iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.30e-28	96.8	172	202
UBD/Beta-Prp	1.20e-73	249.1	102	429

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H d+vtclaf ++  +l+sGs+D t+k++D+
   Q: 172  HVDEVTCLAFhPTeQILASGSRDYTLKLFDY 202
           9**********77799**************7 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.......................lrslsgheaevtavkfspdgkilvt 69
           ++ ++hk+++++ ++s+d++l+atgs+d++ik+ d++++ +                       +r+l++h +evt++ f+p+++il++
   Q: 102  CYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAksampievmmnetaqqnmenhpvIRTLYDHVDEVTCLAFHPTEQILAS 190
           67889*********************************988************************************************ PP
   S: 70   gseDrtikvwdlstgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvs 154
           gs+D+t+k++d+s+++  +++k  ++ ++++s+sf+psgd++++G+++ t+r++d++t qc+ +  ++++h++++++v+++p++n++v+
   Q: 191  GSRDYTLKLFDYSKPSAKRAFKyiQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVScnPQDQHTDAICSVNYNPSANMYVT 279
           *****************99999999***************************************99*********************** PP
   S: 155  GslDrtvrlWdlktgkllrtltgghtdsvysls.fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs....pnderlv 238
           Gs+D++++lWd  ++++++t++++h+++  + + f++n+k+++s ++d+  klw+++tg+++++++g     ++v+ +    +++e ++
   Q: 280  GSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAiFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTqavfNHTEDYI 368
           *********************9999998777666***********************************99999888877789****** PP
   S: 239  sgssDgsiri..Wdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkn 297
              ++++i++  Wd+r+ +  + l+l +++++ + v+s++++ ++++s+d ++++w  +++
   Q: 369  LLPDERTISLccWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRST 429
           ********9888********************************************98765 PP

Organism

Mus musculus

Functional Description
(View)

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity).

Protein Sequence
(Fasta)

MYRTKVGLKD RQQLYKLIIS QLLYDGYISI ANGLINEIKP QSVCAPSEQL LHLIKLGMEN 60
DDTAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE TCYVTSHKGP CRVATYSRDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAGCTGTCG GAGCCCGGAA GTGGTGCACC AACGGCCCGT CCGATCTGCG GCCGTTCTAT 60
CGCCCGCCGT GCTCCCCAGG ATCAGGCGTT CGCCAGTCAC ACACAGCCCT TTGGATTCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0507--mRNA processing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR032028--CSTF1_dimer
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF16699--CSTF1_dimer
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0006397--P:mRNA processing

KEGG

mmu:67337

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002163	Ailuropoda melanoleuca	99.77	0.00e+00	907.00
IUUC-Atr-002687	Amborella trichopoda	38.16	2.00e-67	249.00
IUUC-Apl-003438	Anas platyrhynchos	98.14	0.00e+00	894.00
IUUC-Aca-005178	Anolis carolinensis	97.22	0.00e+00	889.00
IUUC-Aly-005791	Arabidopsis lyrata	37.03	2.00e-79	289.00
IUUC-Ath-006689	Arabidopsis thaliana	38.21	4.00e-80	291.00
IUUC-Ame-011217	Astyanax mexicanus	92.25	3.00e-163	566.00
IUUC-Bta-012619	Bos taurus	99.54	0.00e+00	906.00
IUUC-Bdi-014515	Brachypodium distachyon	43.12	6.00e-79	287.00
IUUC-Bra-017450	Brassica rapa	36.49	2.00e-74	273.00
IUUC-Cel-018151	Caenorhabditis elegans	51.97	2.00e-133	468.00
IUUC-Cja-019304	Callithrix jacchus	99.54	0.00e+00	905.00
IUUC-Cfa-020208	Canis familiaris	99.77	0.00e+00	907.00
IUUC-Cpo-022245	Cavia porcellus	99.77	0.00e+00	907.00
IUUC-Csa-023066	Chlorocebus sabaeus	99.54	0.00e+00	905.00
IUUC-Cho-024770	Choloepus hoffmanni	99.73	0.00e+00	789.00
IUUC-Cin-025621	Ciona intestinalis	57.14	8.00e-152	530.00
IUUC-Csv-026071	Ciona savignyi	60.14	5.00e-163	567.00
IUUC-Dre-028254	Danio rerio	90.02	0.00e+00	832.00
IUUC-Dno-029903	Dasypus novemcinctus	99.77	0.00e+00	907.00
IUUC-Dor-030423	Dipodomys ordii	99.54	0.00e+00	907.00
IUUC-Dme-031993	Drosophila melanogaster	55.11	4.00e-133	468.00
IUUC-Ete-032689	Echinops telfairi	98.66	2.00e-82	299.00
IUUC-Eca-033316	Equus caballus	99.54	0.00e+00	906.00
IUUC-Eeu-035001	Erinaceus europaeus	94.66	0.00e+00	863.00
IUUC-Fca-036447	Felis catus	99.77	0.00e+00	907.00
IUUC-Fal-037601	Ficedula albicollis	98.14	0.00e+00	894.00
IUUC-Gmo-038531	Gadus morhua	88.22	0.00e+00	801.00
IUUC-Gga-040869	Gallus gallus	97.91	0.00e+00	893.00
IUUC-Gac-042380	Gasterosteus aculeatus	89.40	0.00e+00	822.00
IUUC-Gma-043478	Glycine max	38.81	2.00e-83	303.00
IUUC-Ggo-045302	Gorilla gorilla	99.54	0.00e+00	905.00
IUUC-Hsa-045678	Homo sapiens	99.54	0.00e+00	905.00
IUUC-Hvu-047301	Hordeum vulgare	43.62	6.00e-81	294.00
IUUC-Itr-048259	Ictidomys tridecemlineatus	99.77	0.00e+00	907.00
IUUC-Lch-050319	Latimeria chalumnae	94.43	0.00e+00	867.00
IUUC-Lpe-051440	Leersia perrieri	40.45	2.00e-66	246.00
IUUC-Loc-052035	Lepisosteus oculatus	91.65	0.00e+00	842.00
IUUC-Laf-054275	Loxodonta africana	99.77	0.00e+00	907.00
IUUC-Mcc-055857	Macaca mulatta	86.31	0.00e+00	751.00
IUUC-Meu-056194	Macropus eugenii	99.37	5.00e-92	330.00
IUUC-Mtr-058667	Medicago truncatula	38.32	7.00e-76	277.00
IUUC-Mga-059710	Meleagris gallopavo	97.91	0.00e+00	893.00
IUUC-Mmr-060604	Microcebus murinus	99.77	0.00e+00	907.00
IUUC-Mdo-062953	Monodelphis domestica	99.07	0.00e+00	903.00
IUUC-Mac-064568	Musa acuminata	44.14	4.00e-78	284.00
IUUC-Mpu-066294	Mustela putorius furo	67.79	8.00e-164	570.00
IUUC-Mlu-067995	Myotis lucifugus	98.84	0.00e+00	897.00
IUUC-Nle-069322	Nomascus leucogenys	99.54	0.00e+00	905.00
IUUC-Opr-070580	Ochotona princeps	99.30	0.00e+00	904.00
IUUC-Ont-072554	Oreochromis niloticus	91.88	0.00e+00	845.00
IUUC-Oan-072856	Ornithorhynchus anatinus	98.61	0.00e+00	899.00
IUUC-Ocu-074150	Oryctolagus cuniculus	87.96	0.00e+00	766.00
IUUC-Oba-075585	Oryza barthii	36.60	3.00e-69	255.00
IUUC-Obr-076069	Oryza brachyantha	38.46	1.00e-74	273.00
IUUC-Ogl-077045	Oryza glaberrima	39.74	2.00e-79	289.00
IUUC-Ogu-078697	Oryza glumaepatula	39.74	4.00e-75	276.00
IUUC-Oin-080119	Oryza indica	39.74	2.00e-79	289.00
IUUC-Olo-081093	Oryza longistaminata	31.56	7.00e-44	173.00
IUUC-Ome-081718	Oryza meridionalis	32.82	5.00e-56	212.00
IUUC-Oni-082072	Oryza nivara	36.60	3.00e-69	255.00
IUUC-Opu-084080	Oryza punctata	34.71	2.00e-56	213.00
IUUC-Oru-085070	Oryza rufipogon	36.88	1.00e-68	255.00
IUUC-Osa-086149	Oryza sativa	39.74	2.00e-79	289.00
IUUC-Ola-086697	Oryzias latipes	91.42	0.00e+00	844.00
IUUC-Oga-088697	Otolemur garnettii	99.77	0.00e+00	907.00
IUUC-Oar-089774	Ovis aries	99.77	0.00e+00	907.00
IUUC-Ptr-090924	Pan troglodytes	99.54	0.00e+00	905.00
IUUC-Pan-092373	Papio anubis	99.54	0.00e+00	904.00
IUUC-Psi-094001	Pelodiscus sinensis	97.91	0.00e+00	892.00
IUUC-Pma-094274	Petromyzon marinus	73.89	0.00e+00	695.00
IUUC-Ppa-095562	Physcomitrella patens	36.18	2.00e-80	293.00
IUUC-Pfo-097235	Poecilia formosa	91.42	0.00e+00	841.00
IUUC-Pab-098608	Pongo abelii	99.54	0.00e+00	905.00
IUUC-Pca-100268	Procavia capensis	99.54	0.00e+00	906.00
IUUC-Ppe-101425	Prunus persica	41.56	1.00e-82	300.00
IUUC-Pva-103183	Pteropus vampyrus	99.77	0.00e+00	907.00
IUUC-Rno-105097	Rattus norvegicus	100.00	0.00e+00	907.00
IUUC-Sha-107642	Sarcophilus harrisii	99.07	0.00e+00	903.00
IUUC-Smo-108680	Selaginella moellendorffii	35.83	2.00e-77	283.00
IUUC-Sit-110471	Setaria italica	40.89	5.00e-82	298.00
IUUC-Sly-111143	Solanum lycopersicum	33.89	2.00e-33	135.00
IUUC-Stu-111926	Solanum tuberosum	44.10	5.00e-33	133.00
IUUC-Sar-112947	Sorex araneus	100.00	7.00e-175	605.00
IUUC-Sbi-113769	Sorghum bicolor	42.73	3.00e-79	288.00
IUUC-Ssc-115736	Sus scrofa	99.77	0.00e+00	907.00
IUUC-Tgu-117457	Taeniopygia guttata	98.14	0.00e+00	894.00
IUUC-Tru-117760	Takifugu rubripes	91.18	0.00e+00	842.00
IUUC-Tsy-118943	Tarsius syrichta	98.84	0.00e+00	893.00
IUUC-Tni-120081	Tetraodon nigroviridis	91.88	0.00e+00	846.00
IUUC-Tca-121190	Theobroma cacao	40.19	5.00e-86	311.00
IUUC-Tae-125535	Triticum aestivum	44.51	8.00e-84	304.00
IUUC-Tur-126329	Triticum urartu	44.51	2.00e-83	303.00
IUUC-Tbe-127878	Tupaia belangeri	98.35	0.00e+00	880.00
IUUC-Ttr-128985	Tursiops truncatus	99.77	0.00e+00	907.00
IUUC-Vpa-130147	Vicugna pacos	99.54	0.00e+00	905.00
IUUC-Vvi-130935	Vitis vinifera	39.07	5.00e-85	308.00
IUUC-Xtr-132482	Xenopus tropicalis	95.13	0.00e+00	870.00
IUUC-Xma-133929	Xiphophorus maculatus	91.42	0.00e+00	841.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence