUF1041
SM00233--PH

Gene Ontology

GO:0030054--C:cell junction
GO:0030659--C:cytoplasmic vesicle membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005654--C:nucleoplasm
GO:0045211--C:postsynaptic membrane
GO:0042734--C:presynaptic membrane
GO:0008289--F:lipid binding
GO:0046872--F:metal ion binding
GO:0009267--P:cellular response to starvation
GO:1990504--P:dense core granule exocytosis
GO:0045921--P:positive regulation of exocytosis
GO:0015031--P:protein transport
GO:0016082--P:synaptic vesicle priming

KEGG

hsa:93664

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001725	Ailuropoda melanoleuca	96.71	0.00e+00	2288.00
IUUC-Bgr-012026	Blumeria graminis	34.78	8.60e-01	27.70
IUUC-Cre-022782	Chlamydomonas reinhardtii	26.03	4.40e+00	26.20
IUUC-Eca-034201	Equus caballus	97.10	0.00e+00	2073.00
IUUC-Ggr-039787	Gaeumannomyces graminis	23.46	1.40e-02	36.20
IUUC-Gga-041250	Gallus gallus	90.85	0.00e+00	2253.00
IUUC-Gac-041624	Gasterosteus aculeatus	76.11	0.00e+00	1880.00
IUUC-Lpe-051658	Leersia perrieri	26.32	4.20e-01	27.70
IUUC-Mcc-055130	Macaca mulatta	98.46	0.00e+00	2519.00
IUUC-Mmu-063531	Mus musculus	96.35	0.00e+00	2450.00
IUUC-Ont-072216	Oreochromis niloticus	74.49	0.00e+00	1901.00
IUUC-Oan-072855	Ornithorhynchus anatinus	92.94	0.00e+00	2154.00
IUUC-Pgr-103271	Puccinia graminis	30.61	2.50e+00	28.50
IUUC-Ssc-115989	Sus scrofa	96.84	0.00e+00	2353.00
IUUC-Tgu-116803	Taeniopygia guttata	90.39	0.00e+00	2135.00
IUUC-Tru-118142	Takifugu rubripes	74.30	0.00e+00	1905.00
IUUC-Tre-122055	Trichoderma reesei	31.52	2.20e-02	34.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence