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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105306
UUCD1 version UUC-RaN-00009
Ensembl Protein ID ENSRNOP00000009559.1
UniProt Accession Q91ZY8; TRIM9_RAT
Genbank Protein ID AAL27988.1
Protein Name E3 ubiquitin-protein ligase TRIM9; RING-type E3 ubiquitin transferase TRIM9; SNAP-25-interacting RING finger protein; Tripartite motif-containing protein 9
Genbank Nucleotide ID AF350422
Gene Name Trim9; Spring
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000007031.5 ENSRNOT00000009560.2 ENSRNOP00000009559.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusUniProt
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20352094
Classification
Family E-value Score Start End
E3 activity/RING/RING 3.30e-05 24.7 10 131
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw.pglknssskefr............................................... 41
           C++C + +++ p++lpC H  ++ C  ++ ++ + s+s++ r                                               
   Q: 10   CPVCGSFYRE-PIILPCSHNLCQACARNIlVQTPESESPQSRrasgsgvsdydyldldkmslyseadsgygsyggfasapttpcqkspn 97
           ****888877.**************9777788887888777767777777888888888888888888888888888888888777777 PP
   S: 42   ..............................CPlC 45
                                         CP C
   Q: 98   gvrvfppamppppthlspalapvprnscitCPQC 131
           7777777777777777777777777777777777 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions (By similarity). May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
 E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions (By similarity). May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
Protein Sequence
(Fasta)
MEEMEEELKC PVCGSFYREP IILPCSHNLC QACARNILVQ TPESESPQSR RASGSGVSDY 60
DYLDLDKMSL YSEADSGYGS YGGFASAPTT PCQKSPNGVR VFPPAMPPPP THLSPALAPV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105306|E3,RING|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAGCGCGTC CTGGGGAGTC GGCGCCTAGG CGACGCGGAA AGGCGCCACC ACCGCCGCCG 60
CTGGCCAAGG TGCTGGACAC CACAGGCCTA TCGACTGCTT CGCCAGGTCA GGCCCCCTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105306|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0965--Cell junction
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0770--Synapse
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003649--Bbox_C
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50853--FN3
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00041--fn3
PF00622--SPRY
PF00643--zf-B_box
SMART

SM00502--BBC
SM00336--BBOX
SM00060--FN3
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0008021--C:synaptic vesicle
GO:0000149--F:SNARE binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045955--P:negative regulation of calcium ion-dependent exocytosis
GO:0035544--P:negative regulation of SNARE complex assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016079--P:synaptic vesicle exocytosis
KEGG rno:155812
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002033 Ailuropoda melanoleuca 95.88 0.00e+00 886.00
IUUC-Apl-004004 Anas platyrhynchos 91.90 0.00e+00 1146.00
IUUC-Aca-004773 Anolis carolinensis 65.05 0.00e+00 977.00
IUUC-Ame-011775 Astyanax mexicanus 81.64 0.00e+00 910.00
IUUC-Bta-013184 Bos taurus 97.61 0.00e+00 1420.00
IUUC-Cel-018432 Caenorhabditis elegans 36.80 3.00e-132 465.00
IUUC-Cja-019517 Callithrix jacchus 66.20 0.00e+00 975.00
IUUC-Cfa-020744 Canis familiaris 98.50 0.00e+00 1060.00
IUUC-Cpo-021775 Cavia porcellus 99.25 0.00e+00 1045.00
IUUC-Csa-024085 Chlorocebus sabaeus 99.25 0.00e+00 1065.00
IUUC-Cho-024738 Choloepus hoffmanni 86.15 9.00e-126 443.00
IUUC-Cin-025387 Ciona intestinalis 48.34 1.00e-169 589.00
IUUC-Csv-025851 Ciona savignyi 44.79 0.00e+00 644.00
IUUC-Dre-027691 Danio rerio 83.10 0.00e+00 1276.00
IUUC-Dno-029047 Dasypus novemcinctus 98.17 0.00e+00 1429.00
IUUC-Dor-030823 Dipodomys ordii 82.58 0.00e+00 820.00
IUUC-Dme-031822 Drosophila melanogaster 46.36 6.00e-167 580.00
IUUC-Ete-032674 Echinops telfairi 57.54 0.00e+00 848.00
IUUC-Eca-034107 Equus caballus 67.79 0.00e+00 970.00
IUUC-Eeu-034494 Erinaceus europaeus 97.92 0.00e+00 767.00
IUUC-Fca-036046 Felis catus 93.12 0.00e+00 981.00
IUUC-Fal-036997 Ficedula albicollis 75.89 0.00e+00 788.00
IUUC-Gmo-039639 Gadus morhua 77.17 0.00e+00 1165.00
IUUC-Gga-040951 Gallus gallus 91.40 0.00e+00 1332.00
IUUC-Gac-041390 Gasterosteus aculeatus 78.32 0.00e+00 1208.00
IUUC-Ggo-045059 Gorilla gorilla 98.88 0.00e+00 1063.00
IUUC-Hsa-046503 Homo sapiens 97.89 0.00e+00 1426.00
IUUC-Itr-049084 Ictidomys tridecemlineatus 98.88 0.00e+00 1043.00
IUUC-Lch-049521 Latimeria chalumnae 93.82 0.00e+00 1004.00
IUUC-Loc-052213 Lepisosteus oculatus 83.24 0.00e+00 1230.00
IUUC-Laf-054442 Loxodonta africana 98.31 0.00e+00 1431.00
IUUC-Mcc-054887 Macaca mulatta 98.17 0.00e+00 1429.00
IUUC-Meu-056251 Macropus eugenii 88.20 0.00e+00 936.00
IUUC-Mga-059961 Meleagris gallopavo 75.91 0.00e+00 767.00
IUUC-Mmr-061677 Microcebus murinus 98.73 0.00e+00 1436.00
IUUC-Mdo-062987 Monodelphis domestica 96.07 0.00e+00 1044.00
IUUC-Mmu-063314 Mus musculus 94.40 0.00e+00 1361.00
IUUC-Mpu-066785 Mustela putorius furo 98.50 0.00e+00 1060.00
IUUC-Mlu-067137 Myotis lucifugus 98.17 0.00e+00 1428.00
IUUC-Nle-070127 Nomascus leucogenys 98.31 0.00e+00 1431.00
IUUC-Opr-070763 Ochotona princeps 84.86 0.00e+00 1288.00
IUUC-Ont-071416 Oreochromis niloticus 84.47 0.00e+00 1286.00
IUUC-Oan-072901 Ornithorhynchus anatinus 92.22 1.00e-138 486.00
IUUC-Ocu-074241 Oryctolagus cuniculus 99.06 0.00e+00 1067.00
IUUC-Ola-086349 Oryzias latipes 79.72 1.00e-103 369.00
IUUC-Oga-088969 Otolemur garnettii 98.50 0.00e+00 1061.00
IUUC-Oar-089807 Ovis aries 96.76 0.00e+00 1401.00
IUUC-Ptr-090952 Pan troglodytes 98.13 0.00e+00 1048.00
IUUC-Pan-092565 Papio anubis 89.65 0.00e+00 1386.00
IUUC-Psi-093885 Pelodiscus sinensis 92.57 0.00e+00 935.00
IUUC-Pfo-096684 Poecilia formosa 83.10 0.00e+00 1280.00
IUUC-Pab-097638 Pongo abelii 98.31 0.00e+00 1425.00
IUUC-Pca-101102 Procavia capensis 97.75 0.00e+00 1048.00
IUUC-Pva-103204 Pteropus vampyrus 96.15 9.00e-144 504.00
IUUC-Sha-106771 Sarcophilus harrisii 75.16 0.00e+00 786.00
IUUC-Sar-113631 Sorex araneus 97.94 0.00e+00 1046.00
IUUC-Sbi-114403 Sorghum bicolor 26.89 5.00e-05 42.00
IUUC-Ssc-115634 Sus scrofa 97.89 0.00e+00 1426.00
IUUC-Tgu-117319 Taeniopygia guttata 71.48 0.00e+00 885.00
IUUC-Tru-117583 Takifugu rubripes 84.08 0.00e+00 1274.00
IUUC-Tsy-119427 Tarsius syrichta 96.54 2.00e-145 509.00
IUUC-Tni-120847 Tetraodon nigroviridis 83.78 0.00e+00 1274.00
IUUC-Tbe-127239 Tupaia belangeri 97.36 0.00e+00 674.00
IUUC-Ttr-129238 Tursiops truncatus 94.23 1.00e-138 486.00
IUUC-Vpa-130241 Vicugna pacos 95.47 0.00e+00 984.00
IUUC-Xtr-131998 Xenopus tropicalis 89.78 0.00e+00 1317.00
Created Date 25-Jun-2017

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