iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000054213.7	ENSDART00000076344.5	ENSDARP00000070818.4
ENSDARG00000054213.7	ENSDART00000152000.1	ENSDARP00000126492.1
ENSDARG00000054213.7	ENSDART00000152057.1	ENSDARP00000126451.1
ENSDARG00000054213.7	ENSDART00000164981.1	ENSDARP00000133558.1
ENSDARG00000054213.7	ENSDART00000076340.4	ENSDARP00000070814.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.10e-119	398.8	2118	2576

Active Site

Position(s)	Description	Evidence
2545	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q+++lg++l++++  d+e++q++   glk+p                     
   Q: 2118 HADRKSVLEVEFQGEEGTGL-GPTLEFYALVAAEFQRTSLGIWLCDDDfpDDESRQVDLGGGLKPPgyyvqrscglfpapfpqdsde 2203
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF flG++l+k++qd+rl+dlp+s++f+kll                                                  
   Q: 2204 leRITKLFLFLGIFLAKCIQDNRLVDLPISQPFFKLLcmgdiksnmskllyqtrgesdchfseiqseasteegqdtysvgsfdedsk 2290
           *************************************99999999999999999999999999999988888888888888777777 PP
   S: 101  ...............lgkklsledleevdpelykslkeikena........es..........................dieelgld 138
                           +  l++ed+e v+p+++ +lke+k++         ++                           +e+lgl+
   Q: 2291 sefildppkpkppawYHGILTWEDFELVNPHRALFLKELKALSvkrrqilgNKslsedekntrlqdlmlknpmgsgpplCVEDLGLN 2377
           7777666666655555557*********************99866655555116667777889999999999999***9******** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeid 225
           ++f++s+++ g  +++ Lkp+Ge+++Vt++N+eeYv+l++++++++gi++q+eafreGfn+v+p+e+ls+F+++e+++++cG+   +
   Q: 2378 FQFCPSSKVHGFSSVD-LKPNGEDEMVTMDNAEEYVELMFDFCMHTGIQKQMEAFREGFNKVFPMEKLSSFSHKEVQMILCGN---Q 2460
           ******9988888777.******************************************************************...5 PP
   S: 226  vedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfn 306
           ++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+++rk da+d+++Ps+nTC++
   Q: 2461 SPSWTAEDivNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTIVRKvDATDASYPSVNTCVH 2547
           555555555544555************************************************************************ PP
   S: 307  yLkLPeYsskeilkekLlyAieetkgFels 336
           yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2548 YLKLPEYSSEEIMRERLLAATME-KGFHLN 2576
           ***********************.****86 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACAATTTCG CAATATAGGT GAATGAATGT CTGATCTGTT TTTTTGTCGA CCTCGATGAA 60
GGCGAGGTGT TTTAGCACCC CCTGTCGCTG AGCCGCATCG CTGCGTGTTT CTGACCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

dre:100002034

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	87.03	0.00e+00	4108.00
IUUC-Apl-003493	Anas platyrhynchos	87.54	0.00e+00	4125.00
IUUC-Aca-004521	Anolis carolinensis	88.02	0.00e+00	4116.00
IUUC-Ame-011258	Astyanax mexicanus	93.70	0.00e+00	4282.00
IUUC-Bta-012835	Bos taurus	86.91	0.00e+00	4113.00
IUUC-Cel-018153	Caenorhabditis elegans	52.24	2.00e-168	588.00
IUUC-Cja-019174	Callithrix jacchus	86.11	0.00e+00	4032.00
IUUC-Cfa-021115	Canis familiaris	86.88	0.00e+00	4065.00
IUUC-Cpo-022382	Cavia porcellus	83.19	0.00e+00	3869.00
IUUC-Csa-023230	Chlorocebus sabaeus	86.95	0.00e+00	4108.00
IUUC-Cho-024711	Choloepus hoffmanni	84.63	0.00e+00	1478.00
IUUC-Cin-025342	Ciona intestinalis	52.59	0.00e+00	1359.00
IUUC-Csv-026031	Ciona savignyi	51.79	0.00e+00	1391.00
IUUC-Dno-029954	Dasypus novemcinctus	87.03	0.00e+00	4082.00
IUUC-Dor-030734	Dipodomys ordii	90.76	0.00e+00	1372.00
IUUC-Dme-031739	Drosophila melanogaster	60.66	0.00e+00	1633.00
IUUC-Ete-033192	Echinops telfairi	86.76	0.00e+00	1142.00
IUUC-Eca-033434	Equus caballus	86.60	0.00e+00	4080.00
IUUC-Eeu-035031	Erinaceus europaeus	79.03	0.00e+00	1033.00
IUUC-Fca-035998	Felis catus	85.54	0.00e+00	4000.00
IUUC-Fal-037468	Ficedula albicollis	87.78	0.00e+00	4083.00
IUUC-Gmo-038495	Gadus morhua	92.57	0.00e+00	1385.00
IUUC-Gga-040736	Gallus gallus	88.55	0.00e+00	4091.00
IUUC-Gac-041777	Gasterosteus aculeatus	94.34	0.00e+00	2461.00
IUUC-Ggo-044677	Gorilla gorilla	82.88	0.00e+00	3843.00
IUUC-Hsa-045879	Homo sapiens	86.95	0.00e+00	4108.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	86.88	0.00e+00	4110.00
IUUC-Lch-050444	Latimeria chalumnae	89.25	0.00e+00	2561.00
IUUC-Loc-051986	Lepisosteus oculatus	89.72	0.00e+00	4234.00
IUUC-Laf-054230	Loxodonta africana	86.45	0.00e+00	4049.00
IUUC-Mcc-054787	Macaca mulatta	86.95	0.00e+00	4108.00
IUUC-Meu-056502	Macropus eugenii	81.68	0.00e+00	1221.00
IUUC-Mga-059409	Meleagris gallopavo	95.21	0.00e+00	1899.00
IUUC-Mmr-061667	Microcebus murinus	86.59	0.00e+00	4076.00
IUUC-Mdo-061960	Monodelphis domestica	87.57	0.00e+00	4108.00
IUUC-Mmu-063941	Mus musculus	86.38	0.00e+00	4071.00
IUUC-Mpu-065939	Mustela putorius furo	87.07	0.00e+00	4113.00
IUUC-Mlu-068112	Myotis lucifugus	86.99	0.00e+00	4084.00
IUUC-Nle-069001	Nomascus leucogenys	86.91	0.00e+00	4105.00
IUUC-Opr-071222	Ochotona princeps	90.37	0.00e+00	2033.00
IUUC-Ont-072101	Oreochromis niloticus	88.81	0.00e+00	4147.00
IUUC-Oan-072814	Ornithorhynchus anatinus	87.37	0.00e+00	4095.00
IUUC-Ocu-074011	Oryctolagus cuniculus	86.91	0.00e+00	4108.00
IUUC-Ola-086412	Oryzias latipes	94.41	0.00e+00	2463.00
IUUC-Oar-089668	Ovis aries	86.91	0.00e+00	4106.00
IUUC-Ptr-090517	Pan troglodytes	86.62	0.00e+00	4070.00
IUUC-Pan-091849	Papio anubis	84.51	0.00e+00	3942.00
IUUC-Psi-093390	Pelodiscus sinensis	86.63	0.00e+00	3991.00
IUUC-Pma-094628	Petromyzon marinus	82.46	0.00e+00	1539.00
IUUC-Ppa-095264	Physcomitrella patens	33.02	4.00e-81	296.00
IUUC-Pfo-097075	Poecilia formosa	95.29	0.00e+00	2516.00
IUUC-Pab-098176	Pongo abelii	86.95	0.00e+00	4108.00
IUUC-Pca-101123	Procavia capensis	75.41	0.00e+00	2003.00
IUUC-Pva-103008	Pteropus vampyrus	95.67	0.00e+00	1545.00
IUUC-Rno-105885	Rattus norvegicus	86.80	0.00e+00	4104.00
IUUC-Sha-107048	Sarcophilus harrisii	87.43	0.00e+00	4116.00
IUUC-Sar-113071	Sorex araneus	89.78	0.00e+00	1231.00
IUUC-Ssc-115963	Sus scrofa	86.22	0.00e+00	4105.00
IUUC-Tgu-117167	Taeniopygia guttata	80.98	0.00e+00	2298.00
IUUC-Tru-118626	Takifugu rubripes	95.20	0.00e+00	2530.00
IUUC-Tsy-119504	Tarsius syrichta	86.38	0.00e+00	2079.00
IUUC-Tni-119877	Tetraodon nigroviridis	94.64	0.00e+00	2474.00
IUUC-Tbe-127602	Tupaia belangeri	87.12	0.00e+00	1011.00
IUUC-Ttr-128394	Tursiops truncatus	81.38	0.00e+00	2628.00
IUUC-Vpa-130280	Vicugna pacos	85.88	0.00e+00	3881.00
IUUC-Xtr-131787	Xenopus tropicalis	80.05	0.00e+00	3769.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence