iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000099949.18	ENST00000215739.12	ENSP00000215739.8
ENSG00000099949.18	ENST00000414985.5	ENSP00000397247.1
ENSG00000099949.18	ENST00000443265.5	ENSP00000406466.1
ENSG00000099949.18	ENST00000415354.6	ENSP00000393765.2
ENSG00000099949.18	ENST00000439171.5	ENSP00000390836.1
ENSG00000099949.18	ENST00000452988.5	ENSP00000408789.1
ENSG00000099949.18	ENST00000415817.1	ENSP00000397252.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.10e-20	75.4	667	735

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd..vqpevfrallkFlYtgklden 68
           +D++l ++g   +ahk++Laa+Ss+F+a+f + ++e   +  + i +   + ++f+ +l+++Y g+++++
   Q: 667  CDITLLLDGHPRPAHKAILAARSSYFEAMFRSFMPEDG-QVNISIGEmvPSRQAFESMLRYIYYGEVNMP 735
           8**********************************987.7888888888999**************9876 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAGPGSTGGQ IGAAALAGGA RSKVAPSVDF DHSCSDSVEY LTLNFGPFET VHRWRRLPPC 60
DEFVGARRSK HTVVAYKDAI YVFGGDNGKT MLNDLLRFDV KDCSWCRAFT TGTPPAPRYH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCGCAC TAGGAAGAGG CCGGTAAGAA CTCGCTGGCG GCAAGGCTAC GAACTACCTA 60
AAAGGACGTA TGGAGCAGGG CCTGGGCGGG GTTAGGAGGG GATCCTGTGA CGTCTCGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011498--Kelch_2
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF00651--BTB
PF01344--Kelch_1
PF07646--Kelch_2

SMART

SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0009653--P:anatomical structure morphogenesis

KEGG

hsa:8216

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001645	Ailuropoda melanoleuca	96.95	0.00e+00	1561.00
IUUC-Apl-003187	Anas platyrhynchos	87.24	0.00e+00	1282.00
IUUC-Aca-005240	Anolis carolinensis	83.78	0.00e+00	1419.00
IUUC-Ame-010863	Astyanax mexicanus	78.05	0.00e+00	1000.00
IUUC-Bgr-012217	Blumeria graminis	29.81	1.00e-15	78.60
IUUC-Bta-012889	Bos taurus	93.79	0.00e+00	1545.00
IUUC-Cfa-020575	Canis familiaris	95.98	0.00e+00	1583.00
IUUC-Cpo-021855	Cavia porcellus	97.44	0.00e+00	1659.00
IUUC-Csa-023483	Chlorocebus sabaeus	97.93	0.00e+00	1664.00
IUUC-Cgl-026387	Colletotrichum gloeosporioides	31.06	9.00e-16	79.00
IUUC-Dre-027795	Danio rerio	82.13	0.00e+00	1387.00
IUUC-Dno-029959	Dasypus novemcinctus	96.59	0.00e+00	1592.00
IUUC-Dor-030779	Dipodomys ordii	93.78	0.00e+00	1578.00
IUUC-Dme-031621	Drosophila melanogaster	52.39	0.00e+00	815.00
IUUC-Ete-032307	Echinops telfairi	92.44	0.00e+00	1513.00
IUUC-Eca-034178	Equus caballus	95.48	0.00e+00	1420.00
IUUC-Eeu-034815	Erinaceus europaeus	91.34	0.00e+00	1498.00
IUUC-Fca-036259	Felis catus	95.76	0.00e+00	1537.00
IUUC-Fal-037201	Ficedula albicollis	84.40	0.00e+00	1404.00
IUUC-Gmo-039641	Gadus morhua	80.02	0.00e+00	1320.00
IUUC-Ggr-039868	Gaeumannomyces graminis	33.10	1.00e-14	75.90
IUUC-Gga-041236	Gallus gallus	78.49	0.00e+00	855.00
IUUC-Gac-042539	Gasterosteus aculeatus	81.74	0.00e+00	1363.00
IUUC-Gma-044305	Glycine max	26.97	3.00e-09	57.00
IUUC-Ggo-044796	Gorilla gorilla	99.17	0.00e+00	1650.00
IUUC-Itr-048271	Ictidomys tridecemlineatus	96.34	0.00e+00	1613.00
IUUC-Lch-049842	Latimeria chalumnae	83.66	0.00e+00	1401.00
IUUC-Loc-052639	Lepisosteus oculatus	84.40	0.00e+00	1425.00
IUUC-Laf-054178	Loxodonta africana	96.47	0.00e+00	1601.00
IUUC-Mcc-055897	Macaca mulatta	93.69	0.00e+00	1566.00
IUUC-Meu-055973	Macropus eugenii	85.40	0.00e+00	1409.00
IUUC-Mga-059441	Meleagris gallopavo	84.43	0.00e+00	1303.00
IUUC-Mmr-061048	Microcebus murinus	95.62	0.00e+00	1588.00
IUUC-Mdo-062170	Monodelphis domestica	83.42	0.00e+00	1360.00
IUUC-Mmu-063890	Mus musculus	96.10	0.00e+00	1595.00
IUUC-Mpu-066468	Mustela putorius furo	97.44	0.00e+00	1612.00
IUUC-Mlu-068212	Myotis lucifugus	96.71	0.00e+00	1579.00
IUUC-Nle-070128	Nomascus leucogenys	97.61	0.00e+00	1654.00
IUUC-Ont-072422	Oreochromis niloticus	83.64	0.00e+00	1407.00
IUUC-Oan-073403	Ornithorhynchus anatinus	88.24	7.00e-59	219.00
IUUC-Ocu-073745	Oryctolagus cuniculus	96.49	0.00e+00	1596.00
IUUC-Osa-085827	Oryza sativa	29.05	6.00e-10	59.30
IUUC-Ola-087296	Oryzias latipes	81.77	0.00e+00	1373.00
IUUC-Oga-088787	Otolemur garnettii	94.40	0.00e+00	1573.00
IUUC-Ptr-090622	Pan troglodytes	99.88	0.00e+00	1671.00
IUUC-Pan-091982	Papio anubis	98.18	0.00e+00	1665.00
IUUC-Psi-093764	Pelodiscus sinensis	86.82	0.00e+00	1334.00
IUUC-Pma-094632	Petromyzon marinus	75.43	0.00e+00	706.00
IUUC-Pfo-096914	Poecilia formosa	81.50	0.00e+00	1365.00
IUUC-Pab-098648	Pongo abelii	96.90	0.00e+00	1635.00
IUUC-Pop-099596	Populus trichocarpa	25.86	2.00e-10	60.80
IUUC-Pca-100970	Procavia capensis	91.83	0.00e+00	1528.00
IUUC-Ppe-101872	Prunus persica	27.17	6.00e-10	59.30
IUUC-Pva-103195	Pteropus vampyrus	97.20	0.00e+00	1598.00
IUUC-Rno-105266	Rattus norvegicus	96.09	0.00e+00	1586.00
IUUC-Ssc-115775	Sus scrofa	95.86	0.00e+00	1570.00
IUUC-Tgu-117360	Taeniopygia guttata	87.80	0.00e+00	1468.00
IUUC-Tru-118151	Takifugu rubripes	84.10	0.00e+00	1396.00
IUUC-Tni-119806	Tetraodon nigroviridis	83.89	0.00e+00	1400.00
IUUC-Tca-120928	Theobroma cacao	26.97	3.00e-09	57.00
IUUC-Tbe-127786	Tupaia belangeri	96.23	0.00e+00	1001.00
IUUC-Ttr-128653	Tursiops truncatus	96.10	0.00e+00	1560.00
IUUC-Vda-129868	Verticillium dahliae	28.75	2.00e-14	74.70
IUUC-Vvi-131645	Vitis vinifera	26.97	5.00e-09	56.20
IUUC-Xtr-132600	Xenopus tropicalis	76.63	0.00e+00	1261.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence