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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046885
UUCD1 version UUC-HoS-00066
Ensembl Protein ID ENSP00000369594.3
UniProt Accession P35637; Q9H4A8; FUS_HUMAN
Genbank Protein ID AAB27102.1; AAB27103.1; CAA50558.1; CAA50559.1; AAC35285.1; AAC35284.1; AAH00402.1; AAH02459.1; CAC15058.1
Protein Name RNA-binding protein FUS; 75 kDa DNA-pairing protein; Oncogene FUS; Oncogene TLS; POMp75; Translocated in liposarcoma protein
Genbank Nucleotide ID S62140; S62138; X71427; X71428; AF071213; AF071213; AC009088; BC002459; AJ295163
Gene Name FUS; TLS
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000089280.18 ENST00000254108.11 ENSP00000254108.7
ENSG00000089280.18 ENST00000566605.5 ENSP00000455073.1
ENSG00000089280.18 ENST00000380244.7 ENSP00000369594.3
ENSG00000089280.18 ENST00000568685.1 ENSP00000455282.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 19946338
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP.Interacts with LRSAM1 (PubMed:27615052).
 Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP.Interacts with LRSAM1 (PubMed:27615052).
Protein Sequence
(Fasta)
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTSGY GQSSYSSYGQ 60
SQNSYGTQST PQGYGSTGGY GSSQSSQSSY GQQSSYPGYG QQPAPSSTSG SYGSSSQSSS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046885|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTTAAGCTT CGACGCAGGA GGCGGGGCTG CTCAGTCCTC CAGGCGTCGG TACTCAGCGG 60
TGTTGGAACT TCGTTGCTTG CTTGCCTGTG CGCGCGTGCG CGGACATGGC CTCAAACGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046885|E3,E3 activity/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0036--Amyotrophic lateral sclerosis
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0488--Methylation
KW-0523--Neurodegeneration
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR034459--FUS
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR001876--Znf_RanBP2
PROSITE

PS50102--RRM
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF00076--RRM_1
PF00641--zf-RanBP
SMART

SM00360--RRM
SM00547--ZnF_RBZ
Gene Ontology

GO:0044327--C:dendritic spine head
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043204--C:perikaryon
GO:0048471--C:perinuclear region of cytoplasm
GO:0005844--C:polysome
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0000166--F:nucleotide binding
GO:0003723--F:RNA binding
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0071277--P:cellular response to calcium ion
GO:0000398--P:mRNA splicing, via spliceosome
KEGG hsa:2521
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001251 Ailuropoda melanoleuca 100.00 3.00e-60 226.00
IUUC-Bta-012425 Bos taurus 100.00 3.00e-77 282.00
IUUC-Cel-018311 Caenorhabditis elegans 39.56 1.00e-12 67.80
IUUC-Cja-019524 Callithrix jacchus 100.00 7.00e-77 281.00
IUUC-Cfa-020792 Canis familiaris 99.25 1.00e-75 276.00
IUUC-Cho-024940 Choloepus hoffmanni 96.63 1.00e-65 243.00
IUUC-Cin-025316 Ciona intestinalis 57.32 3.00e-24 104.00
IUUC-Dno-029527 Dasypus novemcinctus 99.62 2.00e-77 283.00
IUUC-Dor-031027 Dipodomys ordii 100.00 7.00e-61 228.00
IUUC-Dme-031985 Drosophila melanogaster 50.00 1.00e-22 100.00
IUUC-Ete-033069 Echinops telfairi 92.02 6.00e-50 191.00
IUUC-Eeu-034445 Erinaceus europaeus 100.00 3.00e-77 282.00
IUUC-Gac-042021 Gasterosteus aculeatus 84.44 3.00e-42 166.00
IUUC-Itr-048085 Ictidomys tridecemlineatus 100.00 1.00e-71 263.00
IUUC-Laf-053348 Loxodonta africana 93.61 2.00e-74 273.00
IUUC-Meu-056142 Macropus eugenii 97.87 3.00e-79 289.00
IUUC-Mmr-060597 Microcebus murinus 100.00 5.00e-77 281.00
IUUC-Mdo-062406 Monodelphis domestica 98.87 3.00e-85 309.00
IUUC-Mmu-063450 Mus musculus 100.00 4.00e-72 265.00
IUUC-Mpu-066821 Mustela putorius furo 99.62 9.00e-77 281.00
IUUC-Mlu-067643 Myotis lucifugus 99.25 1.00e-78 286.00
IUUC-Nle-069461 Nomascus leucogenys 100.00 3.00e-77 282.00
IUUC-Oan-073686 Ornithorhynchus anatinus 98.40 2.00e-70 260.00
IUUC-Oar-090388 Ovis aries 100.00 1.00e-71 263.00
IUUC-Ptr-091157 Pan troglodytes 100.00 2.00e-77 283.00
IUUC-Pab-098761 Pongo abelii 86.42 9.00e-55 207.00
IUUC-Pca-100284 Procavia capensis 100.00 3.00e-52 199.00
IUUC-Pva-102411 Pteropus vampyrus 98.86 1.00e-84 307.00
IUUC-Pgr-103625 Puccinia graminis 25.27 1.80e-02 33.90
IUUC-Rno-105994 Rattus norvegicus 99.47 9.00e-72 264.00
IUUC-Ssc-116079 Sus scrofa 99.62 2.00e-77 283.00
IUUC-Tsy-119631 Tarsius syrichta 91.98 4.00e-69 255.00
IUUC-Tni-119747 Tetraodon nigroviridis 70.77 4.00e-59 222.00
Created Date 25-Jun-2017

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