iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045884

Ensembl Protein ID

ENSP00000233055.4

UniProt Accession

Q8IWB7; Q53S17; Q9H9D5; Q9P2B3; WDFY1_HUMAN

Genbank Protein ID

CAC83947.1; AAL04161.1; BAA92673.1; BAB14294.1; AAY14924.1; EAW70817.1; AAH40525.1; AAH65934.1

Protein Name

WD repeat and FYVE domain-containing protein 1; FENS-1; Phosphoinositide-binding protein 1; WD40- and FYVE domain-containing protein 1; Zinc finger FYVE domain-containing protein 17

Genbank Nucleotide ID

AJ310568; AF411977; AB037856; AK022888; AC073641; CH471063; BC040525; BC065934

Gene Name

WDFY1; KIAA1435; WDF1; ZFYVE17

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000085449.14	ENST00000233055.8	ENSP00000233055.4
ENSG00000085449.14	ENST00000429915.1	ENSP00000395416.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha	InWeb_IM
Disease-associated Variation
GWAS Central
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
UniProt	PHOSIDA	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.80e-18	65.2	240	271

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDl 30
           gH d+v +l++   ++ lvs+s Dg i vW++
   Q: 240  GHHDKVQSLCYlqLTRQLVSCSSDGGIAVWNM 271
           899*******9884489*************97 PP

Organism

Homo sapiens

Functional Description
(View)

Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines (PubMed:25736436).

Protein Sequence
(Fasta)

MAAEIHSRPQ SSRPVLLSKI EGHQDAVTAA LLIPKEDGVI TASEDRTIRV WLKRDSGQYW 60
PSIYHTMASP CSAMAYHHDS RRIFVGQDNG AVMEFHVSED FNKMNFIKTY PAHQNRVSAI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGAGGCCCC AGCAGCCGAA GGGAAACCGG CGCGTCCCCC GCCCGCCCAG GCGTCAGCTG 60
ATGGGCTGCC TGCCGAGGAG GCCGCAGCAG TCGCCGCGCG AACATGGCGG CCGAAATCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0967--Endosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS50178--ZF_FYVE

Pfam

PF01363--FYVE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00064--FYVE
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005634--C:nucleus
GO:0005545--F:1-phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0034141--P:positive regulation of toll-like receptor 3 signaling pathway
GO:0034145--P:positive regulation of toll-like receptor 4 signaling pathway

KEGG

hsa:57590

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001526	Ailuropoda melanoleuca	96.28	0.00e+00	818.00
IUUC-Apl-003661	Anas platyrhynchos	91.80	0.00e+00	730.00
IUUC-Aca-005225	Anolis carolinensis	90.93	0.00e+00	785.00
IUUC-Ame-011044	Astyanax mexicanus	76.28	0.00e+00	661.00
IUUC-Bta-012602	Bos taurus	97.80	0.00e+00	851.00
IUUC-Cja-019529	Callithrix jacchus	98.78	0.00e+00	854.00
IUUC-Cfa-020512	Canis familiaris	96.72	0.00e+00	750.00
IUUC-Cpo-022239	Cavia porcellus	95.85	0.00e+00	825.00
IUUC-Csa-023535	Chlorocebus sabaeus	98.55	0.00e+00	715.00
IUUC-Cho-024858	Choloepus hoffmanni	79.51	0.00e+00	656.00
IUUC-Dre-028520	Danio rerio	79.90	0.00e+00	686.00
IUUC-Dno-030005	Dasypus novemcinctus	98.29	0.00e+00	849.00
IUUC-Dor-030500	Dipodomys ordii	96.64	5.00e-177	613.00
IUUC-Ete-032870	Echinops telfairi	80.84	3.00e-147	514.00
IUUC-Eca-033284	Equus caballus	94.89	0.00e+00	813.00
IUUC-Fca-036212	Felis catus	97.80	0.00e+00	757.00
IUUC-Fal-037595	Ficedula albicollis	91.91	0.00e+00	811.00
IUUC-Gmo-038664	Gadus morhua	81.33	0.00e+00	730.00
IUUC-Gga-040400	Gallus gallus	92.16	0.00e+00	811.00
IUUC-Gac-041434	Gasterosteus aculeatus	82.11	0.00e+00	736.00
IUUC-Itr-048815	Ictidomys tridecemlineatus	99.06	0.00e+00	666.00
IUUC-Lch-049995	Latimeria chalumnae	87.80	0.00e+00	777.00
IUUC-Loc-052075	Lepisosteus oculatus	85.43	0.00e+00	753.00
IUUC-Laf-054345	Loxodonta africana	96.83	0.00e+00	846.00
IUUC-Mcc-055293	Macaca mulatta	98.54	0.00e+00	847.00
IUUC-Mga-059585	Meleagris gallopavo	90.96	0.00e+00	727.00
IUUC-Mmr-061268	Microcebus murinus	98.54	0.00e+00	854.00
IUUC-Mdo-061857	Monodelphis domestica	92.65	0.00e+00	815.00
IUUC-Mmu-063789	Mus musculus	97.80	0.00e+00	848.00
IUUC-Mpu-066391	Mustela putorius furo	97.80	0.00e+00	846.00
IUUC-Mlu-067636	Myotis lucifugus	96.16	0.00e+00	751.00
IUUC-Nle-068974	Nomascus leucogenys	99.27	0.00e+00	854.00
IUUC-Opr-070553	Ochotona princeps	84.39	0.00e+00	708.00
IUUC-Oan-073659	Ornithorhynchus anatinus	94.74	0.00e+00	694.00
IUUC-Ocu-074034	Oryctolagus cuniculus	98.05	0.00e+00	850.00
IUUC-Ola-087030	Oryzias latipes	81.86	0.00e+00	736.00
IUUC-Oga-087962	Otolemur garnettii	97.81	0.00e+00	762.00
IUUC-Oar-089377	Ovis aries	97.80	0.00e+00	851.00
IUUC-Ptr-090728	Pan troglodytes	99.51	0.00e+00	857.00
IUUC-Pan-092130	Papio anubis	98.29	0.00e+00	847.00
IUUC-Psi-093886	Pelodiscus sinensis	92.56	0.00e+00	730.00
IUUC-Pfo-097254	Poecilia formosa	83.41	0.00e+00	743.00
IUUC-Pab-097594	Pongo abelii	99.76	0.00e+00	857.00
IUUC-Pca-100741	Procavia capensis	87.64	0.00e+00	658.00
IUUC-Pva-102441	Pteropus vampyrus	95.07	0.00e+00	701.00
IUUC-Rno-105767	Rattus norvegicus	97.07	0.00e+00	846.00
IUUC-Sha-106731	Sarcophilus harrisii	93.11	0.00e+00	730.00
IUUC-Ssc-115316	Sus scrofa	97.16	1.00e-124	439.00
IUUC-Tgu-116691	Taeniopygia guttata	91.91	0.00e+00	810.00
IUUC-Tru-118169	Takifugu rubripes	82.60	0.00e+00	738.00
IUUC-Tsy-119047	Tarsius syrichta	84.89	0.00e+00	633.00
IUUC-Tni-120708	Tetraodon nigroviridis	83.37	0.00e+00	736.00
IUUC-Tbe-127442	Tupaia belangeri	98.08	0.00e+00	760.00
IUUC-Ttr-128779	Tursiops truncatus	86.59	0.00e+00	733.00
IUUC-Vpa-130488	Vicugna pacos	94.71	8.00e-120	422.00
IUUC-Xtr-131994	Xenopus tropicalis	81.42	0.00e+00	728.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence