iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000092140.14	ENST00000553504.5	ENSP00000451653.1
ENSG00000092140.14	ENST00000552515.5	ENSP00000448515.1
ENSG00000092140.14	ENST00000548934.1	ENSP00000446535.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	18511420; 20175895

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	1.80e-42	147.6	418	726

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsks 95
           + +ev +v E+   g +++G+++efl+ll+++l+n++  lf  + + +++l+ n+++      +++l++ +G++l+++l++g + + ++sk+
   Q: 418  YAIEVAYVIENdnfGSEHPGSKQEFLSLLMQHLENSS--LF--EGSLSKNLSLNSQAL-----KENLYYEAGKMLAISLVHGGPSPGFFSKT 500
           56788898887777***********************..45..677788888888885.....689************************** PP
   S: 96   fyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegi 186
           ++++l+  +   e+++ + +++ ++ + +i  +   ++ ++ +dl++      ++e++++  + g+ +   t ++k++ vk+++ y++ +++
   Q: 501  LFNCLVYGP---ENTQPILDDVSDFdVAQIIIRI--NTATTVADLKSI-----INECYNYLELIGCLRLITTLSDKYMLVKDILGYHVIQRV 582
           ********8...*************988888774..555555788765.....88999**99****************************** PP
   S: 187  keqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq....FvTgssr 273
           ++ +e+f++G++++  le+++++ e  +++l+++ e+++++ l++   ++ ++ +d +a+  Fw+ + +++++ + ++ ++    F+Tg+s+
   Q: 583  HTPFESFKQGLKTLGVLEKIQAYPEAFCSILCHKPESLSAKILSE--LFTVHTLPDVKAL-GFWNSYlQAVEDGKSTTTMEdiliFATGCSS 671
           *********************************************..888899******8.899876578877777766666666******* PP
   S: 274  lPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +P++Gf++ + ++ +++      ++P  n+C n+L +P  +++++++e++ ++i++t ++e
   Q: 672  IPPAGFKPTP-SIECLHV-----DFPVGNKCNNCLAIPITNTYKEFQENMDFTIRNTLRLE 726
           *********9.99****9.....********************************987665 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.

Protein Sequence
(Fasta)

MLIPALQISD SESVGLEDGI EQSAYLTESK MNESKPGDSQ NLACVFCRKH DDCPNKYGEK 60
KTKEKWNLTV HYYCLLMSSG IWQRGKEEEG VYGFLIEDIR KEVNRASKLK CCVCKKNGAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCGCTCTT TCCGGGTTTG CGAGCGGAAG TGGACGAATT TGAATCCTGT GGGCCGTTGA 60
ATGTGGCTGC TCGCGGTCGG CGTGCCCCGA CGTACAGCGG GCCGGGAAAA GTGGCACTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007275--P:multicellular organism development

KEGG

hsa:55632

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	91.64	0.00e+00	1366.00
IUUC-Apl-003763	Anas platyrhynchos	60.60	0.00e+00	859.00
IUUC-Aca-004328	Anolis carolinensis	61.10	0.00e+00	872.00
IUUC-Ame-011288	Astyanax mexicanus	40.08	8.00e-162	564.00
IUUC-Bta-012496	Bos taurus	86.65	0.00e+00	1294.00
IUUC-Cja-019756	Callithrix jacchus	94.74	0.00e+00	1392.00
IUUC-Cfa-020806	Canis familiaris	89.39	0.00e+00	1345.00
IUUC-Cpo-022519	Cavia porcellus	85.98	0.00e+00	1267.00
IUUC-Csa-023957	Chlorocebus sabaeus	98.02	0.00e+00	1446.00
IUUC-Cho-024375	Choloepus hoffmanni	83.26	0.00e+00	1191.00
IUUC-Cin-025325	Ciona intestinalis	40.88	3.00e-65	241.00
IUUC-Csv-026262	Ciona savignyi	42.66	1.00e-66	247.00
IUUC-Dre-027829	Danio rerio	40.48	5.00e-154	538.00
IUUC-Dno-029362	Dasypus novemcinctus	89.42	0.00e+00	1321.00
IUUC-Dor-030710	Dipodomys ordii	83.29	0.00e+00	1256.00
IUUC-Dse-031248	Dothistroma septosporum	40.38	3.00e-03	37.40
IUUC-Dme-031692	Drosophila melanogaster	34.83	7.00e-42	165.00
IUUC-Ete-032282	Echinops telfairi	80.99	0.00e+00	1166.00
IUUC-Eca-033963	Equus caballus	89.80	0.00e+00	1355.00
IUUC-Eeu-035029	Erinaceus europaeus	86.24	0.00e+00	1292.00
IUUC-Fca-036229	Felis catus	90.65	0.00e+00	1365.00
IUUC-Fal-037015	Ficedula albicollis	58.33	0.00e+00	875.00
IUUC-Gmo-039715	Gadus morhua	38.71	2.00e-75	276.00
IUUC-Gga-040298	Gallus gallus	59.03	0.00e+00	904.00
IUUC-Gac-041444	Gasterosteus aculeatus	39.43	2.00e-143	502.00
IUUC-Ggo-045456	Gorilla gorilla	99.29	0.00e+00	1459.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	88.67	0.00e+00	936.00
IUUC-Lch-050287	Latimeria chalumnae	67.32	5.00e-106	378.00
IUUC-Loc-052839	Lepisosteus oculatus	57.58	1.00e-31	128.00
IUUC-Laf-053581	Loxodonta africana	88.44	0.00e+00	1306.00
IUUC-Mcc-055615	Macaca mulatta	97.15	0.00e+00	1461.00
IUUC-Meu-056753	Macropus eugenii	49.49	5.00e-130	458.00
IUUC-Mga-059902	Meleagris gallopavo	59.24	0.00e+00	910.00
IUUC-Mmr-061522	Microcebus murinus	92.52	0.00e+00	1416.00
IUUC-Mdo-063022	Monodelphis domestica	66.32	0.00e+00	911.00
IUUC-Mmu-063609	Mus musculus	77.17	0.00e+00	1175.00
IUUC-Mpu-066656	Mustela putorius furo	89.96	0.00e+00	1358.00
IUUC-Mlu-067011	Myotis lucifugus	88.26	0.00e+00	1317.00
IUUC-Nle-069949	Nomascus leucogenys	99.01	0.00e+00	1454.00
IUUC-Opr-071224	Ochotona princeps	83.46	5.00e-133	468.00
IUUC-Ont-072174	Oreochromis niloticus	37.77	5.00e-139	488.00
IUUC-Oan-072712	Ornithorhynchus anatinus	68.72	0.00e+00	987.00
IUUC-Ocu-073776	Oryctolagus cuniculus	91.08	0.00e+00	1353.00
IUUC-Ola-087247	Oryzias latipes	36.83	3.00e-129	456.00
IUUC-Oga-088094	Otolemur garnettii	88.18	0.00e+00	1238.00
IUUC-Oar-090248	Ovis aries	86.38	0.00e+00	1286.00
IUUC-Ptr-090634	Pan troglodytes	99.58	0.00e+00	1465.00
IUUC-Pan-092876	Papio anubis	98.16	0.00e+00	1446.00
IUUC-Psi-093580	Pelodiscus sinensis	61.84	0.00e+00	889.00
IUUC-Pma-094295	Petromyzon marinus	53.97	4.00e-74	270.00
IUUC-Pfo-096351	Poecilia formosa	36.99	2.00e-144	506.00
IUUC-Pab-097596	Pongo abelii	99.15	0.00e+00	1457.00
IUUC-Pca-100309	Procavia capensis	82.15	0.00e+00	1221.00
IUUC-Pva-102526	Pteropus vampyrus	92.01	0.00e+00	859.00
IUUC-Rno-105432	Rattus norvegicus	82.24	0.00e+00	1230.00
IUUC-Sha-107089	Sarcophilus harrisii	65.64	0.00e+00	1015.00
IUUC-Sar-113667	Sorex araneus	69.03	0.00e+00	979.00
IUUC-Ssc-116200	Sus scrofa	89.52	0.00e+00	1340.00
IUUC-Tgu-116467	Taeniopygia guttata	58.10	0.00e+00	855.00
IUUC-Tru-117690	Takifugu rubripes	38.26	2.00e-153	536.00
IUUC-Tsy-119481	Tarsius syrichta	88.00	0.00e+00	922.00
IUUC-Tni-119669	Tetraodon nigroviridis	37.54	4.00e-135	475.00
IUUC-Tbe-127241	Tupaia belangeri	82.39	0.00e+00	1169.00
IUUC-Ttr-129057	Tursiops truncatus	81.30	0.00e+00	1163.00
IUUC-Vpa-130685	Vicugna pacos	87.62	0.00e+00	1271.00
IUUC-Xtr-132555	Xenopus tropicalis	53.25	0.00e+00	755.00
IUUC-Xma-133723	Xiphophorus maculatus	49.65	7.00e-82	296.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence