iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000101336.12	ENST00000375862.6	ENSP00000365022.2
ENSG00000101336.12	ENST00000486475.5	ENSP00000420457.1
ENSG00000101336.12	ENST00000262651.3	ENSP00000262651.3
ENSG00000101336.12	ENST00000375852.2	ENSP00000365012.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
AREsite	circRNADb	CircNet	microRNA
TRANSFAC	RepTar	miRcode	RAID2
Protein-protein Interaction
HINT	InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.30e-15	58.8	82	137

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            v +lydyea + ++L+++kGd++ v+   e++++W+k+ + ++ k+G +P+n+v++++
   Q: 82   IVVALYDYEAIHHEDLSFQKGDQMVVL---EESGEWWKARSLATRKEGYIPSNYVARVD 137
           689************************...99*************************97 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

LGGRSSCEDP GCPRDEERAP RMGCMKSKFL QVGGNTFSKT ETSASPHCPV YVPDPTSTIK 60
PGPNSHNSNT PGIREAGSED IIVVALYDYE AIHHEDLSFQ KGDQMVVLEE SGEWWKARSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGTTAGCC TCGCTCAGGG CGCGGCTAAG GCGCCCAGAT GGCCTGCGGG CGCCACCACG 60
TCCCTGGTCC CAGCTCGGGA GCACATCAGA GGCTTAGAGG CGAGTGGGAA GGGACTCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	30.62	9.00e-22	99.40
IUUC-Aml-001284	Ailuropoda melanoleuca	90.70	0.00e+00	987.00
IUUC-Apl-003285	Anas platyrhynchos	78.45	0.00e+00	815.00
IUUC-Aca-004724	Anolis carolinensis	78.24	0.00e+00	798.00
IUUC-Ame-011954	Astyanax mexicanus	75.74	0.00e+00	773.00
IUUC-Bta-013060	Bos taurus	91.25	0.00e+00	999.00
IUUC-Bdi-014122	Brachypodium distachyon	31.40	7.00e-22	99.40
IUUC-Cja-019817	Callithrix jacchus	95.26	0.00e+00	984.00
IUUC-Cfa-020511	Canis familiaris	91.44	0.00e+00	998.00
IUUC-Cpo-022538	Cavia porcellus	90.53	0.00e+00	951.00
IUUC-Csa-024143	Chlorocebus sabaeus	98.02	0.00e+00	1031.00
IUUC-Dre-028157	Danio rerio	75.74	0.00e+00	795.00
IUUC-Dno-029761	Dasypus novemcinctus	89.31	0.00e+00	939.00
IUUC-Eca-034090	Equus caballus	88.40	0.00e+00	958.00
IUUC-Fca-035937	Felis catus	88.76	0.00e+00	939.00
IUUC-Fal-036624	Ficedula albicollis	78.24	0.00e+00	806.00
IUUC-Gmo-039009	Gadus morhua	72.48	0.00e+00	759.00
IUUC-Gga-040296	Gallus gallus	78.90	0.00e+00	785.00
IUUC-Gac-042362	Gasterosteus aculeatus	74.12	0.00e+00	786.00
IUUC-Ggo-044570	Gorilla gorilla	99.62	0.00e+00	1085.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	87.64	0.00e+00	949.00
IUUC-Loc-052904	Lepisosteus oculatus	78.30	0.00e+00	825.00
IUUC-Laf-053654	Loxodonta africana	89.96	0.00e+00	939.00
IUUC-Mcc-055317	Macaca mulatta	98.02	0.00e+00	1033.00
IUUC-Mga-060194	Meleagris gallopavo	80.89	0.00e+00	769.00
IUUC-Mmr-061510	Microcebus murinus	89.50	0.00e+00	943.00
IUUC-Mdo-062035	Monodelphis domestica	83.50	0.00e+00	877.00
IUUC-Mmu-064037	Mus musculus	89.73	0.00e+00	984.00
IUUC-Mpu-066874	Mustela putorius furo	90.69	0.00e+00	954.00
IUUC-Mlu-068202	Myotis lucifugus	86.96	0.00e+00	899.00
IUUC-Nle-069222	Nomascus leucogenys	98.02	0.00e+00	1022.00
IUUC-Opr-070705	Ochotona princeps	87.64	0.00e+00	971.00
IUUC-Ont-072347	Oreochromis niloticus	82.74	0.00e+00	771.00
IUUC-Ocu-074490	Oryctolagus cuniculus	89.11	0.00e+00	928.00
IUUC-Ola-086521	Oryzias latipes	81.61	0.00e+00	781.00
IUUC-Oga-088153	Otolemur garnettii	92.09	0.00e+00	969.00
IUUC-Oar-090184	Ovis aries	90.02	0.00e+00	964.00
IUUC-Ptr-090505	Pan troglodytes	96.01	0.00e+00	1033.00
IUUC-Pan-092260	Papio anubis	98.22	0.00e+00	1036.00
IUUC-Pma-094311	Petromyzon marinus	75.73	0.00e+00	734.00
IUUC-Pfo-096566	Poecilia formosa	75.49	0.00e+00	796.00
IUUC-Pab-097908	Pongo abelii	79.28	0.00e+00	825.00
IUUC-Pva-103021	Pteropus vampyrus	90.50	0.00e+00	949.00
IUUC-Rno-105309	Rattus norvegicus	89.70	0.00e+00	940.00
IUUC-Sha-107099	Sarcophilus harrisii	83.01	0.00e+00	876.00
IUUC-Tgu-116912	Taeniopygia guttata	78.22	0.00e+00	797.00
IUUC-Tru-118449	Takifugu rubripes	81.35	0.00e+00	764.00
IUUC-Tae-123192	Triticum aestivum	31.01	3.00e-22	100.00
IUUC-Tur-126022	Triticum urartu	31.01	3.00e-22	100.00
IUUC-Tbe-128144	Tupaia belangeri	77.57	0.00e+00	823.00
IUUC-Xma-133902	Xiphophorus maculatus	75.30	0.00e+00	792.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence