iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000099364.16	ENST00000565690.5	ENSP00000454344.1
ENSG00000099364.16	ENST00000427128.5	ENSP00000397913.1
ENSG00000099364.16	ENST00000566320.2	ENSP00000455337.2
ENSG00000099364.16	ENST00000565939.1	ENSP00000457199.1
ENSG00000099364.16	ENST00000380310.6	ENSP00000369666.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	22660580; 23871831

Classification

Family	E-value	Score	Start	End
E3 activity/RING/PHD	4.20e-12	47.7	86	150

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggede......k....slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrs 53
           +vCl+Cge+g+++      +    sl+eC++C+e++Hp+Clk+      ++ e pn+  w+Cp+C++
   Q: 86   AVCLLCGEAGKEDtvegeeEkfglSLMECTICNEIVHPGCLKMGkaegvINAEIPNC--WECPRCTQ 150
           79**********977766516889*******************99************..******97 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Protein Sequence
(Fasta)

MGMKVPGKGE SGPSALLTPP MSSSSRGPGA GARRRRTRCR RCRACVRTEC GDCHFCRDMK 60
KFGGPGRMKQ SCLLRQCTAP VLPHTAVCLL CGEAGKEDTV EGEEEKFGLS LMECTICNEI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCTTGCTTG TAGTCCTCTT TCCTTTTCAC CTTTCCATTG TTCCTGACGA GTAGAAATGG 60
CAGCGGGAAG GCAGCAGATG GACTGCGACT CCCGTCAGGT ACCACACACG CGGAGGGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0433--Leucine-rich repeat
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR019786--Zinc_finger_PHD-type_CS
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51058--ZF_CXXC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00646--F-box
PF16866--PHD_4
PF02008--zf-CXXC

SMART

SM00256--FBOX
SM00367--LRR_CC
SM00249--PHD

Gene Ontology

GO:0005829--C:cytosol
GO:0019005--C:SCF ubiquitin ligase complex
GO:0003677--F:DNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

KEGG

hsa:54620

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001680	Ailuropoda melanoleuca	97.99	0.00e+00	917.00
IUUC-Aca-004456	Anolis carolinensis	62.52	0.00e+00	702.00
IUUC-Ame-010726	Astyanax mexicanus	60.00	1.00e-96	348.00
IUUC-Bta-012874	Bos taurus	99.28	0.00e+00	991.00
IUUC-Cja-019918	Callithrix jacchus	98.85	0.00e+00	995.00
IUUC-Cfa-020078	Canis familiaris	99.28	0.00e+00	981.00
IUUC-Cpo-021482	Cavia porcellus	99.54	0.00e+00	972.00
IUUC-Csa-023072	Chlorocebus sabaeus	99.85	0.00e+00	985.00
IUUC-Dno-029532	Dasypus novemcinctus	90.84	0.00e+00	848.00
IUUC-Dor-030932	Dipodomys ordii	98.92	0.00e+00	964.00
IUUC-Eca-033707	Equus caballus	99.69	0.00e+00	979.00
IUUC-Eeu-034841	Erinaceus europaeus	97.47	4.00e-153	534.00
IUUC-Fca-036214	Felis catus	98.70	0.00e+00	980.00
IUUC-Gmo-039631	Gadus morhua	62.18	5.00e-83	301.00
IUUC-Ggo-045362	Gorilla gorilla	99.83	0.00e+00	909.00
IUUC-Itr-048488	Ictidomys tridecemlineatus	99.85	0.00e+00	971.00
IUUC-Lch-049586	Latimeria chalumnae	60.71	1.00e-113	404.00
IUUC-Laf-053994	Loxodonta africana	99.42	0.00e+00	766.00
IUUC-Mcc-054810	Macaca mulatta	100.00	0.00e+00	971.00
IUUC-Meu-056447	Macropus eugenii	99.09	6.00e-145	508.00
IUUC-Mvi-060552	Microbotryum violaceum	29.17	1.00e-03	39.70
IUUC-Mmr-060961	Microcebus murinus	99.14	0.00e+00	996.00
IUUC-Mmu-063602	Mus musculus	97.37	0.00e+00	1004.00
IUUC-Mpu-066470	Mustela putorius furo	99.54	0.00e+00	965.00
IUUC-Mlu-068033	Myotis lucifugus	97.57	0.00e+00	843.00
IUUC-Nle-069352	Nomascus leucogenys	99.57	0.00e+00	981.00
IUUC-Opr-070370	Ochotona princeps	98.98	0.00e+00	899.00
IUUC-Ont-071246	Oreochromis niloticus	61.82	2.00e-92	334.00
IUUC-Ocu-074480	Oryctolagus cuniculus	97.98	0.00e+00	966.00
IUUC-Oba-075194	Oryza barthii	46.43	1.70e-02	32.70
IUUC-Oga-088335	Otolemur garnettii	99.14	0.00e+00	982.00
IUUC-Oar-090135	Ovis aries	82.82	0.00e+00	812.00
IUUC-Ptr-091271	Pan troglodytes	98.82	4.00e-179	620.00
IUUC-Pan-092365	Papio anubis	99.28	0.00e+00	1000.00
IUUC-Pab-097786	Pongo abelii	93.03	0.00e+00	858.00
IUUC-Pca-100857	Procavia capensis	98.77	6.00e-166	577.00
IUUC-Pva-102613	Pteropus vampyrus	99.38	0.00e+00	981.00
IUUC-Rno-106113	Rattus norvegicus	97.83	0.00e+00	1001.00
IUUC-Sha-106914	Sarcophilus harrisii	87.84	0.00e+00	825.00
IUUC-Ssc-115503	Sus scrofa	98.85	0.00e+00	961.00
IUUC-Tru-118079	Takifugu rubripes	64.36	3.00e-92	332.00
IUUC-Tni-120597	Tetraodon nigroviridis	63.64	5.00e-89	322.00
IUUC-Tur-126327	Triticum urartu	35.06	4.00e-04	39.70
IUUC-Tbe-127536	Tupaia belangeri	91.19	0.00e+00	855.00
IUUC-Ttr-128198	Tursiops truncatus	100.00	0.00e+00	949.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence