iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000100393.11	ENST00000263253.8	ENSP00000263253.7
ENSG00000100393.11	ENST00000634690.1	ENSP00000489397.1
ENSG00000100393.11	ENST00000634728.1	ENSP00000488981.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	TRANSFAC	miRWalk	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	12690203

Organism

Homo sapiens

Functional Description
(View)

Functional Description

Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone targets. Acetylates 'Lys-131' of ALX1 and acts as its coactivator. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function. Acetylates HDAC1 leading to its inactivation and modulation of transcription. Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2. Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acetylates FOXO1 and enhances its transcriptional activity. Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity. Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter. Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:10733570, PubMed:11430825, PubMed:11701890, PubMed:12402037, PubMed:12586840, PubMed:12929931, PubMed:14645221, PubMed:15186775, PubMed:15890677, PubMed:16617102, PubMed:16762839, PubMed:18722353, PubMed:18995842, PubMed:23415232, PubMed:23911289, PubMed:23934153, PubMed:8945521). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D.

Protein Sequence
(Fasta)

MAENVVEPGP PSAKRPKLSS PALSASASDG TDFGSLFDLE HDLPDELINS TELGLTNGGD 60
INQLQTSLGM VQDAASKHKQ LSELLRSGSS PNLNMGVGGP GQVMASQAQQ SSPGLGLINS 120

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Nucleotide Sequence
(Fasta)

CTTGTTTGTG TGCTAGGCTG GGGGGGAGAG AGGGCGAGAG AGAGCGGGCG AGAGTGGGCA 60
AGCAGGACGC CGGGCTGAGT GCTAACTGCG GGAGCCAGAG AGTGCGGAGG GGAGTCGGGT 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0012--Acyltransferase
KW-0090--Biological rhythms
KW-0103--Bromodomain
KW-0131--Cell cycle
KW-0160--Chromosomal rearrangement
KW-0164--Citrullination
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR031162--CBP_P300_HAT
IPR013178--Histone_AcTrfase_Rtt109/CBP
IPR003101--KIX_dom
IPR009110--Nuc_rcpt_coact
IPR014744--Nuc_rcpt_coact_CREBbp
IPR010303--RING_CBP-p300
IPR000197--Znf_TAZ
IPR000433--Znf_ZZ

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51727--CBP_P300_HAT
PS50952--KIX
PS50134--ZF_TAZ
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF00439--Bromodomain
PF09030--Creb_binding
PF06001--DUF902
PF08214--HAT_KAT11
PF02172--KIX
PF02135--zf-TAZ
PF00569--ZZ

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM01250--KAT11
SM00551--ZnF_TAZ
SM00291--ZnF_ZZ

Gene Ontology

GO:0005829--C:cytosol
GO:0000123--C:histone acetyltransferase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005667--C:transcription factor complex
GO:0016407--F:acetyltransferase activity
GO:0033613--F:activating transcription factor binding
GO:0050681--F:androgen receptor binding
GO:0008013--F:beta-catenin binding
GO:0003682--F:chromatin binding
GO:0031490--F:chromatin DNA binding
GO:0001047--F:core promoter binding
GO:0003684--F:damaged DNA binding
GO:0003677--F:DNA binding
GO:0004402--F:histone acetyltransferase activity
GO:0004468--F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO:0035257--F:nuclear hormone receptor binding
GO:0034212--F:peptide N-acetyltransferase activity
GO:0061733--F:peptide-lysine-N-acetyltransferase activity
GO:0097157--F:pre-mRNA intronic binding
GO:0008022--F:protein C-terminus binding
GO:0001102--F:RNA polymerase II activating transcription factor binding
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003713--F:transcription coactivator activity
GO:0008134--F:transcription factor binding
GO:0001228--F:transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0016746--F:transferase activity, transferring acyl groups
GO:0008270--F:zinc ion binding
GO:0009887--P:animal organ morphogenesis
GO:0006915--P:apoptotic process
GO:0030183--P:B cell differentiation
GO:1904837--P:beta-catenin-TCF complex assembly
GO:0034644--P:cellular response to UV
GO:0007623--P:circadian rhythm
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0045444--P:fat cell differentiation
GO:0007507--P:heart development
GO:0043969--P:histone H2B acetylation
GO:0043967--P:histone H4 acetylation
GO:0018393--P:internal peptidyl-lysine acetylation
GO:0006475--P:internal protein amino acid acetylation
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0030324--P:lung development
GO:0010742--P:macrophage derived foam cell differentiation
GO:0035855--P:megakaryocyte development
GO:0018076--P:N-terminal peptidyl-lysine acetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007399--P:nervous system development
GO:0007219--P:Notch signaling pathway
GO:0030220--P:platelet formation
GO:0043923--P:positive regulation by host of viral transcription
GO:0045815--P:positive regulation of gene expression, epigenetic
GO:0032092--P:positive regulation of protein binding
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0006990--P:positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0032481--P:positive regulation of type I interferon production
GO:0006473--P:protein acetylation
GO:0016579--P:protein deubiquitination
GO:0050821--P:protein stabilization
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0010506--P:regulation of autophagy
GO:0051726--P:regulation of cell cycle
GO:1900034--P:regulation of cellular response to heat
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0006355--P:regulation of transcription, DNA-templated
GO:0090043--P:regulation of tubulin deacetylation
GO:0043627--P:response to estrogen
GO:0001666--P:response to hypoxia
GO:0007519--P:skeletal muscle tissue development
GO:0001756--P:somitogenesis
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0016032--P:viral process

KEGG

hsa:2033

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002027	Ailuropoda melanoleuca	96.05	0.00e+00	1933.00
IUUC-Aca-005040	Anolis carolinensis	81.26	0.00e+00	1842.00
IUUC-Ame-011395	Astyanax mexicanus	86.00	0.00e+00	1469.00
IUUC-Bta-012649	Bos taurus	93.07	0.00e+00	2009.00
IUUC-Cel-018691	Caenorhabditis elegans	50.43	0.00e+00	846.00
IUUC-Cja-019649	Callithrix jacchus	96.29	0.00e+00	2161.00
IUUC-Cfa-020764	Canis familiaris	96.40	0.00e+00	1797.00
IUUC-Cpo-022345	Cavia porcellus	91.08	0.00e+00	3332.00
IUUC-Cre-022852	Chlamydomonas reinhardtii	34.84	4.00e-65	243.00
IUUC-Csa-023866	Chlorocebus sabaeus	98.76	0.00e+00	2112.00
IUUC-Cho-024951	Choloepus hoffmanni	97.70	0.00e+00	1237.00
IUUC-Csv-026122	Ciona savignyi	65.08	0.00e+00	677.00
IUUC-Dre-028500	Danio rerio	78.51	0.00e+00	1466.00
IUUC-Dor-030287	Dipodomys ordii	93.58	0.00e+00	1197.00
IUUC-Ete-032979	Echinops telfairi	90.03	0.00e+00	1771.00
IUUC-Eca-034048	Equus caballus	96.46	0.00e+00	1907.00
IUUC-Fca-035891	Felis catus	95.19	0.00e+00	2043.00
IUUC-Fal-037585	Ficedula albicollis	85.70	0.00e+00	1919.00
IUUC-Gmo-039348	Gadus morhua	84.97	0.00e+00	1447.00
IUUC-Gga-040916	Gallus gallus	84.81	0.00e+00	1924.00
IUUC-Gac-041642	Gasterosteus aculeatus	87.84	0.00e+00	1421.00
IUUC-Ggo-045189	Gorilla gorilla	98.34	0.00e+00	2114.00
IUUC-Itr-048564	Ictidomys tridecemlineatus	96.77	0.00e+00	1883.00
IUUC-Laf-054423	Loxodonta africana	94.45	0.00e+00	2191.00
IUUC-Mcc-054847	Macaca mulatta	99.45	0.00e+00	2122.00
IUUC-Meu-056217	Macropus eugenii	83.25	0.00e+00	1926.00
IUUC-Mga-059250	Meleagris gallopavo	81.08	0.00e+00	1945.00
IUUC-Mmr-061496	Microcebus murinus	95.59	0.00e+00	2086.00
IUUC-Mdo-062478	Monodelphis domestica	85.42	0.00e+00	1936.00
IUUC-Mmu-063456	Mus musculus	94.53	0.00e+00	1896.00
IUUC-Mac-064767	Musa acuminata	40.00	1.00e-75	278.00
IUUC-Mpu-065963	Mustela putorius furo	93.63	0.00e+00	1885.00
IUUC-Mlu-067185	Myotis lucifugus	95.66	0.00e+00	1906.00
IUUC-Ncr-068795	Neurospora crassa	37.97	1.00e-13	71.20
IUUC-Nle-069907	Nomascus leucogenys	99.50	0.00e+00	1905.00
IUUC-Opr-070324	Ochotona princeps	88.54	0.00e+00	1190.00
IUUC-Ont-072211	Oreochromis niloticus	79.43	0.00e+00	1458.00
IUUC-Oan-073723	Ornithorhynchus anatinus	88.63	0.00e+00	1857.00
IUUC-Ocu-074707	Oryctolagus cuniculus	95.58	0.00e+00	1896.00
IUUC-Oba-075590	Oryza barthii	33.52	2.00e-103	371.00
IUUC-Ogu-078580	Oryza glumaepatula	33.38	1.00e-103	372.00
IUUC-Ome-081615	Oryza meridionalis	33.52	3.00e-103	370.00
IUUC-Oni-082636	Oryza nivara	33.52	2.00e-103	371.00
IUUC-Opu-084073	Oryza punctata	32.97	5.00e-100	360.00
IUUC-Oru-084994	Oryza rufipogon	33.52	2.00e-103	371.00
IUUC-Osa-085860	Oryza sativa	42.26	8.00e-63	236.00
IUUC-Olu-087701	Ostreococcus lucimarinus	35.44	3.00e-62	234.00
IUUC-Oga-088700	Otolemur garnettii	94.99	0.00e+00	3457.00
IUUC-Oar-089787	Ovis aries	91.17	0.00e+00	2005.00
IUUC-Ptr-091620	Pan troglodytes	98.89	0.00e+00	2115.00
IUUC-Pan-092166	Papio anubis	97.93	0.00e+00	2137.00
IUUC-Psi-093992	Pelodiscus sinensis	82.94	0.00e+00	1973.00
IUUC-Ppa-095569	Physcomitrella patens	38.19	8.00e-71	262.00
IUUC-Pfo-097342	Poecilia formosa	85.01	0.00e+00	1383.00
IUUC-Pab-098235	Pongo abelii	98.00	0.00e+00	2107.00
IUUC-Pop-098947	Populus trichocarpa	40.00	5.00e-74	273.00
IUUC-Pca-100780	Procavia capensis	88.99	0.00e+00	1459.00
IUUC-Pva-103071	Pteropus vampyrus	94.58	0.00e+00	2180.00
IUUC-Sha-106736	Sarcophilus harrisii	91.94	0.00e+00	1671.00
IUUC-Smo-109420	Selaginella moellendorffii	38.01	2.00e-71	265.00
IUUC-Sar-113162	Sorex araneus	92.04	0.00e+00	852.00
IUUC-Ssc-116077	Sus scrofa	94.65	0.00e+00	2110.00
IUUC-Tgu-116872	Taeniopygia guttata	85.06	0.00e+00	1939.00
IUUC-Tru-118047	Takifugu rubripes	81.08	0.00e+00	1459.00
IUUC-Tsy-119451	Tarsius syrichta	95.49	0.00e+00	1325.00
IUUC-Tca-121835	Theobroma cacao	39.14	2.00e-73	272.00
IUUC-Tvi-122536	Trichoderma virens	43.04	2.00e-15	77.00
IUUC-Tae-124383	Triticum aestivum	38.73	8.00e-69	256.00
IUUC-Tur-126284	Triticum urartu	37.66	2.00e-68	255.00
IUUC-Tbe-127772	Tupaia belangeri	85.78	0.00e+00	1303.00
IUUC-Ttr-128325	Tursiops truncatus	97.92	0.00e+00	1459.00
IUUC-Vpa-130766	Vicugna pacos	93.38	0.00e+00	1312.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence