iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046245

UUCD1 version

UUC-HoS-01181

Ensembl Protein ID

ENSP00000215574.2

UniProt Accession

P49427; A8K689; UB2R1_HUMAN

Genbank Protein ID

AAC37534.1; AAP35305.1; AAT46688.1; BAF84243.1; EAW61190.1; AAH09850.1; AAH18143.1; AAH23979.1

Protein Name

Ubiquitin-conjugating enzyme E2 R1; (E3-independent) E2 ubiquitin-conjugating enzyme R1; E2 ubiquitin-conjugating enzyme R1; Ubiquitin-conjugating enzyme E2-32 kDa complementing; Ubiquitin-conjugating enzyme E2-CDC34; Ubiquitin-protein ligase R1

Genbank Nucleotide ID

L22005; BT006659; AY650399; AK291554; CH471242; BC009850; BC018143; BC023979

Gene Name

CDC34; UBCH3; UBE2R1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000099804.8	ENST00000215574.8	ENSP00000215574.2
ENSG00000099804.8	ENST00000586283.6	ENSP00000475282.3
ENSG00000099804.8	ENST00000607527.5	ENSP00000476107.2
ENSG00000099804.8	ENST00000606065.3	ENSP00000475610.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
miRecords	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
Manually
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	18704118; 19118899; 17978571; 18463149; 18056378; 17341663; 16332694; 14707120; 15660529

Classification

Family	E-value	Score	Start	End
E2/UBC	1.30e-47	162.7	15	153

Active Site

Position(s)	Description	Evidence
93	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 4    kelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk........ 87
            elk l+++p+eg+++++vde dl++wev+i+Gp++t+Yegg+Fk++++fp dYP++PP ++fltk++hPn+ye+G+vC+sil+        
   Q: 15   LELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHppvddpqs 106
           599********************************************************************************999999999 PP
   S: 88   ...eeekWspalsvesvllsiqsllaepnpesplneeaaellkknre 131
              ++e+W+p+++v+++lls++sll+epn+ sp+n++a+ +++k++e
   Q: 107  gelPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKE 153
           *9******************************************998 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooperates with the SCF(SKP2) E3 ligase complex to regulate cell proliferation through ubiquitination and degradation of MYBL2 and KIP1. Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. Involved in the regulation of the cell cycle G2/M phase through its targeting of the WEE1 kinase for ubiquitination and degradation. Also involved in the degradation of beta-catenin. Is target of human herpes virus 1 protein ICP0, leading to ICP0-dependent dynamic interaction with proteasomes.

Protein Sequence
(Fasta)

MARPLVPSSQ KALLLELKGL QEEPVEGFRV TLVDEGDLYN WEVAIFGPPN TYYEGGYFKA 60
RLKFPIDYPY SPPAFRFLTK MWHPNIYETG DVCISILHPP VDDPQSGELP SERWNPTQNV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCGCGCG GGCCCGGCCA AGGCAAGCGC CGGTGGGGCG GCGGCGCCAG AGCTGCTGGA 60
GCGCTCGGGG TCCCCGGGCG GCGGCGGCGG CGCAGAGGAG GAGGCAGGCG GCGGCCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0035458--P:cellular response to interferon-beta
GO:0006270--P:DNA replication initiation
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0043951--P:negative regulation of cAMP-mediated signaling
GO:0090261--P:positive regulation of inclusion body assembly
GO:0043525--P:positive regulation of neuron apoptotic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0070848--P:response to growth factor

KEGG

hsa:997

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001600	Ailuropoda melanoleuca	99.11	2.00e-130	458.00
IUUC-Ame-011425	Astyanax mexicanus	89.55	1.00e-108	385.00
IUUC-Bta-012516	Bos taurus	99.51	2.00e-120	424.00
IUUC-Cja-018852	Callithrix jacchus	89.91	4.00e-104	370.00
IUUC-Cfa-020203	Canis familiaris	99.11	3.00e-121	427.00
IUUC-Cpo-022139	Cavia porcellus	91.23	1.00e-120	425.00
IUUC-Csa-023371	Chlorocebus sabaeus	99.11	1.00e-122	432.00
IUUC-Dre-028367	Danio rerio	89.05	4.00e-108	384.00
IUUC-Dor-030875	Dipodomys ordii	100.00	2.00e-123	434.00
IUUC-Fca-035832	Felis catus	98.19	8.00e-95	338.00
IUUC-Gmo-039414	Gadus morhua	90.05	2.00e-109	388.00
IUUC-Gga-040694	Gallus gallus	96.19	5.00e-123	433.00
IUUC-Gac-042485	Gasterosteus aculeatus	88.56	5.00e-109	386.00
IUUC-Ggo-044806	Gorilla gorilla	100.00	6.00e-123	432.00
IUUC-Loc-052932	Lepisosteus oculatus	91.54	4.00e-111	393.00
IUUC-Mcc-054665	Macaca mulatta	95.54	1.00e-115	408.00
IUUC-Mga-060075	Meleagris gallopavo	95.76	1.00e-122	431.00
IUUC-Mmr-061165	Microcebus murinus	95.98	2.00e-121	428.00
IUUC-Mdo-061825	Monodelphis domestica	98.21	2.00e-120	424.00
IUUC-Mmu-064168	Mus musculus	100.00	1.00e-120	425.00
IUUC-Mpu-066009	Mustela putorius furo	99.11	3.00e-130	457.00
IUUC-Opr-070826	Ochotona princeps	93.49	2.00e-109	387.00
IUUC-Ont-071745	Oreochromis niloticus	90.15	1.00e-110	392.00
IUUC-Oan-073287	Ornithorhynchus anatinus	91.53	4.00e-118	417.00
IUUC-Ocu-074902	Oryctolagus cuniculus	95.63	2.00e-116	411.00
IUUC-Oga-088845	Otolemur garnettii	97.32	3.00e-126	444.00
IUUC-Ptr-090916	Pan troglodytes	99.03	1.00e-117	415.00
IUUC-Pan-092577	Papio anubis	99.11	1.00e-122	432.00
IUUC-Psi-093039	Pelodiscus sinensis	94.38	3.00e-88	317.00
IUUC-Pfo-096435	Poecilia formosa	89.55	1.00e-109	389.00
IUUC-Pab-098200	Pongo abelii	100.00	2.00e-111	394.00
IUUC-Pca-100169	Procavia capensis	86.43	6.00e-66	243.00
IUUC-Pva-102875	Pteropus vampyrus	98.79	2.00e-85	308.00
IUUC-Rno-106079	Rattus norvegicus	100.00	1.00e-120	425.00
IUUC-Ssc-115699	Sus scrofa	89.30	2.00e-88	317.00
IUUC-Tgu-117466	Taeniopygia guttata	94.07	7.00e-121	426.00
IUUC-Tni-120864	Tetraodon nigroviridis	86.07	2.00e-105	374.00
IUUC-Xtr-132285	Xenopus tropicalis	89.50	4.00e-117	413.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence