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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045751
Ensembl Protein ID ENSP00000215793.7
UniProt Accession Q15459; E9PAW1; SF3A1_HUMAN
Genbank Protein ID CAA59494.1; CAG30461.1; AAC23435.1; AAH01976.1; AAH07684.1
Protein Name Splicing factor 3A subunit 1; SF3a120; Spliceosome-associated protein 114
Genbank Nucleotide ID X85237; CR456575; AC004997; BC001976; BC007684
Gene Name SF3A1; SAP114
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000099995.18 ENST00000215793.12 ENSP00000215793.7
ENSG00000099995.18 ENST00000411423.1 ENSP00000412715.1
ENSG00000099995.18 ENST00000444440.1 ENSP00000400862.1
ENSG00000099995.18 ENST00000447376.1 ENSP00000397267.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UDP/UBQ/UBQ_Other UBQ_Other 15571810; 15209385
Classification
Family E-value Score Start End
ULD/UDP/UBQ/UBQ_Other 2.10e-16 61.2 707 790
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UBQ/UBQ_Other
   S: 1    vqvtvksldgs.eltlk....v...npsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllekksgg 76
           ++v+v++++++ e++l+    v   + +d+V+++K ki++++g+p+ +q+L+y+G+ ++d ++La+y++ +g +ihl +k++gg
   Q: 707  IKVQVPNMQDKtEWKLNgqvlVftlPLTDQVSVIKVKIHEATGMPAGKQKLQYEGIFIKDSNSLAYYNMANGAVIHLALKERGG 790
           6899*************996516658888**************************************************99875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Identified in the spliceosome C complex. Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interacts with SF3A3.
 Identified in the spliceosome C complex. Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interacts with SF3A3.
Protein Sequence
(Fasta)
MPAGPVQAVP PPPPVPTEPK QPTEEEASSK EDSAPSKPVV GIIYPPPEVR NIVDKTASFV 60
ARNGPEFEAR IRQNEINNPK FNFLNPNDPY HAYYRHKVSE FKEGKAQEPS AAIPKVMQQQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045751|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTCCCGGAA GTGCGCCAGT CGTACCTTCG CGGCCGCAAC TCGCTCGGCC GCCGCCATCT 60
TGCGAGCTCG TCGTACTGAC CGAGCGGGGA GGCTGTCTTG AGGCGGCACC GCTCACCGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045751|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0832--Ubl conjugation
Interpro

IPR022030--SF3A1
IPR000061--Surp
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
PROSITE

PS50128--SURP
PS50053--UBIQUITIN_2
Pfam

PF12230--PRP21_like_P
PF01805--Surp
PF00240--ubiquitin
SMART

SM00648--SWAP
SM00213--UBQ
Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005681--C:spliceosomal complex
GO:0005686--C:U2 snRNP
GO:0071004--C:U2-type prespliceosome
GO:0005684--C:U2-type spliceosomal complex
GO:0003723--F:RNA binding
GO:0000389--P:mRNA 3'-splice site recognition
GO:0006397--P:mRNA processing
GO:0000398--P:mRNA splicing, via spliceosome
GO:0000381--P:regulation of alternative mRNA splicing, via spliceosome
KEGG hsa:10291
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000319 Aegilops tauschii 35.90 2.00e-48 187.00
IUUC-Aml-002416 Ailuropoda melanoleuca 98.83 0.00e+00 1138.00
IUUC-Atr-003001 Amborella trichopoda 48.57 7.00e-66 245.00
IUUC-Apl-003584 Anas platyrhynchos 92.47 0.00e+00 949.00
IUUC-Aca-004690 Anolis carolinensis 86.45 0.00e+00 1016.00
IUUC-Aly-005487 Arabidopsis lyrata 44.81 1.00e-55 211.00
IUUC-Ath-007275 Arabidopsis thaliana 44.77 2.00e-57 217.00
IUUC-Acl-008320 Aspergillus clavatus 43.21 1.00e-47 184.00
IUUC-Afl-008707 Aspergillus flavus 46.69 8.00e-58 218.00
IUUC-Afu-008786 Aspergillus fumigatus 41.11 1.00e-46 181.00
IUUC-Ani-009307 Aspergillus nidulans 44.25 1.00e-52 200.00
IUUC-Ang-009761 Aspergillus niger 46.34 1.00e-56 214.00
IUUC-Aor-010067 Aspergillus oryzae 46.69 8.00e-58 218.00
IUUC-Ate-010515 Aspergillus terreus 47.04 1.00e-57 217.00
IUUC-Ame-011842 Astyanax mexicanus 79.15 0.00e+00 1006.00
IUUC-Bgr-012204 Blumeria graminis 35.44 9.00e-66 244.00
IUUC-Bta-013525 Bos taurus 99.09 0.00e+00 1133.00
IUUC-Bci-013842 Botrytis cinerea 46.07 5.00e-50 192.00
IUUC-Bdi-014436 Brachypodium distachyon 36.40 6.00e-74 272.00
IUUC-Bol-015903 Brassica oleracea 44.11 3.00e-53 203.00
IUUC-Bra-017856 Brassica rapa 36.83 1.00e-55 211.00
IUUC-Cel-018261 Caenorhabditis elegans 50.69 2.00e-81 296.00
IUUC-Cja-018989 Callithrix jacchus 99.48 0.00e+00 1130.00
IUUC-Cfa-020629 Canis familiaris 98.83 0.00e+00 1129.00
IUUC-Cpo-021759 Cavia porcellus 98.70 0.00e+00 1120.00
IUUC-Cre-022603 Chlamydomonas reinhardtii 38.93 2.00e-22 100.00
IUUC-Csa-023750 Chlorocebus sabaeus 99.87 0.00e+00 1133.00
IUUC-Cho-024581 Choloepus hoffmanni 98.15 6.00e-123 434.00
IUUC-Cin-025640 Ciona intestinalis 57.66 1.00e-147 517.00
IUUC-Csv-025855 Ciona savignyi 55.74 9.00e-143 501.00
IUUC-Cgl-026573 Colletotrichum gloeosporioides 42.27 6.00e-46 178.00
IUUC-Cne-026952 Cryptococcus neoformans 40.59 9.00e-50 191.00
IUUC-Dre-028055 Danio rerio 81.27 0.00e+00 980.00
IUUC-Dno-029259 Dasypus novemcinctus 98.83 0.00e+00 1132.00
IUUC-Dor-031081 Dipodomys ordii 98.57 0.00e+00 1128.00
IUUC-Dse-031438 Dothistroma septosporum 39.37 5.00e-48 186.00
IUUC-Dme-031975 Drosophila melanogaster 60.00 1.00e-147 516.00
IUUC-Ete-033177 Echinops telfairi 97.01 0.00e+00 897.00
IUUC-Eca-033670 Equus caballus 99.09 0.00e+00 1138.00
IUUC-Eeu-035100 Erinaceus europaeus 93.57 0.00e+00 701.00
IUUC-Fca-036176 Felis catus 98.83 0.00e+00 1130.00
IUUC-Fal-036776 Ficedula albicollis 92.44 0.00e+00 936.00
IUUC-Fox-037706 Fusarium oxysporum 40.83 8.00e-49 188.00
IUUC-Fso-038313 Fusarium solani 42.39 4.00e-45 176.00
IUUC-Gmo-038887 Gadus morhua 80.70 0.00e+00 1000.00
IUUC-Ggr-039932 Gaeumannomyces graminis 38.02 1.00e-34 141.00
IUUC-Gga-041184 Gallus gallus 91.92 0.00e+00 924.00
IUUC-Gac-042118 Gasterosteus aculeatus 83.64 0.00e+00 984.00
IUUC-Gma-042726 Glycine max 39.53 3.00e-82 300.00
IUUC-Ggo-045641 Gorilla gorilla 97.13 0.00e+00 1117.00
IUUC-Hvu-047702 Hordeum vulgare 32.84 2.00e-30 127.00
IUUC-Itr-047960 Ictidomys tridecemlineatus 98.96 0.00e+00 1137.00
IUUC-Kpa-049400 Komagataella pastoris 29.31 5.00e-31 129.00
IUUC-Lch-050152 Latimeria chalumnae 85.66 0.00e+00 919.00
IUUC-Lpe-051570 Leersia perrieri 45.78 8.00e-33 135.00
IUUC-Loc-051753 Lepisosteus oculatus 83.90 0.00e+00 1030.00
IUUC-Lma-053219 Leptosphaeria maculans 36.58 1.00e-34 141.00
IUUC-Laf-053643 Loxodonta africana 98.96 0.00e+00 1098.00
IUUC-Mcc-055091 Macaca mulatta 99.74 0.00e+00 1133.00
IUUC-Meu-056036 Macropus eugenii 86.41 0.00e+00 798.00
IUUC-Mor-057214 Magnaporthe oryzae 37.36 6.00e-35 142.00
IUUC-Mpo-057385 Magnaporthe poae 30.00 1.00e-12 67.00
IUUC-Mtr-057954 Medicago truncatula 38.08 1.00e-81 298.00
IUUC-Mla-059020 Melampsora laricipopulina 36.42 9.00e-49 189.00
IUUC-Mga-060176 Meleagris gallopavo 93.25 0.00e+00 951.00
IUUC-Mvi-060278 Microbotryum violaceum 38.51 6.00e-53 202.00
IUUC-Mmr-061602 Microcebus murinus 99.22 0.00e+00 1151.00
IUUC-Mdo-062047 Monodelphis domestica 96.49 0.00e+00 1064.00
IUUC-Mmu-063377 Mus musculus 96.77 0.00e+00 1120.00
IUUC-Mac-065644 Musa acuminata 46.30 1.00e-60 228.00
IUUC-Mpu-066047 Mustela putorius furo 98.70 0.00e+00 1138.00
IUUC-Mlu-067039 Myotis lucifugus 98.83 0.00e+00 1105.00
IUUC-Nfi-068434 Neosartorya fischeri 45.96 4.00e-53 202.00
IUUC-Ncr-068912 Neurospora crassa 39.41 3.00e-39 156.00
IUUC-Nle-069540 Nomascus leucogenys 99.87 0.00e+00 1133.00
IUUC-Opr-071157 Ochotona princeps 98.44 0.00e+00 1111.00
IUUC-Ont-072229 Oreochromis niloticus 84.90 0.00e+00 990.00
IUUC-Oan-073616 Ornithorhynchus anatinus 98.23 3.00e-33 134.00
IUUC-Ocu-074002 Oryctolagus cuniculus 98.83 0.00e+00 1131.00
IUUC-Oba-075659 Oryza barthii 33.73 1.00e-34 141.00
IUUC-Obr-076465 Oryza brachyantha 46.25 8.00e-34 139.00
IUUC-Ogl-077461 Oryza glaberrima 37.08 2.00e-53 204.00
IUUC-Ogu-078515 Oryza glumaepatula 38.02 4.00e-53 203.00
IUUC-Oin-080201 Oryza indica 46.88 2.00e-33 137.00
IUUC-Olo-080751 Oryza longistaminata 33.73 1.00e-34 141.00
IUUC-Ome-081201 Oryza meridionalis 36.15 2.00e-74 274.00
IUUC-Oni-082951 Oryza nivara 46.88 3.00e-33 137.00
IUUC-Opu-083560 Oryza punctata 34.73 5.00e-64 239.00
IUUC-Oru-084440 Oryza rufipogon 37.08 3.00e-53 203.00
IUUC-Osa-085699 Oryza sativa 37.08 2.00e-53 204.00
IUUC-Ola-086705 Oryzias latipes 80.33 0.00e+00 962.00
IUUC-Olu-087794 Ostreococcus lucimarinus 36.27 4.00e-62 233.00
IUUC-Oga-088896 Otolemur garnettii 99.35 0.00e+00 1129.00
IUUC-Oar-090155 Ovis aries 94.52 0.00e+00 1098.00
IUUC-Ptr-090754 Pan troglodytes 99.87 0.00e+00 1121.00
IUUC-Pan-092464 Papio anubis 99.87 0.00e+00 1133.00
IUUC-Psi-093166 Pelodiscus sinensis 92.37 0.00e+00 740.00
IUUC-Pma-094280 Petromyzon marinus 85.04 2.00e-128 452.00
IUUC-Pno-095106 Phaeosphaeria nodorum 37.59 3.00e-31 130.00
IUUC-Ppa-095510 Physcomitrella patens 47.12 6.00e-57 216.00
IUUC-Pfo-096212 Poecilia formosa 76.46 0.00e+00 808.00
IUUC-Pab-098482 Pongo abelii 99.87 0.00e+00 1133.00
IUUC-Pop-099479 Populus trichocarpa 44.15 3.00e-56 213.00
IUUC-Pca-100776 Procavia capensis 99.50 5.00e-79 289.00
IUUC-Ppe-101626 Prunus persica 36.87 8.00e-76 278.00
IUUC-Pva-102981 Pteropus vampyrus 97.99 0.00e+00 1064.00
IUUC-Pgr-103503 Puccinia graminis 33.68 6.00e-69 256.00
IUUC-Ptt-103994 Puccinia triticina 39.31 1.00e-46 182.00
IUUC-Pte-104226 Pyrenophora teres 35.40 4.00e-36 145.00
IUUC-Pyt-104732 Pyrenophora triticirepentis 36.24 6.00e-39 155.00
IUUC-Rno-105225 Rattus norvegicus 96.63 0.00e+00 1117.00
IUUC-Sce-106278 Saccharomyces cerevisiae 22.94 7.00e-11 61.20
IUUC-Sha-107353 Sarcophilus harrisii 94.24 0.00e+00 1008.00
IUUC-Sja-107876 Schizosaccharomyces japonicus 35.78 4.00e-61 228.00
IUUC-Spo-108266 Schizosaccharomyces pombe 41.98 6.00e-52 198.00
IUUC-Ssl-108518 Sclerotinia sclerotiorum 45.74 3.00e-54 206.00
IUUC-Smo-109675 Selaginella moellendorffii 45.00 1.00e-51 198.00
IUUC-Sit-110019 Setaria italica 45.28 7.00e-33 135.00
IUUC-Sly-111621 Solanum lycopersicum 45.65 4.00e-63 236.00
IUUC-Stu-112703 Solanum tuberosum 46.35 1.00e-63 238.00
IUUC-Sar-113166 Sorex araneus 95.47 0.00e+00 1049.00
IUUC-Sbi-114746 Sorghum bicolor 35.96 4.00e-52 199.00
IUUC-Sre-115196 Sporisorium reilianum 40.27 2.00e-50 194.00
IUUC-Ssc-115573 Sus scrofa 98.96 0.00e+00 1133.00
IUUC-Tgu-117284 Taeniopygia guttata 93.40 0.00e+00 942.00
IUUC-Tru-118236 Takifugu rubripes 77.24 0.00e+00 920.00
IUUC-Tsy-119219 Tarsius syrichta 95.94 0.00e+00 1014.00
IUUC-Tni-119929 Tetraodon nigroviridis 84.39 9.00e-101 361.00
IUUC-Tca-121156 Theobroma cacao 44.59 3.00e-61 230.00
IUUC-Tre-122179 Trichoderma reesei 42.24 2.00e-44 174.00
IUUC-Tvi-122326 Trichoderma virens 40.85 1.00e-47 184.00
IUUC-Tae-124733 Triticum aestivum 34.81 4.00e-71 263.00
IUUC-Tur-126352 Triticum urartu 35.49 1.00e-48 188.00
IUUC-Tme-126996 Tuber melanosporum 42.80 1.00e-51 197.00
IUUC-Tbe-127271 Tupaia belangeri 91.44 0.00e+00 988.00
IUUC-Ttr-128433 Tursiops truncatus 97.00 0.00e+00 1125.00
IUUC-Uma-129357 Ustilago maydis 31.08 2.00e-47 184.00
IUUC-Vda-130010 Verticillium dahliae 40.50 2.00e-42 167.00
IUUC-Vvi-131734 Vitis vinifera 46.29 4.00e-63 236.00
IUUC-Xtr-132013 Xenopus tropicalis 86.49 0.00e+00 1001.00
IUUC-Xma-134244 Xiphophorus maculatus 80.85 0.00e+00 934.00
IUUC-Yli-134579 Yarrowia lipolytica 36.29 2.00e-32 133.00
IUUC-Zma-135600 Zea mays 35.96 3.00e-51 197.00
Created Date 25-Jun-2017

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