iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000088833.17	ENST00000353088.6	ENSP00000338643.2
ENSG00000088833.17	ENST00000476071.5	ENSP00000418529.1
ENSG00000088833.17	ENST00000216879.8	ENSP00000216879.4
ENSG00000088833.17	ENST00000381653.9	ENSP00000434067.1
ENSG00000088833.17	ENST00000470376.5	ENSP00000473400.1
ENSG00000088833.17	ENST00000489203.2	ENSP00000473616.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	12411482
ULD/UDP/UFD/UBX	UBX	11243799; 14988733

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	7.40e-05	24.4	4	43
ULD/UDP/UFD/UBX	7.90e-17	63.2	292	367

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlve.MGFdreealqaLraannnleaAveyLld 40
           e++++l+++v+ +G ++++a+  L++a+++l+ A++ +++
   Q: 4    ERQEALREFVAvTGAEEDRARFFLESAGWDLQIALASFYE 43
           6899*******************************99875 PP

ULD/UDP/UFD/UBX

   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfve.yllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsll 78
           +++++++qiRl+dG rlv+kF++s+++++i+ f+   +  +  + F L+++fP+++l++e++  tl+ea+L++  +++
   Q: 292  SEPTTNIQIRLADGGRLVQKFNHSHRISDIRLFIVdARPAMAATSFILMTTFPNKELADESQ--TLKEANLLNAVIVQ 367
           5779*******************************9999***********************..*********99986 PP

Organism

Homo sapiens

Functional Description
(View)

Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro).

Protein Sequence
(Fasta)

MAAERQEALR EFVAVTGAEE DRARFFLESA GWDLQIALAS FYEDGGDEDI VTISQATPSS 60
VSRGTAPSDN RVTSFRDLIH DQDEDEEEEE GQRFYAGGSE RSGQQIVGPP RKKSPNELVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAAGCTGA AACAGCAGGA AAGCATGGAG GTGGTTCTCC ACTAACTGGA GGTGGGTCCC 60
ACCTGCCCTT GCAAGCCCCC TAGCCCTGTA GGGCCCTGCA TGAGCTGGTC CCTGCCACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0333--Golgi apparatus
KW-0446--Lipid-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR012989--SEP_domain
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS51399--SEP
PS50033--UBX

Pfam

PF08059--SEP
PF00789--UBX

SMART

SM00553--SEP
SM00166--UBX

Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0005795--C:Golgi stack
GO:0045111--C:intermediate filament cytoskeleton
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:1990730--C:VCP-NSFL1C complex
GO:0005543--F:phospholipid binding
GO:0043130--F:ubiquitin binding
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0031468--P:nuclear envelope reassembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

KEGG

hsa:55968

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000550	Aegilops tauschii	37.09	2.00e-36	145.00
IUUC-Aml-001919	Ailuropoda melanoleuca	95.72	0.00e+00	704.00
IUUC-Atr-002543	Amborella trichopoda	31.25	2.00e-40	159.00
IUUC-Apl-003388	Anas platyrhynchos	87.68	0.00e+00	635.00
IUUC-Aca-005210	Anolis carolinensis	87.47	0.00e+00	649.00
IUUC-Aly-006329	Arabidopsis lyrata	35.71	3.00e-37	149.00
IUUC-Ath-007064	Arabidopsis thaliana	35.92	5.00e-36	144.00
IUUC-Ago-007933	Ashbya gossypii	28.18	3.00e-19	89.70
IUUC-Afu-008919	Aspergillus fumigatus	39.69	3.00e-29	122.00
IUUC-Ani-009398	Aspergillus nidulans	31.87	1.00e-40	160.00
IUUC-Ang-009594	Aspergillus niger	29.00	6.00e-32	131.00
IUUC-Ate-010455	Aspergillus terreus	34.84	8.00e-35	141.00
IUUC-Ame-011089	Astyanax mexicanus	72.97	2.00e-150	525.00
IUUC-Bgr-012256	Blumeria graminis	29.04	1.00e-27	117.00
IUUC-Bta-012898	Bos taurus	96.76	0.00e+00	718.00
IUUC-Bci-013750	Botrytis cinerea	33.46	1.00e-30	127.00
IUUC-Bdi-014746	Brachypodium distachyon	34.77	5.00e-37	148.00
IUUC-Bol-015874	Brassica oleracea	30.91	4.00e-37	149.00
IUUC-Bra-017734	Brassica rapa	37.10	1.00e-35	143.00
IUUC-Cel-018169	Caenorhabditis elegans	39.17	3.00e-38	152.00
IUUC-Cja-018993	Callithrix jacchus	99.19	0.00e+00	728.00
IUUC-Cfa-020958	Canis familiaris	97.03	0.00e+00	720.00
IUUC-Cpo-021417	Cavia porcellus	97.84	0.00e+00	722.00
IUUC-Csa-023244	Chlorocebus sabaeus	99.46	0.00e+00	733.00
IUUC-Cho-024335	Choloepus hoffmanni	73.76	2.00e-97	348.00
IUUC-Cin-025686	Ciona intestinalis	47.30	4.00e-92	331.00
IUUC-Csv-025945	Ciona savignyi	44.96	7.00e-88	317.00
IUUC-Cne-026798	Cryptococcus neoformans	38.42	2.00e-36	146.00
IUUC-Cme-027347	Cyanidioschyzon merolae	32.87	8.00e-30	124.00
IUUC-Dre-028748	Danio rerio	72.70	2.00e-149	522.00
IUUC-Dno-029977	Dasypus novemcinctus	95.70	0.00e+00	709.00
IUUC-Dor-030203	Dipodomys ordii	96.14	0.00e+00	640.00
IUUC-Dse-031256	Dothistroma septosporum	31.80	1.00e-31	130.00
IUUC-Dme-031878	Drosophila melanogaster	44.41	3.00e-60	225.00
IUUC-Ete-032997	Echinops telfairi	94.32	0.00e+00	697.00
IUUC-Eca-034132	Equus caballus	97.62	0.00e+00	657.00
IUUC-Eeu-035097	Erinaceus europaeus	71.56	6.00e-84	304.00
IUUC-Fca-036037	Felis catus	96.46	0.00e+00	649.00
IUUC-Fal-037100	Ficedula albicollis	87.03	4.00e-175	607.00
IUUC-Fso-038190	Fusarium solani	27.23	4.00e-31	129.00
IUUC-Gmo-039429	Gadus morhua	65.85	4.00e-131	461.00
IUUC-Gga-040864	Gallus gallus	88.32	0.00e+00	660.00
IUUC-Gac-041589	Gasterosteus aculeatus	69.97	5.00e-147	513.00
IUUC-Gma-044296	Glycine max	35.59	1.00e-36	147.00
IUUC-Ggo-044601	Gorilla gorilla	99.46	0.00e+00	730.00
IUUC-Itr-047949	Ictidomys tridecemlineatus	96.51	0.00e+00	716.00
IUUC-Kpa-049322	Komagataella pastoris	32.37	4.00e-29	122.00
IUUC-Lch-050608	Latimeria chalumnae	74.32	2.00e-161	561.00
IUUC-Lpe-050944	Leersia perrieri	35.58	4.00e-32	133.00
IUUC-Loc-052555	Lepisosteus oculatus	73.64	1.00e-158	552.00
IUUC-Laf-054237	Loxodonta africana	95.70	0.00e+00	710.00
IUUC-Mcc-055472	Macaca mulatta	99.19	0.00e+00	728.00
IUUC-Meu-056093	Macropus eugenii	72.78	2.00e-125	442.00
IUUC-Mor-057220	Magnaporthe oryzae	25.88	9.00e-30	124.00
IUUC-Mtr-058376	Medicago truncatula	35.34	5.00e-35	141.00
IUUC-Mla-059077	Melampsora laricipopulina	33.02	3.00e-35	142.00
IUUC-Mga-059836	Meleagris gallopavo	87.94	1.00e-174	605.00
IUUC-Mvi-060292	Microbotryum violaceum	38.74	2.00e-32	133.00
IUUC-Mmr-060897	Microcebus murinus	96.51	0.00e+00	714.00
IUUC-Mdo-062066	Monodelphis domestica	90.74	0.00e+00	679.00
IUUC-Mmu-063686	Mus musculus	95.70	0.00e+00	711.00
IUUC-Mac-065403	Musa acuminata	32.53	3.00e-33	136.00
IUUC-Mpu-065688	Mustela putorius furo	97.30	0.00e+00	722.00
IUUC-Mlu-067566	Myotis lucifugus	93.80	0.00e+00	677.00
IUUC-Nle-069169	Nomascus leucogenys	99.41	0.00e+00	666.00
IUUC-Opr-070979	Ochotona princeps	93.20	6.00e-178	616.00
IUUC-Ont-071803	Oreochromis niloticus	68.55	6.00e-145	506.00
IUUC-Ocu-074276	Oryctolagus cuniculus	97.04	0.00e+00	718.00
IUUC-Oba-075011	Oryza barthii	34.89	3.00e-34	138.00
IUUC-Obr-076164	Oryza brachyantha	35.64	4.00e-28	118.00
IUUC-Ogl-077805	Oryza glaberrima	34.89	3.00e-34	138.00
IUUC-Ogu-078942	Oryza glumaepatula	34.89	3.00e-34	139.00
IUUC-Oin-079497	Oryza indica	34.33	2.00e-31	130.00
IUUC-Olo-080254	Oryza longistaminata	39.57	7.00e-31	128.00
IUUC-Oni-082258	Oryza nivara	34.89	3.00e-34	138.00
IUUC-Oru-084748	Oryza rufipogon	34.89	3.00e-34	139.00
IUUC-Osa-085359	Oryza sativa	34.89	3.00e-34	138.00
IUUC-Ola-086761	Oryzias latipes	69.35	1.00e-139	489.00
IUUC-Olu-087598	Ostreococcus lucimarinus	33.80	1.00e-32	134.00
IUUC-Oga-088533	Otolemur garnettii	98.38	0.00e+00	726.00
IUUC-Oar-089450	Ovis aries	97.03	0.00e+00	719.00
IUUC-Ptr-090926	Pan troglodytes	100.00	0.00e+00	735.00
IUUC-Pan-092100	Papio anubis	99.73	0.00e+00	733.00
IUUC-Psi-093446	Pelodiscus sinensis	86.05	2.00e-166	578.00
IUUC-Pma-094475	Petromyzon marinus	65.95	1.00e-104	372.00
IUUC-Pno-094769	Phaeosphaeria nodorum	33.11	5.00e-36	145.00
IUUC-Ppa-095833	Physcomitrella patens	34.64	5.00e-36	145.00
IUUC-Pfo-096193	Poecilia formosa	70.51	6.00e-150	523.00
IUUC-Pab-097971	Pongo abelii	100.00	0.00e+00	735.00
IUUC-Pop-098970	Populus trichocarpa	36.79	2.00e-43	169.00
IUUC-Pca-100390	Procavia capensis	94.98	4.00e-126	443.00
IUUC-Pva-102504	Pteropus vampyrus	87.90	0.00e+00	639.00
IUUC-Pgr-103447	Puccinia graminis	30.57	7.00e-34	138.00
IUUC-Ptt-103729	Puccinia triticina	32.59	1.00e-36	147.00
IUUC-Pte-104083	Pyrenophora teres	33.90	2.00e-40	159.00
IUUC-Pyt-104504	Pyrenophora triticirepentis	32.88	5.00e-36	145.00
IUUC-Rno-105448	Rattus norvegicus	96.49	0.00e+00	718.00
IUUC-Sce-106457	Saccharomyces cerevisiae	30.77	1.00e-30	127.00
IUUC-Sja-107717	Schizosaccharomyces japonicus	33.68	3.00e-31	129.00
IUUC-Spo-108358	Schizosaccharomyces pombe	29.95	2.00e-33	137.00
IUUC-Smo-109535	Selaginella moellendorffii	35.49	7.00e-34	137.00
IUUC-Sit-110328	Setaria italica	35.19	4.00e-35	142.00
IUUC-Sly-111135	Solanum lycopersicum	31.94	2.00e-41	163.00
IUUC-Stu-112733	Solanum tuberosum	35.00	9.00e-38	150.00
IUUC-Sar-113445	Sorex araneus	77.96	2.00e-127	448.00
IUUC-Sbi-114761	Sorghum bicolor	35.99	1.00e-33	137.00
IUUC-Sre-115176	Sporisorium reilianum	39.69	4.00e-31	129.00
IUUC-Ssc-116008	Sus scrofa	97.84	0.00e+00	723.00
IUUC-Tgu-117238	Taeniopygia guttata	88.04	0.00e+00	656.00
IUUC-Tru-118521	Takifugu rubripes	64.15	7.00e-137	480.00
IUUC-Tni-119705	Tetraodon nigroviridis	67.56	8.00e-141	493.00
IUUC-Tca-121370	Theobroma cacao	33.57	4.00e-29	122.00
IUUC-Tre-121941	Trichoderma reesei	34.34	4.00e-30	125.00
IUUC-Tvi-122602	Trichoderma virens	27.59	6.00e-28	118.00
IUUC-Tae-123686	Triticum aestivum	37.81	8.00e-39	154.00
IUUC-Tur-126267	Triticum urartu	37.81	2.00e-33	135.00
IUUC-Tme-127193	Tuber melanosporum	31.90	5.00e-38	152.00
IUUC-Tbe-127716	Tupaia belangeri	95.39	1.00e-163	568.00
IUUC-Ttr-128262	Tursiops truncatus	95.43	0.00e+00	702.00
IUUC-Uma-129600	Ustilago maydis	30.43	1.00e-41	164.00
IUUC-Vda-129743	Verticillium dahliae	29.62	6.00e-30	125.00
IUUC-Vpa-130068	Vicugna pacos	96.75	5.00e-170	590.00
IUUC-Vvi-131338	Vitis vinifera	33.09	1.00e-33	136.00
IUUC-Xma-133944	Xiphophorus maculatus	70.24	4.00e-150	524.00
IUUC-Zma-135978	Zea mays	35.66	2.00e-34	139.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence