iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100083.18	ENST00000343632.8	ENSP00000341344.4
ENSG00000100083.18	ENST00000381756.9	ENSP00000371175.5
ENSG00000100083.18	ENST00000405147.7	ENSP00000384030.3
ENSG00000100083.18	ENST00000325180.12	ENSP00000321288.8
ENSG00000100083.18	ENST00000449944.5	ENSP00000390416.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/GAT	GAT	17494868

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/GAT	9.00e-52	176.1	171	298

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/GAT

   S: 1    deeksklLerLlkskkPeDLreAnkLikelvkededkaekikkliseleevksnvkllnemlselspegeep.ednellqelyetckaarpk 91
           deeksk+L+rLlks++PeDLr+AnkLike+v+ed++++eki+k+++++eev++nvkll+em++++s++g+++ ++++l++ely++c+++rp+
   Q: 171  DEEKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGGAAAgSSEDLMKELYQRCERMRPT 262
           79*********************************************************************9999***************** PP
   S: 92   llklieeeedndellaellkanDelnqvlnkykqlk 127
           l++l++++ednde+lae+l+anD+l+qv+n ykql+
   Q: 263  LFRLASDTEDNDEALAEILQANDNLTQVINLYKQLV 298
           *********************************987 PP

Organism

Homo sapiens

Functional Description
(View)

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

Protein Sequence
(Fasta)

MEPAMEPETL EARINRATNP LNKELDWASI NGFCEQLNED FEGPPLATRL LAHKIQSPQE 60
WEAIQALTVL ETCMKSCGKR FHDEVGKFRF LNELIKVVSP KYLGSRTSEK VKNKILELLY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGTGGCCT CAGAGCCCCT CAGCAACATG CCCGCAGAGA ATTCTTCCGG AGGCGGTCAC 60
AGACATCTCC GTGACGCAGA ACGAGTTAGA GCGTCCCTTG GGGTTTCCAT GGTGCTGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation

Interpro

IPR008152--Clathrin_a/b/g-adaptin_app_Ig
IPR008153--Clathrin_g-adaptin_app
IPR013041--Coatomer/clathrin_app_Ig-like
IPR008942--ENTH_VHS
IPR004152--GAT_dom
IPR002014--VHS_dom

PROSITE

PS50180--GAE
PS50909--GAT
PS50179--VHS

Pfam

PF02883--Alpha_adaptinC2
PF03127--GAT
PF00790--VHS

SMART

SM00809--Alpha_adaptinC2
SM00288--VHS

Gene Ontology

GO:0030131--C:clathrin adaptor complex
GO:0031901--C:early endosome membrane
GO:0010008--C:endosome membrane
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0044267--P:cellular protein metabolic process
GO:0006886--P:intracellular protein transport
GO:0061024--P:membrane organization
GO:0045732--P:positive regulation of protein catabolic process
GO:1901998--P:toxin transport
GO:0016192--P:vesicle-mediated transport

KEGG

hsa:26088

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001226	Ailuropoda melanoleuca	86.91	0.00e+00	988.00
IUUC-Apl-003932	Anas platyrhynchos	81.41	3.00e-152	532.00
IUUC-Aca-004431	Anolis carolinensis	84.52	2.00e-141	496.00
IUUC-Acl-008243	Aspergillus clavatus	27.13	1.00e-18	88.60
IUUC-Afl-008682	Aspergillus flavus	27.41	7.00e-21	95.90
IUUC-Ang-009840	Aspergillus niger	26.59	1.00e-15	78.60
IUUC-Aor-010219	Aspergillus oryzae	27.41	8.00e-21	95.50
IUUC-Ate-010290	Aspergillus terreus	26.52	7.00e-15	75.90
IUUC-Ame-011684	Astyanax mexicanus	72.28	9.00e-140	490.00
IUUC-Bta-012975	Bos taurus	93.43	0.00e+00	1059.00
IUUC-Cel-018437	Caenorhabditis elegans	30.08	1.00e-32	134.00
IUUC-Cja-019098	Callithrix jacchus	84.74	0.00e+00	907.00
IUUC-Cfa-020394	Canis familiaris	93.27	0.00e+00	1035.00
IUUC-Cpo-022352	Cavia porcellus	92.64	0.00e+00	1053.00
IUUC-Csa-024037	Chlorocebus sabaeus	98.44	0.00e+00	1055.00
IUUC-Dre-027709	Danio rerio	63.95	0.00e+00	713.00
IUUC-Dno-029170	Dasypus novemcinctus	82.22	0.00e+00	894.00
IUUC-Dor-030638	Dipodomys ordii	88.34	0.00e+00	1035.00
IUUC-Dse-031293	Dothistroma septosporum	26.07	2.00e-18	87.80
IUUC-Dme-031654	Drosophila melanogaster	32.76	2.00e-38	154.00
IUUC-Eca-034275	Equus caballus	91.71	0.00e+00	1055.00
IUUC-Eeu-035068	Erinaceus europaeus	72.30	0.00e+00	819.00
IUUC-Fca-036278	Felis catus	97.00	5.00e-160	558.00
IUUC-Fal-036971	Ficedula albicollis	79.10	0.00e+00	875.00
IUUC-Fox-037776	Fusarium oxysporum	28.46	6.00e-17	82.80
IUUC-Gmo-039301	Gadus morhua	55.52	3.00e-140	492.00
IUUC-Ggr-039779	Gaeumannomyces graminis	28.36	5.00e-16	79.70
IUUC-Gga-040880	Gallus gallus	76.29	0.00e+00	847.00
IUUC-Gac-041955	Gasterosteus aculeatus	62.62	0.00e+00	674.00
IUUC-Ggo-045652	Gorilla gorilla	97.10	0.00e+00	1043.00
IUUC-Itr-048105	Ictidomys tridecemlineatus	90.03	0.00e+00	1073.00
IUUC-Lch-049488	Latimeria chalumnae	67.43	0.00e+00	760.00
IUUC-Laf-053697	Loxodonta africana	90.45	0.00e+00	999.00
IUUC-Mcc-054687	Macaca mulatta	92.24	0.00e+00	958.00
IUUC-Meu-056352	Macropus eugenii	74.37	0.00e+00	813.00
IUUC-Mor-057096	Magnaporthe oryzae	27.76	1.00e-15	78.60
IUUC-Mpo-057584	Magnaporthe poae	28.57	9.00e-09	55.10
IUUC-Mga-059936	Meleagris gallopavo	80.84	0.00e+00	892.00
IUUC-Mmr-060805	Microcebus murinus	88.84	0.00e+00	1001.00
IUUC-Mdo-061808	Monodelphis domestica	74.23	0.00e+00	863.00
IUUC-Mmu-063131	Mus musculus	90.92	0.00e+00	979.00
IUUC-Mpu-066602	Mustela putorius furo	91.11	0.00e+00	1046.00
IUUC-Mlu-068220	Myotis lucifugus	91.86	0.00e+00	996.00
IUUC-Ncr-068625	Neurospora crassa	27.10	1.00e-16	82.00
IUUC-Nle-069039	Nomascus leucogenys	96.49	0.00e+00	1036.00
IUUC-Opr-070709	Ochotona princeps	83.61	0.00e+00	961.00
IUUC-Ont-072069	Oreochromis niloticus	61.53	0.00e+00	692.00
IUUC-Oan-072906	Ornithorhynchus anatinus	71.40	0.00e+00	779.00
IUUC-Ola-086728	Oryzias latipes	56.70	0.00e+00	647.00
IUUC-Oga-088189	Otolemur garnettii	86.36	0.00e+00	961.00
IUUC-Oar-089226	Ovis aries	89.67	0.00e+00	1017.00
IUUC-Pan-092529	Papio anubis	98.75	0.00e+00	1058.00
IUUC-Psi-093412	Pelodiscus sinensis	76.92	4.00e-166	578.00
IUUC-Pma-094269	Petromyzon marinus	64.04	8.00e-106	376.00
IUUC-Pfo-096458	Poecilia formosa	61.38	0.00e+00	702.00
IUUC-Pab-097684	Pongo abelii	97.81	0.00e+00	992.00
IUUC-Pca-100546	Procavia capensis	89.12	0.00e+00	772.00
IUUC-Pva-102877	Pteropus vampyrus	83.99	0.00e+00	962.00
IUUC-Rno-104917	Rattus norvegicus	90.64	0.00e+00	865.00
IUUC-Sha-107248	Sarcophilus harrisii	82.35	2.00e-145	509.00
IUUC-Ssc-115539	Sus scrofa	84.38	3.00e-122	431.00
IUUC-Tgu-117227	Taeniopygia guttata	78.95	0.00e+00	872.00
IUUC-Tru-118666	Takifugu rubripes	59.59	0.00e+00	684.00
IUUC-Tni-120663	Tetraodon nigroviridis	61.63	0.00e+00	659.00
IUUC-Tbe-127589	Tupaia belangeri	90.08	0.00e+00	1000.00
IUUC-Ttr-128616	Tursiops truncatus	90.69	0.00e+00	1054.00
IUUC-Xtr-132596	Xenopus tropicalis	64.35	1.00e-153	536.00
IUUC-Xma-133092	Xiphophorus maculatus	58.46	0.00e+00	680.00
IUUC-Yli-134564	Yarrowia lipolytica	26.04	4.00e-16	79.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence