iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000094880.10	ENST00000394886.6	ENSP00000378350.2
ENSG00000094880.10	ENST00000483961.6	ENSP00000422505.1
ENSG00000094880.10	ENST00000511383.5	ENSP00000422902.1
ENSG00000094880.10	ENST00000394884.7	ENSP00000378348.3
ENSG00000094880.10	ENST00000505120.1	ENSP00000423704.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C	APC_C	21107322; 16763193

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C	32.73	7.00e-66	246.00	IUUC-Sce-106199

Organism

Homo sapiens

Functional Description
(View)

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MAASTSMVPV AVTAAVAPVL SINSDFSDLR EIKKQLLLIA GLTRERGLLH SSKWSAELAF 60
SLPALPLAEL QPPPPITEED AQDMDAYTLA KAYFDVKEYD RAAHFLHGCN SKKAYFLYMY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATTGGCT GGAGTGGCCC GAGTCGGGAA AATGGCTGCG AGTACCTCCA TGGTCCCGGT 60
GGCTGTGACG GCGGCAGTGG CGCCTGTCCT GTCCATAAAC AGCGATTTCT CAGATTTGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR007192--APC8
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat

PROSITE

PS50005--TPR
PS50293--TPR_REGION

Pfam

PF04049--ANAPC8
PF13414--TPR_11
PF13181--TPR_8

SMART

SM00028--TPR

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007091--P:metaphase/anaphase transition of mitotic cell cycle
GO:0007080--P:mitotic metaphase plate congression
GO:0007067--P:mitotic nuclear division
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070979--P:protein K11-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0007096--P:regulation of exit from mitosis
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
GO:0051439--P:regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:8697

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000540	Aegilops tauschii	48.76	1.00e-103	370.00
IUUC-Aml-002139	Ailuropoda melanoleuca	99.48	0.00e+00	1152.00
IUUC-Atr-002658	Amborella trichopoda	48.03	8.00e-123	434.00
IUUC-Apl-004020	Anas platyrhynchos	95.20	0.00e+00	1037.00
IUUC-Aca-005101	Anolis carolinensis	91.80	0.00e+00	1071.00
IUUC-Aly-006437	Arabidopsis lyrata	46.34	4.00e-116	412.00
IUUC-Ath-006712	Arabidopsis thaliana	46.34	2.00e-114	406.00
IUUC-Ago-007953	Ashbya gossypii	34.32	1.00e-69	257.00
IUUC-Acl-008166	Aspergillus clavatus	36.51	3.00e-89	323.00
IUUC-Afl-008420	Aspergillus flavus	36.43	3.00e-90	326.00
IUUC-Afu-009028	Aspergillus fumigatus	36.56	1.00e-88	320.00
IUUC-Ani-009390	Aspergillus nidulans	36.15	3.00e-91	329.00
IUUC-Ang-009704	Aspergillus niger	37.57	8.00e-90	324.00
IUUC-Aor-009990	Aspergillus oryzae	36.62	2.00e-90	326.00
IUUC-Ate-010510	Aspergillus terreus	36.10	2.00e-88	320.00
IUUC-Ame-011724	Astyanax mexicanus	67.86	0.00e+00	788.00
IUUC-Bgr-012007	Blumeria graminis	35.25	2.00e-79	290.00
IUUC-Bta-013310	Bos taurus	99.13	0.00e+00	1185.00
IUUC-Bci-013833	Botrytis cinerea	37.60	5.00e-84	305.00
IUUC-Bdi-014957	Brachypodium distachyon	46.22	4.00e-117	415.00
IUUC-Bol-016105	Brassica oleracea	47.04	1.00e-119	423.00
IUUC-Bra-017168	Brassica rapa	46.67	5.00e-110	391.00
IUUC-Cel-018142	Caenorhabditis elegans	37.08	4.00e-81	295.00
IUUC-Cja-019339	Callithrix jacchus	99.13	0.00e+00	1159.00
IUUC-Cfa-020690	Canis familiaris	99.48	0.00e+00	1152.00
IUUC-Cpo-021859	Cavia porcellus	98.16	0.00e+00	1167.00
IUUC-Cre-022698	Chlamydomonas reinhardtii	41.83	5.00e-76	278.00
IUUC-Csa-024176	Chlorocebus sabaeus	99.48	0.00e+00	1197.00
IUUC-Cho-024903	Choloepus hoffmanni	97.46	0.00e+00	982.00
IUUC-Cin-025468	Ciona intestinalis	45.45	1.00e-128	453.00
IUUC-Csv-026223	Ciona savignyi	44.74	2.00e-137	483.00
IUUC-Cgl-026453	Colletotrichum gloeosporioides	36.69	1.00e-81	297.00
IUUC-Cne-027038	Cryptococcus neoformans	35.40	3.00e-81	296.00
IUUC-Cme-027161	Cyanidioschyzon merolae	37.24	4.00e-72	265.00
IUUC-Dre-027972	Danio rerio	80.52	0.00e+00	938.00
IUUC-Dno-029164	Dasypus novemcinctus	98.79	0.00e+00	1153.00
IUUC-Dor-030344	Dipodomys ordii	88.93	0.00e+00	1011.00
IUUC-Dse-031277	Dothistroma septosporum	43.83	6.00e-54	204.00
IUUC-Dme-031895	Drosophila melanogaster	49.17	3.00e-144	505.00
IUUC-Ete-032942	Echinops telfairi	94.81	0.00e+00	1019.00
IUUC-Eca-034355	Equus caballus	98.78	0.00e+00	1149.00
IUUC-Eeu-035313	Erinaceus europaeus	98.74	8.00e-176	610.00
IUUC-Fca-035799	Felis catus	99.30	0.00e+00	1147.00
IUUC-Fal-037373	Ficedula albicollis	93.19	0.00e+00	1074.00
IUUC-Fox-037722	Fusarium oxysporum	34.46	5.00e-78	285.00
IUUC-Fso-038295	Fusarium solani	33.52	5.00e-72	265.00
IUUC-Gmo-039241	Gadus morhua	79.45	0.00e+00	931.00
IUUC-Ggr-039994	Gaeumannomyces graminis	41.31	4.00e-74	273.00
IUUC-Gga-040280	Gallus gallus	92.35	0.00e+00	1069.00
IUUC-Gac-042265	Gasterosteus aculeatus	80.17	0.00e+00	949.00
IUUC-Gma-043161	Glycine max	45.67	7.00e-116	411.00
IUUC-Ggo-044898	Gorilla gorilla	92.25	0.00e+00	1058.00
IUUC-Hvu-047296	Hordeum vulgare	51.40	1.00e-103	370.00
IUUC-Itr-048205	Ictidomys tridecemlineatus	99.31	0.00e+00	1158.00
IUUC-Kpa-049344	Komagataella pastoris	38.51	3.00e-72	266.00
IUUC-Lch-049878	Latimeria chalumnae	85.10	0.00e+00	973.00
IUUC-Lpe-050917	Leersia perrieri	52.13	3.00e-118	419.00
IUUC-Loc-052893	Lepisosteus oculatus	59.07	5.00e-179	620.00
IUUC-Lma-053031	Leptosphaeria maculans	37.07	3.00e-87	316.00
IUUC-Laf-053888	Loxodonta africana	98.95	0.00e+00	1150.00
IUUC-Mcc-055617	Macaca mulatta	94.64	0.00e+00	1088.00
IUUC-Meu-056377	Macropus eugenii	91.81	0.00e+00	1055.00
IUUC-Mor-057030	Magnaporthe oryzae	36.06	5.00e-79	288.00
IUUC-Mpo-057558	Magnaporthe poae	40.88	2.00e-74	273.00
IUUC-Mtr-058778	Medicago truncatula	46.17	2.00e-116	412.00
IUUC-Mla-058861	Melampsora laricipopulina	36.61	5.00e-72	265.00
IUUC-Mga-059809	Meleagris gallopavo	90.88	0.00e+00	1041.00
IUUC-Mvi-060381	Microbotryum violaceum	37.88	8.00e-80	291.00
IUUC-Mmr-060669	Microcebus murinus	94.29	0.00e+00	1082.00
IUUC-Mdo-062293	Monodelphis domestica	95.82	0.00e+00	1108.00
IUUC-Mmu-064261	Mus musculus	97.73	0.00e+00	1134.00
IUUC-Mac-065082	Musa acuminata	51.06	6.00e-119	421.00
IUUC-Mpu-066465	Mustela putorius furo	86.55	0.00e+00	976.00
IUUC-Mlu-067770	Myotis lucifugus	98.10	0.00e+00	1187.00
IUUC-Nfi-068311	Neosartorya fischeri	40.89	3.00e-86	313.00
IUUC-Ncr-068653	Neurospora crassa	37.26	1.00e-80	294.00
IUUC-Nle-069036	Nomascus leucogenys	99.65	0.00e+00	1165.00
IUUC-Opr-070229	Ochotona princeps	96.97	0.00e+00	810.00
IUUC-Ont-072218	Oreochromis niloticus	80.42	0.00e+00	968.00
IUUC-Oan-073467	Ornithorhynchus anatinus	86.15	2.00e-30	124.00
IUUC-Ocu-073869	Oryctolagus cuniculus	98.96	0.00e+00	1159.00
IUUC-Oba-075863	Oryza barthii	50.71	2.00e-115	409.00
IUUC-Obr-076071	Oryza brachyantha	51.42	3.00e-116	412.00
IUUC-Ogl-077026	Oryza glaberrima	50.90	2.00e-108	386.00
IUUC-Ogu-078601	Oryza glumaepatula	45.42	1.00e-115	410.00
IUUC-Oin-079443	Oryza indica	50.71	4.00e-115	408.00
IUUC-Olo-080836	Oryza longistaminata	51.23	1.00e-112	400.00
IUUC-Ome-081640	Oryza meridionalis	46.09	2.00e-113	403.00
IUUC-Oni-083014	Oryza nivara	50.71	3.00e-115	409.00
IUUC-Opu-083788	Oryza punctata	50.95	2.00e-115	409.00
IUUC-Oru-085205	Oryza rufipogon	50.35	4.00e-115	409.00
IUUC-Osa-085809	Oryza sativa	50.71	2.00e-115	409.00
IUUC-Ola-087272	Oryzias latipes	78.86	0.00e+00	929.00
IUUC-Olu-087775	Ostreococcus lucimarinus	42.63	6.00e-102	364.00
IUUC-Oga-088234	Otolemur garnettii	99.30	0.00e+00	1155.00
IUUC-Oar-089533	Ovis aries	99.13	0.00e+00	1185.00
IUUC-Ptr-090956	Pan troglodytes	100.00	0.00e+00	1166.00
IUUC-Pan-091781	Papio anubis	99.65	0.00e+00	1162.00
IUUC-Psi-093533	Pelodiscus sinensis	92.50	0.00e+00	1104.00
IUUC-Pma-094153	Petromyzon marinus	71.28	0.00e+00	830.00
IUUC-Pno-095099	Phaeosphaeria nodorum	36.45	8.00e-77	281.00
IUUC-Ppa-095917	Physcomitrella patens	49.36	2.00e-123	436.00
IUUC-Pfo-096378	Poecilia formosa	80.07	0.00e+00	963.00
IUUC-Pab-098457	Pongo abelii	99.83	0.00e+00	1202.00
IUUC-Pop-099359	Populus trichocarpa	46.48	4.00e-114	405.00
IUUC-Pca-100406	Procavia capensis	98.84	7.00e-156	544.00
IUUC-Ppe-101636	Prunus persica	45.61	6.00e-116	411.00
IUUC-Pva-103102	Pteropus vampyrus	97.65	0.00e+00	1158.00
IUUC-Pgr-103324	Puccinia graminis	36.54	2.00e-83	303.00
IUUC-Ptt-103755	Puccinia triticina	39.49	4.00e-79	289.00
IUUC-Pte-104290	Pyrenophora teres	37.57	4.00e-89	322.00
IUUC-Pyt-104739	Pyrenophora triticirepentis	37.25	5.00e-89	322.00
IUUC-Rno-105205	Rattus norvegicus	97.98	0.00e+00	1080.00
IUUC-Sce-106199	Saccharomyces cerevisiae	34.83	3.00e-59	223.00
IUUC-Sha-107218	Sarcophilus harrisii	95.47	0.00e+00	1105.00
IUUC-Sja-107667	Schizosaccharomyces japonicus	38.86	6.00e-98	351.00
IUUC-Spo-108380	Schizosaccharomyces pombe	42.09	2.00e-98	353.00
IUUC-Smo-109350	Selaginella moellendorffii	48.73	3.00e-118	418.00
IUUC-Sit-110418	Setaria italica	45.80	3.00e-119	422.00
IUUC-Sly-111724	Solanum lycopersicum	46.80	1.00e-115	410.00
IUUC-Stu-112247	Solanum tuberosum	49.50	1.00e-105	377.00
IUUC-Sar-113502	Sorex araneus	86.51	0.00e+00	984.00
IUUC-Sbi-113784	Sorghum bicolor	45.89	2.00e-120	426.00
IUUC-Sre-115116	Sporisorium reilianum	33.41	2.00e-57	217.00
IUUC-Ssc-115914	Sus scrofa	98.96	0.00e+00	1188.00
IUUC-Tgu-117390	Taeniopygia guttata	93.02	0.00e+00	1070.00
IUUC-Tru-118703	Takifugu rubripes	79.90	0.00e+00	946.00
IUUC-Tsy-118972	Tarsius syrichta	96.09	0.00e+00	769.00
IUUC-Tni-119710	Tetraodon nigroviridis	79.38	0.00e+00	936.00
IUUC-Tca-121327	Theobroma cacao	47.62	1.00e-115	410.00
IUUC-Tre-121974	Trichoderma reesei	37.10	1.00e-72	267.00
IUUC-Tvi-122260	Trichoderma virens	36.86	4.00e-72	266.00
IUUC-Tae-124866	Triticum aestivum	48.08	8.00e-69	254.00
IUUC-Tme-127161	Tuber melanosporum	37.94	9.00e-101	360.00
IUUC-Tbe-127932	Tupaia belangeri	98.68	0.00e+00	891.00
IUUC-Ttr-129091	Tursiops truncatus	98.95	0.00e+00	1185.00
IUUC-Uma-129376	Ustilago maydis	34.46	3.00e-58	220.00
IUUC-Vda-129821	Verticillium dahliae	32.93	1.00e-76	280.00
IUUC-Vpa-130644	Vicugna pacos	99.13	0.00e+00	1187.00
IUUC-Vvi-130971	Vitis vinifera	46.48	2.00e-115	409.00
IUUC-Xtr-132050	Xenopus tropicalis	90.24	0.00e+00	1057.00
IUUC-Xma-133078	Xiphophorus maculatus	79.90	0.00e+00	943.00
IUUC-Yli-134413	Yarrowia lipolytica	38.56	6.00e-85	308.00
IUUC-Zma-135224	Zea mays	45.60	2.00e-119	422.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence