iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063950

UUCD1 version

UUC-MuM-00006

Ensembl Protein ID

ENSMUSP00000107732.1

UniProt Accession

O70583; B1AV00; O35418; Q7TPT6; TRI18_MOUSE

Genbank Protein ID

CAA75113.1; AAB83986.1; CAM15638.1; CAM15638.1; CAM28195.1; CAM28195.1; AAH53704.1

Protein Name

E3 ubiquitin-protein ligase Midline-1; Midin; RING finger protein Midline-1; RING-type E3 ubiquitin transferase Midline-1; Tripartite motif-containing protein 18

Genbank Nucleotide ID

Y14848; AF026565; AL672015; CR478112; CR478112; AL672015; BC053704

Gene Name

Mid1; Fxy; Trim18

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000035299.16	ENSMUST00000112104.7	ENSMUSP00000107732.1
ENSMUSG00000035299.16	ENSMUST00000078947.11	ENSMUSP00000077974.5
ENSMUSG00000035299.16	ENSMUST00000112107.7	ENSMUSP00000107735.1
ENSMUSG00000035299.16	ENSMUST00000079443.5	ENSMUSP00000078412.5

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20181585

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.20e-07	33.2	10	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw......pglknssskefrCPlCr 46
           C+iCle f+d pl+lpC H  +++C +++       + + +s ++f+CP+Cr
   Q: 10   CPICLELFED-PLLLPCAHSLCFNCAHRIlvshcaTNEPVESINAFQCPTCR 60
           **********.999************99999****999999**********8 PP

Organism

Mus musculus

Functional Description
(View)

Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.

Protein Sequence
(Fasta)

METLESELTC PICLELFEDP LLLPCAHSLC FNCAHRILVS HCATNEPVES INAFQCPTCR 60
HVITLSQRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSET RRERAFDANT MSSAEKVLCQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTCCCAGC TGGACAGAGC AAGCTTCCTG AACGCCCCAG CCATTCAGCT GATCCGAGGC 60
GAAGAGCAGT CTGTACTTGC CCCGGAGCAG CCTCCTTGGA GGACCCACAG GTTTGATTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0479--Metal-binding
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003649--Bbox_C
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR027727--MID1
IPR006574--PRY
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50853--FN3
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00041--fn3
PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00502--BBC
SM00336--BBOX
SM00060--FN3
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005881--C:cytoplasmic microtubule
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0042802--F:identical protein binding
GO:0008017--F:microtubule binding
GO:0051219--F:phosphoprotein binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0016740--F:transferase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0032874--P:positive regulation of stress-activated MAPK cascade
GO:0035372--P:protein localization to microtubule

KEGG

mmu:17318

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001734	Ailuropoda melanoleuca	91.03	0.00e+00	1265.00
IUUC-Apl-004060	Anas platyrhynchos	90.41	0.00e+00	1262.00
IUUC-Aca-005182	Anolis carolinensis	90.29	0.00e+00	1269.00
IUUC-Ame-010973	Astyanax mexicanus	78.23	0.00e+00	1108.00
IUUC-Bta-013266	Bos taurus	92.94	0.00e+00	1296.00
IUUC-Cja-019993	Callithrix jacchus	93.24	0.00e+00	1295.00
IUUC-Cfa-020747	Canis familiaris	93.09	0.00e+00	1299.00
IUUC-Cpo-021998	Cavia porcellus	93.53	0.00e+00	1305.00
IUUC-Csa-023229	Chlorocebus sabaeus	93.38	0.00e+00	1303.00
IUUC-Cin-025118	Ciona intestinalis	40.94	9.00e-154	537.00
IUUC-Csv-026320	Ciona savignyi	40.96	1.00e-152	533.00
IUUC-Dre-027831	Danio rerio	75.76	0.00e+00	1075.00
IUUC-Dno-028977	Dasypus novemcinctus	92.65	0.00e+00	1294.00
IUUC-Dor-030720	Dipodomys ordii	97.90	0.00e+00	837.00
IUUC-Ete-032898	Echinops telfairi	85.15	0.00e+00	1161.00
IUUC-Eca-033732	Equus caballus	92.79	0.00e+00	1295.00
IUUC-Fca-036267	Felis catus	93.09	0.00e+00	1300.00
IUUC-Fal-037274	Ficedula albicollis	90.56	0.00e+00	1263.00
IUUC-Gga-040837	Gallus gallus	90.27	0.00e+00	1256.00
IUUC-Gac-041958	Gasterosteus aculeatus	78.14	0.00e+00	1136.00
IUUC-Ggo-044572	Gorilla gorilla	83.72	0.00e+00	1177.00
IUUC-Hsa-045947	Homo sapiens	93.38	0.00e+00	1303.00
IUUC-Lch-049502	Latimeria chalumnae	87.73	0.00e+00	1032.00
IUUC-Loc-052454	Lepisosteus oculatus	85.90	0.00e+00	1192.00
IUUC-Laf-053708	Loxodonta africana	93.54	0.00e+00	1313.00
IUUC-Mcc-055664	Macaca mulatta	93.24	0.00e+00	1300.00
IUUC-Meu-056180	Macropus eugenii	86.32	0.00e+00	1199.00
IUUC-Mga-059764	Meleagris gallopavo	89.71	0.00e+00	1242.00
IUUC-Mmr-060771	Microcebus murinus	92.94	0.00e+00	1298.00
IUUC-Mdo-062566	Monodelphis domestica	91.18	0.00e+00	1276.00
IUUC-Mpu-065690	Mustela putorius furo	92.79	0.00e+00	1296.00
IUUC-Mlu-067067	Myotis lucifugus	90.95	0.00e+00	1291.00
IUUC-Nle-069446	Nomascus leucogenys	93.24	0.00e+00	1302.00
IUUC-Ont-072567	Oreochromis niloticus	79.68	0.00e+00	1118.00
IUUC-Oan-073348	Ornithorhynchus anatinus	90.59	0.00e+00	1268.00
IUUC-Ola-087138	Oryzias latipes	77.91	0.00e+00	1109.00
IUUC-Oga-088162	Otolemur garnettii	92.79	0.00e+00	1298.00
IUUC-Oar-090200	Ovis aries	91.67	0.00e+00	1296.00
IUUC-Ptr-091126	Pan troglodytes	93.24	0.00e+00	1296.00
IUUC-Pan-091898	Papio anubis	93.38	0.00e+00	1303.00
IUUC-Psi-093184	Pelodiscus sinensis	89.56	0.00e+00	1262.00
IUUC-Pma-094517	Petromyzon marinus	25.69	2.00e-50	194.00
IUUC-Pfo-097477	Poecilia formosa	78.27	0.00e+00	1117.00
IUUC-Pab-098582	Pongo abelii	93.24	0.00e+00	1301.00
IUUC-Pca-100517	Procavia capensis	97.63	0.00e+00	738.00
IUUC-Pva-103254	Pteropus vampyrus	94.86	0.00e+00	1078.00
IUUC-Rno-105259	Rattus norvegicus	93.68	0.00e+00	1301.00
IUUC-Sha-107060	Sarcophilus harrisii	91.39	0.00e+00	1267.00
IUUC-Sar-113538	Sorex araneus	91.15	0.00e+00	1273.00
IUUC-Ssc-115887	Sus scrofa	92.79	0.00e+00	1295.00
IUUC-Tgu-116818	Taeniopygia guttata	90.56	0.00e+00	1263.00
IUUC-Tru-117868	Takifugu rubripes	78.65	0.00e+00	1075.00
IUUC-Tsy-119648	Tarsius syrichta	93.38	0.00e+00	1303.00
IUUC-Tni-120841	Tetraodon nigroviridis	77.37	0.00e+00	1099.00
IUUC-Tbe-127963	Tupaia belangeri	87.94	0.00e+00	1242.00
IUUC-Ttr-129089	Tursiops truncatus	92.65	0.00e+00	1293.00
IUUC-Vpa-130092	Vicugna pacos	89.12	0.00e+00	1226.00
IUUC-Xtr-132778	Xenopus tropicalis	87.46	0.00e+00	1033.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence