iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046263

UUCD1 version

UUC-HoS-00408

Ensembl Protein ID

ENSP00000471536.1

UniProt Accession

Q9P0N8; A6NP10; Q5H785; Q8N5A3; Q96B78; MARH2_HUMAN

Genbank Protein ID

BAD89359.1; AAF36160.1; AAH32624.1; AAH15910.1; AAI11389.1

Protein Name

E3 ubiquitin-protein ligase MARCH2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING finger protein 172; RING-type E3 ubiquitin transferase MARCH2

Genbank Nucleotide ID

AB197929; AF151074; AC136469; BC015910; BC111388

Gene Name

MARCH2; RNF172; HSPC240

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000099785.10	ENST00000381035.8	ENSP00000370423.3
ENSG00000099785.10	ENST00000601283.5	ENSP00000469386.1
ENSG00000099785.10	ENST00000602117.1	ENSP00000471536.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17980554

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.0028	19.8	64	109

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHv.....fhadClqkwpglknssskefrCPlC 45
           C iC+e    + l+ pCg +      h++Cl+kw     sss++ +C lC
   Q: 64   CRICHEGANGECLLSPCGCTgtlgaVHKSCLEKW----LSSSNTSYCELC 109
           ******99888999****98999*99********....88********** PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.

Protein Sequence
(Fasta)

MTTGDCCHLP GSLCDCSGSP AFSKVVEATG LGPPQYVAQV TSRDGRLLST VIRALDTPSD 60
GPFCRICHEG ANGECLLSPC GCTGTLGAVH KSCLEKWLSS SNTSYCELCH TEFAVEKRPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTCCGCGGC GCTGTCGGCT CGGCGGGCGG TGCCCGGACG CAGGTGCCGG CCGGAGCGGA 60
GCTAGTGGCG CCGACGGGCC GGGCCGGGCC GGGACCGGGG CCGAGGCGAA CCGAGGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0254--Endocytosis
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0010008--C:endosome membrane
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0016567--P:protein ubiquitination

KEGG

hsa:51257

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002189	Ailuropoda melanoleuca	95.53	3.00e-132	464.00
IUUC-Apl-004200	Anas platyrhynchos	82.01	1.00e-113	402.00
IUUC-Ame-010786	Astyanax mexicanus	78.86	2.00e-107	381.00
IUUC-Bta-012678	Bos taurus	93.09	1.00e-133	468.00
IUUC-Cja-019315	Callithrix jacchus	97.34	4.00e-107	380.00
IUUC-Cfa-020820	Canis familiaris	94.76	1.00e-136	478.00
IUUC-Cpo-021511	Cavia porcellus	94.31	2.00e-136	478.00
IUUC-Dre-028107	Danio rerio	77.11	4.00e-104	370.00
IUUC-Dno-029379	Dasypus novemcinctus	93.09	9.00e-124	436.00
IUUC-Dor-031059	Dipodomys ordii	93.50	3.00e-135	474.00
IUUC-Eca-034013	Equus caballus	90.65	1.00e-123	435.00
IUUC-Eeu-035139	Erinaceus europaeus	91.94	5.00e-63	232.00
IUUC-Fca-035894	Felis catus	95.53	2.00e-137	481.00
IUUC-Fal-037434	Ficedula albicollis	78.86	1.00e-104	372.00
IUUC-Gmo-039276	Gadus morhua	74.90	8.00e-104	369.00
IUUC-Gga-041224	Gallus gallus	80.49	7.00e-113	399.00
IUUC-Gac-042104	Gasterosteus aculeatus	73.39	2.00e-105	375.00
IUUC-Ggo-045297	Gorilla gorilla	100.00	3.00e-113	400.00
IUUC-Hvu-047389	Hordeum vulgare	25.41	6.00e-10	57.80
IUUC-Itr-048963	Ictidomys tridecemlineatus	94.72	3.00e-136	477.00
IUUC-Lch-050103	Latimeria chalumnae	79.67	3.00e-109	387.00
IUUC-Lpe-051137	Leersia perrieri	24.75	6.00e-11	61.20
IUUC-Loc-052480	Lepisosteus oculatus	70.73	2.00e-101	362.00
IUUC-Laf-054410	Loxodonta africana	94.31	5.00e-137	479.00
IUUC-Mcc-054712	Macaca mulatta	99.59	1.00e-143	501.00
IUUC-Mga-060053	Meleagris gallopavo	80.08	3.00e-115	407.00
IUUC-Mdo-062010	Monodelphis domestica	80.89	7.00e-118	416.00
IUUC-Mmu-064040	Mus musculus	92.28	9.00e-133	466.00
IUUC-Mpu-066205	Mustela putorius furo	95.12	3.00e-137	480.00
IUUC-Mlu-067013	Myotis lucifugus	89.96	2.00e-127	448.00
IUUC-Opr-070698	Ochotona princeps	70.73	2.00e-86	311.00
IUUC-Ont-071768	Oreochromis niloticus	75.00	5.00e-106	377.00
IUUC-Oan-073269	Ornithorhynchus anatinus	63.71	1.00e-85	308.00
IUUC-Ocu-074212	Oryctolagus cuniculus	94.31	6.00e-136	476.00
IUUC-Ogl-077311	Oryza glaberrima	27.64	1.00e-09	56.60
IUUC-Osa-085741	Oryza sativa	27.64	1.00e-09	56.60
IUUC-Ola-087137	Oryzias latipes	72.29	3.00e-93	334.00
IUUC-Oga-088712	Otolemur garnettii	95.53	7.00e-138	482.00
IUUC-Oar-090175	Ovis aries	93.09	8.00e-132	462.00
IUUC-Ptr-091210	Pan troglodytes	71.95	1.00e-89	321.00
IUUC-Pan-092276	Papio anubis	99.19	7.00e-143	499.00
IUUC-Psi-094007	Pelodiscus sinensis	80.49	7.00e-116	409.00
IUUC-Pfo-097509	Poecilia formosa	78.03	3.00e-100	357.00
IUUC-Pca-100424	Procavia capensis	92.28	4.00e-133	467.00
IUUC-Pva-102806	Pteropus vampyrus	94.31	6.00e-137	479.00
IUUC-Rno-105029	Rattus norvegicus	95.53	1.00e-136	478.00
IUUC-Sha-106628	Sarcophilus harrisii	80.89	1.00e-117	415.00
IUUC-Ssc-115689	Sus scrofa	95.93	2.00e-138	484.00
IUUC-Tgu-116681	Taeniopygia guttata	79.27	2.00e-114	404.00
IUUC-Tru-118517	Takifugu rubripes	71.77	2.00e-96	345.00
IUUC-Tni-120353	Tetraodon nigroviridis	68.67	8.00e-97	346.00
IUUC-Ttr-128265	Tursiops truncatus	95.93	3.00e-138	484.00
IUUC-Xtr-132814	Xenopus tropicalis	78.46	7.00e-110	389.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence