iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	19498170

Organism

Homo sapiens

Functional Description
(View)

GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, GNB2 and GNB3. May be involved in selected striatal competencies, mainly locomotor activity and motor coordination.

Protein Sequence
(Fasta)

MMKTLSSGNC TLSVPAKNSY RMVVLGASRV GKSSIVSRFL NGRFEDQYTP TIEDFHRKVY 60
NIRGDMYQLD ILDTSGNHPF PAMRRLSILT GDVFILVFSL DNRESFDEVK RLQKQILEVK 120

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Nucleotide Sequence
(Fasta)

GCGCGGGGAG AAAGAAGCCG TCCCTCCGGC GCTGGGAGAG CTGCAGAGCC GCGGGCAGAG 60
AAGGAGGCCG CGGCCGAGCC CGGCAGCCCG ATACCCCCCA TCCGAGCGAC CCCCTTTGGG 120

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Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0488--Methylation
KW-0547--Nucleotide-binding
KW-0636--Prenylation
KW-1185--Reference proteome

Interpro

IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR020849--Small_GTPase_Ras

PROSITE

PS51421--RAS

Pfam

PF00071--Ras

Gene Ontology

GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0031681--F:G-protein beta-subunit binding
GO:0005525--F:GTP binding
GO:0003924--F:GTPase activity
GO:0007626--P:locomotory behavior
GO:0031397--P:negative regulation of protein ubiquitination
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0033235--P:positive regulation of protein sumoylation
GO:0043949--P:regulation of cAMP-mediated signaling
GO:0007264--P:small GTPase mediated signal transduction
GO:0001963--P:synaptic transmission, dopaminergic

KEGG

hsa:23551

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002300	Ailuropoda melanoleuca	99.62	1.00e-159	555.00
IUUC-Apl-003857	Anas platyrhynchos	89.85	5.00e-145	506.00
IUUC-Aca-004240	Anolis carolinensis	90.23	3.00e-144	504.00
IUUC-Bta-013228	Bos taurus	98.50	2.00e-157	547.00
IUUC-Cja-018957	Callithrix jacchus	98.87	1.00e-158	551.00
IUUC-Cfa-020131	Canis familiaris	97.74	2.00e-156	544.00
IUUC-Cpo-021614	Cavia porcellus	94.36	1.00e-151	528.00
IUUC-Csa-023844	Chlorocebus sabaeus	100.00	5.00e-160	556.00
IUUC-Dno-029174	Dasypus novemcinctus	98.50	1.00e-157	548.00
IUUC-Dor-031033	Dipodomys ordii	96.62	2.00e-155	541.00
IUUC-Dme-031780	Drosophila melanogaster	48.52	1.00e-63	237.00
IUUC-Ete-032309	Echinops telfairi	97.71	3.00e-101	360.00
IUUC-Eca-034018	Equus caballus	98.87	2.00e-158	551.00
IUUC-Fca-035875	Felis catus	98.12	2.00e-157	548.00
IUUC-Fal-037653	Ficedula albicollis	89.10	2.00e-143	501.00
IUUC-Gga-040943	Gallus gallus	90.23	5.00e-145	506.00
IUUC-Ggo-044688	Gorilla gorilla	100.00	6.00e-160	556.00
IUUC-Itr-048300	Ictidomys tridecemlineatus	97.74	3.00e-156	543.00
IUUC-Lch-050232	Latimeria chalumnae	81.67	8.00e-124	436.00
IUUC-Laf-053676	Loxodonta africana	98.12	9.00e-158	549.00
IUUC-Meu-056249	Macropus eugenii	95.86	2.00e-153	534.00
IUUC-Mga-059257	Meleagris gallopavo	90.23	2.00e-145	507.00
IUUC-Mdo-061991	Monodelphis domestica	95.86	2.00e-153	534.00
IUUC-Mmu-063268	Mus musculus	95.11	4.00e-152	530.00
IUUC-Mpu-066901	Mustela putorius furo	99.25	6.00e-159	552.00
IUUC-Mlu-067258	Myotis lucifugus	98.12	4.00e-157	546.00
IUUC-Nle-068973	Nomascus leucogenys	100.00	6.00e-160	556.00
IUUC-Opr-070743	Ochotona princeps	98.12	3.00e-157	547.00
IUUC-Oan-072868	Ornithorhynchus anatinus	92.88	1.00e-148	518.00
IUUC-Ocu-074790	Oryctolagus cuniculus	97.74	6.00e-157	546.00
IUUC-Oga-088431	Otolemur garnettii	98.50	4.00e-158	550.00
IUUC-Oar-089258	Ovis aries	99.03	5.00e-121	426.00
IUUC-Ptr-090978	Pan troglodytes	100.00	5.00e-160	556.00
IUUC-Pan-092088	Papio anubis	98.32	1.00e-139	488.00
IUUC-Psi-093630	Pelodiscus sinensis	91.35	2.00e-146	511.00
IUUC-Pma-094385	Petromyzon marinus	36.41	4.00e-26	111.00
IUUC-Pab-098310	Pongo abelii	100.00	5.00e-160	556.00
IUUC-Pca-100098	Procavia capensis	95.49	1.00e-150	525.00
IUUC-Pva-102212	Pteropus vampyrus	96.62	8.00e-155	539.00
IUUC-Rno-105257	Rattus norvegicus	95.11	4.00e-152	530.00
IUUC-Sha-106504	Sarcophilus harrisii	96.24	2.00e-154	537.00
IUUC-Sar-113244	Sorex araneus	94.89	1.00e-97	348.00
IUUC-Tgu-116948	Taeniopygia guttata	88.35	1.00e-142	498.00
IUUC-Tbe-127818	Tupaia belangeri	99.62	1.00e-159	555.00
IUUC-Ttr-128286	Tursiops truncatus	98.50	2.00e-157	548.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence