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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045984
UUCD1 version UUC-HoS-00139
Ensembl Protein ID ENSP00000331682.4
UniProt Accession Q53GT1; A8K3Q4; A8MTV3; B7Z2G1; D3DX30; Q96B68; Q96KC6; KLH22_HUMAN
Genbank Protein ID CAG30238.1; BAB55007.1; BAF83358.1; BAH11847.1; BAD96570.1; EAX02961.1; EAX02962.1; EAX02963.1; AAH15923.1
Protein Name Kelch-like protein 22
Genbank Nucleotide ID CR456352; AK027266; AK290669; AK294682; AK222850; AC007731; CH471176; CH471176; BC015923
Gene Name KLHL22
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000099910.16 ENST00000328879.8 ENSP00000331682.4
ENSG00000099910.16 ENST00000444967.5 ENSP00000403999.1
ENSG00000099910.16 ENST00000443285.5 ENSP00000397882.1
ENSG00000099910.16 ENST00000431430.1 ENSP00000409092.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 19995937
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 7.60e-19 69.5 51 115
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.00e-07 31.2 150 179
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           Dv+lvv+g++++ah+i Laas+++F+ +f ++l+e++ +++v i++v++ ++ ++l+F+Yt++l++
   Q: 51   DVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEME-QEEVLIHGVSYNAMCQILHFIYTSELEL 115
           9***********************************8.*************************986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhF 31
           eN l+++r+A+l+d+++L ++ +++ilk+F
   Q: 150  ENILDVYRLAELFDLSRLTEQLDTYILKNF 179
           8***************************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.
Protein Sequence
(Fasta)
MAEEQEFTQL CKLPAQPSHP HCVNNTYRSA QHSQALLRGL LALRDSGILF DVVLVVEGRH 60
IEAHRILLAA SCDYFRGMFA GGLKEMEQEE VLIHGVSYNA MCQILHFIYT SELELSLSNV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045984|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACGTGACGGC CCAGGCCCCC GCCCCGCCGG CTCCTCTCGC CCAGCCTCCC GCCTCGCGCC 60
TCCCGCCTCC CGCCTCCCGC CTCCCTCCAG CTGCGAGTGC GGCCTCGGCT GGCGGCGGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045984|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030575--KLHL22
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0005813--C:centrosome
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0072686--C:mitotic spindle
GO:0005827--C:polar microtubule
GO:0051301--P:cell division
GO:0000070--P:mitotic sister chromatid segregation
GO:0007094--P:mitotic spindle assembly checkpoint
GO:0006513--P:protein monoubiquitination
KEGG hsa:84861
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002097 Ailuropoda melanoleuca 97.95 0.00e+00 1239.00
IUUC-Apl-004081 Anas platyrhynchos 78.21 0.00e+00 1031.00
IUUC-Aca-005015 Anolis carolinensis 66.29 0.00e+00 852.00
IUUC-Ame-011712 Astyanax mexicanus 60.24 0.00e+00 721.00
IUUC-Bta-012594 Bos taurus 94.16 0.00e+00 1227.00
IUUC-Cja-019752 Callithrix jacchus 99.01 0.00e+00 1049.00
IUUC-Cfa-020884 Canis familiaris 98.42 0.00e+00 1304.00
IUUC-Cpo-021711 Cavia porcellus 97.32 0.00e+00 1270.00
IUUC-Csa-023211 Chlorocebus sabaeus 99.84 0.00e+00 1318.00
IUUC-Dre-028395 Danio rerio 60.06 0.00e+00 753.00
IUUC-Dno-030096 Dasypus novemcinctus 94.20 0.00e+00 1227.00
IUUC-Dor-030709 Dipodomys ordii 95.95 0.00e+00 708.00
IUUC-Eca-033388 Equus caballus 98.26 0.00e+00 1300.00
IUUC-Eeu-034616 Erinaceus europaeus 86.44 0.00e+00 1108.00
IUUC-Fca-035815 Felis catus 98.26 0.00e+00 1301.00
IUUC-Fal-037311 Ficedula albicollis 80.49 0.00e+00 1011.00
IUUC-Gmo-039571 Gadus morhua 52.43 6.00e-158 550.00
IUUC-Gga-040992 Gallus gallus 78.06 0.00e+00 1030.00
IUUC-Gac-042041 Gasterosteus aculeatus 55.17 0.00e+00 681.00
IUUC-Ggo-045141 Gorilla gorilla 94.16 0.00e+00 1220.00
IUUC-Itr-048890 Ictidomys tridecemlineatus 98.42 0.00e+00 1306.00
IUUC-Lch-049700 Latimeria chalumnae 60.50 0.00e+00 728.00
IUUC-Loc-052141 Lepisosteus oculatus 61.36 0.00e+00 807.00
IUUC-Laf-053487 Loxodonta africana 95.71 0.00e+00 1233.00
IUUC-Mcc-054682 Macaca mulatta 99.61 0.00e+00 1040.00
IUUC-Meu-055937 Macropus eugenii 74.76 0.00e+00 969.00
IUUC-Mga-059953 Meleagris gallopavo 78.06 0.00e+00 1030.00
IUUC-Mmr-061743 Microcebus murinus 97.95 0.00e+00 1270.00
IUUC-Mdo-062328 Monodelphis domestica 83.07 0.00e+00 1091.00
IUUC-Mmu-063979 Mus musculus 94.58 0.00e+00 1219.00
IUUC-Mpu-066750 Mustela putorius furo 98.26 0.00e+00 1299.00
IUUC-Mlu-066960 Myotis lucifugus 96.06 0.00e+00 1243.00
IUUC-Nle-069690 Nomascus leucogenys 100.00 0.00e+00 1162.00
IUUC-Opr-071059 Ochotona princeps 90.24 0.00e+00 1153.00
IUUC-Ont-072004 Oreochromis niloticus 57.97 0.00e+00 682.00
IUUC-Oan-073172 Ornithorhynchus anatinus 63.41 0.00e+00 741.00
IUUC-Ocu-074310 Oryctolagus cuniculus 96.59 8.00e-156 542.00
IUUC-Ola-086599 Oryzias latipes 57.54 0.00e+00 698.00
IUUC-Oga-087980 Otolemur garnettii 97.32 0.00e+00 1261.00
IUUC-Oar-089956 Ovis aries 79.15 0.00e+00 920.00
IUUC-Ptr-090598 Pan troglodytes 99.82 0.00e+00 1165.00
IUUC-Pan-092387 Papio anubis 99.22 0.00e+00 1039.00
IUUC-Psi-093484 Pelodiscus sinensis 79.15 0.00e+00 1057.00
IUUC-Pma-094224 Petromyzon marinus 49.59 2.00e-171 595.00
IUUC-Pfo-096149 Poecilia formosa 57.63 0.00e+00 709.00
IUUC-Pab-098097 Pongo abelii 99.84 0.00e+00 1319.00
IUUC-Pca-100118 Procavia capensis 95.41 0.00e+00 701.00
IUUC-Pva-103174 Pteropus vampyrus 96.58 1.00e-156 546.00
IUUC-Rno-105350 Rattus norvegicus 94.97 0.00e+00 1205.00
IUUC-Sha-106817 Sarcophilus harrisii 83.15 2.00e-134 473.00
IUUC-Sar-113490 Sorex araneus 96.21 0.00e+00 650.00
IUUC-Ssc-115827 Sus scrofa 96.21 0.00e+00 1256.00
IUUC-Tgu-116748 Taeniopygia guttata 82.89 0.00e+00 906.00
IUUC-Tru-118644 Takifugu rubripes 58.01 0.00e+00 693.00
IUUC-Tsy-118888 Tarsius syrichta 92.29 0.00e+00 1056.00
IUUC-Tni-120060 Tetraodon nigroviridis 54.45 9.00e-175 606.00
IUUC-Ttr-129183 Tursiops truncatus 95.88 0.00e+00 1120.00
IUUC-Xtr-132780 Xenopus tropicalis 68.37 0.00e+00 899.00
Created Date 25-Jun-2017

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