iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000103194.15	ENST00000219473.11	ENSP00000219473.7
ENSG00000103194.15	ENST00000563892.5	ENSP00000458089.1
ENSG00000103194.15	ENST00000540269.6	ENSP00000445589.2
ENSG00000103194.15	ENST00000562283.5	ENSP00000455712.1
ENSG00000103194.15	ENST00000563048.5	ENSP00000454902.1
ENSG00000103194.15	ENST00000570191.5	ENSP00000457411.1
ENSG00000103194.15	ENST00000563386.5	ENSP00000454943.1
ENSG00000103194.15	ENST00000569038.5	ENSP00000462762.1
ENSG00000103194.15	ENST00000570053.1	ENSP00000454751.1
ENSG00000103194.15	ENST00000569925.1	ENSP00000454987.1
ENSG00000103194.15	ENST00000567526.1	ENSP00000455865.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	21245042; 20096447

Classification

Family	E-value	Score	Start	End
DUB/USP	2.90e-69	235.5	416	794

Active Site

Position(s)	Description	Evidence
424	Nucleophile
749	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw......kskkk.............avsprell 74
           Gl N gN CY+N++LQ+L+++p++ +l++   +   +  +++ +++++++s+ +l++e++      k ++              a++p+ ++
   Q: 416  GLINKGNWCYINATLQALVACPPMYHLMKF-IPLYSK-VQRPCTSTPMIDSFVRLMNEFTnmpvppKPRQAlgdkivrdirpgaAFEPTYIY 505
           9***************************99.333333.334799***************7666654333337777888888888******** PP
   S: 75   kalkkeaeefs.gyeqqDaqEflaflldqleeelkk.................eknkpkeeeeeedkselsdeaeekkkkknk......... 139
           + l   ++++s + +q+Da+E+l f+l++l+ee+ +                  kn++++eee+e++ e s++++e+   +nk         
   Q: 506  RLLTVNKSSLSeKGRQEDAEEYLGFILNGLHEEMLNlkkllspsnekltisngPKNHSVNEEEQEEQGEGSEDEWEQVGPRNKtsvtrqadf 597
           ***99999866599********************5456689999999999999888888888888888888887777777777777777778 PP
   S: 140  ..slisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPev 229
             ++i+ +F+g+++ +++ ++  ++s + +pf++l+l++++++ +   ++qd+Les +++e+++g    y++k k+++e +++++l+klP+v
   Q: 598  vqTPITGIFGGHIR-SVVYQQSSKESATLQPFFTLQLDIQSDKIR---TVQDALESLVARESVQG----YTTKTKQEVEISRRVTLEKLPPV 681
           88***********9.688999999*******************99...****************8....99999****************** PP
   S: 230  LilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke...kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVte 316
           L+lhLkRf ++++++++ k+ k++e+p  L++s+ + sp  k+k+   +++Y+L+avv+H+G s+ +GHY+++v +   + Wl++dD++V++
   Q: 682  LVLHLKRFVYEKTGGCQ-KLIKNIEYPVDLEISKELLSPGVKNKNfkcHRTYRLFAVVYHHGnSATGGHYTTDVFQIGLNgWLRIDDQTVKV 772
           **********9998886.****************999988777777879***************************87777*********** PP
   S: 317  vkeeevleetg.staYvlfYkr 337
           +++ +v++ t+ +taY+l+Y+r
   Q: 773  INQYQVVKPTAeRTAYLLYYRR 794
           ********9889********98 PP

Organism

Homo sapiens

Functional Description
(View)

Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989).

Protein Sequence
(Fasta)

MALHSPQYIF GDFSPDEFNQ FFVTPRSSVE LPPYSGTVLC GTQAVDKLPD GQEYQRIEFG 60
VDEVIEPSDT LPRTPSYSIS STLNPQAPEF ILGCTASKIT PDGITKEASY GSIDCQYPGS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCAGGCGC GGCGGCCGAT GCGAGTGTGT ATGTGCGGGC GAGAAGATGG CGGCGGCGGG 60
GGAAGCAGCG TGAGCAGCCG GAGGATCGCG GAGTCCCAAT GAAACGGGCA GCCATGGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0234--DNA repair
KW-0967--Endosome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR009818--Ataxin-2_C
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF07145--PAM2
PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0004197--F:cysteine-type endopeptidase activity
GO:0044325--F:ion channel binding
GO:0002039--F:p53 binding
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0006914--P:autophagy
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071347--P:cellular response to interleukin-1
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0016579--P:protein deubiquitination
GO:0010506--P:regulation of autophagy
GO:0019985--P:translesion synthesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:9100

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000082	Aegilops tauschii	30.93	3.00e-45	176.00
IUUC-Aml-001584	Ailuropoda melanoleuca	88.51	0.00e+00	1333.00
IUUC-Atr-002927	Amborella trichopoda	35.22	6.00e-58	218.00
IUUC-Apl-003988	Anas platyrhynchos	78.87	0.00e+00	1152.00
IUUC-Aca-004461	Anolis carolinensis	89.22	3.00e-164	570.00
IUUC-Aly-006038	Arabidopsis lyrata	36.15	1.00e-54	207.00
IUUC-Ath-007328	Arabidopsis thaliana	35.90	2.00e-53	203.00
IUUC-Ago-007717	Ashbya gossypii	30.11	5.00e-43	169.00
IUUC-Acl-008188	Aspergillus clavatus	33.12	1.00e-62	234.00
IUUC-Afl-008456	Aspergillus flavus	38.08	2.00e-47	183.00
IUUC-Afu-009067	Aspergillus fumigatus	36.02	4.00e-65	243.00
IUUC-Ani-009483	Aspergillus nidulans	33.41	5.00e-62	233.00
IUUC-Ang-009639	Aspergillus niger	35.20	9.00e-60	225.00
IUUC-Aor-010040	Aspergillus oryzae	35.85	1.00e-59	225.00
IUUC-Ate-010310	Aspergillus terreus	31.79	2.00e-61	230.00
IUUC-Ame-011012	Astyanax mexicanus	73.96	2.00e-162	566.00
IUUC-Bgr-012311	Blumeria graminis	34.59	8.00e-43	169.00
IUUC-Bta-013299	Bos taurus	87.00	0.00e+00	1270.00
IUUC-Bci-013783	Botrytis cinerea	36.76	2.00e-58	220.00
IUUC-Bdi-015039	Brachypodium distachyon	32.06	1.00e-49	191.00
IUUC-Bol-015806	Brassica oleracea	37.50	1.00e-62	234.00
IUUC-Bra-017076	Brassica rapa	37.50	7.00e-63	234.00
IUUC-Cja-018715	Callithrix jacchus	95.83	0.00e+00	1480.00
IUUC-Cfa-020194	Canis familiaris	89.39	0.00e+00	1348.00
IUUC-Cpo-022272	Cavia porcellus	75.16	0.00e+00	1059.00
IUUC-Cre-022713	Chlamydomonas reinhardtii	34.11	3.00e-34	140.00
IUUC-Csa-023310	Chlorocebus sabaeus	97.98	0.00e+00	1507.00
IUUC-Cho-024966	Choloepus hoffmanni	78.73	0.00e+00	961.00
IUUC-Cin-025616	Ciona intestinalis	43.72	3.00e-105	376.00
IUUC-Csv-026043	Ciona savignyi	46.57	3.00e-98	352.00
IUUC-Cgl-026421	Colletotrichum gloeosporioides	33.87	3.00e-46	180.00
IUUC-Cne-026962	Cryptococcus neoformans	34.97	5.00e-50	193.00
IUUC-Cme-027113	Cyanidioschyzon merolae	30.45	2.00e-37	150.00
IUUC-Dre-028072	Danio rerio	78.49	0.00e+00	717.00
IUUC-Dno-029489	Dasypus novemcinctus	88.65	0.00e+00	1368.00
IUUC-Dor-031068	Dipodomys ordii	73.92	3.00e-138	485.00
IUUC-Dse-031553	Dothistroma septosporum	36.18	4.00e-56	213.00
IUUC-Dme-031759	Drosophila melanogaster	40.72	9.00e-83	302.00
IUUC-Ete-032549	Echinops telfairi	77.78	0.00e+00	883.00
IUUC-Eca-033380	Equus caballus	87.52	0.00e+00	1352.00
IUUC-Eeu-034818	Erinaceus europaeus	84.11	0.00e+00	1258.00
IUUC-Fca-035535	Felis catus	86.76	0.00e+00	1204.00
IUUC-Fal-036627	Ficedula albicollis	76.20	0.00e+00	1099.00
IUUC-Fox-037904	Fusarium oxysporum	36.49	1.00e-52	201.00
IUUC-Fso-038170	Fusarium solani	33.71	4.00e-52	200.00
IUUC-Gmo-039499	Gadus morhua	70.59	0.00e+00	667.00
IUUC-Ggr-040042	Gaeumannomyces graminis	35.64	2.00e-61	231.00
IUUC-Gga-040571	Gallus gallus	78.38	0.00e+00	1144.00
IUUC-Gac-041345	Gasterosteus aculeatus	76.51	0.00e+00	662.00
IUUC-Gma-044407	Glycine max	35.04	3.00e-58	219.00
IUUC-Ggo-044652	Gorilla gorilla	99.75	0.00e+00	1572.00
IUUC-Hvu-047071	Hordeum vulgare	32.75	2.00e-52	200.00
IUUC-Itr-048216	Ictidomys tridecemlineatus	90.05	0.00e+00	1014.00
IUUC-Kpa-049132	Komagataella pastoris	30.04	3.00e-45	176.00
IUUC-Lch-050040	Latimeria chalumnae	69.07	0.00e+00	922.00
IUUC-Loc-052449	Lepisosteus oculatus	74.85	0.00e+00	715.00
IUUC-Lma-053248	Leptosphaeria maculans	35.81	4.00e-57	216.00
IUUC-Laf-054121	Loxodonta africana	88.27	0.00e+00	1328.00
IUUC-Mcc-055514	Macaca mulatta	98.23	0.00e+00	1510.00
IUUC-Meu-056873	Macropus eugenii	72.37	0.00e+00	821.00
IUUC-Mor-057243	Magnaporthe oryzae	33.93	2.00e-58	221.00
IUUC-Mpo-057439	Magnaporthe poae	35.90	7.00e-61	229.00
IUUC-Mtr-058457	Medicago truncatula	33.33	1.00e-56	214.00
IUUC-Mla-058929	Melampsora laricipopulina	31.58	2.00e-56	214.00
IUUC-Mga-060157	Meleagris gallopavo	76.79	0.00e+00	1140.00
IUUC-Mvi-060442	Microbotryum violaceum	33.46	7.00e-56	213.00
IUUC-Mmr-061062	Microcebus murinus	92.26	0.00e+00	1456.00
IUUC-Mdo-062798	Monodelphis domestica	80.48	0.00e+00	1209.00
IUUC-Mmu-064050	Mus musculus	83.23	0.00e+00	1282.00
IUUC-Mac-065619	Musa acuminata	34.27	2.00e-53	203.00
IUUC-Mpu-066554	Mustela putorius furo	88.02	0.00e+00	1305.00
IUUC-Mlu-068003	Myotis lucifugus	86.59	0.00e+00	1320.00
IUUC-Nfi-068612	Neosartorya fischeri	34.46	3.00e-63	236.00
IUUC-Ncr-068878	Neurospora crassa	35.14	2.00e-52	201.00
IUUC-Nle-069661	Nomascus leucogenys	99.12	0.00e+00	1536.00
IUUC-Opr-070944	Ochotona princeps	76.27	2.00e-169	589.00
IUUC-Ont-071266	Oreochromis niloticus	58.40	0.00e+00	805.00
IUUC-Oan-073442	Ornithorhynchus anatinus	79.20	0.00e+00	1134.00
IUUC-Ocu-073788	Oryctolagus cuniculus	80.91	0.00e+00	1134.00
IUUC-Oba-075085	Oryza barthii	33.45	1.00e-37	150.00
IUUC-Obr-076663	Oryza brachyantha	32.91	4.00e-46	179.00
IUUC-Ogl-076937	Oryza glaberrima	29.85	5.00e-48	185.00
IUUC-Ogu-078909	Oryza glumaepatula	30.63	3.00e-46	180.00
IUUC-Oin-079617	Oryza indica	30.93	1.00e-47	184.00
IUUC-Olo-081043	Oryza longistaminata	26.04	8.00e-25	108.00
IUUC-Ome-081646	Oryza meridionalis	24.74	1.00e-23	104.00
IUUC-Oni-082914	Oryza nivara	29.57	3.00e-46	179.00
IUUC-Oru-084878	Oryza rufipogon	29.57	4.00e-46	179.00
IUUC-Osa-085822	Oryza sativa	30.93	5.00e-50	192.00
IUUC-Ola-086931	Oryzias latipes	70.35	0.00e+00	667.00
IUUC-Oga-088443	Otolemur garnettii	92.30	0.00e+00	1440.00
IUUC-Oar-089325	Ovis aries	84.49	0.00e+00	1184.00
IUUC-Ptr-091584	Pan troglodytes	96.62	0.00e+00	1475.00
IUUC-Pan-092551	Papio anubis	96.12	0.00e+00	1483.00
IUUC-Psi-093366	Pelodiscus sinensis	74.62	0.00e+00	695.00
IUUC-Pno-095136	Phaeosphaeria nodorum	35.23	8.00e-52	199.00
IUUC-Ppa-095574	Physcomitrella patens	36.22	3.00e-59	223.00
IUUC-Pfo-097462	Poecilia formosa	77.25	0.00e+00	695.00
IUUC-Pab-098547	Pongo abelii	99.25	0.00e+00	1536.00
IUUC-Pop-099529	Populus trichocarpa	36.29	5.00e-61	228.00
IUUC-Pca-101066	Procavia capensis	78.97	0.00e+00	1177.00
IUUC-Ppe-102110	Prunus persica	35.88	7.00e-59	221.00
IUUC-Pva-103015	Pteropus vampyrus	83.23	0.00e+00	1254.00
IUUC-Ptt-103998	Puccinia triticina	32.59	6.00e-53	202.00
IUUC-Pte-104417	Pyrenophora teres	33.92	1.00e-54	208.00
IUUC-Pyt-104820	Pyrenophora triticirepentis	35.20	7.00e-55	209.00
IUUC-Rno-105533	Rattus norvegicus	84.12	0.00e+00	1280.00
IUUC-Sce-106160	Saccharomyces cerevisiae	27.84	1.00e-36	148.00
IUUC-Sha-106590	Sarcophilus harrisii	80.85	0.00e+00	1208.00
IUUC-Sja-107669	Schizosaccharomyces japonicus	35.61	4.00e-57	215.00
IUUC-Spo-108353	Schizosaccharomyces pombe	36.75	5.00e-64	238.00
IUUC-Ssl-108599	Sclerotinia sclerotiorum	36.22	8.00e-58	218.00
IUUC-Smo-108842	Selaginella moellendorffii	35.84	4.00e-37	147.00
IUUC-Sit-110781	Setaria italica	31.75	1.00e-55	211.00
IUUC-Sly-111797	Solanum lycopersicum	33.76	8.00e-55	207.00
IUUC-Stu-112188	Solanum tuberosum	34.77	2.00e-55	210.00
IUUC-Sbi-114862	Sorghum bicolor	33.06	1.00e-45	177.00
IUUC-Sre-115162	Sporisorium reilianum	34.79	3.00e-66	247.00
IUUC-Ssc-115505	Sus scrofa	95.79	1.00e-165	575.00
IUUC-Tgu-116535	Taeniopygia guttata	76.17	0.00e+00	1104.00
IUUC-Tru-117542	Takifugu rubripes	57.41	0.00e+00	811.00
IUUC-Tni-120200	Tetraodon nigroviridis	58.00	0.00e+00	805.00
IUUC-Tca-121548	Theobroma cacao	34.60	2.00e-43	170.00
IUUC-Tre-122124	Trichoderma reesei	33.67	2.00e-61	231.00
IUUC-Tvi-122457	Trichoderma virens	34.85	6.00e-54	206.00
IUUC-Tae-125646	Triticum aestivum	34.18	2.00e-55	210.00
IUUC-Tme-127180	Tuber melanosporum	39.35	3.00e-69	256.00
IUUC-Tbe-127530	Tupaia belangeri	75.35	0.00e+00	1053.00
IUUC-Ttr-128549	Tursiops truncatus	80.08	0.00e+00	1189.00
IUUC-Uma-129381	Ustilago maydis	33.41	1.00e-64	241.00
IUUC-Vda-129889	Verticillium dahliae	32.11	2.00e-52	201.00
IUUC-Vpa-130100	Vicugna pacos	81.61	0.00e+00	1209.00
IUUC-Vvi-131366	Vitis vinifera	35.11	2.00e-62	233.00
IUUC-Xtr-132048	Xenopus tropicalis	63.37	0.00e+00	903.00
IUUC-Xma-133593	Xiphophorus maculatus	77.73	0.00e+00	692.00
IUUC-Yli-134338	Yarrowia lipolytica	30.92	5.00e-33	136.00
IUUC-Zma-135586	Zea mays	31.21	2.00e-48	186.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence